鼻内窥镜手术与传统手术治疗慢性鼻窦炎鼻息肉的疗效对比分析

目的探究鼻内窥镜手术和传统手术治疗慢性鼻窦炎鼻息肉的临床效果。方法选取2013年7月至2015年7月禹州市第二人民医院收治的慢性鼻窦炎鼻息肉患者92例,随机分为两组,各46例。对照组采用传统手术治疗,观察组采用鼻内窥镜手术治疗,对比两组临床治疗有效率和治疗后12个月主要症状评分情况。结果观察组有效率优于对照组(P<0.05);观察组治疗后12个月各项临床症状评分均显著低于对照组(P<0.05)。结论相比于传统手术,采用鼻内窥镜手术治疗慢性鼻窦炎鼻息肉疗效更佳,可有效缓解患者各种症状,值得临床推广。     

鼻内窥镜手术治疗鼻窦炎鼻息肉的临床价值研究

目的探究鼻内窥镜手术治疗鼻窦炎鼻息肉的临床疗效。方法选取我院收治的60例鼻窦炎伴鼻息肉患者,随机分为对照和观察两组,对照组采用常规手术方案,观察组采用鼻内窥镜手术,对比两组治疗效果。结果观察组患者手术时间、术中出血量、住院时间、VAS评分及术后并发症发生率、治疗有效率均明显优于对照组(P0.05)。结论鼻内窥镜手术治疗相较于传统手术方式疗效更为显著。     

鼻内窥镜治疗慢性鼻窦炎鼻息肉58例疗效观察

目的观察鼻内窥镜治疗慢性鼻窦炎鼻息肉的疗效。方法将116例患者随机分为治疗组和对照组。手术前两组均积极完善术前准备及各项实验室理化检查。治疗组58例,采用鼻内窥镜以Messerklinger术式切除鼻息肉。对照组58例采用鼻内窥镜以Wigand术式切除鼻息肉。结果治疗组总有效率96.55%,对照组总有效率85.71%,两组相比结果有统计学意义（P〈0.05）。结论应用鼻内窥镜采用Messerklinger术式治疗慢性鼻窦炎鼻息肉方法简单,疗效好,损伤小,复发率低。     

鼻内窥镜手术与传统手术对慢性鼻窦炎鼻息肉疗效的影响

目的:探讨鼻内窥镜手术与传统手术对慢性鼻窦炎鼻息肉疗效的影响。方法:选取慢性鼻窦炎患者68例,随机分为观察组和对照组各34例,观察组实施鼻内窥镜手术治疗,对照组实施传统手术治疗,比较两组临床疗效。结果:观察组治疗后的总有效率明显高于对照组,两组比较差异有显著性意义(P<0.05)。结论:慢性鼻窦炎鼻息肉采用鼻内窥镜手术治疗疗效满意,值得临床推广应用。     

鼻内镜治疗老年慢性鼻窦炎鼻息肉临床效果分析

目的探讨鼻内镜治疗老年慢性鼻窦炎鼻息肉的临床效果。方法选取50例老年慢性鼻窦炎鼻息肉患者作为临床研究对象。随机分组:对照组25例,采用传统手术治疗;观察组25例,采用鼻内镜下手术治疗。对两组患者的临床疗效以及术后并发症等情况进行对比分析。结果观察组患者的治疗总有效率明显高于对照组,术后并发症发生率明显低于对照组,结果对比差异显著(P0.05)。结论鼻内镜下治疗老年慢性鼻窦炎鼻息肉的临床效果良好,值得推广使用。     

鼻内窥镜治疗慢性鼻窦炎鼻息肉的临床疗效分析

目的：观察鼻内窥镜在治疗慢性鼻窦炎鼻息肉的临床应用效果。方法以60例慢性鼻窦炎鼻息肉患者为研究对象,随机分为2组(n=30)。对照组采用传统手术方式治疗,研究组则使用鼻内窥镜的手术方式进行治疗,就2组患者的临床疗效及并发症发生情况施以比较。结果研究组患者的治疗总有效率为93.33%,显著高于对照组的70.00%,差异有统计学意义（P＜0.05）;研究组患者的术后并发症发生率为6.67%,显著低于对照组的36.67%,差异有统计学意义（P＜0.05）。结论慢性鼻窦炎鼻息肉采用鼻内窥镜治疗较传统术式效果更为确切,且术后并发症较少,临床推广及应用价值较高。     

鼻内窥镜下手术治疗慢性鼻窦炎鼻息肉的临床疗效观察

目的 探究鼻内窥镜下手术治疗慢性鼻窦炎鼻息肉的临床疗效。方法 选取在宜兴市人民医院治疗的慢性鼻窦炎息肉患者80例,均分为对照组和观察组（n=40）。对照组应用传统根治手术治疗;观察组应用鼻内窥镜手术治疗的方法,对比2组患者的治疗效果。结果 观察组患者的总有效率为95.0%,高于对照组的70.0%,差异具有统计学意义（P〈0.05）;观察组患者的慢性鼻窦炎鼻息肉复发率为5.0%,低于对照组的22.5%,差异具有统计学意义（P〈0.05）。结论 鼻内窥镜下手术治疗慢性鼻窦炎鼻息肉,临床效果较好,术后复发率较低,值得临床推广。     

鼻内窥镜微创手术在慢性鼻窦炎并鼻息肉治疗中的临床探讨

目的:探讨鼻内窥镜微创手术在慢性鼻窦炎并鼻息肉治疗中的效果。方法:分析研究对象为2016年7月-2017年7月本院收治的67例慢性鼻窦炎并鼻息肉患者,随机分为对照组(30例)与观察组(37例)。对照组采用传统手术方法治疗,观察组采用鼻内窥镜微创手术治疗。比较不同手术方法的疗效。结果:观察组治疗总有效率、术中出血量、鼻黏膜恢复正常时间及并发症发生率与对照组比较,差异均有统计学意义(P0.05)。结论:鼻内窥镜微创手术治疗慢性鼻窦炎合并鼻息肉,手术创伤小,有利于鼻黏膜早日恢复,具有广泛的临床应用价值。     

鼻内窥镜治疗慢性鼻窦炎鼻息肉76例临床疗效分析

目的:观察鼻内窥镜手术治疗慢性鼻窦炎鼻息肉的临床疗效。方法:随机选取76例慢性鼻窦炎鼻息肉患者,经鼻内窥镜手术治疗,另取76例同期患者采取传统手术治疗,观察对比两组患者临床治疗效果。结果:治疗组总有效率89.47%;对照组总有效率65.79%,两组患者比较有显著性差异(P<0.05)。结论:鼻内窥镜手术治疗慢性鼻窦炎鼻息肉安全可靠、疗效确切,值得临床推广应用。     

鼻内窥镜手术治疗慢性鼻窦炎并鼻息肉的临床疗效分析

目的分析鼻内窥镜手术治疗慢性鼻窦炎并鼻息肉的临床疗效。方法选择我院2010年6月-2011年6月92例慢性鼻窦炎并鼻息肉患者,采用鼻内窥镜下手术,本组患者设为内镜组。选择同期采用传统根治术的患者60例作为对照组,所有患者均进行3-12个月的随访,观察两种手术方法治疗后的效果及术后复发情况。结果内镜组总有效率为92.39%,高于对照组的71.67%,差异有统计学意义（P〈0.05）。随访期间内镜组复发率6.52%（6/92）,对照组复发率18.33%（11/60）,差异有统计学意义（P〈0.05）。结论鼻内窥镜手术治疗慢性鼻窦炎并鼻息肉治愈率高,并发症少,复发率低,安全有效。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.