Diagnostic accuracy of acute maxillary sinusitis in adults in primary care

OBJECTIVE: To evaluate the diagnostic value of symptoms and signs used in diagnosing acute community-acquired maxillary sinusitis (ACAMS), and to find useful clinical predictors for diagnosing it in adults in primary care. DESIGN: Prospective study in the study group and retrospective study in the reference group. SETTING: One primary care centre in the study group and another in the reference group. Subjects: 50 adults with prolonged upper respiratory tract infection > or = 7 days) or self-suspected maxillary sinusitis. As a reference group, an analysis of records and diagnoses made by GP of 45 adult patients with the same inclusion criteria from another primary care clinic. MAIN OUTCOME MEASURES: The signs and symptoms associated with the diagnosis of ACAMS by GP and otorhinolaryngologist. The value of CRP, ultrasound and peak nasal expiratory flow in the diagnosis. RESULTS: Neither ultrasound nor any of the clinical signs increased the accuracy of diagnosis. Peak nasal expiratory flow below the normal range was associated with the diagnosis of ACAMS (p = 0.03). The presence of an otorhinolaryngologist had an influence on GP practice when compared with the reference group. CONCLUSION: The diagnosis of ACAMS is difficult with the available clinical methods. Peak nasal expiratory flow needs further study. New diagnostic means are needed.     

Treatment of acute rhinosinusitis diagnosed by clinical criteria or ultrasound in primary care. A placebo-controlled randomised trial

OBJECTIVES: To compare antibiotics and placebo in patients with clinically diagnosed acute maxillary sinusitis (AMS). To study whether sinus ultrasound examination would help to detect those patients who benefit from antibiotic therapy. DESIGN: A double-blind, randomised, placebo-controlled multicentre trial. SETTING: Nine primary care sites in Finland. SUBJECTS: 150 adult patients (mean age 39.7 years) with a clinical diagnosis of sinusitis. INTERVENTION: Antibiotics (amoxicillin 750 mg x 2, doxycycline 100 mg x 2 or penicillin V 1500 mg x 2) or placebo twice daily for 7 days; all patients were examined with sinus ultrasound after randomisation. MAIN OUTCOME MEASURE: Clinical success (patients' report of recovery) in telephone interview at 2 weeks. RESULTS: A total of 146 patients completed the 2-week follow-up. Patients receiving antibiotics achieved a slightly higher rate of clinical success than patients receiving placebo (80% vs 66%; p = 0.068). CONCLUSIONS: Antibiotics hasten symptom relief in AMS. Yet many patients recover in 2 weeks without antimicrobial treatment. Only half of patients with a clinical diagnosis of AMS have sinusitis in ultrasound examination.     

Comparison of B-mode ultrasound and computed tomography in the diagnosis of maxillary sinusitis in mechanically ventilated patients.

OBJECTIVE: To compare B-mode ultrasound with sinus computed tomograph (CT) scan in the diagnosis of sinusitis in intubated patients undergoing mechanical ventilation. DESIGN: Prospective, clinical investigation. SETTING: Medical intensive care unit of a university hospital. PATIENTS: Fifty patients undergoing intubation and mechanical ventilation more than 2 days, with a clinical suspicion of paranasal sinusitis with purulent nasal discharge. INTERVENTIONS: One hundred paranasal sinuses were examined. A paranasal CT scan and a B-mode ultrasound were performed the same day. Radiologic maxillary sinusitis (RMS) was defined as complete opacification of the sinus or as the presence of an air-fluid level. Absence of RMS was defined as normal sinus or as the presence of mucosal thickening. Important RMS was defined by total opacity or air-fluid level larger than half of the sinus area. Moderate RMS was defined by air-fluid level inferior than half of the sinus area. For ultrasonographic procedure, the image defined as normal was an acoustic shadow arising from the front wall. Two levels of positive echography were described: 1) a moderate lesion was defined as the visualization only of the hyperechogenic posterior wall of the sinus; 2) an important lesion was defined as the hyperechogenic visualization of posterior wall and the extension by the internal wall of the sinus outlining the hypoechogenic sinus cavity. MEASUREMENTS AND MAIN RESULTS: Sensibility, specificity, positive predictive value, and negative predictive value of B-mode ultrasound compared with CT were, respectively: 100% (95% confidence intervals [95% CI] = 94.9-100.0), 96.7% (95% CI = 82.8-99.9), 98.6% (95% CI = 92.4-99.9), and 100% (95% CI = 88.1-100). The concordance between a moderate B-mode ultrasound lesion and a moderate RMS on CT, and between an important B-mode ultrasound lesion and an important RMS on CT, assessed using kappa statistics was 93%. The concordance between B-mode ultrasound's results and CT's results assessed using weighted kappa statistics was 97%. CONCLUSION: B-mode ultrasound may be proposed first-line in a ventilated patient with suspicion of maxillary sinusitis.     

鼻内镜下真菌性上颌窦炎的术式选择及疗效评估

目的鼻内镜下采用3种不同入路手术治疗真菌性上颌窦炎并对其临床疗效进行观察,为临床个体化治疗真菌性上颌窦炎提供参考。方法以该院2016年1月-2017年12月收治的84例非侵袭性真菌性上颌窦炎的手术患者作为研究对象,术前常规行鼻内镜检查和鼻窦CT检查,根据病变的部位范围选择手术方式,将患者分为3组:A组30例,行鼻腔外侧壁保留黏膜瓣的下鼻道入路;B组20例,行上颌窦自然口入路手术;C组34例,行联合入路手术。结果 84例患者均治愈,血涕、面部胀痛、头痛或鼻腔异味症状逐步消失,鼻内镜复查见术腔愈合好,上皮化良好,各鼻道无异常分泌物,术腔病变无残留,无鼻腔粘连、前鼻孔狭窄、鼻泪管损伤或其他并发症。术后6个月复查鼻窦CT无病变残留,下鼻道黏膜瓣愈合良好。结论术前根据病变部位及范围选择手术方式个体化治疗真菌性上颌窦炎,能充分暴露上颌窦窦腔,有效清除病变,避免损伤鼻腔鼻窦的正常结构,达到既微创又能彻底清除病灶的目的。     

Prevention of nosocomial maxillary sinusitis in the ICU: the effects of topically applied α-adrenergic agonists and corticosteroids

Objective We investigated the efficacy of locally applied nasal decongestant agents and corticosteroids for preventing nosocomial maxillary sinusitis in mechanically ventilated patients with multiple trauma. Design and setting A prospective, open-label randomized study in two intensive care units (ICUs). Patients 79 consecutive multiple trauma patients admitted to the ICU who were expected to be mechanically ventilated for more than 3 days. Interventions Patients were randomly assigned to receive either a combination of a locally applied nasal decongestant agents: 2 drops twice/day of xylometazoline nasal solution 0.1% and 100 μg budesonide (NDCA group, n = 39) or placebo (control group, n = 40). Measurements For the diagnosis of radiological maxillary sinusitis patients underwent paranasal computed tomography within 48 h of admission and thereafter every 4–7 days. Infectious maxillary sinusitis was diagnosed by microbiological analysis of fluid aspirated after transnasal puncture of maxillary sinuses. Results Radiological maxillary sinusitis was detected in 54% of patients in the NDCA group (n = 21) but in 82% of controls (p < 0.01), and infectious maxillary sinusitis in 8% of the NDCA group (n = 3) but in 20% of controls (n = 8; p = 0.11). The most common pathogen micro-organisms identified from maxillary aspirates were Acinetobacter (32%) followed by anaerobes (21%). Conclusion Our results indicate that the combination of locally applied xylometazoline hydrochloride and budesonide reduces the incidence of radiological maxillary sinusitis and may reduce also that of nosocomial maxillary sinusitis in mechanically ventilated patients with multiple trauma. Supported by a grant from the Society for Pulmonary and Critical Care Research of East Macedonia and Thrace     

B超对上颌窦炎的诊断及指导治疗价值

目的：评价B超对上颌窦炎的诊断及指导治疗价值。方法：对疑为上颌窦炎的29例患者分别行超声、放射学检查,并与刺结果比较,结果：与穿刺结果比较,两法上上颌窦炎的检出无显著性差异（P＞0．05）,该病检出的灵敏度、特异度亦相似。结论：超声检查可作为上颌窦炎的初筛方法之一,特别适合儿童及孕妇,且对指导临床床选择穿刺病例有实用价值。     

真菌性鼻窦炎19例诊治体会

目的:通过回顾分析19例真菌性鼻窦炎的临床资料,以提高该病的诊断和治疗水平。方法;对收治的19例真菌性鼻窦炎患者作鼻窦CT检查和鼻内镜检查,并行相应手术治疗。结果:所有病例均为单侧鼻窦发病,其中病变单纯累及上颌窦者12例、单纯累及筛窦者2例、单纯累及蝶窦者1例,有3例同时累及上颌窦和筛窦,有1例同时累及上颌窦、筛窦和蝶窦。有15例(78.9%)窦腔软组织团块影中可见斑点状钙化灶,5例窦腔有不同程度的骨质吸收和破坏。术后随访2年,有3例复发。结论:真菌性鼻窦炎好发于上颌窦,多为单侧鼻窦发病,CT具有较高的诊断价值,手术具有较好的治疗效果。     

鼻内窥镜手术上颌窦自然开口的处理

目的 :通过对鼻内窥镜手术不同术式的治疗效果的观察 ,探讨慢性上颌窦炎、鼻息肉的治疗方法。方法 :75例慢性鼻窦炎及鼻息肉患者随机分成两组 ,治疗组 4 0例 ,清除中鼻道病变及异常结构不扩大上颌窦自然开口。对照组 35例术中切除中鼻道病变及异常结构的同时扩大上颌窦自然开口。术后随访 1年以上。结果 :两组病例治愈率无明显差异 (χ2 =0 .0 3　P >0 .0 5 ) ,治疗组减少手术操作 ,减少并发症。结论 :慢性鼻窦炎及鼻息肉手术中主要清除窦口周围异常结构及病变 ,上颌窦自然开口如无明显狭窄不必扩大     

Treatment of acute rhinosinusitis diagnosed by clinical criteria or ultrasound in primary care

Scand J Prim Health Care 2003;21:00-00. ISSN 0281-34323 Objectives &#114 - &#114 To compare antibiotics and placebo in patients with clinically diagnosed acute maxillary sinusitis (AMS). To study whether sinus ultrasound examination would help to detect those patients who benefit from antibiotic therapy. Design &#114 - &#114 A double-blind, randomised, placebo-controlled multicentre trial. Setting &#114 - &#114 Nine primary care sites in Finland. Subjects &#114 - &#114 150 adult patients (mean age 39.7 years) with a clinical diagnosis of sinusitis. Intervention &#114 - &#114 Antibiotics (amoxicillin 750 mg &#50 2, doxycycline 100 mg &#50 2 or penicillin V 1500 mg &#50 2) or placebo twice daily for 7 days; all patients were examined with sinus ultrasound after randomisation. Main outcome measure &#114 - &#114 Clinical success (patients' report of recovery) in telephone interview at 2 weeks. Results &#114 - &#114 A total of 146 patients completed the 2-week follow-up. Patients receiving antibiotics achieved a slightly higher rate of clinical success than patients receiving placebo (80% vs 66%; p=0.068). Conclusions &#114 - &#114 Antibiotics hasten symptom relief in AMS. Yet many patients recover in 2 weeks without antimicrobial treatment. Only half of patients with a clinical diagnosis of AMS have sinusitis in ultrasound examination.     

单侧鼻窦疾病的临床特征分析

【目的】探讨单侧鼻窦发病的规律。【方法】回顾性分析了1998年1月至2004年10月间收治的6266例鼻窦疾病患者中793例单侧鼻窦疾病患者的诊断资料。【结果】793例患者中慢性鼻窦炎者425例，占53．6％；鼻窦真菌病102例，占12．9％；鼻窦乳头状瘤51例，占6．4％；鼻窦囊肿117例，占14．8％；上颌窦出血坏死性息肉23例，占42、9％；上颌骨骨纤维组织异常增殖症2例．占0.25％；骨瘤11例，占1．4％；上颌窦血管瘤2例，占0.25％；脑膜或脑膜-脑膨出5例，占0.6％；恶性肉芽肿19例，占2．4％；恶性肿瘤36例，占4．6％。【结论】有近半数(46．4％)的单侧鼻窦疾病患者所患的疾病为非普通的性性炎症性疾病，这对于指导临床诊断思维有重要意义。     

鼻内镜下上颌窦窦口开放联合下鼻道开窗入路手术治疗真菌性鼻窦炎的有效性和安全性

目的探讨鼻内镜下上颌窦窦口开放联合下鼻道开窗入路手术治疗真菌性鼻窦炎的有效性和安全性。方法选取2013年9月至2018年8月于我院行手术治疗的真菌性鼻窦炎患者146例,依患者意愿分为对照组(n=69)和研究组(n=77),分别行鼻内镜下上颌窦窦口开放术和鼻内镜下上颌窦窦口开放联合下鼻道开窗入路术治疗,随访3个月。比较两组手术前及随访结束后的鼻内镜评分、生存质量、术后并发症发生情况。结果随访结束后,两组患者的鼻内镜评分和生存质量评分均明显低于手术前,且研究组低于对照组(P<0.05)。两组患者术后并发症总发生率比较,差异无统计学意义(P>0.05)。结论鼻内镜下上颌窦窦口开放联合下鼻道开窗入路术治疗真菌性鼻窦炎可改善患者的临床症状,提高其生存质量,且并发症少。     

Effect of pulsed ultrasound on chronic rhinosinusitis: A case report

This case report demonstrates that pulsed ultrasound (US), when used for a total of 20 treatment sessions, provided symptom relief to a patient with chronic rhinosinusitis (CRS). A 16-year-old boy with a 12-month history of rhinosinusitis and candidate for sinus surgery was referred for ultrasound therapy. He presented with facial pain/pressure, nasal obstruction, and postnasal drip (total sinusitis score=7). On computed tomographic (CT) scanning, the total opacification of the right maxillary sinus was observed. The ostiomeatal complex was occluded (total CT score=6). Pulsed ultrasound was administered three times a week, every other day. After 10 treatment sessions, his symptoms were resolved with exception of nasal obstruction being mild (total sinusitis score=2). On CT scan, right maxillary sinus showed partial improvement (total CT score=2). After additional 10 treatments, the nasal obstruction was resolved, and follow-up CT scan of his sinuses showed that right maxillary sinus was clear and normal. At 6-month follow-up, the positive effects were maintained and the patient reported no recurrence of symptoms. Twenty sessions of pulsed ultrasound therapy eradicated the CRS and resolved the symptoms.     

Patients' and physicians' views on the management of acute maxillary sinusitis

OBJECTIVES: To study the views of patients and physicians on the management of suspected acute maxillary sinusitis and on suggested changes in practice. DESIGN: Cross-sectional survey and focus group interviews of both patients and physicians. SETTING: Primary care in Finland. RESULTS: A total of 175 patients and 245 physicians replied to the survey (response rates 88% and 70%, respectively). Eight focus groups were conducted, four with patients (n = 22) and four with physicians (n = 20). Patients had less trust than physicians in the natural healing process of acute maxillary sinusitis: only 33% as opposed to 95% of physicians agreed that acute maxillary sinusitis might heal without medication. The patients emphasised the importance of careful diagnosis. Physicians experienced the diagnostic uncertainty and the demands from authorities to use fewer antibiotics as problematic. CONCLUSIONS: Most patients with suspected acute maxillary sinusitis primarily want the physician to aim at making a specific diagnosis. Physicians feel they are forced to prescribe too many antibiotics for sinusitis because of patient's expectations and lack of good diagnostic means for acute maxillary sinusitis. Better diagnostic tools, both national and local guidelines, and patient information might help to change practice towards the use of fewer antibiotics.     

A multicenter, randomized, investigator-blinded study of 5- and 10-day gatifloxacin versus 10-day amoxicillin/clavulanate in patients with acute bacterial sinusitis

BACKGROUND: Treatment guidelines for acute bacterial sinusitis recommend 10 to 14 days of therapy with amoxicillin/clavulanate, high-dose amoxicillin, cefpodoxime, cefuroxime, or a newer fluoroquinolone. Objective: This study compared the clinical efficacy of short-course (5-day) gatifloxacin with standard 10-day regimens of amoxicillin/clavulanate or gatifloxacin in patients with a diagnosis of acute, uncomplicated maxillary sinusitis. METHODS: This was a multicenter, investigator-blinded study in adult patients (age >18 years) with physical findings, signs and symptoms (for at least 7 days), and radiographic findings indicating acute, uncomplicated maxillary sinusitis. Patients were randomized to receive gatifloxacin 400 mg once daily for 5 days, gatifloxacin 400 mg once daily for 10 days, or amoxicillin/clavulanate 875 mg twice daily for 10 days. Clinical response was assessed once between days 3 and 5 of treatment, once I to 3 days after the completion of study treatment, once 7 to 14 days posttreatment (test-of-cure visit), and once 21 to 28 days posttreatment. Safety was assessed throughout the study. RESULTS: The study enrolled 445 patients. The treatment groups were similar in terms of history of sinusitis, presenting signs and symptoms, and radiographic findings. The most common presenting symptoms were nasal congestion, sinus tenderness, and purulent nasal discharge (>90% of patients); 99% of patients had abnormal radiographic findings. At the test-of-cure visit, clinical cure rates for clinically evaluable patients in the 3 treatment groups were 74% (102/137) for 5-day gatifloxacin, 80% (101/127) for 10-day gatifloxacin, and 72% (101/ 141) for 10-day amoxicillin/clavulanate (95% CI for the difference in cure rates: 5-day gatifloxacin vs amoxicillin/clavulanate, -7.6 to 13.2; 5- vs 10-day gatifloxacin, -15.2 to 5.1; 10-day gatifloxacin vs amoxicillin/clavulanate, -2.3 to 18.1). The distribution and incidence of drug-related adverse events (AEs) were comparable between treatment groups, and the majority (>95%) were mild or moderate in severity. The most common drug-related AEs included vaginitis, diarrhea, and nausea. CONCLUSION: In this population of patients with acute, uncomplicated sinusitis of presumed bacterial origin, a short course (5 days) of gatifloxacin therapy was associated with comparable clinical cure rates and tolerability to those of standard 10-day therapy with gatifloxacin or amoxicillin/clavulanate.     

Transnasal puncture based on echographic sinusitis evidence in mechanically ventilated patients with suspicion of nosocomial maxillary sinusitis

Objective The aim of this prospective study was to evaluate the value of sinus echography results to directly indicate a transnasal puncture in intubated patients with suspicion of nosocomial maxillary sinusitis.Design prospective clinical investigation.Setting medical intensive care unit.Patients sixty patients undergoing intubation and mechanical ventilation more than 2 days, with a clinical suspicion of maxillary sinusitis with purulent nasal discharge.Interventions 120 sinuses were examined by sinus ultrasound. The image defined as normal was an acoustic shadow arising from the front wall. Two levels of positive echography were described: (1) a partial sinusogram was defined as the visualization of the hyperechogenic posterior wall of the sinus; and (2) a complete sinusogram was defined as the hyperechogenic visualization of posterior wall and the extension by the internal and external walls of the sinus. When sinus ultrasound was positive, a transnasal puncture was performed the same day. The transnasal puncture was positive if a fluid was obtained from sinus aspiration. The transnasal puncture was negative if there was no aspirated material. Measurements and results sinus ultrasound was positive in 84 cases (54 complete sinusograms and 30 partial sinusograms). Seventy-eight of 84 transnasal punctures were positive. Sensitivity of a sinusogram for obtaining positive transnasal puncture was 100%, and specificity was 86% (100% in case of complete sinusogram) in a clinically selected population. The only six negative transnasal punctures were performed in patients with partial sinusogram. Conclusions Ultrasound sinusitis evidence seems to be of value to indicate and perform a transnasal puncture directly, avoiding CT exam.     

Phase III, randomized, double-blind study of clarithromycin extended-release and immediate-release formulations in the treatment of adult patients with acute maxillary sinusitis

BACKGROUND: Clarithromycin has an established bacteriologic efficacy and safety profile in the treatment of respiratory tract infections. OBJECTIVE: This study compares the efficacy and tolerability of extended-release and immediate-release formulations of clarithromycin in patients with acute maxillary sinusitis. METHODS: Fourteen days' treatment with once-daily clarithromycin was compared with the immediate-release, twice-daily formulation in a phase III, randomized, double-blind, parallel-group, multicenter study. Patients aged > or =12 years with signs, symptoms, and a radiologically confirmed diagnosis of acute maxillary sinusitis were eligible. Patients were assessed before treatment, within 48 hours after treatment, on study days 16 to 18, and at the test-of-cure visit on study days 24 to 31. Patients who received > or =1 dose of study drug were included in the safety analysis. RESULTS: Of 283 patients treated, 245 were included in the efficacy analysis (122 in the extended-release group, 123 in the immediate-release group). Treatment groups were well matched with respect to demographic characteristics and medical condition and history. At the test-of-cure visit, 85% of patients in the clarithromycin extended-release group and 79% in the immediate-release group were deemed clinical cures; 89% and 91% in the extended-release and immediate-release groups, respectively, demonstrated radiographic success. Overall incidences of study drug-related adverse events were similar in the 2 treatment groups (32% in the extended-release group and 28% in the immediate-release group); however, significantly fewer patients receiving extended-release clarithromycin (2/142 11%]), compared with those receiving the immediate-release formulation (10/141 [7%]: P = 0.02) discontinued therapy because of drug-related gastrointestinal symptoms or abnormal taste. No clinically meaningful changes in laboratory values or vital signs were observed during the study. CONCLUSION: Although the efficacy of the 2 formulations was comparable, once-daily clarithromycin extended-release was better tolerated than the twice-daily immediate-release formulation by patients with acute maxillary sinusitis.     

慢性上颌窦炎影响因素的CT分析

目的探讨窦口鼻道复合体病变及解剖变异与慢性上颌窦炎的关系.方法对CT诊断的52例单侧慢性上颌窦炎进行两侧对比分析.结果患侧与健侧筛泡截面分别为(77.75±33.51) mm2和(34±20.27) mm2(P<0.01).两侧分别有19个及10个大筛泡.患侧伴有32组筛窦炎,对侧21组.鼻息肉11例,单发于上颌窦炎侧9例,对侧仅1例,双侧1例.结论大筛泡、前中组筛窦炎症、鼻息肉与慢性上颌窦炎有关.     

B-mode ultrasound in the diagnosis of maxillary sinusitis in intensive care unit

Radiological maxillary sinusitis (RMS) is not an easily diagnosed in Intensive Care Unit (ICU). B-mode ultrasound of paranasal sinuses, validated for the ambulatory patients, was evaluated in a prospective study. One hundred fifty three ultrasound examinations were performed on 30 critically ill patients and compared to CT scan or radiography (Blondeau's view). Two levels of positive echographia are described: positive echographia corresponding with a moderate lesion, cupuliform echographia when the lesion is more significant. Its good predictive negative value when the echographia is negative and its predictive positive value of 100 % when the echographia is cupuliform allow to recommend B-mode ultrasound as the best investigation for the diagnosis of maxillary sinusitis in a ICU. Diagnostic ultrasound represents a rapid, painless, innocuous and easily reproducible means of monitoring. Received:21 May 1997 Accepted: 4 September 1997     

Acute bacterial maxillary sinusitis: time to symptom resolution and return to normal activities with moxifloxacin

Objectives: This prospective, single‐arm, open‐label, multicentre phase IV (postmarketing surveillance) study determined time to resolution of key symptoms and return to normal activities in adults with acute bacterial maxillary sinusitis treated with moxifloxacin 400 mg qd for 10 days. The study also assessed whether responses to the Sino‐Nasal Outcome Test‐16 (SNOT‐16) questionnaire [not yet validated for acute bacterial sinusitis (ABS)] accurately reflect clinical findings in these patients. Methods: Adults with a clinical diagnosis of acute bacterial maxillary sinusitis with signs/symptoms present for ≥ 7 but < 28 days took part. Patients were evaluated bacteriologically and clinically on day 1 (pretherapy), days 2–4 and 10–13 (test of cure), for bacterial presence and improvement/resolution of the signs/symptoms of acute bacterial maxillary sinusitis. They completed SNOT‐16 and Activity Impairment Assessment questionnaires daily, before receiving moxifloxacin, until day 10. Results: In both the bacteriologically and clinically evaluable populations, over 85% of patients showed clinical improvement by day 2, rising to over 96% by day 4. Pretherapy, according to the SNOT‐16 questionnaire, almost all of the bacteriologically evaluable patients reported facial pain/pressure but this proportion had fallen to below 50% by day 4. In the bacteriologically evaluable population, 32/42 (76%) patients reported an improvement in facial pain/pressure from the pretherapy visit to day 4. Of patients showing improvement, 50% improved from ‘moderate‐to‐severe facial pain’ at pretherapy to ‘no problem’ at day 4. At day 4, 45–50% of patients reported impairment of normal activities, compared with 79–88% pretherapy. Conclusions: Moxifloxacin rapidly improves the signs and symptoms of acute bacterial maxillary sinusitis and results in clinical cure in most patients. Responses to the SNOT‐16 questionnaire accurately reflected clinical assessments, indicating that when fully validated the SNOT‐16 questionnaire may be a valuable tool for the assessment of patient outcomes in ABS.     

110例真菌性上颌窦炎鼻内镜手术的临床分析

目的 探讨真菌性上颌窦炎鼻内镜下手术方式的选择.方法 通过对110例真菌性上颌窦炎鼻内镜下手术的分析,寻找清除上颌窦病灶的好方法.结果 随访6～12个月,一次性治愈107例,一次性治愈率97.3%,复发3例,占2.7%.影响疗效的主要因素是上颌窦腔内病灶清除的彻底性.结论 选择合理的手术方法,尽量扩大上颌窦开口是治疗真菌性上颌窦炎的关键.