康妇炎胶囊在慢性盆腔炎患者中的应用

目的 探讨康妇炎胶囊在慢性盆腔炎患者中的治疗效果.方法 选择2018年7月至2019年7月医院收治的90例慢性盆腔炎患者为研究对象,按照随机原则分为对照组与试验组,每组45例,其中对照组给予阿奇霉素治疗,试验组则在对照组的基础上给予康妇炎胶囊治疗,比较两组的治疗效果.结果 治疗后,试验组中医症状积分低于对照组,白细胞介...     

康妇炎胶囊配合甲硝唑灌肠治疗盆腔炎61例

<正>盆腔炎是妇科常见病、多发病,其发病率高,病情顽固,易反复发作,可引起严重的并发症,严重影响了妇女的身心健康和生育能力,进而影响其工作和生活质量。我中心妇科应用康妇炎胶囊口服配合甲硝唑液灌肠综合治疗盆腔炎61例,取得满意效果,现将结果报道如下。     

康妇炎胶囊用于治疗女性盆腔炎性疾病（PID）的疗效分析

目的：研究分析康妇炎胶囊应用于女性盆腔炎疾病（英简PID）的治疗效果。方法选择我院在2013年07月—2014年07月期间接收治疗的90例盆腔炎疾病患者,按照抽签的法则将其平均分成两组,对照组45例患者应用单纯西药进行治疗;研究组45例患者应用康妇炎胶囊进行治疗。结果研究组45例患者的临床总有效率为93.33%（42/45）显著性大于对照组的82.22%（37/45）, P<0.05差异有统计学意义。研究组患者发生盆腔炎性渗出、包块的概率显著小于对照组,差异P<0.05有统计学意义。结论康妇炎胶囊应用于女性盆腔炎疾病的治疗效果更加显著,抗炎效果理想,更加适用于临床治疗。     

康妇炎胶囊联合抗生素治疗盆腔炎性包块临床疗效观察

目的观察康妇炎胶囊联合抗生素治疗盆腔炎性包块的临床疗效。方法选取我院妇保门诊自2015年3月~2016年6月收治的80例盆腔炎性包块患者随机分为观察组和对照组各40例,两组患者均给予头孢曲松钠、甲硝唑静脉滴注,观察组加用康妇炎胶囊口服治疗,连续治疗2个疗程后观察2组的治疗效果。结果观察组的总有效率高于对照组(P﹤0.05),有统计学意义。两组治疗期间均未发现明显的不良反应。结论康妇炎胶囊联合抗生素治疗盆腔炎性包块的疗效优于单纯应用抗生素治疗,且安全方便。     

康妇炎胶囊联合抗生素治疗慢性盆腔炎的疗效分析

目的分析康妇炎胶囊联合奥硝唑及阿奇霉素治疗慢性盆腔炎的疗效及安全性。方法选取天津市宁河区潘庄医院2017年8月-2019年2月期间收治的64例慢性盆腔炎患者为研究对象,根据不同的治疗药物将其分为对照组和研究组各32例。对照组采用奥硝唑联合阿奇霉素进行治疗,研究组在对照组治疗基础上采用康妇炎胶囊进行治疗。观察两组患者的症状缓解时间、治疗有效率以及不良反应发生率。结果研究组患者的宫颈举痛缓解时间和小腹坠痛缓解时间均短于对照组,差异有统计学意义(P<0.05);研究组治疗总有效率为93.75%,高于对照组的78.13%,差异有统计学意义(P<0.05);研究组和对照组患者的不良反应发生率分别为12.50%和9.38%,差异无统计学意义(P>0.05)。结论对慢性盆腔炎患者,采用康妇炎胶囊联合奥硝唑治疗,有助于取得更好的治疗效果。     

达克宁栓联合康妇炎胶囊治疗霉菌性阴道炎疗效探讨

采用达克宁栓联合康妇炎胶囊治疗霉菌性阴道炎,可提高达克宁栓抗真菌的活性能力,增强疗效.     

探讨康妇炎胶囊联合中药外敷治疗盆腔炎性疾病的临床疗效

目的:探讨分析对盆腔炎性疾病使用康妇炎胶囊联合中药外敷进行治疗的临床疗效.方法:随机选取我院2017年3月至2018年3月内门诊治疗100例盆腔炎性疾病患者,所有患者以治疗差异分为参照组(50例,康妇炎胶囊治疗)和研究组(50例,康妇炎胶囊联合中药外敷治疗),对比分析两组患者的最终治疗效果及不良反应发生率(恶心、头晕、...     

康妇炎胶囊联合甲氨蝶呤治疗非破裂型异位妊娠疗效观察

目的观察康妇炎胶囊联合甲氨蝶呤治疗异位妊娠的临床疗效,探讨其临床价值和优越性。方法将我院2012年4月至2015年10月住院保守治疗的62例异位妊娠患者随机分为观察组和对照组,观察组32例给予康妇炎胶囊联合甲氨蝶呤治疗,对照组30例给予单用甲氨蝶呤杀胚治疗,比较两组患者临床疗效及包块消失时间,血β-HCG降至正常水平时间。结果观察组治愈率为93.75%,高于对照组的70%,包块消失及血β-HCG降低至正常水平时间均少于对照组,差异比较有统计学意义(P﹤0.05)。结论康妇炎胶囊联合甲氨蝶呤治疗非破裂型异位妊娠有显著疗效,可消除盆腔的炎症和粘连,降低了重复异位妊娠概率的发生,安全实用,值得临床推广应用。     

布洛芬解热镇痛抗炎多面手

剂量不同疗效有异 问题一：布洛芬如何发挥疗效？儿童退热可以用布洛芬吗？ 前列腺素是人体内与致热、疼痛和炎症反应有关的物质,布洛芬通过抑制人体内前列腺素的合成,从而发挥解热、镇痛和抗炎作用。     

康妇炎胶囊联合外用硝酸咪康唑治疗阴道炎伴外阴瘙痒的疗效观察

目的:于阴道炎伴随外阴瘙痒患者中康妇炎胶囊+外用硝酸咪康唑治疗的效果进行评价.方法:选2016年2月至2016年12月间在我院就诊的阴道炎伴随外阴瘙痒患者(36例)开展研究,双盲法分为乙组同甲组,各18例.乙组以外用硝酸咪康唑治疗为主,甲组是在乙组治疗基础上加康妇炎胶囊治疗,对比两组的症状消失时间以及治疗效果等.结果:甲组的疼痛消失时间、外阴瘙痒消失时间、粘膜充血消失时间、白带恢复正常时间、治疗总有效率都显著优于乙组(P<0.05).结论:通过硝酸咪康唑(外用)+康妇炎胶囊对阴道炎伴随外阴瘙痒患者进行治疗可取得良好的治疗效果,可快速消除症状、利于白带恢复正常.     

Preliminary evaluation on anti-inflammatory and analgesic effects of Sideritis syriaca L. herba extracts

We studied the anti-inflammatory and analgesic activity of extracts of Sideritis syriaca L. herba. Samples were collected from the wild plant, dried, powdered, and extracted with hexane and methanol. The extracts were evaporated to dryness and then suspended in suitable solvent. They were then tested for anti-inflammatory activity in the carrageenin rat paw edema test and for analgesic activity in the Randall and Selitto test and in the tail-flick test. At 24 hours after the treatment, the gastric mucosa of each rat was observed macroscopically. Based on these results the hexane extract was fractionated by column chromatography, and the fractions were obtained tested in the same way. Results showed interesting anti-inflammatory activity only for the hexane extract and all the fractions obtained from it. All the extracts and all the other fractions showed both peripheral and central analgesic activity. In rats treated with the tested compounds hyperemia and ulcers were absent. The data from this preliminary study reveal interesting pharmacological properties of S. syriaca L. herba extracts related to the marked analgesic activity and the absence of gastric ulcerogenic activity. The same is for anti-inflammatory activity, but in this case it seems to be related only to the apolar fraction.     

An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols

Extracts obtained from the seeds of Nigella sativa are used as a spice or remedy for the treatment of various inflammatory diseases. The purpose of this study was to examine the analgesic and anti-inflammatory effects of its polyphenols. N. sativa seed polyphenols were prepared, and analgesic and anti-inflammatory effects were studied in mice and rats using the acetic acid-induced writhing, formalin, light tail flick, carrageenan-induced paw edema, and croton oil-induced ear edema tests. In the acetic acid-induced writhing test, oral administration of N. sativa polyphenols (NSP) decreased the number of abdominal constrictions. Both oral and intraperitoneal administration of NSP significantly suppressed in a dose-dependent manner the nociceptive response in the early and late phases of the formalin test, and the effect on the late phase was more pronounced. Pretreatment with naloxone failed to reverse the analgesic activity of NSP in this test. NSP did not produce a significant analgesia in the light tail flick test in mice. Oral administration of NSP did not produce a significant reduction in carrageenan-induced paw edema. However, when injected intraperitoneally, NSP inhibited paw edema in a dosedependent manner. NSP when applied topically failed to reduce croton oil-induced ear edema. These results suggest that NSP have analgesic and anti-inflammatory effects. The lack of analgesic effect of NSP in the light tail flick test and also the failure of naloxone to reverse the analgesia in the formalin test reveal that mechanisms other than stimulation of opioid receptors are involved.     

荭草煎剂对小鼠抗炎镇痛作用初探

目的 探讨荭草的抗炎、镇痛作用.方法 采用二甲苯致小鼠耳廓肿胀,观察高、中、低剂量荭草水煎剂的抗炎作用;采用热板法致痛,观察高、中、低剂量荭草水煎剂的镇痛作用.结果 高、中、低剂量荭草水煎剂明显抑制二甲苯所致小鼠耳廓的肿胀度,与生理盐水对照组比较差异有统计学意义(P＜0.05),与赖氨匹林组比较差异无统计学意义(P＞0.05).高剂量荭草水煎剂显著提高热板法所致小鼠的痛阈值,与生理盐水对照组比较和自身给药前比较差异有统计学意义(P＜0.05);中剂量荭草水煎剂给药后30、60 min显著提高热板法所致小鼠的痛阈值,与生理盐水对照组比较和自身给药前比较差异有统计学意义(P＜0.05).结论 荭草水煎剂具有抗炎、镇痛作用.     

An investigation of the anti-inflammatory and analgesic effects of Orthosiphon stamineus leaf extract

Anti-inflammatory and analgesic activities of a standardized Orthosiphon stamineus methanol:water (50:50 vol/vol) leaf extract (SEOS) were evaluated in animal models. Oral administration of SEOS at doses of 500 and 1,000 mg/kg significantly reduced the hind paw edema in rats at 3 and 5 hours after carrageenan administration (P < .01 and P < .01; P < .01 and P < .05, respectively). SEOS (1,000 mg/kg, p.o.) also produced significant (P < .05) analgesic activity in both the acetic acid-induced writhing test and the formalin-induced licking test (late phase) in mice and rats, respectively. However, SEOS showed no effect on the tail flick and hot plate tests in mice. The results of the present study support the proposal that O. stamineus has anti-inflammatory and non-narcotic analgesic activities. These findings justify the traditional use of the plant for treating pain and inflammation.     

Synthesis of novel triheterocyclic thiazoles as anti-inflammatory and analgesic agents

Triheterocyclic thiazoles containing coumarin and carbostyril (1-aza coumarin) have been synthesized by the reaction of the in situ generated 4-thioureidomethyl carbostyril and 3-bromoacetyl coumarins. The new compounds have been tested for their in vivo analgesic and anti-inflammatory activities. Qualitative SAR studies indicate that, the chloro substitution at C-7 in carbostyril and 6,8-dibromo substitution in the coumarin ring enhance anti-inflammatory activity. These compounds were also found to provide significant protection against acetic acid writhing in animal models. All the compounds have been characterized by IR, (1)H NMR, (13)C NMR and mass spectrometry.     

白芍总苷对大鼠佐剂关节炎抗炎作用及机制研究

目的 探讨白芍总苷(total glucosides of paeonia:TGP)对佐剂关节炎大鼠足爪组织中核转录因子NF-κB/p65蛋白表达的抑制作用和对大鼠足爪组织病理改变的影响及血清中血管内皮生长因子(VEGF)和白介素-17(IL-17)含量的影响.方法 建立Ⅱ型胶原诱导的佐剂关节炎大鼠模型,用免疫组化染色法检测足爪组织中NF-κB/p65蛋白的表达.病理切片观察不同剂量的TGP对佐剂关节炎大鼠的治疗效果.用ELISA法检测佐剂关节炎大鼠血清中VEGF和IL-17的含量.结果 大、中剂量组的胞浆内NF-κB/p65的阳性表达比模型对照组明显降低(P＜0.01),TGP大、中剂量治疗组与地塞米松组能明显改变佐剂关节炎大鼠皮下组织细胞排列、炎性细胞浸润及血管增生现象,TGP小剂量组对改善佐剂关节炎大鼠足部皮肤的病理状况无明显作用.中、大剂量的TGP组和地塞米松组血清VEGF和IL-17的含量明显降低(P＜0.01).结论 TGP能抑制佐剂关节炎大鼠的炎症反应,其机制可能是TGP可下调NF-κB/p65蛋白的表达,降低炎性细胞因子IL-17和血清VEGF的产生,最终抑制血管增生及炎性细胞浸润.     

不同镇痛方式对分娩的镇痛效果及其对分娩结局的影响

目的探讨不同镇痛方式对分娩的镇痛效果及其对分娩结局的影响。方法选择2019年3月至2020年3月间,于温岭市妇幼保健院自愿要求分娩镇痛的140例自然分娩产妇为研究对象,按照不同分娩镇痛方式分为观察组(70例)与对照组(70例)。对照组给予罗哌卡因与舒芬太尼联合硬膜外自控分娩镇痛;观察组给予瑞芬太尼静脉自控分娩镇痛。比较两组镇痛前、镇痛后10min和镇痛后60min数字疼痛分级法(NRS),镇痛时间和镇痛泵有效按压次数,不同产程时间,新生儿出生1min和5min的Apgar评分。结果两组镇痛前NRS评分比较无统计学差异(t=0.280,P>0.05);观察组镇痛后10min和镇痛后60min的NRS评分显著低于对照组(t值分别为16.058、8.212,均P<0.05)。观察组镇痛时间显著长于对照组,镇痛泵的有效按压次数显著少于对照组(t值分别为8.977、11.630,均P<0.05)。两组第一产程时间、第二产程时间和第三产程时间比较无统计学差异(t值分别为0.565,0.363、0.639,均P>0.05)。两组新生儿出生1min和5min的Apgar评分比较无统计学差异(t值分别为0.446、0.942,均P>0.05)。观察组产妇对分娩镇痛总满意率(95.71%)显著高于对照组(80.00%)(χ²=8.101,P<0.05)。结论瑞芬太尼静脉自控分娩镇痛法对分娩产妇镇痛效果优于罗哌卡因与舒芬太尼联合硬膜外自控分娩镇痛法,且产妇对瑞芬太尼静脉自控分娩镇痛法的满意度高,且两种方式间的分娩结局无显著差异。