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1.
本文采用毛细管气相色谱法测定撒烈痛片的含量。色谱柱:交联SE-54弹性石英毛细管柱(0.25mmid×25m),氢火焰离子化检测器(FID),进样量在0.3mg-1.3mg内4种成分与峰面积比呈直线相关(非那西丁:y=2.9554x-0.1281,r=0.9995;咖啡因:y=1.5584x-0.0257,r=0.9994;氨基比林:y=1.1653x-0.0893,r=0.9992;苯巴比妥:y=2.535x-0.1754,r=0.9998)。平均回收率±标准差分别为100.2%±1.17%、99.8%±1.94%、100.5%±1.46%、98.4%±1.82%。 相似文献
2.
GC 法测定榄香烯注射液中有效成分 总被引:7,自引:1,他引:6
采用气相色谱法,以水杨酸甲酯为内标物,测定榄香烯注射液中的有效成分β-,γ-,δ-榄香烯含量.榄香烯浓度在0.5~1.5mg/mL范围内峰面积比与浓度呈良好的线性关系,y=1.32x-0.03,r=0.9999(n=5).平均回收率100.9%,RSD0.5%. 相似文献
3.
曾苏 《中国药物依赖性杂志》1995,(1)
本文建立了测定人尿中美沙酮浓度的气相色谱/离子阶检测器(GC/ITD)分析方法。美沙酮浓度在5-1000ng·ml-1范围内线性良好,回归方程为:y=0.01225x+0.0115(r=0.9993);平均回收率为88.76±s5.66(n=6);并已用于酶倍增免疫测定筛选试验呈阳性尿样中美沙酮的含量测定。 相似文献
4.
用数学分析方法对初均速法测定的误差进行了估算。将初均速法的方程式lnV0=-Ea/RT+lnA′推导为lnV0=-Ea/RT+lnA(1-x)nCn,发现初均速法所得贮存期比经典法偏高,与分解率x,反应级数n有关,当x=0.1,n=1时偏高6% 相似文献
5.
荧光分光光度法测定氧氟沙星片剂的含量 总被引:3,自引:0,他引:3
用荧光分光光度法测定氧氟沙星片剂的含量。选用0.05mol/L盐酸为溶剂,在Ex=293nm、Em=507nm处测定荧光强度。在0.10~0.35ug/ml范围内,荧光强度与浓度呈线性关系,回归方程为C=0.0736F—0.0069(r=0.9998)。平均回收率为99.53%,RSD为0.89%(n=8)。本法灵敏度高,操作简便,结果准确。 相似文献
6.
“鼻炎愈”的药剂学研究 总被引:1,自引:0,他引:1
目的:研制以氧氟沙星(OFLX)、盐酸麻黄碱为主药并配伍透明质酸(HA)的滴鼻剂。方法:HPLC法测定含量、稳定性试验及临床观察。结果:OFLX和盐酸麻黄碱含量测定的标准曲线分别是C=1.455A-0.0089,=0.9994(n=3)和C=0.0387-0.0001,=0.9994(n=3),回收率(x±s)分别为101.1±1.80%(n=3)和101.0±0.48%(n=3)。稳定性试验显示,处方中氧氟沙星对光较敏感,制剂在40℃、75%RH条件下3个月无明显变化。3所医院临床疗效观察130例,总有效率91.9%。结论:本制剂处方合理,质控方法可靠,疗效满意。贮存期暂定2年。 相似文献
7.
HPLC测定定晕宁颗粒中葛根素的含量 总被引:5,自引:0,他引:5
采用HPLC法,选用Symmetry-C18柱和甲醇:水(25:75),乙酸调pH4.2。测定定晕宁颗粒中葛根素含量,结果回归方程为Y=1.77x-0.2813,r=0.999(n=5),线性范围为0.614 ̄6.14μg,平均回收率为99.03%,RSD为3.98%。 相似文献
8.
周期性回归分析孕妇血象白细胞计数结果 总被引:1,自引:1,他引:0
采用余弦模型对孕妇白细胞计数结果的孕龄变化规律进行调期性回归。其第二谐量余弦模型为^y = 8 .81 + 1 .02cos(ti- 235 .7) + 0 .76cos(2ti- 202 .2) ,其回归相关指数R2 为0 .7535 ,x2 = 0 .1481 ,P> 0 .995 ,回归理论值与实际观察值之间没有统计差别,表明利用余弦模型描述孕妇血象白细胞含量随孕龄周期性变化规律能获得满意的结果。 相似文献
9.
一阶导数光谱法测定醋柳碘酊中水杨酸的含量 总被引:1,自引:0,他引:1
本文应用一阶导数光谱法测定醋柳碘酊中水杨酸的含量,可以排除其它组分形成的背景干扰。采用峰-谷法,以D值(|△A1|+|△A2|)计算样品的含量。D值与浓度的关系为D=8.623×10^-2C+7.2×10^-3(x=0.9999)。方法简便、实用、重现性好。平均回收率为99.98%(cv=0.30%,n=9)。 相似文献
10.
本文用荧光分光光度法不经分离直接测定复方制剂中盐酸普鲁卡因的含量。其最大激发波长及最大发射波长分别为290.0nm,356.0nm。标准曲线浓度范围为0.6~1.4μm/ml,回归方程为Y=48.8417X+6.305(n=6),r=0.9998,4种样品平均回收率为99.95%(n=6),RSD=0.47%。 相似文献
12.
Clinical and in vitro investigations were carried out to test the efficacy of gut lavage, hemodialysis, and hemoperfusion in the treatment of poisoning with paraquat or diquat. In a patient suffering from diquat intoxication 130 times more diquat was removed by gut lavage 30 h after ingestion than was removed by complete aspiration of the gastric contents.Determination of in vitro clearances for paraquat and diquat by hemodialysis showed that, at serum concentrations of 1–2 ppm, such as are frequently encountered in poisoning in man, toxicologically relevant quantities of herbicide cannot be removed from the body. At a concentration of 20 ppm, on the other hand, hemodialysis proved to be effective, the clearance being 70 ml/min at a blood flow rate of 100 ml/min. The efficacy of hemoperfusion with coated activated charcoal was on the whole better. Especially at concentrations around 1–2 ppm, the clearance values for hemoperfusion were some 5–7 times higher than those for hemodialysis.In a patient suffering from paraquat poisoning, both hemodialysis as well as hemoperfusion were carried out. The in vitro results could be confirmed: At serum concentrations of paraquat less than 1 ppm no clearance could be obtained by hemodialysis while by hemoperfusion with activated charcoal quite high clearance values were measured and the serum level dropped down to zero.
Zusammenfassung Klinische Untersuchungen und Laboratoriumsversuche wurden durchgeführt, um die Wirksamkeit von Darmspülung, Hämodialyse und Hämoperfusion bei Paraquat- und Deiquat-Vergiftungen zu prüfen.Bei einem Patienten wurde 30 Std nach Deiquat-Aufnahme durch Darmspülung 130mal mehr Deiquat entfernt als durch vollständige Aspiration des Mageninhaltes. In vitro-Versuche ergaben, daß bei Blutserumkonzentrationen von 1–2 ppm, die bei Vergiftungen oft gemessen werden, durch Hämodialyse keine toxikologisch relevanten Paraquat- oder Deiquat-Mengen entfernt werden können. Dagegen erwies sich die Hämodialyse bei 20 ppm und einer Blutumlaufgeschwindigkeit von 100 ml/min mit einer Clearance von 70 ml/min als wirksam. Die Hämoperfusion mit beschicheter Aktivkohle war in diesen Versuchen aber eindeutig überlegen, denn insbesondere bei Konzentrationen um 1–2 ppm waren die Clearance-Werte 5–7mal höher als bei der Hämodialyse.Die in vitro-Ergebnisse wurden bei einem Patienten mit einer Paraquat-Vergiftung bestätigt: Bei Konzentrationen unter 1 ppm war die Hämodialyse wirkungslos, während durch Hämoperfusion relativ hohe Clearance-Werte erreicht wurden, so daß der Serumspiegel rasch unter die Nachweisgrenze abfiel.相似文献
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14.
Petrikovics I McGuinn WD Sylvester D Yuzapavik P Jiang J Way JL Papahadjopoulos D Hong K Yin R Cheng TC DeFrank JJ 《Drug delivery》2000,7(2):83-89
This study describes a new approach for organophosphorous (OP) antidotal treatment by encapsulating an OP hydrolyzing enzyme, OPA anhydrolase (OPAA), within sterically stabilized liposomes. The recombinant OPAA enzyme was derived from Alteromonas strain JD6. It has broad substrate specificity to a wide range of OP compounds: DFP and the nerve agents, soman and sarin. Liposomes encapsulating OPAA (SL)* were made by mechanical dispersion method. Hydrolysis of DFP by (SL)* was measured by following an increase of fluoride ion concentration using a fluoride ion selective electrode. OPAA entrapped in the carrier liposomes rapidly hydrolyze DFP, with the rate of DFP hydrolysis directly proportional to the amount of (SL)* added to the solution. Liposomal carriers containing no enzyme did not hydrolyze DFP. The reaction was linear and the rate of hydrolysis was first order in the substrate. This enzyme carrier system serves as a biodegradable protective environment for the recombinant OP-metabolizing enzyme, OPAA, resulting in prolongation of enzymatic concentration in the body. These studies suggest that the protection of OP intoxication can be strikingly enhanced by adding OPAA encapsulated within (SL)* to pralidoxime and atropine. 相似文献
16.
《Critical reviews in toxicology》2013,43(5-6):327-369
AbstractThe uptake of metals from food and water sources by insects is thought to be additive. For a given metal, the proportions taken up from water and food will depend both on the bioavailable concentration of the metal associated with each source and the mechanism and rate by which the metal enters the insect. Attempts to correlate insect trace metal concentrations with the trophic level of insects should be made with a knowledge of the feeding relationships of the individual taxa concerned. Pathways for the uptake of essential metals, such as copper and zinc, exist at the cellular level, and other nonessential metals, such as cadmium, also appear to enter via these routes. Within cells, trace metals can be bound to proteins or stored in granules. The internal distribution of metals among body tissues is very heterogeneous, and distribution patterns tend to be both metal and taxon specific. Trace metals associated with insects can be both bound on the surface of their chitinous exoskeleton and incorporated into body tissues. The quantities of trace meals accumulated by an individual reflect the net balance between the rate of metal influx from both dissolved and particulate sources and the rate of metal efflux from the organism. The toxicity of metals has been demonstrated at all levels of biological organization: cell, tissue, individual, population, and community. Much of the literature pertaining to the toxic effects of metals on aquatic insects is based on laboratory observations and, as such, it is difficult to extrapolate the data to insects in nature. The few experimental studies in nature suggest that trace metal contaminants can affect both the distribution and the abundance of aquatic insects. Insects have a largely unexploited potential as biomonitors of metal contamination in nature. A better understanding of the physico-chemical and biological mechanisms mediating trace metal bioavailability and exchange will facilitate the development of general predictive models relating trace metal concentrations in insects to those in their environment. Such models will facilitate the use of insects as contaminant biomonitors. 相似文献
17.
《Expert opinion on investigational drugs》2013,22(1):79-86
Advances in the molecular biological knowledge of neuronal nicotinic acetylcholine receptors (nAChRs) have led to a growing interest by the pharmaceutical industry in the development of novel compounds that selectively modulate nAChR function. The ability of (-)-nicotine, an activator of nAChRs, to enhance attentional aspects of cognition in animals and humans, to exert neuroprotective and anxiolytic-like effects, and presumably to mediate the negative correlation between smoking and Alzheimer's (and Parkinson's) Disease, has focused interest on the potential therapeutic utility of modulators of nAChR function for treatment of some of the deficits associated with these progressive, neurodegenerative conditions. Numerous compounds are known which activate nAChRs and which might serve as lead compounds toward the development of such agents. The pharmacologic diversity of neuronal nAChR subtypes suggests the possibility of developing selective compounds which would have more favourable side-effect profiles than existing agents. This broader class of agents, collectively called cholinergic channel modulators (ChCMs), is anticipated to encompass compounds which would have more favourable side-effect profiles than existing agents, which generally exhibit low selectivity. This selectivity may be achieved by preferentially activating some subtypes of nAChRs (i.e., Cholinergic Channel Activators, ChCAs) or inhibiting the function of other subtypes (Cholinergic Channel Inhibitors, ChCIs). An overview of the biology of nAChRs and the rationale for the use of ChCMs for the treatment of dementia related to neurodegenerative diseases are presented, followed by a discussion of lead compounds and compounds under consideration for clinical evaluation. 相似文献
18.
Chang Min Kim Kun Ho Son Sung Hwan Kim Hyun Pyo Kim 《Archives of pharmacal research》1991,14(4):305-310
In order to find out the values of the steroid resources for the future use. the compositions and contents of steroidal sapogenins
from 13 domestic plants have been investigated. As a result,Dioscorea nipponica, D. quinqueloba andSmilax china were found to have large amount of diosgenin. And pennogenin inTrillium kamtschaticum andParis verticillata, yuccagenin inAllium fistulosum, hecogenin inAgave americana and neochlorogenin inSolanum nigum were appeared to be major steroidal sapogenins. 相似文献
19.
Alberto García-Lled Javier Gmez-Pavn Juan Gonzlez del Castillo Teresa Hernndez-Sampelayo Mari Cruz Martín-Delgado Francisco Javier Martín Snchez Manuel Martínez-Sells Jos María Molero García Santiago Moreno Guilln Fernando Rodríguez-Artalejo Julin Ruiz-Galiana Rafael Cantn Pilar De Lucas Ramos Alejandra García-Botella Emilio Bouza 《Rev Esp Quimioter》2022,35(2):115
The precocity and efficacy of the vaccines developed so far against COVID-19 has been the most significant and saving advance against the pandemic. The development of vaccines has not prevented, during the whole period of the pandemic, the constant search for therapeutic medicines, both among existing drugs with different indications and in the development of new drugs. The Scientific Committee of the COVID-19 of the Illustrious College of Physicians of Madrid wanted to offer an early, simplified and critical approach to these new drugs, to new developments in immunotherapy and to what has been learned from the immune response modulators already known and which have proven effective against the virus, in order to help understand the current situation. 相似文献