瘦素、胰岛素样生长因子-1和胰岛素样生长因子结合蛋白-3在绝经后骨质疏松患者血清中的表达及意义

目的观察瘦素、胰岛素生长因子-1(IGF-1)和胰岛素样生长因子结合蛋白-3(IGFBP-3)在绝经后骨质疏松(PMOP)患者血清中的表达,并探讨其临床意义。方法 60例PMOP患者根据是否伴随骨折分为无骨折组(34例)和伴骨折组(26例),同期选择40例未发生PMOP的绝经后妇女作为对照组,采用ELISA法检测各组血清瘦素、IGF-1、IGFBP-3表达水平,采用骨密度(BMD)仪检测各组腰椎(L1~L4)、股骨颈、Wards三角部位的BMD,比较各组差异性并分析血清瘦素、IGF-1、IGFBP-3与BMD的相关性关系。结果观察组血清瘦素、IGF-1和IGFBP-3表达水平及BMD均明显低于对照组(P0.05);PMOP伴骨折组患者血清瘦素、IGF-1、IGFBP-3表达水平及BMD均明显低于PMOP无骨折组(P0.05);血清瘦素、IGF-1、IGFBP-3三者之间,及其与BMD均呈正相关性关系(P0.05)。结论血清瘦素、IGF-1、IGFBP-3可作为早期诊断PMOP和评估其严重程度的敏感性实验室指标。     

Insulin-like growth factor-1 and binding protein-3 in a 2-year soya intervention among premenopausal women

Soya foods may protect against the development of breast cancer. Insulin-like growth factor (IGF)-1 is under investigation as a possible link between nutrition and cancer. We examined the effect of soya foods on circulating IGF-1 and IGF binding protein (BP)-3 levels among 196 healthy premenopausal women in a 2-year randomised nutritional trial. The intervention group consumed two daily servings of soya foods including tofu, soya milk, soya nuts and soya protein powder (equivalent to 50 mg isoflavones and 5-22 g soya protein per serving); the controls maintained their regular diet. Five serum samples at baseline, 3, 6, 12, and 24 months were collected in the morning during the luteal phase and analysed for IGF-1 and IGFBP-3 by double-antibody ELISA. We applied mixed models to investigate the intervention effect and predictors of serum levels while considering the repeated measurement design. Adherence with the study regimen was high and dropout rates were acceptable. Randomisation resulted in similar mean IGF-1 and IGFBP-3 levels by group. We did not observe a significant intervention effect on IGF-1, IGFBP-3, and their molar ratio during the entire study period. However, urinary isoflavone excretion during the study period was positively associated with IGF-1 (P=0.04) and the IGF-1:IGFBP-3 ratio (P=0.06). The effect was consistent over time. Adding soya foods to the diet of premenopausal women does not appear to lower serum levels of IGF-1 and IGFBP-3; if anything, the greater protein intake from soya may lead to a small increase in IGF-1 serum levels.     

Association between insulin-like growth factor-1, insulin-like growth factor-binding protein-1 and leptin levels with nutritional status in 1-3-year-old children, residing in the central region of Limpopo Province, South Africa

The present study evaluated levels of growth factors and their associations with nutritional status with emphasis on stunting in children at 1 and 3 years of age. A follow-up study on a birth cohort (n 219) of children from villages in the central region of the Limpopo Province was undertaken. Of the original cohort, 156 and 162 could be traced and assessed at ages 1 and 3 years, respectively. Data collected included socio-demographic characteristics, anthropometric measurements, dietary intake and fasting blood (collected from 116 and 145 children at 1 and 3 years, respectively) for growth factor analysis (insulin-like growth factor (IGF)-1, IGF binding protein (BP)-1, IGFBP-3, leptin, glucose and insulin). At 1 year it was found that stunted children had lower leptin levels while their IGFBP-1 levels were higher than that in normal children. These differences were, however, not observed at 3 years. Furthermore at 1 year the biochemical parameters were more related to length measures whereas at 3 years the parameters were more associated with weight measures. The observed stunting in this group of children may be a result of chronic undernutrition resulting in long-term growth faltering which is already evident at 1 year. Thus the observed phenomenon might be an adaptive mechanism adopted by children's metabolic processes as they grow up in an environment with inadequate essential nutrients due to poor weaning practices and consumption of a diet of poor quality, resulting in them gaining more weight at the expense of linear growth.     

Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women

OBJECTIVE: The aim of this study was to examine the relationship of diet with serum insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in women. DESIGN: Cross-sectional study. SETTING AND SUBJECTS: The population are 2109 women who were control subjects in a case-control study of breast cancer nested in the European Prospective Investigation into Cancer and Nutrition. Control subjects were randomly chosen among risk sets consisting of female cohort members alive and free of cancer (except non-melanoma skin cancer) at the time of diagnosis of the index case. Matching criteria were age at enrolment, follow-up time, time of the day of blood collection and study centre. Diet was measured through validated questionnaires. Serum hormone concentrations were measured by enzyme-linked immunosorbent assays. The relationship between serum IGF-I, IGFBP-3, and intake of nutrients and foods was explored by linear regression in models adjusted for energy intake, age, body mass index, smoking, physical activity, centre and laboratory batch. RESULTS: Serum IGF-I levels were positively related to protein intake (P(trend)<0.001), but not related to energy, fat or carbohydrate intake. Positive relationships were observed with the intake of milk (P(trend)=0.007), calcium (P(trend)<0.001), magnesium (P(trend)=0.003), phosphorus (P(trend)<0.001), potassium (P(trend)=0.002), vitamin B6 (P(trend)=0.03), vitamin B2 (P(trend)=0.001) and inverse relationships with vegetables (P(trend)=0.02) and beta-carotene (P(trend)=0.02). IGFBP-3 was not related with most of the nutrients and foods in this study. CONCLUSIONS: In this population, circulating IGF-I is modestly related with the intake of protein and minerals, and with milk and cheese, while IGFBP-3 does not appear to be related with diet.     

先天性甲状腺功能减低患儿胰岛素样生长因子及其结合蛋白的变化

【目的】观察先天性甲状腺功能减低(CH)新生儿及经替代治疗的CH患儿血清中胰岛素样生长因子．1(IGF-1)及胰岛素样生长因子结合蛋白-3(IGFBP-3)的变化。【方法】收集22例CH新生儿、21例替代治疗后的CH患儿静脉血清，采用放射免疫分析法(RIA)测定ICF-1水平，免疫放射分析法(IRMA)测定IGFBP-3水平，并与20例正常新生儿做对照。【结果】与正常新生儿组比较，CH新生儿血清IGF-1和IGFBP-3水平显著降低；替代治疗1～6月后，CH患儿血清IGF-1和IGFBP．3水平较CH新生儿明显升高。各组内IGF-1与IGFBP-3呈正相关，CH新生儿血清IGF-1和IGFBP-3水平与T4、TSH无明显相关性。【结论】CH患儿治疗前血清中IGF-1和IGFBP-3水平明显降低，替代治疗后水平升高。     

血清IGF-1、IGFBP-3水平和大肠癌关系的Meta分析

目的综合评价血清胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)水平和大肠癌的关系。方法利用Meta分析法对6篇关于血清IGF-1、IGFBP-3水平与大肠癌关系的研究文献进行定量综合分析。结果对于IGF-1，合并OR=1．56(95％CI：1．14～2．13)；按实验方法不同分层，间接酶联免疫吸附试验(ELISA)合并OR=1．92(95％CI：1．26～2．93)，IRMA法合并OR=1．23(95％CI：0．78～1．94)；对于IGFBP-3，合并OR=0．78(95％CJ：0．43～1．44)；按实验方法不同分层，ELISA法合并OR=0．46(95％CI：0．29～0．74)，免疫放射测定法(IRMA)合并OR=1．44(95％CI：0．93～2．23)。结论血清IGF-1高水平为大肠癌的独立危险因子，IGFBP-3与大肠癌的关联不具有统计学意义；IGFBP-3与大肠癌关系的各研究之间异质性是由实验方法不同而引起，但该结论尚需大样本并同时进行两种方法的测量证实。     

胰岛素样生长因子及其结合蛋白与妊娠期高血压疾病的相关性研究

目的:研究妊娠期高血压疾病患者血清胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白-1(IGFBP-1)的水平与病情程度及新生儿出生体重之间的关系。方法:采用放射免疫方法测定并比较38例妊娠期高血压疾病患者与38例正常血压妊娠妇女的血清IGF-1、IGFBP-1的水平。结果:子痫前期组IGF-1显著低于妊娠期高血压组和正常组,而IGFBP-1水平显著高于妊娠期高血压组和正常组;妊娠期高血压组与正常组间IGF-1、IGFBP-1的水平比较,差异均无统计学意义。IGF-1水平与收缩压、舒张压及平均动脉压呈显著负相关,与新生儿出生体重呈显著正相关,而IGFBP-1与收缩压、舒张压及平均动脉压呈显著正相关,与新生儿出生体重呈显著负相关。结论:妊娠期高血压疾病患者的发病及严重程度与IGF-1、IGFBP-1有明显的关系,IGF-1、IGFBP-1与胎儿的发育及新生儿出生体重有明显的相关性。     

Effect of lycopene supplementation on insulin-like growth factor-1 and insulin-like growth factor binding protein-3: a double-blind, placebo-controlled trial

OBJECTIVE: Studies have suggested a link between lycopene and insulin-like growth factor-1 (IGF-1). The aim of this study was to test the effect of lycopene supplementation on IGF-1 and binding protein-3 (IGFBP-3) status in healthy male volunteers. DESIGN, SETTING, SUBJECTS AND INTERVENTION: This was a 4 week randomized, double-blind, placebo-controlled study of lycopene supplementation (15 mg/day) in healthy male volunteers (n=20). Fasting blood samples were collected at baseline and after 4 weeks. Samples were analysed for lycopene by high-performance liquid chromatography (HPLC) and IGF-1 and IGFBP-3 by enzyme-linked immunosorbent assay (ELISA). Changes in end points from baseline were compared in those who received placebo versus those who received the lycopene supplement. RESULTS: Median change in lycopene from baseline (post-supplement - baseline) was higher in subjects in the intervention than those on placebo (lycopene group 0.29 (0.09, 0.46); placebo group 0.03 (-0.11, 0.08) micromol/l; median (25th, 75th percentiles), P<0.01). There was no difference in median change in IGF-1 concentrations (lycopene group -0.6 (-2.6, 1.9); placebo group -1.15 (-2.88, 0.95) nmol/l, P=0.52), or median change in IGFBP-3 concentrations (lycopene group 245 (-109, 484); placebo group 101 (-34, 234) nmol/l, P=0.55) between intervention and control groups. Change in lycopene concentration was associated with the change in IGFBP-3 in the intervention group (r=0.78; P=0.008; n=10). CONCLUSIONS: Lycopene supplementation in healthy male subjects has no effect on IGF-1 or IGFBP-3 concentrations in a healthy male population. However, the association between change in lycopene concentration and change in IGFBP-3 in the intervention group suggests a potential effect of lycopene supplementation on IGFBP-3.     

Decreased serum estradiol concentration associated with high dietary intake of soy products in premenopausal Japanese women

We examined the cross‐sectional relationship of soy product intake to serum concentrations of estradiol (E2) and sex hormone‐binding globulin (SHBG) in 50 healthy premenopausal Japanese women. Intakes of soy products and various nutrients were estimated through a semiquantitative food‐frequency questionnaire. Blood samples were drawn from each subject on Days 11 and22 of her menstrual cycle. The intake of soy products was inversely correlated with E2 on Days 11 and 22 of the cycle after controlling for age, body mass index, cycle length, and intakes of total energy, fat, and crude fiber (r = ‐0.23, p = 0.08 and r = —0.32, p = 0.04, respectively). No significant correlation was observed between soy product intake and SHBG. There was a tendency for the intake of individual soy foods such as tofu and miso to be inversely correlated with E2 on Days 11 and 22 of the menstrual cycle. Miso intake was inversely significantly correlated with SHBG on Day 22 of the cycle (r = ‐0.36, p = 0.02). If the observed association is causal, our results suggest that the consumption of soy products lowers the risk of developing breast cancer risk modifying estrogen metabolism.     

Hyperinsulinemia,insulin-like growth factor-I,insulin-like growth factor-binding protein-1, and sex-hormone binding-globulin in prepubertal and pubertal girls with premature adrenarche

Precocious adrenarche is defined as the development of pubic hair before the age of 8 years in girls and 9 years in boys. Pubarche caused premature adrenarche in girls has been considered as a normal variant of pubertal development for years. Recently, it is cleared that premature pubarche can be considered as a marker of increased risk for endocrine and metabolic abnormalities. Precocious adrenarche in affected girls is associated with hyperinsulinaemia and functional ovarian hyperandrogenism during puberty. Authors investigated serum levels of insulin-like growth factor-I (IGF-I), insulin-like growth factor-binding protein-1 (IGFBP-1), insulin-like growth factor-binding protein-3 (IGFBP-3), sex hormone binding-globulin (SHBG) and levels of insulin during oral glucose tolerance test in 34 girls with premature adrenarche in 38 age- and BMI-matched healthy controls. Affected girls were assigned into prepubertal and pubertal subgroups. It has been shown that hyperinsulinaemia, decrease in IGFBP-1 and increase IGF-I levels may be present in some affected prepubertal patients. In the pubertal group, in addition to hyprinsulinaemia, decreased IGFBP-1 and increased IGF-I levels an attenuated SHBG level was observed. According to the authors, these laboratory parameters may predict endocrine and metabolic abnormalities in later life. The observed correlations support the hypothesis that insulin/IGF system plays role in the pathogenesis of hyperandrogenism in premature adrenarche and in later hormonal and metabolic changes.     

食管癌血清转化生长因子-β1、胰岛素样生长因子-1变化与疾病恶性程度及与预后的关系

目的 探讨食管癌患者血清中转化生长因子-β1(transforming growth factor-β1,TGF-β1)、胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)的变化及其意义。 方法 选取濮阳市油田总医院确诊的90例食管癌患者为食管癌组、选取45例体检健康对象作为对照组,检测分析两组的血清IGF-1、TGF-β1水平,并分析不同TNM分期、肿瘤分化程度、肿瘤浸润程度、淋巴结转移情况的食管癌患者血清IGF-1、TGF-β1水平差异;采用Cox比例风险回归模型分析血清IGF-1、TGF-β1水平与患者预后的相关性。 结果 食管癌组患者的血清IGF-1、TGF-β1分别为(254.9±88.4)μg/L、(49.6±14.1)μg/L,高于对照组的(40.1±13.0)μg/L、(28.5±8.0)μg/L,差异均有统计学意义(均P<0.05);在不同TNM分期、是否发生淋巴结转移、不同分化程度的食管癌组患者的血清IGF-1水平组间比较,差异均有统计学意义(P<0.05);在不同TNM分期、是否发生淋巴结转移的食管癌组患者的血清TGF-β1水平组间比较,差异均有统计学意义(P<0.05);Cox比例风险模型进行分析显示:食管癌患者的TNM分期增高、分化程度降低、发生淋巴结转移、血清IGF-1及TGF-β1水平升高是患者不良预后的独立性危险因素(P<0.05)。 结论 食管癌组患者的血清IGF-1、TGF-β1水平较健康人群升高,并且与患者肿瘤恶性程度增加及预后不良有关。     

血清胰岛素样生长因子-1与高血压前期的联系

目的研究高血压前期与胰岛素样生长因子-1（IGF-1）之间的关系,探讨高血压的相关发病机制,从而为高血压的早预防、早诊断、早治疗提供新的思路和理论依据。方法采用自然抽样法选择天津市内六区的40—70岁常住居民非高血压390例为研究对象,根据血压水平分为高血压前期组（195例）与正常血压对照组（195例）,对其进行全面体检。采用酶联免疫吸附（ELISA）法测定两组的IGF-1水平,然后进行统计分析。结果高血压前期组IGF-1水平[（114．81±72．62）μg／L]明显高于正常血压对照组（99．48±62．08）wg／L],差异有统计学意义（t=2．241,P〈0．05）。logistic多元回归分析显示,IGF-1水平、性别、年龄和体质指数为高血压前期的相关独立危险因素[OR值分别为1．637（95％CI：1．056—2．536）、2．092（95％CI：1．213—3．607）、2．035（95％CI：1．469—2．821）和3．190（95％CI：2．052～4．958）,P〈0．05]。结论高血压前期患者的IGF-1水平升高,IGF-1可能参与了高血压前期的发生与发展。     

高磷酸化胰岛素样生长因子结合蛋白-1联合宫颈长度预测早产

目的:探讨检测早产高危孕妇宫颈分泌物中高磷酸化胰岛素样生长因子结合蛋白-1(phIGFBP-1)、腹部超声检查宫颈长度预测早产的价值。方法:孕24~34周用分娩预测试纸检测宫颈分泌物中phIGFBP-1(Actim Partus test),同时腹部超声检测宫颈长度(cervical length,CL),观察记录分娩结局。结果:早产组phIGFBP-1阳性率38.89%(7/18),足月产组phIGFBP-1阳性率10.61%(7/66),两组比较差异有统计学意义(P<0.01)。根据受试者工作特性曲线(ROC曲线),CL≤4.0 cm为最佳参考值。以CL≤4.0 cm为临界点,结合宫颈分泌物phIGFBP-1,预测早产的敏感性38.89%(7/18)、特异性66.67%(44/66)、阳性预测值58.33%(7/12)、阴性预测值91.67%(44/48)。结论:孕妇宫颈分泌物phIGFBP-1阳性、CL≤4.0 cm是预测早产发生的敏感、可靠指标。     

学龄前肥胖儿童血清IGF-Ⅰ、IGF-BP_3与其他激素相互关系的研究

【目的】研究学龄前肥胖儿童血清胰岛素样生长因子-Ⅰ（IGF-Ⅰ）、胰岛素样生长因子结合蛋白-3（IGF-BP3）与瘦素（Leptin）、胰岛素（Ins）、雌二醇（E2）及睾酮（T）的相互关系,探讨IGF-I在肥胖发病机制中的作用,为肥胖儿童的早期干预提供理论依据。【方法】对122例学龄前肥胖儿童及61例正常儿童血清IGF-Ⅰ、IGF-BP3、Leptin、Ins、E2和T水平进行测定,并分析IGF-Ⅰ、IGF-BP3与其他激素的相互关系。【结果】学龄前肥胖儿童血清IGF-Ⅰ、IGF-BP3、Leptin、Ins和E2水平明显高于对照组（P值均〈0.001）,两组间睾酮水平差异无显著性（P〉0.05）;血清IGF-Ⅰ、IGF-BP3与Leptin、Ins、E2及睾酮水平显著正相关（P值均〈0.01）,且Leptin与Ins、E2水平显著正相关（P值均〈0.001）;多元线性回归分析显示IGF-BP3、Ins和E2是影响IGF-Ⅰ的重要因素。【结论】学龄前肥胖儿童IGF-Ⅰ、Leptin和Ins在调节机体能量代谢过程中不仅作为独立的外周因子发挥作用,同时提示IGF-Ⅰ对儿童生长发育以及性发育的调控受Leptin、Ins及性激素多种激素水平的共同影响,IGF-Ⅰ是儿童肥胖又一敏感检测指标。     

Insulin-like growth factor 1, insulin-like growth factor-binding protein 3, and testicular germ-cell tumor risk

Studies have consistently shown that taller men are at increased risk of testicular germ-cell tumors. Thus, it is plausible that factors associated with height may also influence risk of these tumors. The authors examined associations between testicular germ-cell tumor risk and circulating concentrations of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor-binding protein 3 (IGFBP-3) among 517 cases and 790 controls from the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) Study (2002-2005). Odds ratios and 95% confidence intervals were estimated using logistic regression models, adjusting for age, race/ethnicity, height, and body mass index. All tests of significance were two-sided. Overall, there were no associations between IGF-1 or IGFBP-3 concentrations and risk of testicular germ-cell tumors (p > 0.05). However, when cases were separated by histologic type, there was a suggestion of a reduction in seminoma risk associated with the highest concentrations of IGF-1 as compared with the lowest concentrations (odds ratio = 0.66, 95% confidence interval: 0.40, 1.09). Although there were no overall associations with insulin-like growth factor, contrary to expectation, there was a suggestion that IGF-1 concentrations may be inversely associated with risk of seminoma.     

Factors associated with serum levels of estradiol and sex hormone-binding globulin among premenopausal Japanese women.

We measured serum levels of estradiol (E(2)) and sex hormone-binding globulin (SHBG) among 50 healthy premenopausal Japanese women in 1994 in Gifu, Japan, to investigate the relationships between potential risk factors for breast cancer and hormone levels. Using a self-administered questionnaire, we collected data on body size, physical activity, and previous disease history, as well as menstrual and reproductive histories of the woman and her mother. Blood samples were drawn from each subject on the 11th and 22nd days of her menstrual cycle. Higher serum E(2) levels were observed for women with shorter menstrual cycles. Age as well as cycle length were included in the regression models to determine the associations between hormone levels and study variables. Body mass index (BMI) was inversely related to SHBG level measured at the 11th day of the cycle, after adjusting for age and cycle length (r = -0.33; p = 0. 03). Women born in spring/summer had higher levels of E(2) on the 22nd day (p = 0.07) and higher levels of SHBG on both the 11th and 22nd days of the cycle (p = 0.01 and p = 0.06, respectively) than those born in other seasons. Physical activity at 13-15 years of age was inversely related to E(2) level on the 11th day of the cycle after controlling for age, cycle length, BMI, and birth month (r = -0.35; p = 0.04).     

人胰岛素样生长因子-1与肠外营养

人胰岛素样生长因子－１是一种对机体生长和代谢具有广泛作用的分泌蛋白,与机体的营养调节密切相关。本文综述其对机体代谢的作用、作用机制,讨论其在肠外营养条件下的辅助治疗作用。     

新生儿缺氧缺血性脑病血清和脑脊液中胰岛素样生长因子-I水平变化及相关性研究

目的观察新生儿缺氧缺血性脑病(HIE)血清、脑脊液中胰岛素样生长因子-I(IGF-I)水平的变化及相关性,探讨IGF-I在新生儿HIE发病机制及预后中的作用。方法用放射免疫法(RIA)检测 41例HIE组新生儿生后12 h-24 h及10 d-12 d血清、脑脊液及10例正常足月新生儿(对照组)血清中 IGF-I的水平变化。结果①生后12 h-24 h,轻、中、重度HIE组血清IGF-I的水平分别为(32．94± 8.43)ng／ml,(22．56土5．51)ng／ml,(15．77土3．60)ng／ml,明显低于对照组(79．28士13．28)ng／ml(P< 0.01);且HIE程度越重,IGF-I的水平越低(P<0．05)。②生后10d-12d,轻、中度HIE组及重度HIE无症状组血清中IGF-I的水平分别为(67．22±21．52)ng／ml,(68．54±22．88)ng／ml,(52．58土14．11) ng／ml,分别较各组生后12 h-24 h的水平增高(P<0．01),仍低于对照组(P<0．01),其脑脊液中的水平分别为(6．18土0．87)ng／ml,(5．74±0．94)ng／ml,(5．08±0．87)ng／ml,也较生后12 h-24 h时的水平,分别为(4．43±1．16)ng／ml,(3．19±0．84)ng／ml,(1．97±0．45)ng／ml均明显增高(P<0．01);重度HIE有症状组血清和脑脊液的IGF-I水平分别为(22．49±10．58)ng／ml和(2．26±0．70)ng／ml,虽较生后12 h -24 h增高,分别为(14．22±3．37)ng／ml,(1．87±0．80)ng／ml,但差异无显著意义(P>0．05),然而却明显低于其他各组的水平(P<0．01)。③HIE组血清与脑脊液的IGF-I水平呈正相关关系(r=0．84,P< 0．05)。结论 IGF-I是一种重要的神经保护因子,其水平的改变可能与新生儿HIE的发生、发展及预后有关。     

新生儿缺氧缺血性脑病血清和脑脊液中胰岛素样生长因子-Ⅰ水平变化及相关性研究

目的观察新生儿缺氧缺血性脑病(HIE)血清、脑脊液中胰岛素样生长因子-Ⅰ(IGF-Ⅰ)水平的变化及相关性,探讨IGF-Ⅰ在新生儿HIE发病机制及预后中的作用.方法用放射免疫法(RIA)检测41例HIE组新生儿生后12 h～24 h及10 d～12 d血清、脑脊液及10例正常足月新生儿(对照组)血清中IGF-Ⅰ的水平变化.结果①生后12 h～24 h,轻、中、重度HIE组血清IGF-Ⅰ的水平分别为(32.94±8.43)ng/ml,(22.56±5.51)ng/ml,(15.77±3.60)ng/ml,明显低于对照组(79.28±13.28)ng/ml(P＜0.01);且HIE程度越重,IGF-Ⅰ的水平越低(P＜0.05).②生后10d～12d,轻、中度HIE组及重度HIE无症状组血清中IGF-Ⅰ的水平分别为(67.22±21.52)ng/ml,(68.54±22.88)ng/ml,(52.58±14.11)ng/ml,分别较各组生后12 h～24 h的水平增高(P＜0.01),仍低于对照组(P＜0.01),其脑脊液中的水平分别为(6.18±0.87)ng/ml,(5.74±0.94)ng/ml,(5.08±0.87)ng/ml,也较生后12 h～24 h时的水平,分别为(4.43±1.16)ng/ml,(3.19±0.84)ng/ml,(1.97±0.45)ng/ml均明显增高(P＜0.01);重度HIE有症状组血清和脑脊液的IGF-Ⅰ水平分别为(22.49±10.58)ng/ml和(2.26±0.70)ng/ml,虽较生后12 h～24 h增高,分别为(14.22±3.37)ng/ml,(1.87±0.80)ng/ml,但差异无显著意义(P＞0.05),然而却明显低于其他各组的水平(P＜0.01).③HIE组血清与脑脊液的IGF-Ⅰ水平呈正相关关系(r=0.84,P＜0.05).结论IGF-Ⅰ是一种重要的神经保护因子,其水平的改变可能与新生儿HIE的发生、发展及预后有关.     

Association between birth weight and serum lipid concentration in premenopausal Japanese women

BACKGROUND: The relationships between birth weight and serum lipid concentrations in pre-menopausal Japanese women were not well identified and also diet and serum hormone status in these women would be considered. METHODS: A total of 59 premenopausal Japanese women completed a self-administered questionnaire including basic demographic information, disease histories, and menstrual and reproductive histories. They were asked to obtain information on birth weight recorded in mother-and-baby notebook issued by municipality from their mother. Diet was assessed by daily diet records from day 2 through day 10 of the menstrual cycle. Blood sample was collected on day 11 of the cycle to measure serum lipid and hormone concentrations (total and high-density lipoprotein [HDL] cholesterols, triglyceride, estrone, estradiol, and sex hormone-binding globulin). RESULTS: Birth weight was significantly correlated with HDL cholesterol (r = 0.32, p = 0.03), but not with total cholesterol and triglyceride after controlling for age. Neither estrogen nor sex hormone-binding globulin was significantly correlated with serum lipid concentrations after controlling for age and the number of days prior to the next menses. The correlation between birth weight and HDL cholesterol was not affected after additional adjustment for serum estrogen and intakes of protein, calcium, and iron. CONCLUSION: These data suggest that intrauterine growth may be associated with lipid profile.