545例老年脂溢性角化病患者血脂、血糖及血压检测分析

对545例老年脂溢性角化病患者总胆固醇、甘油三酯、高密度脂蛋白及低密度脂蛋白、血糖、血压作相关的检测分析。并与正常对照组比较。结果发现脂溢性角化病患者血脂、血糖及血压异常率明显高于正常对照组。     

巨大脂溢性角化病

报告1例巨大脂溢性角化病。患者女,59岁。因右臀部皮肤逐渐增大的褐色斑块30余年就诊。皮损约20 cm×15 cm,表面粗糙,无浸润。皮损组织病理检查示表皮角化过度伴角化不全,棘层肥厚,乳头瘤样增生,以基底样细胞为主,见假性角囊肿形成。诊断为脂溢性角化病。     

巨大脂溢性角化病1例

患者女,68岁,维吾尔族.因头部长肿物2年,于2010年3月10日就诊于我院.患者2年前右侧颞部头皮出现一黑褐色扁平斑块,渐增大,并突起,偶有瘙痒,无破溃及出血.     

耳蜗脂溢性角化一例

患者男,78岁。因左耳窝褐色肿物6年余于2004年2月15日来我所就诊。患者6年前发现左耳窝褐色肿物,约黄豆大小。无明显痛痒。肿物随时间增长逐渐增大,近1年来增长速度较前加快,突出耳廓,表面凸凹不平,有时肿物出现部分破溃,流血水且有臭味。患者曾外用多种糖皮质激素、癣药膏等治疗,无明显缓解。此外,近年来患者面额部、头皮、颈部、躯干及双上肢出现散在深褐色斑块和褐色赘生物,无痛痒。近几个月来,因左     

沿皮肤切线分布的脂溢性角化病1例

患者女，６５岁，背部多数褐黄色丘疹３年。皮损位于背部，呈圆形、椭圆形、梭形及彗星形，直径１ｍｍ～２ｃｍ，腰背部皮损沿皮肤切线分布，呈流线型排列。组织病理示角化过度，棘层肥厚与乳头瘤样增生，主要为鳞状细胞和基底样细胞     

额部巨大脂溢性角化病

<正>患者,男,84岁。主诉:额部黑色肿物10余年。现病史:患者于10年前左右额部开始出现一黑色丘疹,随时间推移逐渐增大,隆起皮面,曾于当地医院就诊,具体不详,效果欠佳。自诉近半年内肿物增大明显,伴少许瘙痒,于当地医院诊断为恶性黑色素瘤?未行治疗,即于2017年4月6日来我院就诊,门诊以1.额部脂溢性角化;2.额部恶性黑素瘤待排查收入院。患者发病以来一般情况尚可,二便正常,体重无明显改变。家族史、既往史:家族中无类似病史。既往体健。     

81例脂溢性角化病临床与病理分析

脂溢性角化病是多种原因引起以角质形成细胞成熟迟缓所致的一种老年性良性表皮内肿瘤。一般无自觉症状 ,皮损受刺激或感染后表面可结痂或出血 ,易误诊为恶性黑色素瘤 ,极少发生恶变。本病病理上有某些特征及变异。我们对 81例脂溢性角化病患者的临床与病理进行分析 ,现报告如下。1　临床资料本资料为我院 1991年 1月～ 1997年12月经病理确诊为脂溢性角化病的皮肤科、外科、眼科及耳鼻喉科门诊病人共 81例。其中男 48例 (5 9% ) ,女 33例 (4 1% ) ;年龄最小 2 6岁 ,最大 79岁 ,平均 5 5 .6岁 ,39岁以下 6例 (7% ) ,40～ 5 9岁 45例(5 6 % ) ,…     

脂溢性角化病的研究进展

脂溢性角化病是临床上常见的皮肤病,但是其病因不甚明了。近期的研究认为其发病与年龄、日光照射、细胞凋亡受阻等相关,因而新的治疗方法也应运而生。     

153例脂溢性角化病的临床与病理分析

回顾性分析我科近4年诊断为脂溢性角化病153例的临床及组织病理学情况。病理诊断主要是棘层肥厚型、角化过度型、棘层肥厚型和角化过度型的混合型、腺样型、刺激型、菌落型与黑素棘皮瘤型。该病临床诊断与组织病理之间有一定的差异性,本组临床诊断为脂溢性角化病的115例中,组织病理符合91例,临床误诊率为20.9%;病理诊断为脂溢性角化病的153例中临床误诊62例。应注意与相关疾病鉴别,日光对脂溢性角化病的形成及其发病年龄提前有一定影响。     

穴位封闭疗法治愈胫前粘液性水肿1例

穴位封闭疗法治愈胫前粘液性水肿１例桂林市中西医结合医院皮肤科邓翠荣患者女性，５７岁，因双小腿下部斑块伴破溃、流脓半年就诊。既往有甲亢病史，检查：双小腿下１／３部位皮肤呈环状肿胀，有大小不等、形状不规则之斑块，压之无凹陷，局部破溃，诊断：胫前粘液性水肿...     

EGF、EGFr在脂溢性角化病组织中的表达

为探讨以皮肤衰老为特征之一的脂溢性角化病（seborrheic keratosis,SK)病变组织中角质形成细胞成熟迟缓的发病机理,采用免疫组织化学二步法对32例脂溢性角化病皮损组织及作对照的10名正常皮肤组织石蜡标本中表皮生长因子（EGF）及其受体（EGFr)进行检测。结果SK组的EGF和EGFr在阳性表达强度上均高于正常对照组（P＜0．01）,EGFr在脂溢性角化病皮损角质层,颗粒层和棘细胞上层中有广泛的表达,并且棘层肥厚伴角化过度或乳头状瘤样增殖者表达呈强阳性。提示EGF和EGFr的这种异常或超表达可能与脂溢性角化病角质形成细胞的过度增殖的发生有一定的关系。     

High expression level of homocitrulline is correlated with seborrheic keratosis and skin aging

BackgroudHomocitrulline (Hcit), is involved in the pathological processes of some diseases. However, the role and function of Hcit (CBL) in human skin remains largely obscure.ObjectiveTo investigate the correlation of the level of Hcit in seborrheic keratosis, skin aging, and its clinical significance.MethodsImmunohistochemistry was used to analyze the level of Hcit in skin lesions of seborrheic keratosis (SK), unaffected skin (distant 0.5 centimeters from SK lesion), and normal skin of healthy subjects in the control group. ELISA test was used to detect the serum level of CBL in SK patients and healthy subjects of different ages.ResultsHcit was mainly localized in the nucleus of epidermal cells. In healthy control skin, the expression of Hcit increased with age and showed a positive correlation with age (the correlation coefficient was 0.806, p = 0.0002). The expressional level of Hcit in SK lesions was higher than that in healthy control skin (Z = −3.703, p = 0.0002). The serum level of CBL in healthy subjects and in SK patients increased with age (the correlation coefficient were 0.5763, p = 0.0032; 0.682, p = 0.004. respectively). The serum level of CBL in SK patients was higher than that in healthy subjects (Z = −2.19, p = 0.030).Study limitationsThe small serum sample size in the study.ConclusionThe high expressional level of Hcit is correlated with seborrheic keratosis and skin aging. HCit may be one of the potential biomarkers of skin aging.     

Smad7在脂溢性角化病、日光性角化病及基底细胞癌中的表达

目的： 检测Smad7在脂溢性角化病、日光性角化病以及基底细胞癌中的表达。方法：对脂溢性角化病、日光性角化病及基底细胞癌标本（各30例）和30例正常标本进行免疫组化染色。结果：23例脂溢性角化病标本、23例日光性角化病标本和28例基底细胞癌标本中Smad7染色阳性,阳性细胞率分别为（31.0±23.0）%,（32.7±26.3）%和（62.6±32.1）%,均显著高于正常组织的（6.7±5.0%）。结论： Samd7可能与脂溢性角化病、日光性角化病以及基底细胞癌的发病有关。     

调Q开关倍频Nd：YAG激光和超脉冲CO2激光对早期脂溢性角化病的疗效比较

目的探讨两种治疗方法对于早期脂溢性角化病的临床效果。方法将患者随机分为两组,分别用调Q开关Nd：YAG激光和超脉冲CO2激光治疗,对比观察治疗效果：结果调Q开关Nd：YAG激光总有效率为96．12％,超咏冲CO2激光治疗组总有效率97．24％,没有统计学差异。术后两组色素沉着率分别为8．74％和25．35％;色素减退率分别为4．37％和7．38％;调Q开关Nd：YAG激光没有疤痕形成,超脉冲CO2激光疤痕形成率为4．15％;均有统计学差异。结论表明调Q开关Nd：YAG激光是一种理想的治疗手段。     

A comparison of dermoscopic features among lentigo senilis/initial seborrheic keratosis, seborrheic keratosis, lentigo maligna and lentigo maligna melanoma on the face

Clinical differentiation of facial lentigo senilis/initial seborrheic keratosis (LS/ISK), seborrheic keratosis (SK), lentigo maligna (LM), and lentigo maligna melanoma (LMM) can be difficult. Dermoscopy improves the diagnoses in pigmented skin lesions (PSLs), but it is not helpful for the sun-exposed face because of the flat rete ridges without network-derived features. Therefore, development of new diagnostic criteria for this particular localization is a current issue of dermatology. In this retrospective study, dermoscopic slides of facial pigmented skin lesions of 66 patients referred to two clinics in Turkey were evaluated. Our aim was to determine the reliability of dermoscopy in the differentiation of these entities. The facial PSLs of 66 patients (34 males and 32 females) (median age: 58.2) were photographed with a Dermaphot (Heine, Hersching, Germany) over a five year period from November of 1995 to May of 2000. All of the dermoscopic slides were analysed according to 27 dermoscopic criteria developed by Schiffner et al. This data set contained 22 histologically proven malignant (14 LM, 8 early LMM) and 44 benign (18 SK, 26 LS/ISK) PSLs. In general, asymmetric pigmented follicular openings, dark streaks, slate-gray streaks, dark globules, slate-gray globules, dark dots, dark rhomboidal structures, light brown rhomboidal structures, dark homogeneous areas and dark pseudonetworks were statistically significant for malignant growth. On the other hand, milia-like cysts, pseudofollicular openings, cerebriform structures, light brown globules, light brown dots, light brown homogeneous areas, yellow opaque homogeneous areas, and light brown pseudonetworks were statistically significant for benign growth. This research emphasizes that dermoscopic features on the face differ from criteria used in other locations of the body. Analysis of the data suggests that dermoscopy can be used in the differentiation of LS/ISK, SK, LM and LMM from each other.     

皮肤镜诊断黑素细胞痣、脂溢性角化和日光性角化与组织病理诊断的一致性

目的：评价皮肤镜诊断黑素细胞痣、脂溢性角化、日光性角化的准确度。方法：收集临床怀疑为黑素细胞痣、脂溢性角化和日光性角化的病例,由两位医生参照目前皮肤镜诊断标准对该三种皮肤肿瘤进行盲法独立诊断,并与组织病理结果相对照。结果：与组织病理诊断比较,(1)A、B两位医生使用皮肤镜诊断黑素细胞痣一致率（89.3%、91.2%）、灵敏度（94%、95.2%）、特异度（84.2%、86.8%）、误诊率（15.8%、13.2%）、漏诊率（6%、4.8%）。(2)A、B两位医生使用皮肤镜诊断脂溢性角化一致率（88%、91.7%）、灵敏度（91.7%、95.8%）、特异度（83.6%、86.9%）、误诊率（16.4%、13.5%）、漏诊率（8.3%、4.2%）;(3)A、B两位医生使用皮肤镜诊断日光性角化一致率（84.1%、86.4%）、灵敏度（87.5%、87.5%）、特异度（17.9%、12.5%）、误诊率（82.1%、85.7%）、漏诊率（17.9%、14.3%）。结论：皮肤镜诊断黑素细胞痣、脂溢性角化和日光性角化的结果与病理诊断结果均有较好的一致性。     

An acantholytic variant of seborrheic keratosis

A case of an acantholytic seborrheic keratosis, first reported by Tagami and Yamada, was seen in a 63-year-old woman. It appeared to belong to the irritated type of Lever's classification.     

脂溢性角化病并发基底细胞上皮瘤

报告1例脂溢性角化病并发基底细胞上皮瘤.患者女,60岁.鼻右侧出现新生物2个月,无痛痒.皮损组织病理检查示表皮角化过度,棘层肥厚,乳头瘤样增生,伴角囊肿形成,增生表皮由鳞状细胞和基底样细胞组成,其基底部与两侧正常表皮位于同一平面上;真皮浅层有基底样细胞形成的肿瘤团块,周边细胞呈栅栏状排列.依据临床和组织病理学改变,确诊为脂溢性角化病并发基底细胞上皮瘤.