肌钙蛋白I阳性的非ST段抬高的急性冠状动脉综合征患者的临床和造影特点

目的研究肌钙蛋白I(cTnI)阳性的非ST段抬高的急性冠脉综合征(ACS)患者临床和冠脉造影的特点.方法77例ACS患者根据cTnI是否阳性分成阳性组(46例)和阴性组(31例).分别记录30天内心脏事件发生情况,45例于住院期间接受了冠脉造影(cTnI阳性组26例,阴性组19例),分析冠脉病变的特点.结果cTnI阳性组人院前24小时心绞痛的发作次数及持续时间显著长于阴性组,有显著性差异(P＜0.05).心性死亡的发生率分别为1.33%vs 0%(P＜0.05).阳性组多支血管病变占69.2%,阴性组占44.4%(P＜0.01).结论复杂的冠脉病变及在此基础上的血栓形成所引起严重的反复发作的心绞痛可能是急性冠脉综合征患者cTnI阳性的主要原因.     

高敏C反应蛋白、心肌肌钙蛋白I对急性冠脉综合征的诊断价值

目的 :探讨急性冠脉综合征 (ACS)的早期诊断方法。方法 :6 8例冠心病 (CHD)患者分成 3组 ,其中急性心肌梗死 (AMI)组 2 1例 ,不稳定型心绞痛 (UA)组 2 7例 ,稳定型心绞痛 (SA)组 2 0例 ,采用胶乳凝集反应法定量测定高敏 C反应蛋白 (Hs-CRP) ,采用固相层析免疫法定性测定肌钙蛋白 I(c Tn I)。结果 :AMI组与 UA组的 Hs-CRP含量及 c Tn I阳性率均明显高于 SA组 ,差异均有显著性 (P<0 .0 5 ) ;AMI组与 UA组比较差异有显著性 (P<0 .0 5 )。结论 :Hs-CRP和 c Tn I的增高与急性冠脉综合征密切相关。     

肌钙蛋白I对急性冠脉综合征的临床意义

目的:探讨血中肌钙蛋白I(c Tn I)的检测在急性冠脉综合征(ACS)的诊断及临床中的应用价值。方法:选择临床诊断为ACS的患者94例,其中急性心肌梗死(AMI)35例,不稳定型心绞痛(UAP)30例,稳定型心绞痛(SAP)29例,71例健康体检作为对照组,检测其c Tn I的含量,并作相互比较。结果:AMI组c Tn I水平显著高于UAP组、SAP组和对照组(P0.05);UAP组c Tn I水平显著高于SAP组和对照组(P0.05);SAP组和对照组相比较差异无统计学意义(P0.05)。结论:检测患者c Tn I水平对ACS患者疾病诊断及预后预测具有重要的临床意义。     

急性冠脉综合征患者CRP检测的临床意义

目的 :探讨C反应蛋白 (C -reactionproteinCRP)升高在急性冠脉综合征 (ACS)患者中的临床意义。方法 :测定经冠脉造影确诊的冠心病患者 65例 ,其中急性冠脉综合征 (ACS) 4 5例 ,稳定型心绞痛 (SAP) 2 0例 ,及冠脉造影排除冠心病的患者 3 0例的血清CRP浓度。结果 :ACS组血CRP浓度显著增高 ,与SAP组及对照组之间比较有显著性差异 (P <0 .0 5 ) ,SAP组与对照组之间CRP浓度无显著性差异。结论 :急性冠脉综合征与炎症反应显著相关。CRP升高提示冠心病患者病情不稳定。CRP可作为临床ACS患者的监测指标     

青年急性冠脉综合征冠脉造特点及随访

目的:探讨青年急性冠状动脉综合征(ACS)冠状动脉(冠状)造影特点及其与远期心脏事件的关系。方法:比较青年ACS与老年ACS患者冠脉病变程度、范围,并进行心脏事件随访。结果:78例青年ACS患者有冠脉病变74例(94.9％),单支病变46例(58.9％);171例老年ACS患者有冠脉病变166例(97.1％),单支病变41例(23.9％)。平均随访9个月,青年ACS患者发生心脏事件者10例(12.8％),其中心绞痛再入院6例(7.7％);老年ACS患者发生心脏事件者47例(27.5％),其中心绞痛再入院30例(17.5％),两组比较差异有显著性(P<0.05)。结论:ACS患者冠状动脉粥样硬化青年时期之前已经发生,ACS预后与冠脉病变程度和年龄呈正相关。     

心肌肌钙蛋白I与不稳定性心绞痛冠脉造影特征的关系

目的 :分析心肌肌钙蛋白I(cTnI)与不稳定性心绞痛患者冠脉造影病变特征。方法 :选择我院 2 0 0 1年 8月～ 2 0 0 2年 8月间于我院心内科住院的不稳定性心绞痛的病人共 82例 ,分别于入院的第 1、2、3天取血测定cTnI,按cTnI≥ 1.0ng ml为阳性 ,按cTnI是否阳性将病人分为两组 ,其中cTnI阳性患者 3 1例 ,cTnI阴性患者 5 1例 ,比较两组患者冠脉造影显示的病变特征。结果 :cTnI阳性组患者冠脉造影显示的B2 C型病变发生率明显高于cTnI阴性患者(60 .5 %Vs 2 9.4% ,P <0 .0 5 ) ;cTnI阳性患者及cTnI阴性患者中TIMI血流≥ 2级者为 5 1.6%和 2 1.6% (P <0 .0 5 ) ,冠脉内血栓发生率两组分别为 19.4%和 1.97% (P <0 .0 5 ) ;两组多支病变发生率无显著差别 (4 8.3 %Vs 3 5 .3 % ,P >0 .0 5 )。结论 :cTnI阳性患者冠脉病变更严重 ,较cTnI预后阴性者有更加不良的预后     

肌钙蛋白及心电图对非ST段抬高急性冠脉综合征患者预后预测的意义

目的评估肌钙蛋白测定及心电图变化对非ST段抬高急性冠脉综合征患者预后预测的价值。方法收集资料完整的非ST段抬高的急性冠状动脉综合征患者238例,入院后即刻行12导联心电图检查及抽取静脉血做血清肌钙蛋白Ⅰ(TnⅠ)检测,并根据心电图变化及TnⅠ水平分组,观察各组住院期间主要心血管事件,并随访1个月￣6个月。结果ST段压低组的反复心绞痛发作及复合心血管事件较正常心电图组明显增多。所有非ST段抬高心肌梗死及31.9%不稳定性心绞痛患者的TnⅠ阳性,TnⅠ阳性组有明确冠心病诊断者较TnⅠ阴性组多,非致命性心肌梗死发生率增高,反复心绞痛发作增加,心血管事件增多。对复合心血管事件的预测,TnⅠ阳性因素较ST段压低因素的敏感性高(P<0.01)。多因素Logistic回归分析显示,TnⅠ阳性较ST段压低因素对患者复合心血管事件有较高的独立预测价值。结论肌钙蛋白测定及心电图变化对非ST段抬高的急性冠脉综合征患者预后预测具有重要意义,而且TnⅠ阳性因素可能具有更高的独立预测性。     

肌钙蛋白I定量检测在急性冠脉综合征中的应用价值

目的:探讨肌钙蛋白I(CTnI)定量检测在急性冠脉综合征(ACS)中的临床应用价值.方法:对139例急性冠脉综合征(ACS)及107例正常对照组进行CTnI定量检测,根据检测结果发现高危患者,观察UA患者CTnI阳性组和CTnI阴性组住院期间心性事件的发生情况,以及CTnI在ACS中的诊断价值.结果:心性事件发生率在UA中CTnI阳性组55.6%(5/9),明显高于CTnI阴性组2.6%(2/77),CTnI定量检测在AMI患者10～24小时阳性率均100%.结论:CTnI定量检测对UA预后判断以及与AMI诊断方面有较好的应用价值.     

冠状动脉支架植入术对血清肌钙蛋白I的影响

0　引言　肌钙蛋白 I是心肌的结构蛋白 ,利用检测血清 c Tn I含量 ,对于心肌的微小损伤比其他心肌酶类更具高敏感性和高特异性[1 - 3] .本研究动态观察冠状动脉内支架置入术前后血清 c Tn I的变化 ,以评价该治疗方法对心肌的可能影响 .1　对象和方法1.1　对象　我院 1999- 12 / 2 0 0 0 - 0 6择期冠状动脉支架植入术(CS)手术的患者 ,4 8例 ,其中不稳定性心绞痛 12例 ,稳定性心绞痛 2 8例 ,心肌梗死 8例 .这些患者同时符合以下条件 :1冠脉造影显示 3支主要冠脉中至少 1支血管的病变狭窄程度≥ 5 0 % ;2心肌梗死患者心肌梗死距进入研究的时…     

变异型心绞痛5例临床表现与冠脉造影的对照分析

目的 探讨变异型心绞痛患者临床表现与冠脉病变的关系.方法 对5例确诊为变异型心绞痛的患者行冠脉造影,将冠脉病变情况与临床表现作对比分析.结果 (1)5例患者中,4例有冠脉狭窄病变(狭窄＞80%),1例冠脉无狭窄病变,但有斑块.(2)5例患者心绞痛发作时,1例为胸前导联ST-T抬高性改变,冠脉造影为前降支狭窄病变.1例为不同发作时分别表现为胸前导联及下壁导联ST-T抬高性改变,冠脉造影为多支病变.1例发作时表现为胸前导联抬高性改变,冠脉造影未发现冠脉狭窄病变.2例发作时表现为下壁导联抬高性ST-T改变,冠脉造影均为左旋支中段狭窄.结论 变异型心绞痛发作多发生在有狭窄病变基础上的冠脉,且发作时心电图ST-T抬高性改变的导联部位与其相关的冠脉痉挛有关.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.