The Short-term Therapeutic Effects of TCM for IgA Nephropathy In Children

Objective: To evaluate the short-term therapeutic effects of TCM for IgA nephropathy in children. Methods: Sixty-two children with primary IgA nephropathy diagnosed for the first time by renal biopsy in the authors’ hospital were randomly divided into a group of 34 cases treated with both TCM and Western medicine and a group of 28 cases treated with Western medicine for six months. The improvements in urinary protein and red blood cell (RBC) were observed and the scores for TCM symptoms and signs were evalu...     

Multicenter clinical study on the treatment of children’s tic disorder with Qufeng Zhidong Recipe (祛风止动方)

Objective:To assess the effect and adverse reaction of Qufeng Zhidong Recipe(袪风止动方, QZR)in treating children's tic disorder(TD).Methods:With multicenter randomized parallel open-controlled method adopted,the patients enrolled were assigned to two groups,41 cases in the Chinese medicine (CM)group and 40 in the Western medicine(WM)group.They were treated by QZR and haloperidol plus trihexyphenidyl respectively for 12 weeks as one course.In total,two courses of treatment were given.The curative effect and a...     

Observation on Treatment of Dizziness Mainly by Acupuncture

Objective: To observe the therapeutic effects of acupuncture on dizziness. Methods: 65 cases were randomly divided into a treatment group of 36 cases, and a control group of 29 cases. In the treatment group, a comprehensive treatment with both drugs and acupuncture was given, with the points Jiaji from C1- C4, Taiyang (EX-HN5) and Touwei (ST 8) mainly selected in the acupuncture treatment; while the control group was treated only with drugs. Results: The treatment group and the control group showed a total effective rate of 91.7% and 79.3% respectively, and a curative rate of 58.3% and 44.8% respectively, with significant differences.     

TREATMENT OF HEPATIC ABSCESSES SUPPLEMENTED BY T.C.M.—A COMPARATIVE OBSERVATION OF THERAPEUTIC EFFECTS ON 64 PATIENTS

From February 1983 to March 1987,64hepatic abscess patients were treated.Patientshad been randomly divided into two groups,the1st group of combined treatment with traditionalChinese herbs and Western medicine(32 cases)and the second,control group(32 cases).Bothgroups received similar treatment with Westernmedicines;however,the former group was alsoadministered herbs to activate Blood circulationand eliminate Blood stasis and to remove toxicHeat.Significant statistical differences wereobserved between the therapeutic effects of thetwo groups.     

GUYIN DECOCTION IN THE TREATMENT OF IMMUNO-STERILITY AND ITS EFFECT ON HUMORAL IMMUNITY

60 cases of immuno-sterility (treated group) were treated with Guyin Decoction and were compared with 25 control cases treated by Western medicine. The results showed that in the treated group 19 cases were cured, 32 improved and 9 failed respond, while in the control group 6 were cured, 8 improved and 11 failed. The decoction had significant effect on serum IgA and IgG.     

Clinical Study on Treatment of the Earthquake-caused Post-traumatic Stress Disorder by Cognitive-behavior Therapy and Acupoint Stimulation

Objective: To study the curative effect of acupoint stimulation on the earthquake-caused post-traumatic stress disorder (PTSD). Methods: The 91 PTSD patients in Wenchuan hit by a strong earthquake were randomly divided into a control group of 24 cases treated by the cognitive-behavior therapy, and a treatment group of 67 cases treated by both cognitive-behavior therapy and acupoint stimulation. The scores were evaluated according to Chinese version of the incident effect scale revised (IES-R) and the self-compiled questionnaire for the major post-traumatic psychological condition, and the curative effect was compared between the two groups. Results: The total scores of IES-R, the scores of all factors and the total scores of the questionnaire in the two groups after treatment were much lower than those before treatment (P<0.01). The comparison of reduction in the factor scores between the two groups showed that the curative effect in the treatment group was better that ofin the control group. Conclusion: The acupoint stimulation is effective for the PTSD patients, with better results than that of cognitive-behavior therapy used alone     

Tiaobu Xinshen Recipe (调补心肾方) Improved Mild Cognitive Impairment of Alzheimer's Disease Patients with Xin (Heart) and Shen (Kidney) Deficiency

Objective: To observe the intervention effects of Tiaobu Xinshen Recipe(调补心肾方, TXR) on patients with mild cognitive impairment caused by Alzheimer's disease(MCI-AD). Methods: Totally 88 MCI-AD patients with syndrome of Xin(Heart) and Shen(Kidney) deficiency were assigned to the experimental group(47 cases, treated with TXR) and the control group(41 cases, treated with donepezil hydrochloride) using a random number table. Final recruited qualified patients were 44 cases in the experimental group and 39 cases in the control group. The therapeutic course was 12 weeks. Neuropsychological scales [mini mental state examination(MMSE) and Montreal cognitive assessment(MoCA)], and Chinese medicine(CM) dementia syndromes scales were performed in all patients, and results were compared between groups or intra-group before and after treatment. Results: MMSE and Mo CA scores of the two groups were increased after treatment compared with those before treatment(P0.05). But there was no statistical difference in MMSE or MOCA scores after treatment between the two groups(P0.05). CM dementia syndrome score was significantly decreased after treatment in the experimental group compared with the control group(P0.01). Visual spatial and executive function scores and delayed recall scores of the two groups were increased compared with those before treatment(P0.01). Conclusion: TXR could effectively improve cognitive impairment of MCI-AD patients with syndrome of Xin and Shen deficiency.     

TREATMENT OF ACUTE PANCREATITIS WITH LIYI TANG -A Report of 50 Cases

Fifty cases of acute pancreatitis (AP) were treated with LIYI TANG (Decoction for AP) as the treatment group, and the other 50 cases of the disease with Western drugs as the control group. The results of one-week clinical observation showed that, in the treatment group, 43 cases were cured, 3 markedly effective, 2 improved and 2 ineffective; while in the control group, 32 cases were cured, 5 markedly effective, 4 improved, and 9 ineffective, showing a statistically significant difference in therapeutic effects between the two groups (P< 0.05).     

The Short-term Therapeutic Effect of the Three-part Massotherapy for Insomnia Due to Deficiency of Both the Heart and the Spleen——A Report of 100 Cases

Objective: To evaluate the short-term therapeutic effect of the three-part massotherapy on insomnia due to deficiency of both the heart and spleen. Methods: Two hundred cases were randomly divided into a treatment group and a control group, each consisting of 100 cases. Patients in the treatment group were treated with the three-part massotherapy, while those in the control group with oral administration of Guipi Wan (归脾丸 Pill for Invigorating the Spleen and Nourishing the Heart). The total clinical therapeutic effects, the total scores of Pittsburgh Sleep Quality Index (PSQI), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS) of the treatment group were compared with those of the control group. Results: After the treatment, the total therapeutic effects, PSQI, SAS, and SDS of the two groups all showed significant improvement (P<0.01), and the scores of the treatment group were superior to those of the control group (P<0.01). Conclusion: The three-part massotherapy has definite therapeutic effects on insomnia due to deficiency of both the heart and the spleen, which is safe and easy to operate, and worthy of popularization.     

Effect of Yiqi Yangyin Decoction(益气养阴方) on the Quality of Life of Patients with Unstable Angina Pectoris

<正>Objective:To observe the effect of Yiqi Yangyin Decoction(益气养阴方,YQYYD) on the quality of life(QOL) of patients with unstable angina pectoris(UAP).Methods:A total of 108 patients with UAP of qi-yin deficiency syndrome confirmed by coronary angiography were enrolled and assigned to the treated group(treated with YQYYD and conventional therapy of Western medicine) and the control group(treated with conventional therapy of Western medicine),by the use of the PROC PLAN of the SAS 6.12 software,in a prospective, randomized,controlled design.The clinical total effective rate,symptom score,QOL scale[Seattle Angina Questionnaire(SAQ)]and incidence of important clinical events were defined as the observation indices to evaluate the interventional effect of YQYYD on the QOL of patients with UAP of the qi-yin deficiency syndrome. Results:During the study,three cases dropped out in the treated group,one case dropped out in the control group,and 104 cases,including 51 cases in the treatment group and 53 cases in the control group,finished the trial.After four weeks of treatment,the total clinical effective rates in the treated group and the control group were 80.4%and 75.5%respectively,and there was no obvious difference between them(P0.05).However,the symptom score of the treated group(9.31±2.02) was significantly lesser than that of the control group(11.62±3.04,P0.05),and the total score of the QOL scale of the treated group(68.76±5.74) was significantly higher than that of the control group(61.06±3.31,P0.01).Among those in the treated group physical limitation, angina stability,angina frequency,and treatment satisfaction were significantly ameliorated when compared with the control group after treatment(P0.05,P0.01).The incidence of important clinical events in the treated group(3.9%) was lower than that in the control group(5.7%) during the 8-month follow-up period,but the difference was insignificant(P0.05).Conclusion:YQYYD could improve the clinical symptoms of patients with UAP of qi-yin deficiency syndrome and greatly improve their QOL.     

CLINICAL INVESTIGATION OF TRADITIONAL CHINESE MEDICINE AND PHARMACY IN TREATING RESPIRATORY TRACT INFECTIONS IN AIDS

Based on the difference in severity of the disease and complications, 80 cases of acquired immune-deficiency syndrome (AIDS) accompanied with cough were divided into 2 groups: One treated by traditional Chinese medicine (TCM group), including 58 cases and the other treated by Integrated Chinese and Western medicine (integrated group), 22 cases. The therapeutic results show that in the TCM group there were 18 cases (31.03%) with clinical cure of the respiratory tract infection, 7 cases with therapeutic effect (12.07%) and 33 cases without any effect (56.90%), for a total rate of 43.10% therapeutic effectiveness; while in the integrated group there were 6 cases with clinical cure (27.27%), 2 cases with therapeutic effect (9.09%) and 14 cases without any effect (63.64%), the total rate of therapeutic effectiveness being 36.36%, slightly lower than in the TCM group and possibly related to greater severity of the disease or complications.     

Clinical study of western medicine combined with Chinese medicine based on syndrome differentiation in the patients with polarized hypertension

<正>Objective:To investigate the effects and safety of Western medicine combined with Chinese medicine(CM) based on syndrome differentiation in the treatment of elderly polarized hypertension(PHPT),or isolated systolic hypertension with low diastolic blood pressure(DBP).Methods:A total of 125 elderly patients with PHPT were randomly assigned to two groups:59 in the control group treated by Western medicine and 66 in the intervention group treated by Western medicine combined with CM treatment.Based on syndrome differentiation,the patients in the intervention group were further divided into subgroups of yang-qi deficiency and yin-qi deficiency.All subjects were treated with Western medicine of Amlodipine Besylate Tablets and Irbesartan Tablets(or Irbesartan and Hydrochlorothiazide Tablets),to decrease their systolic blood pressure (SBP) slowly to 125-135 mm Hg in 2-6 weeks.In the intervention group,Shiyiwei Shenqi Capsule(十一味参芪胶囊) was given additionally to the subgroup of yang-qi deficiency at the dosage of 3-5 capsules,thrice a day, while Dengzhan Shengmai Capsule(灯盏生脉胶囊) was given additionally to the subgroup of yin-qi deficiency at the dosage of 2 capsules,2-3 times per day.For all subjects,SBP,pulse pressure(PP),and DBP were measured before treatment and at the terminal of a 6-week treatment.For subjects in the intervention group, left ventricular ejection fraction(LVEF) was also recorded.Results:After a 6-week treatment,the SBP in the two groups and the PP in the intervention group decreased significantly compared to those before treatment (P0.05),while the PP in the control group showed no significant difference between prior and post-treatment (P0.05).After treatment,the DBP in the control group decreased(P0.05),while the DBP and LVEF in the intervention group showed an increase tendency although it had no statistical significance(P0.05).When subjects in the intervention group were classified further by the course of disease,the DBP and LVEF of subjects whose course of disease were less than 2 years,increased significantly after treatment(P0.05). Conclusion:Western medicine combined with CM treatment based on syndrome differentiation was safer and more effective than Western medicine alone in the treatment of elderly PHPT,because it not only reduced SBP but also improved DBP,which might lower the incidence of the cardiovascular and cerebrovascular events.     

CLINICAL OBSERVATION ON HASHIMOTO'S THYROIDITIS TREATED BY INDIRECT MOXIBUSTION WITH VARIOUS CHINESE MEDICINES

103 cases of Hashimoto’s thyroiditiswere divided into moxibustion group 1(35cases)in which patients were treated byaconite—cake interposed moxibustion withthe Chinese medicine powder for warmingyang under the cakes,moxibustion group 2(36 cases)in which the medicine powder fortonifying qi,warming yang,eliminatingstasis and activating the blood was appliedbetween the cakes and the skin of the pa-tients, and a control group(32 cases)inwhich the patients were treated with     

Effects of Modified Qing'e Pill (加味青娥丸) on Expression of Adiponectin, Bone Morphogenetic Protein 2 and Coagulation-Related Factors in Patients with Nontraumatic Osteonecrosis of Femoral Head

Objective: To observe the regulation of Chinese herbal medicine, Modified Qing'e Pill(加味青娥丸, MQEP), on the expression of adiponectin, bone morphogenetic protein 2(BMP2), osteoprotegerin(OPG) and other potentially relevant risk factors in patients with nontraumatic osteonecrosis of the femoral head(ONFH). Methods: A total of 96 patients with nontraumatic ONFH were unequal randomly divided into treatment group(60 cases) and control group(36 cases). The treatment group were treated with MQEP while the control group were treated with simulated pills. Both groups were given caltrate D. Six months were taken as a treatment course. Patients were followed up every 2 months. The levels of plasma adiponectin, BMP2, OPG, von Willebrand factor(vWF), von Willebrand factor cleaving protease(vWF-cp), plasminogen activator inhibitor 1(PAI-1), tissue plasminogen activator(tPA), C-reactive protein(CRP), blood rheology, bone mineral density(BMD) of the femoral head and Harris Hip Score were measured before and after treatment. Results: After 6 months of treatment, compared with the control group, patients in the treatment group had significantly higher adiponectin and BMP2 levels(P0.01 and P=0.013, respectively), lower vWF, PAI-1 and CRP levels(P=0.019, P0.01 and P0.01, respectively), and lower blood rheology parameters. BMD of the femoral neck, triangle area and Harris Hip Score in the treatment group were significantly higher than those in the control group. Moreover, plasma adiponectin showed a positive association with BMP2(r=0.231, P=0.003) and a negative association with PAI-1(r=–0.159, P0.05). Conclusions: MQEP may play a protective role against nontraumatic ONFH by increasing the expression of adiponectin, regulating bone metabolism and improving the hypercoagulation state, which may provide an experimental base for its clinical effects.     

Clinical effect of Sidong Wubu method in treatment of closed fracture of upper limbs

OBJECTIVE:To objectively evaluate the clinically curative effect of sidong wubu method on closed fracture of upper limbs.METHODS:A single-blind randomized controlled trial was used to divide 654 patients with closed fracture of upper limbs at early stage into two groups.298 patients in the surgical group were treated with open reduction and internal fixation and 356 patients in the treatment group with sidong wubu method for 6 months as a course of treatment.RESULTS:As for short-term curative effect(after 6 courses of treatment),the total effective rate was 97.7% in the treatment group and 92.9% in the control group,and the excellent and good rate was 83.7% and 76.5% respectively.Fracture-healing time,treatment cost,function-recovering time,scores of symptoms and signs obviously declined in both groups with remarkable difference between the two groups.As to long-term curative effect(after follow-up visit for one year to 5 years and 2 months),there was still noticeable difference(χ 2 = 7.536,P<0.05) in total curative effect and in excellent and good rate between the two groups.CONCLUSION:With low cost,short treatment course,good function and other advantages,sidong wubu method can be first used to treat closed fracture of upper limbs.     

控制子宫内膜异位症保守手术后的复发：中医药与西医的比较

Objective： To compare the clinical effect of Chinese medicine （CM） and Western medicine （WM） for controlling the recurrence of pelvic endometriosis after a conservative operation. Methods： The study was a multi-center, randomized, parallel controlled and prospective clinical trial. Patients were randomly divided into two groups： CM group （106 cases） and WM group （102 cases）. Drugs were given to patients during 1--5 days of the first menstruation after a conservative operation in both groups. Patients with stages I and I1 （revised American Fertility Society） were treated for 3 months, while the patients with stages Ill and IV were treated for 6 months. The patients in the CM group were treated using three types of Chinese herbal medicine based on syndrome differentiation. Patients in the WM group were treated using gonadotropin releasing hormone agonist （GnRH-a） or gestrinone. Patients treated with GnRH-a received add-back therapy of Tibolone Tablets once a day after 4 months of treatment. Any cases of dysmenorrheal chronic pelvic pain, menstruation and any adverse reactions of patients were recorded once a month during the preoperative and postoperative periods and once every 3 months during the follow-up period. During the preoperative, postoperative and the follow-up periods, patients underwent type B ultrasonography of the pelvis and measurements of serum CA125 levels, gynecologic examination, routine evaluations of blood, urine, hepatic function （glutamate pyruvate transaminase）, renal function （blood urea nitrogen） and electrocardiograms. Dudng the follow-up period they underwent type B pelvic ultrasonography, measurement of serum CA125 levels and further gynecologic examinations. The two treatments were compared for clinical recurrence rates, pregnancy rates and the incidence of adverse reactions. Results： The incidence and timing of recurrence of endometriosis were not significantly different between the two groups. The first pregnancy achieved by the patient in the CM .qroup was si.clnificantly earlier than that in the WM group （P〈0.05）. Moreover, the incidence of adverse reactions in the WM group was significantly higher than in the CM group （P〈O.01）. Conclusions： Treatment with Chinese herbal medicines prevented the recurrence of endometriosis after a conservative operation, improved the conception rate and showed fewer and lighter adverse reactions than did treatment with WM therapy. Treatment with Chinese herbal medicine meets the need of patients wishing to have a child following endometriosis and is an appropriate form of clinical treatment.     

THE EFFECTS OF CHINESE DRUGS FOR SUPPORTING HEALTHY ENERGY AND REMOVING BLOOD STASIS ON POSTOPERATIVE METASTASIS OF GASTRIC CARCINOMA AND ORNITHINE DECARBOXYLASE

32 postoperative cases of gastric carcinoma were treated by traditional Chinese medicine (TCM) drugs for supporting healthy energy and removing blood stasis, and their therapeutic results were compared with those in the control group treated by western medicine. After 6 months of treatment, in the TCM group, the rate of metastatic recurrence was significantly reduced, and the level of ornithine decarboxylase was also markedly lowered. Therefore, it is considered that the action of anti-metastatic recurrence of TCM drugs in postoperative cases of gastric carcinoma is probably related to the lowered activity of ornithine decarboxylase.     

Integrated treatment for lower-limb stage Ⅱ thromboangiitis obliterans by interventional therapy and oral administration of Chinese medicine: a randomized controlled clinical trial

OBJECTIVE: To observe if integrated treatment is better than other therapies for lower-limb stage thromboangiitis obliterans(TAO).ⅡMETHODS: Ninety lower-limb stage randomly dividedⅡ i or worse TAO patients werento three groups: group A(30 cases) treated by intervention and oral administration of Chinese medicine; groupB(30 cases) treated by intervention alone; and group C(30 cases) treated only with oral administration of Chinese medicine. Therapeutic effects were observed, including the cure rate; the recurrence rate after one month, three months, six months, nine months, and one year; the ankle brachial indexes; the incidence of complications; and the level of C-reactive protein and erythrocyte sedimentation rate.RESULTS: Group A had significantly better clinically curative effects, related indexes, and outcomes during the long-term follow-up survey, than that of groups B and C.CONCLUSION: Integrated treatment is more effective for treating lower-limb stage Ⅱ or worse TAO.     

Clinical Observation on Cervical Spondylopathy of the Vertebroarterial Type Treated by Electro-acupuncture

Objective: To observe the clinical therapeutic effects of electro-acupuncture in the treatment of cervical spondylopathy of the vertebroarterial type. Methods: According to the consulting order, the patients were randomly divided into a treatment group (29 cases treated with electro-acupuncture), and a control group (28 cases treated with simple acupuncture). 20 treatments were given to patients in both groups. Results: The markedly effective rate of the treatment group was 75% and that of the control group was 61.54% (P<0.05). Conclusion: Electro-acupuncture has a better therapeutic effect than the simple acupuncture in the treatment of cervical spondylopathy of the vertebroarterial type.