共查询到16条相似文献,搜索用时 78 毫秒
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目的探讨体外全反式维甲酸(ATRA)对人类骨髓间充质干细胞(BM—MSC)CD106和CD54表达的影响。方法用流式细胞术检测0.01、0.1、1.0、10.0μmol/LATRA处理后BM—MSC细胞表面CD106和CD54的表达,采用MTT法测量细胞生长曲线。结果0.01、0.1、1.0、10.0μmol/L的ATRA能增加BM—MSC细胞表面CD54、CD106的表达。结论ATRA对BM—MSC细胞CD54、CD106有上调的作用。 相似文献
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马芳 《国外医学(肿瘤学分册)》2003,30(2):152-155
外周血造血干细胞的动员在临床得到广泛的应用,该动员过程受到造血生长因子、细胞粘附分子、造血微环境、信号传导途径以及造血干细胞的凋亡等体内多个环节的作用和相互影响,现综述其动员机制最新研究进展。 相似文献
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目的研究脐带源间充质干细胞(UC—MSC)细胞因子分泌特征及其对脐血源CD34^+细胞的造血支持作用,并与骨髓源间充质干细胞(BM—MSC)相对照。方法RT—PCR法检测UC—MSC和BM—MSC细胞因子分泌。将脐血CD34^+细胞分别接种于UC—MSC或BM—MSC滋养层共培养5周,收集贴壁与非贴壁细胞接种于标准甲基纤维素培养基,计数克隆形成细胞(CFC)。结果UC—MSC表达SCF、LIF、M—CSF、Flt-3、IL-6、GM—CSF、G—CSF、SDF-1和VEGFmRNA,不表达IL-3mRNA。与BM—MSC相比,二者表达细胞因子谱相似,但BM—MSC不表达GM—CSF和G—CSFmRNA。共培养5周计数CFC显示,BFU—E、GFU—GM和CFU—GEMM在CD刍细胞/UC—MSC(75.5±27.9,100.0±25.1,9.5±7.3)与CD34^+细胞/BM—MSC(70.5±28.8,108.3±9.5,8.5±5.1)共培养体系差异无统计学意义(P〉0.05)。结论UC—MSC与BM—MSC具有相似的造血支持功能和细胞因子分泌谱。 相似文献
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造血干细胞移植(HSCT)是治疗血液系统疾病、恶性肿瘤及部分遗传性疾病的有效方法。在HSCT过程中,造血干/祖细胞(HS/PC)归巢到造血组织是实现造血功能重建的前提。而HS/PC和骨髓基质的黏附分子(AM)对归巢起到了至关重要的作用。现在就相关AM在HSCT中归巢作用机制的研究进展作一综述。 相似文献
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间充质干细胞在移植中的作用 总被引:1,自引:1,他引:0
间充质干细胞(MSC)是一类具有高度自我更新及多向分化潜能的组织干细胞,易于在体外扩增,在造血干细胞移植(HSCT)及其他系统的移植中发挥重要的作用。详细阐述了MSC支持造血、促进植入,调节免疫及减轻移植后的移植物抗宿主病(GVHD)等方面的功能及机制,并对其在临床上的进一步应用提出建议与展望。 相似文献
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间充质干细胞(mesenchymal stem cells,MSC)是骨髓中除造血干细胞以外的另一种成体干细胞,因为其具有强大的自我更新能力和多向分化的潜能,MSC被越来越多地应用于血液等恶性疾病的治疗,并在再生医学及组织工程中广泛运用。但是,MSC对肿瘤的确切作用还未完全清楚,就MSC对肿瘤生长的影响及其相关机制作一综述, 相似文献
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The purpose of this study is to investigate whether hematopoiesis capacity, immunomodulatory effect and ex vivo expansion potential of mesenchymal stem cells (MSCs) are affected by cryopreservation. Chronic myeloid leukemia (CML) patients' bone marrow MSCs cryopreserved for 3 months, 6 months, and 1 year were thawed and analyzed. Cryopreserved CML-MSCs have more than 90% viability. Cell-doubling time of cryopreserved CML-MSCs is 42 to 54 hours. Cells have been expanded in culture for more than 30 passages. Under suitable conditions, cryopreserved CML-MSCs have the ability of multiple lineages differentiation, including bone, endothelial, fat and nerve. Furthermore, cryopreserved CML-MSCs express hematopoietic cytokines, and possess hematopoietic supportive ability. The growth of normal long-term culture-initiating cell (LTC-IC) on CML-MSCs (including noncryopreserved and cryopreserved CML-MSCs) was similar to that of normal derived MSCs. Cryopreserved CML-MSCs did not express costimulatory molecules CD40, CD80, and CD86. They can inhibit T lymphocyte proliferation induced by mitogens. The immunosuppressive effect of cryopreserved CML-MSCs on T-cell proliferation was dose dependent. These findings indicate that cryopreserved CML derived MSCs may be a useful tool for clinical application. 相似文献
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This work is a comparative study on the features displayed by an epithelial metastatic breast cancer cell line (MCF-7) when set in co-culture with human bone marrow mesenchymal stem cells (MSC) or a feeder layer of 3T3 fibroblasts. MSC, a subset of non-haematopoietic cells in the marrow stroma, display a potential for self-renewal, proliferation and differentiation into precursors for bone, cartilage, connective and muscular tissue. Adhesion of MCF-7 cells to monolayers of MSC or 3T3 was high (95 and 85% respectively). Once attached, MCF-7 grow well on both monolayers. Morphology of MCF-7 cells, as analysed by light and epifluorescence microscopy, revealed that MCF-7 cells grow in clusters on 3T3, but disperse on MSC. Concomitant with the lost of their aggregation status, MCF-7 on MSC express low levels of the intercellular adhesion molecules, E-cadherin and epithelial-specific antigen (ESA). These results suggest that MSC represent an appropriate cell target to investigate the cellular and molecular events occurring at the interface of epithelial-marrow stromal interactions. Together, the model here described should permit to further evaluate the significance and prognostic impact of the shift of micrometastatic cells from a cluster-aggregated into a single-cell status. 相似文献
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