High prevalence of asthma in preschool children in Southern Brazil: a population-based study

The prevalence of asthma is increasing in many countries. To measure asthma's prevalence, a sample of 981 children aged 4 years old belonging to a birth cohort from 1993 was studied in Pelotas, a city in southern Brazil. A standardized questionnaire on asthma was given to the children's mothers. Information was also collected on socioeconomic level, housing conditions, genetic factors, nutritional factors, and previous infectious diseases. Current asthma (asthma diagnosed by a doctor during previous 12 months) and current wheeze (presence of wheezing during previous 12 months) were the main outcomes. The prevalence of current asthma was 18.4%, and current wheeze was 21.1%. The data were analyzed by multiple Poisson regression, and the risk factors that remained significant for both "current asthma and current wheeze" were, respectively, nonwhite color (RR = 1.41 and RR = 1.36), low maternal schooling (RR = 1.75 and RR = 1.68 for 0-4 years), history of asthma or allergy in the family (RR = 1.66 and RR = 1.85), and history of rhinitis and eczema in the child (RR = 2.11 and RR = 1.72). Male sex (RR = 1.36) and bronchiolitis (RR = 1.46) were major risk factors only for "current asthma," while smoking in pregnancy (RR = 1.30) and low birth weight (RR = 1.45) were risk factors only for "current wheeze." These results highlight the importance of asthma as a public health problem due to its high prevalence, and support the need of intervention programs against preventable risk factors.     

Gender differences in effects of obesity and asthma on adolescent lung function: Results from a population-based study

Objective: To investigate lung function associated with asthma and body mass index (BMI) among adolescents at 96 northern Taiwan junior high schools participating in an asthma screening program. Methods: The questionnaires and lung function test results measured for 3669 boys and 3523 girls were included in this study for data analysis. Measures of forced vital capacity (FVC), forced expiratory volume in 1 second (FEV₁) and FEV₁/FVC ratio were compared by sex, asthma status and BMI. Results: Overall mean FVC levels were similar between students with and without asthma, 3.71 L vs. 3.71 L for boys (p = 0.991) and 2.79 vs. 2.78 for girls (p = 0.517). The overall mean FEV₁ levels were also similar between girls with and without asthma. Asthmatic boys had lower FEV₁ than non-asthmatic boys. Mean FEV₁/FVC was significantly lower in students with asthma than those without asthma. Mean FVC and FEV₁ increased with BMI in both sexes. A lower mean FEV₁/FVC was observed among students with asthma and high BMI, and was more pronounced in boys than in girls. Multivariable regression analysis also showed that FEV₁/FVC ratios were negatively associated with asthma and high BMI, stronger in boys than in girls for asthma (β = ?2.176 (standard errors (SE) = 0.268) vs. ?1.085 (SE = 0.258) and for BMI (β = ?0.309 (SE = 0.025) vs. ?0.218 (SE = 0.029)). Conclusion: This northern Taiwan study suggests that FEV₁/FVC is negatively associated with asthma and high BMI in adolescents, stronger for boys than for girls.     

Snapshot of acute asthma: treatment and outcome of patients with acute asthma treated in Australian emergency departments

Abstract
Aims: To characterize presentations due to acute asthma at Australian emergency departments (ED), including their severity, treatment and disposition.
Methods: This prospective, observational study involved 38 departments of emergency medicine throughout ­Australia participating in the Snapshot of Asthma Study Group project 2000 and 2001. Data were collected for patients presenting with acute asthma between 21 August 2000 and 3 September 2000, and 20 August 2001 and 2 September 2001 and included demographics, severity classification, treatment and disposition.
Results: There were 1340 acute asthma presentations in the study periods. Of these presentations, 67% were for children aged <15 years. Asthma severity (according to the Australian National Asthma Guidelines classifi­cation) was 'mild' in 49% of cases; 'moderate' in 45% of cases; and 'severe' in 6% of cases. Treatment administered included: (i) salbutamol to 90%, (ii) ipratropium bromide to 59% and (iii) corticosteroids to 71%. Only six patients received aminophylline. Spacer use for sal­butamol was rare (1%) in adults and only moderate (43%) in children. Sixty-five percent of patients were discharged home from the ED. Less than 1% of patients required ventilatory assistance, of which half was provided non-invasively. One percent of patients were admitted to the intensive-care unit or high-dependency unit.
Conclusion: Overall adherence to treatment guidelines was good. There appears to be underuse of spacers and corticosteroids in some groups and overuse of ipra­tropium bromide. The majority of patients are treated and discharged from the ED. (Intern Med J 2003; 33: 406−413)     

Gender differences in asthma prevalence: Variations with socioeconomic disadvantage

Background and objective: Socioeconomic inequalities in health have been shown to vary for different diseases and by gender. This study aimed to examine gender differences in associations between asthma and socioeconomic disadvantage. Methods: Socioeconomic variables were assessed among men and women in the North West Adelaide Health Study, a representative population cohort (n = 4060) aged 18 years and over in metropolitan South Australia. Asthma was determined from spirometry and self‐reported doctor diagnosis. Results: The prevalence of asthma was 12.0% (95% CI: 11.1–13.1), and was significantly higher among women (13.5%) than men (10.5%). For participants aged 18–64 years a higher prevalence of asthma was associated with an education level of secondary school or lower, or not being in the paid labour force among men, and with a gross annual household income of $20 000 or less among women. Among socioeconomically advantaged groups, the prevalence of asthma was significantly higher among women than men. Conclusions: Socioeconomic disadvantage was associated with higher asthma prevalence, although this varied by gender depending on the indicator of socioeconomic position used. Men with low education or those not employed in the paid labour force had higher asthma prevalence than more socioeconomically advantaged men. Women with low income had higher asthma prevalence than those with higher income. Among all socioeconomically advantaged groups, and also the low‐income group, women experienced a higher prevalence of asthma than men.     

Association between asthma and dysphonia: A population-based study

Objective: We investigated whether asthma predisposes patients to organic laryngeal lesions or increases dysphonia in those without organic laryngeal lesions. Methods: We performed a cross-sectional study with data from the Korea National Health and Nutrition Examination Survey; 19,330 subjects from 2008 through 2011 were included. The associations of asthma with organic laryngeal lesions and dysphonia were analyzed using a simple/multiple logistic regression analysis with complex sampling while adjusting for confounding factors (age, sex, smoking status, stress level, and body mass index) that could contribute to dysphonia. Results: Compared with non-asthma participants, the asthma patients tended to be older and female and to have higher stress levels. These factors were associated with dysphonia (Age, AOR = 1.20, 95% CI = 1.14 = 1.23, P < 0.001; female, AOR = 1.70, 95% CI = 1.33–2.17, P < 0.001; higher stress, AOR = 1.44, 95% CI = 1.23–1.69, P < 0.001). Asthma itself was also associated with dysphonia. Compared with non-asthma participants, asthma patients who had not taken asthma medication recently showed a higher AOR (1.62; 95% CI = 1.0–2.42) for dysphonia, and asthma patients who had taken asthma medication recently showed the highest adjusted odds ratio for dysphonia (AOR = 1.97; 95% confidence interval, CI = 1.28–3.02, P = 0.001). On multiple logistic regression analysis, vocal nodules, laryngeal polyps, and laryngitis were not associated with asthma (all P > 0.05). Conclusions: Asthma patients are predisposed to subjective dysphonia due to demographic and clinical characteristics (older age, female, and higher stress level) as well as to asthma itself. However, asthma was not associated with organic laryngeal lesions in this study.     

Asthma control and productivity loss in those with work-related asthma: A population-based study

Objective: In Canada, asthma is the third leading cause of work loss, yet little is known about the associated productivity loss. The goal of this study was to look at the relationship between asthma control and productivity loss, particularly contrasting those with work-related asthma (WRA) and non-work-related asthma (NWRA). Methods: A population-based random sample of adults with asthma in British Columbia, Canada, was prospectively recruited. Asthma control was graded according to Global Initiative for Asthma classification, while productivity loss and presence of WRA was assessed using questionnaires. Ordinal regression models were then used to associate WRA with asthma control. Generalized linear models were applied to estimate the average productivity loss associated with different levels of asthma control among those with WRA and NWRA. Results: The study included 300 employed adults. Sixty (20%) had WRA. The odds of being controlled were significantly lower in those with WRA (OR = 0.23, 95% CI: 0.09, 0.56; P < 0.01). Those with WRA and uncontrolled asthma had a significant difference in productivity loss due to presenteeism ($659.1 [95% CI: 12.9, 1581.5; P = 0.04]), but not absenteeism ($88.7 [95% CI: ?86.5, 279.6; P = 0.35]), when compared to those with NWRA and uncontrolled asthma. There was no significant difference when a similar comparison was made for those with controlled or partially controlled asthma. Conclusions: WRA is associated with worse asthma control and increased productivity loss. Presenteeism makes a significant contribution to productivity loss and should be considered when evaluating the overall economic burden of asthma, particularly WRA.     

Adolescent flourishing in relation to having asthma: Results from a population-based cross-sectional study

Objective: This study investigated parent report of adolescent behaviors and flourishing of adolescents with asthma from a nationwide sample. Methods: A secondary analysis of the 2011–2012 National Survey of Children's Health was conducted. There were 2,880 youth with asthma in our sample and 25,841 without asthma between 13 and 17 years of age. Analyses examined flourishing among adolescents with and without asthma and the impact of adolescent arguing, bullying, and mood difficulties on adolescent flourishing for adolescents with asthma, while controlling for sex, age, and race. Results: Findings indicated lower flourishing for youth with asthma compared to youth without asthma. Moreover, adolescents with asthma who experienced negative behaviors, such as arguing and bullying, and adolescents who were experiencing sad feelings had lower flourishing. Conclusions: The results were consistent with literature, indicating that relatively poorer behavioral and emotional functioning is related to lower flourishing in adolescents with asthma. The results highlight the importance of screening for emotional functioning in adolescents and the need for further research to understand characteristics of adolescents related to their positive functioning.     

Sex differences in lymphoma incidence and mortality by subtype: A population-based study

It is well established that the male sex is associated with increased risk for, as well as poorer survival of, most cancers. A similar pattern has been described in lymphomas but has not yet been comprehensively assessed. In this nationwide population-based cohort study, we used the Swedish Lymphoma Register to investigate sex differences in lymphoma subtype incidence and excess mortality in adults (age 18–99) diagnosed in 2000–2019. Male-to-female incidence rate ratios (IRRs) and excess mortality ratios (EMRs) adjusted for age and calendar year were predicted using Poisson regression. We identified 36 795 lymphoma cases, 20 738 (56.4%) in men and 16 057 (43.6%) in women. Men were at significantly higher risk of 14 out of 16 lymphoma subtypes with IRRs ranging from 1.15 (95% confidence interval [CI] 1.09–1.22) in follicular lymphoma to 5.95 (95% CI 4.89–7.24) in hairy cell leukemia. EMRs >1 were seen in 13 out of 16 lymphoma subtypes indicating higher mortality in men, although only statistically significant for classical Hodgkin lymphoma 1.26 (95% CI 1.04–1.54), aggressive lymphoma not otherwise specified 1.29 (95% CI 1.08–1.55), and small lymphocytic lymphoma 1.52 (95% CI 1.11–2.07). A corresponding analysis using data from the Danish Lymphoma Register was performed with comparable results. In conclusion, we demonstrate a significantly higher incidence and trend toward higher mortality in men for most lymphoma subtypes. Future studies with large patient material that include detailed clinicopathological prognostic factors are warranted to further delineate and explain sex differences in lymphoma survival to enable optimal management of lymphoma patients regardless of sex.     

Sex and age differences in the effect of obesity on incidence of hypertension in the Japanese population: A large historical cohort study

Elevated risk of death from any cause and stroke associated with high body mass index (BMI) values decline with aging. However, it is not clear whether the effect of obesity on the incidence of hypertension varies by sex or age. Cox regression analyses were performed using a large historical cohort composed of 6803 men and 22,800 women. In the final model, which included the main effect (sex, age, and BMI), all two-way interactions (sex*age, sex*BMI, and age*BMI), a three-way interaction (sex*age*BMI), and adjusted variables determined by backward elimination, the three-way interaction and two of the two-way interactions (age*sex and age*BMI) were not significant; the remaining two-way interaction between sex and BMI was significant (P = .016). In the next step, the effect of BMI on the incidence of hypertension stratified by sex was evaluated. Hazard ratios (HRs) were significantly higher for BMI 27.0 to <29.0 and ≥29.0 kg/m² than for the HR for BMI 21.0 to <23.0 kg/m² in women (HR, 1.45; 95% confidence interval [CI], 1.32–1.59 and HR, 1.46; 95% CI, 1.29–1.65, respectively), but not in men (HR, 1.14; 95% CI, 0.98–1.33 and HR, 1.01; 95% CI, 0.77–1.32, respectively). The effect of obesity on the incidence of hypertension is stronger in women than in men.