Prosthetic joint infection following total hip replacement: results of one-stage versus two-stage exchange

Purpose

Prosthetic hip joint infection remains a challenging socio-economic problem. Curative treatment is usually a one- or two-stage revision surgery, but neither of these options has yet emerged as the treatment of choice. The aim of this study was to evaluate which of these methods produced superior outcomes.

Methods

A retrospective study was performed including 92 patients with deep infections after implantation of primary total hip arthroplasty (THA) who had undergone either one-stage or two-stage revision surgery at a single centre. Infections were classified according to McPherson and we evaluated the rate of persisting infection or reinfection after surgical intervention.

Results

The two-stage revision surgery revealed superior outcomes for the analysed infection categories compared to the one-stage procedure except for the least serious category of infections (i.e. McPherson Stage I/A/1, early postoperative infection, no systemic comorbidities, local status uncompromised).Eradication of prosthetic infection was achieved in 94.5 % (n = 52) within the group of two-stage exchange, and 56.8 % (n = 21) of patients treated with a one-stage procedure. Outcome of patients following a one-stage or a two-stage exchange was overall significantly different with p < 0.001. Further deviations between the described two procedures were noted in the subgroups following the classification described by McPherson.

Conclusions

Our results indicate superiority of two-stage revision surgery in case of serious infections. The authors believe that decisions on the surgical approach for the treatment of deep prosthesis infections should be made on the basis of standardized staging systems.     

Survival following total hip replacement

BACKGROUND: Several studies have shown that patients who undergo total hip replacement live longer than control subjects, but the reason for this apparent protective effect is not clear. The purpose of our investigation was to assess whether the association had the characteristics of a causal relationship or whether it might appear to be due to comorbidity or other factors. METHODS: We compared survival over a six-year period for 28,469 Medicare enrollees who had elective primary total hip replacement in 1996 and a control group from the general Medicare population, matched 5:1 on year of birth, sex, race, and whether the Medicaid program paid the Medicare premium (a proxy for low income). For both the patients treated with total hip replacement and the control subjects, we used Medicare hospital claims to ascertain comorbidity, that is, whether the patient had had any of sixteen serious discharge diagnoses in the year prior to the total hip replacement (or an equivalent date for the controls). The survival patterns for the total hip arthroplasty and control cohorts were compared with use of proportional hazards regression for three follow-up periods: the first ninety days after surgery (or an equivalent date for the controls), ninety days to five years after surgery, and more than five years after surgery. RESULTS: The total hip replacement cohort had less comorbidity than the controls, with an approximately 30% lower prevalence for most serious diseases. Sex, age, Medicaid eligibility, and earlier serious comorbid diagnoses were important predictors of survival, but, even in analyses that adjusted for these variables, the total hip replacement cohort had better long-term survival than the controls. The patients who had a total hip replacement had a higher rate of mortality than the controls immediately after surgery, but, by three months postoperatively, the mortality rate for the patients was well below that for the controls. The overall rate of survival during the first ninety days was comparable for the two groups. From three months to five years after surgery, the mortality rate for the patients who had a total hip replacement was only two-thirds of that for the controls. After five years, the mortality rates for the two groups appeared to be converging. CONCLUSIONS: Total hip replacement recipients survive longer than do matched controls in the Medicare population. The very rapid emergence of the lower mortality rate suggests that it is due to the selection of low-risk patients for elective surgery. However, our admittedly crude adjustment for comorbidity did not diminish the protective effect, so some effect of the procedure itself cannot be ruled out.     

Thromboembolism following total hip replacement

Total hip replacement is an operation that is prone to thromboembolic complications, with potentially life-threatening consequences. However, the risk has declined substantially in the past three decades, reflecting advances in the understanding of the pathophysiology of thromboembolism and perioperative prophylaxis. The old concept of deciding thromboembolic prophylaxis after the completion of surgery is obsolete. In this review, we will concentrate on the main preventive measures that the medical and surgical team should implement prior to, during, and immediately after surgery.     

Prosthetic hip joint infection caused by Listeria monocytogenes

The authors report an unusual case of prosthetic hip joint infection caused by Listeria monocytogenes. The patient, an 87-year-old lady who had undergone a right total hip replacement 10 years previously, presented with pain and restriction of hip motion three weeks after an episode of abdominal pain. Aspiration of the joint yielded a dark fluid, from which Listeria Monocytogenes type 4-b was isolated. Blood cultures remained negative. After prolonged antibiotic therapy, symptoms gradually resolved. A few months later, pain recurred with radiological signs of loosening of the femoral component. One-stage revision arthroplasty was performed combined with antibiotic treatment. The patient remains asymptomatic at one year follow-up. Laboratory data and x-ray control are normal. Prosthetic hip joint infection with Listeria monocytogenes is uncommon; few cases have been reported. The literature review shows that prolonged antibiotic therapy alone may be used in patients for whom removal of the prosthesis is not desirable, although revision arthroplasty or prosthesis removal remains necessary in the other cases.     

Risk factors for periprosthetic joint infection following total ankle replacement

BackgroundIdentifying preoperative patient characteristics that correlate with an increased risk of periprosthetic joint infection (PJI) following total ankle replacement (TAR) is of great interest to orthopaedic surgeons, as this may assist with appropriate patient selection. The purpose of this study is to systematically review the literature to identify risk factors that are associated with PJI following TAR.MethodsUtilizing the terms “(risk factor OR risk OR risks) AND (infection OR infected) AND (ankle replacement OR ankle arthroplasty)” we searched the PubMed/MEDLINE electronic databases. The quality of the included studies was then assessed using the AAOS Clinical Practice Guideline and Systematic Review Methodology. Recommendations were made using the overall strength of evidence.ResultsEight studies met the inclusion criteria. A limited strength of recommendation can be made that the following preoperative patient characteristics correlate with an increased risk of PJI following TAR: inflammatory arthritis, prior ankle surgery, age less than 65 years, body mass index less than 19, peripheral vascular disease, chronic lung disease, hypothyroidism, and low preoperative AOFAS hindfoot scores. There is conflicting evidence in the literature regarding the effect of obesity, tobacco use, diabetes, and duration of surgery.ConclusionsSeveral risk factors were identified as having an association with PJI following TAR. These factors may alert surgeons that a higher rate of PJI is possible. However, because of the low level of evidence of reported studies, only a limited strength of recommendation can be ascribed to regard these as risk factors for PJI at this time.     

全髋关节置换术髋臼旋转中心的回顾性研究

[目的]通过手术前后对髋臼旋转中心的X线测量，探讨髋臼旋转中心的变化对髋关节平衡稳定性的影响。[方法]追溯调查近年本院收治120例155髋，均为首次行全髋关节置换术患者，对比术前术后双髋关节正位X线片，比较术后髋臼假体的旋转中心（HJC1）与解剖髋臼旋转中心（HJC0）的符合率。[结果]旋转中心恢复者98髋（63．23％）（A组），未恢复者57髋（36．77％）（B组）；A、B两组中因人工髋关节松动、脱位、髋部痛等行髋关节假体翻修术分别为6髋（6．12％）、17髋（29．82％）。[结论]髋臼旋转中心的恢复对人工髋关节置换术后的关节稳定性有直接影响。     

Ileopectineal bursitis following total hip replacement

Two cases of ileopectineal bursitis following total hip replacement are presented. Inflammation, infection and trauma are discussed as pathogenic factors. The results of fine needle biopsy, radiologic examination including CT and ultrasonography, as well as bacteriological cultures are described. The therapy was surgical in both cases.     

Haematogenous tuberculous infection following revision of a loosened total hip replacement

A case of tuberculous arthritis complicating revision of a total hip replacement (THR) is reported. Primary THR was performed for arthrosis of the hip and the patient underwent revision because of aseptic loosening. After this surgical procedure, secondary infection with Mycobacterium tuberculosis occurred. Bacterial contamination due to haematogenous spread probably from a reactivated old quiescent tuberculous pleural focus is proposed as the most likely source of infection in this patient. Tuberculous infections in THR are rare but prophylactic use of antituberculous drugs in patients with a history of tuberculosis may reduce the risk of reactivation of old foci and serve to eliminate contamination of prosthetic replacements. Received: 15 May 1997     

Iliopsoas bursitis following total hip replacement

We report the imaging features of a 52-year-old man presenting with a groin mass and gross lower limb oedema secondary to venous occlusion by massive cystic enlargement of the iliopsoas bursa 4 years after uncemented primary total hip replacement. Ultrasonography of the groin mass demonstrated a large cystic lesion extending into the pelvis. CT showed displacement of the external iliac vessels with venous compression. Bursography showed the bursas margins and no communication with the hip joint. Diagnostic aspiration excluded infection, but fluid recollection occurred subsequently. Complete resolution of symptoms, including limb swelling, followed surgical excision with no recurrence at the 5-year follow-up. We believe iliopsoas bursitis occurred as a tissue response to polyethylene wear within the prosthetic hip and occurred even in the absence of loosening or a direct communication between bursa and joint.     

全髋置换并发严重血管损伤

为了探讨全髋关节置换术中发生严重血管损伤的机制及其诊治策略,作者对１９７８年－１９９３年施行全髋置换术的７２１例患者进行了调查,其中发生严重血管损伤者３例,发生率为０．４２％。其中１例为摘除中心型脱位的髋臼假体时,骨水泥团块的锐缘割破髂外静脉;１例为髋臼前半区内安放螺丝钉时气钻打洞刺伤外静脉;另１例为切除关节囊瘢痕组织时切破股动脉。作者对并发严重血管损伤的肌制及临床处理进行了分析和讨论。作者认为,