Identify the susceptibility profile to measles in the general population: Serological survey of measles antibodies in Shaanxi province,China, in 2016

The reported coverage with two doses of the measles vaccine (MCV) in Shaanxi Province, China, is greater than 95%, but the measles incidence over the whole province remains high. Cross-sectional serological surveys of measles antibodies in Shaanxi Province were conducted in 2016 to assess the population’s immunity. The measles IgG levels were measured in serum samples using ELISA. The geometric means concentration (GMC) levels and seroprevalence rates with 95% CIs were calculated by region, gender, and age. A total of 3574 serum samples were collected from participants aged from 2 months to 49 years. The GMC of measles antibodies was 471.3 mIU/ml (95% CI: 445.9–498.2 mIU/ml), and the seroprevalence was only 85.9% (95% CI: 84.8–87.1%). A significant difference in the GMC (P < .05) but not the seroprevalence (P > .05) was observed among the 3 regions. The report measles incidences were high in individuals aged 0–7 months (33.2/100 000) and 8–17 months (26.8/100 000). Although both measles immunity (90.7%) and MCV coverage (89.7%) were low in children aged 8–17 months, the measles seroprevalence in adults was high at greater than 90%. These results revealed that further actions may be taken to increase vaccination coverage in children aged 8 months to 5 years over the whole province and teenagers in the south region. In particular, timely administration of the first MCV dose should be emphasized to prevent measles epidemics in children aged 8–17 months. Vaccination strategies may be varied by age and region.     

Duration of maternally derived antibody against measles: a seroepidemiological study of infants aged under 8 months in Qinghai, China

To estimate the sero-prevalence of protective maternal measles antibodies among young infants and examine patterns of waning immunity in one of the poorest provinces in China, infants aged under 8 months and their mothers were randomly selected by multi-stage probabilistic sampling and blood samples were collected. Measles-specific IgG antibodies were measured in all serum samples by enzyme-linked immunosorbent assay. We determined measles-specific antibody titres for 477 pairs of infants and their mothers. After excluding 44 sub-clinical measles infection in infants, the measles antibody titres were ≧1:200, ≧1:800, and ≧1:3200 in 79.2%, 46.9%, and 17.8% of the 433 infants, respectively. The proportion of infants with titre ≧1:800 declined with age from 90.2% in newborns to 45.5% and 14.9% in the fourth and eighth month, respectively. Among the 433 mothers, measles antibody titres were ≧1:800 in 94.0%. Multivariate regression analysis showed that residence, mother's antibody levels and infant's age were significantly associated with infants’ having a measles antibody titre ≧1:800. The relatively rapid decay of protective antibody in infants suggests that an earlier administration of the first dose of measles vaccination should be considered in China and a high quality interventional study is needed to decide the optimal schedule of measles immunization.     

麻疹控制与消除的研究——全国21个疾病监测点麻疹血清流行病学调查报告

在短时间里集中人力、采用相同试剂、相同器材,在同等条件下检测健康人群麻疹抗体水平,可以增加结果的可比性。本次共选择21个疾病监测点,检测人群、患者及初免者血清共7437份。结果无论城市点还是乡村点(除广东省江门市、北京市东城区及贵州省玉屏县外)免疫接种率及发病率均达到了国家要求的指标,人群抗体阳性率均在90%以上,预计近几年内这些监测点不会有大的爆发流行。但仍有漏种、原发性免疫失败及免疫后抗体逐年阴转的人群存在,一旦有野毒株传入,仍有散发及小爆发流行发生的可能,今后要加强监测工作。     

Assessing age-dependent susceptibility to measles in Japan

BackgroundRoutine vaccination against measles in Japan started in 1978. Whereas measles elimination was verified in 2015, multiple chains of measles transmission were observed in 2016. We aimed to reconstruct the age-dependent susceptibility to measles in Japan so that future vaccination strategies can be elucidated.MethodsAn epidemiological model was used to quantify the age-dependent immune fraction using datasets of vaccination coverage and seroepidemiological survey. The second dose was interpreted in two different scenarios, i.e., booster and random shots. The effective reproduction number, the average number of secondary cases generated by a single infected individual, and the age at infection were explored using the age-dependent transmission model and the next generation matrix.ResultsWhile the herd immunity threshold of measles likely ranges from 90% to 95%, assuming that the basic reproductive number ranges from 10 to 20, the estimated immune fraction in Japan was below those thresholds in 2016, despite the fact that the estimates were above 80% for all ages. If the second dose completely acted as the booster shot, a proportion immune above 90% was achieved only among those aged 5 years or below in 2016. Alternatively, if the second dose was randomly distributed regardless of primary vaccination status, a proportion immune over 90% was achieved among those aged below 25 years. The effective reproduction number was estimated to range from 1.50 to 3.01 and from 1.50 to 3.00, respectively, for scenarios 1 and 2 in 2016; if the current vaccination schedule were continued, the reproduction number is projected to range from 1.50 to 3.01 and 1.39 to 2.78, respectively, in 2025.ConclusionJapan continues to be prone to imported cases of measles. Supplementary vaccination among adults aged 20–49 years would be effective if the chains of transmission continue to be observed in that age group.     

安徽省皖江地区自然人群乙型肝炎流行现况调查

目的 了解安徽省皖汀地区自然人群乙型肝炎(乙肝)病毒(HBV)感染状况.方法 采用分层整群抽样方法对皖汀地区自然人群进行问卷调查并采集血标本,用ELISA方法检测HBV感染标志.结果 在2282例血清标本中,乙肝HBsAg、HBsAb、HBeAg、HBeAb及HBcAb流行率分别为9.8%、43.5%、1.0%、7.8%、10.3%;HBV总感染率(HBV流行率)为40.6%(926/2282).HBsAg流行率男性高于女性(X2=3.992,P＜0.05).乙肝疫苗的接种率为24.7%(539/2178),10岁以下年龄组疫苗接种率最高为97.4%(76/78),学生疫苗接种率较高为78.2%(355/454),乙肝疫苗接种率农村低于城市.接种乙肝疫苗后HBsAg及HBV流行率均显著降低(P＜0.01).结论 皖江地区HBsAg的标化流行率为9.3%,为全国乙肝高流行区;尤其是农村地区乙肝疫苗接种率偏低.     

浙江省一起由免疫接种空白导致的流动人口麻疹暴发

目的 为核实浙江省某村1名麻疹确诊患儿家长报告同村有多名发热、出疹病例,并调查暴发原因.方法 疑似病例定义为2010年6月1日至8月3日,该村及其所在街道和周围邻村居民中出现发热伴出疹症状者;确诊病例为疑似病例中血清麻疹IgM抗体阳性者.在全村范围开展逐户搜索,通过中国疾病预防控制信息系统搜索该村所在街道及相邻村的麻疹报告病例.对全村8月龄至14岁流动儿童开展回顾性队列研究.结果 该村共发现19例麻疹病例(17例确诊和2例疑似),均为流动人口,罹患率以1～2岁组为最高(13%).首发病例6月4日抵该村后发病,在非法私人诊所就医,但未向卫生部门报告疫情,卫生部门通过患儿家长报告识别暴发时,疫情已持续1个月.315名8月龄至14岁流动儿童中,麻疹疫苗接种率为81%.无麻疹疫苗接种史的61名流动儿童中,16名有明确病例接触史者发病风险(88%,14/16)高于45名无病例接触史者(4.4%,2/45)(Fisher精确概率法,RR=20,95%CI:5.7～94).结论 该村流动儿童麻疹疫苗接种率低,非法私人诊所不按规定对病例进行报告、隔离和医疗诊治,是导致此次疫情暴发的主要原因.     

Measles epidemics and seroepidemiology of population in Wujin,Changzhou city,Jiangsu province,China 2015

The measles epidemic was rather severe in Wujin 2015, and a seroprevalence survey of measles antibody was conducted during June to September 2015 in Wjin district of Changzhou city. Blood samples were collected from community health population and convenient samples of residual blood from hospitals. Measles-specific IgG levels were measured by ELISA assay. A total of 122 measles cases were reported 2015 in Wujin district with an incidence of 8.31 per 100 000 populations. A large proportion of measles cases were adults ≥20 years (62.30%) and infants aged <18 months (28.69%). Floating population accounted for 68.57% of all cases. 1070 blood samples aged from 9 months to 49 years old were collected and the overall seroprevalence and geometric mean titer (GMT) of measles were 82.71% and 551.19 mIU/ml, respectively. Although the seroprevalence among children aged 9 months to 4 years was consistently over 90%, it began to decrease since 24 months, and till the age of ≥10 years, the seroprevalences were all <80%, however, the seroprevalence rised to above 80% in people over 40 years. There were no significant differences between the two blood sample sources in the level of seroprevalence and GMT. Also no significant differences were observed in the seroprevalence of measles and GMT levels between genders. The seroprevalence and GMT in people with measles vaccination were higher than those without measles vaccination or people whose measles vaccination are unknown (P < 0.001). Our study indicated that the adult measles cases have become a serious problem in Wujin district, which may mainly relate to the increasing size of the floating population with low measles vaccine coverage. The seroprevalence of measles decreased dramatically with increasing age since teenagers, which may mainly caused by waning vaccine-induced immunity. Therefore, it is necessary to strengthen measles vaccine in these people especially floating population.     

浙江省2013年麻疹疫情时空分布特征

目的 探讨浙江省麻疹疫情的时空演变规律。方法 数据来源于中国疾病预防控制信息系统和中国免疫规划信息管理系统,采用Power-law的时空多成分模型拟合浙江省各县(市、区)2013年麻疹逐日发病个案数据,通过时间自相关、局部特性、空间流行等成分值比较各县(市、区)麻疹的流行特征。结果 浙江省2013年麻疹报告总例数为1494例,发病率为2.72/10万;Power-law算法相比一阶确定性邻近矩阵,模型拟合后的赤池信息量准则更低;麻疹疫情后续传播影响较大的区域主要是柯桥区、萧山区和越城区(时间自相关成分分别为1.39、0.88和0.77);麻疹本地发病风险较大的区域主要是柯桥区、衢江区和萧山区(局部特性成分分别为4.06、3.74和3.55);麻疹疫情受邻近区域影响较大主要是柯桥区、上虞区和建德市(空间流行成分分别为3.08、2.54和2.21)。结论 浙江省各县(市、区)麻疹疫情的时空流行特征存在异质性,针对性地采取相关措施更易控制麻疹疫情。     

Immunity to measles in the Croatian population

In the frame of measles elimination activities, sera from 1205 Croatian citizens from all parts of the country and of all ages were tested, using Gull Laboratories ELISA, for measles IgG. Equivocal results were found in 50 subjects. Of the remaining 1155 participants, 118 or 10.2% were negative and 1037 or 89.8% positive. The proportion of seronegatives ranged from zero (age groups 41–50, 51 and more) up to 21.4% (1 year of age). As for their distribution into age groups suggested by the European Regional Office of WHO, there were 12.7, 8.9, 9.5 and 8.8% negatives in age groups 1–4, 5–9, 10–14 and 15+ years, respectively. According to these results, only the first two age groups meet WHO criteria, indicating that vaccination coverage higher than the reported 90–94% should be attained if one is to expect measles elimination.     

Seroepidemiology of pertussis in China: A population-based,cross-sectional study

BackgroundDespite high pertussis vaccination coverage and significant decrease of pertussis since the adoption of the Expanded Programme on Immunization (1978), increased pertussis incidence has been reported in China from 2013 to 2017. This study aimed at evaluating the immune response to pertussis among vaccinated children and beyond in China.MethodsThe study recruited 2 144 healthy subjects. Serum IgG antibodies against pertussis toxin (anti-PT IgG) were measured by ELISA. Anti-PT IgG concentration (GMC), seropositivity rate (GMC ≥ 40 IU/ml), and recent infection rate (GMC > 100 IU/ml) were calculated. Participants ≤ 2 years-old were further stratified by vaccination schedule intervals and participants ≤ 6 years-old by vaccine used (Domestic DTaP or DTaP-IPV//PRP ~ T (Pentaxim, SP)).ResultsAmong 0–6-year-olds, the anti-PT IgG GMC was 5.99 IU/ml (95%CI 5.39–6.67). The GMC increased in accordance with the primary vaccination series (4–6 months) and the toddler booster (18–23 months), and continuously declined thereafter to its nadir at 6 years-old [3.72 IU/ml (95%CI 2.91–4.77)]. GMCs were markedly higher in those vaccinated with DTaP-IPV/PRP ~ T compared to DTaP. In individuals > 6 years-old, the GMC was 5.67 IU/ml (95%CI 5.36–6.00), the seropositivity rate was 6.7% (95%CI 5.5–7.9) and the recent infection rate was 1.2% (95%CI 0.7–1.7). The seropositivity rates increased from 6 years-old and peaked at 9 years-old (10.3% [95%CI 0.7–19.8]).ConclusionsVaccination against pertussis increases anti-PT IgG, but wanes over time. The sero-estimated infection rates increase from school age and peak at about 9 years-old. These results support the addition of a booster of pertussis vaccine at preschool age.     

Classification of measles cases from 2014 to 2018: Implications for progress towards measles elimination in China

Measles incidence has decreased dramatically in China due to the implement of measles-containing vaccine (MCV). However, a measles epidemic caused resurgence recently, even among vaccinated individuals. To evaluate the effectiveness of current immunization programs and discuss initiatives for the next step in measles elimination in mainland China, the characteristics of 121,969 laboratory-confirmed measles cases reported in the measles surveillance system (MSS) during 2014–2018 were analyzed according to the vaccination status of the cases in this study.Children under 2 years of age without MCV vaccination (44,424, 36.42% of all cases) and adults over 20 years of age with an unknown vaccination history (37,564, 30.80% of all cases) accounted for the majority of measles cases from 2014 to 2018. 42,425 (34.78%) of the 77,384 cases with available vaccination information were categorized as programmatically preventable. 38,840 (91.55%) of the 42,425 cases were aged ≥8 months without the MCV vaccination history. 34,959 (28.66%) cases were categorized as programmatically non-preventable, of whom 22,611 (64.68%) were too young to receive their first MCV dose, 6857 (19.61%) received their first dose and were too young to receive their second dose, 5491 (15.71%) received at least two doses of MCV.15,933 (13.06%) of the 121,969 cases had a history of MCV vaccination. Measles virus infection in cases with an MCV vaccination history mainly occurred within the first month after MCV vaccination, especially in those who received a one-dose measles vaccination. MCV vaccination could reduce the frequencies of clinical symptoms and complications of measles cases.Our study confirmed that the current measles immunization programs used in mainland China is effective in reducing the measles incidence in China. Unvaccinated infants/children aged 8–23 months and high risk susceptible adults over 20 years of age with unknown vaccination histories should be the focus groups of measles immunization activities in China in the future.     

Absence of endemic measles transmission in a highly vaccinated population from 1999 to 2008: Implications of sustained measles elimination in Taiwan

Background

Measles remains a leading vaccine-preventable cause of child mortality worldwide. The impact of vaccination programs can be seen in the increasingly low incidence of measles. However, cases of measles continue to occur in low numbers every year in Taiwan. We assessed the epidemiology of measles in Taiwan from 1999 to 2008 with a focus on domestic versus imported cases.

Methods

We analyzed the data reported to surveillance systems at the Taiwan Center for Disease Control, where viral isolation was performed.

Results

A total of 84 measles cases were reported from 1999 to 2008 in Taiwan with the incidence of measles varying from 0 to 1.5 per 1,000,000 people per year, peaking in 2002 and again in 2008. The incidence decreased with increasing age in both males and females. Among the 84 reported measles cases, 39 (46%) originated internationally, 8 (10%) were epidemiologically linked to imported cases and the source was unknown in 37 (44%) of the cases. The unknown-source cases were analyzed for potential evidence of endemic measles transmission. Most of the measles cases that occurred in Taiwan from 1999 to 2008 were associated with imported cases. No endemic transmission of measles in Taiwan was identified.

Conclusions

This study suggests that maintaining the high rate of vaccination coverage is needed to prevent future outbreak and sustain the elimination of measles in Taiwan.     

Evaluating the population measles susceptibility in Tianjin,China

BackgroundMeasles is a highly infectious illness requiring herd immunity of 95% to interrupt transmission. China has not reached elimination goals despite high vaccination coverage. We estimated the population susceptibility against measles in Tianjin, China and to tailor awareness raising activities in the measles elimination plan.MethodsAge-specific measles seroprevalence was evaluated by Enzyme-Linked Immunosorbent Assay (ELISA) on 12,164 individual aged 0–44 years in 2009–2018. Measles IgG avidity testing was performed to confirm the relationship of the waning immunity after vaccination and secondary vaccination failures (SVF) on 324 confirmed measles cases in 2013–2018.Results11,108 samples (91.32%) tested positive for measles IgG, 239 (1.96%) tested as equivocal and 817 (6.72%) were negative. The age distribution of measles cases in Tianjin followed a U-shaped curve and was highest for those at <8 months and again at 20–39 years which correlated closely with the age distribution of measles susceptibility based on measles IgG antibody status (r = 0.72, P < 0.001). The seropositivity rate and antibody geometric mean concentration (GMC) for the 2018 study population were significantly lower (χ² = 7.45, P = 0.006 and t = 12.01, P < 0.001) compared to 2009. The multivariate stepwise logistic regression analysis showed that age and region were the risk factors for both measles seropositivity rate and GMC after vaccination. The proportion of high avidity cases increased with age, being significantly higher in 75.31% of cases in patients aged 30–34 years (χ² = 18.04, P = 0.003).ConclusionsHigh immunization coverage in children alone will not be adequate to realizing sufficient levels of population herd immunity, particularly given that the potential susceptibility window in adult. Implementation of supplemental immunization activity (SIA) targeted to appropriate group aged 30–34 years is recommended.     

许昌市麻疹实验室2006年-2010年监测数据分析

目的:分析2006年到2010年许昌市麻疹监测结果,掌握许昌市麻疹疫情动态和流行病学特征,为2012消除麻疹的规划提供科学依据。方法:采用酶联免疫捕获法对五年来采集到的912份疑似血清标本进行麻疹抗体监测(M-lgM)。结果:5年来许昌市共采集疑似病例血标本912例,采集率为80.14%,其中M-IgM阳性618例,检测麻疹IgM抗体阳性率为67.76%。发病以散发为主,局部暴发点同时存在。2月-5月为高发季节,发病以15岁以下少年儿童为主,占87.86%,周岁以内发病率为39.16%。结论:许昌市麻疹监测系统保持较高敏感性,许昌麻疹处于低发流行状态,下降趋势明显,无MV免疫史的儿童是麻疹发病的高危人群。0月-7月龄儿童发病率呈上升态势。     

2014 - 2018年昆明市麻疹疑似病例病原学监测结果分析

目的 分析2014 - 2018年昆明市麻疹疑似病例的病原学检测结果,为进一步控制和消除麻疹提供科学依据。方法 采集麻疹疑似病例病原学标本（咽拭子和/或尿液）,使用Real time RT - PCR 法检测麻疹病毒核酸。结果 2014 - 2018年昆明市共报告353例麻疹疑似病例,130例实验室确诊病例,阳性率为36.83%（130/353）。其中咽拭子阳性标本127份,阳性率35.98%（127/353）;尿液阳性标本48份,阳性率为30.97%（48/155）。咽拭子阳性率及尿液阳性率差异无统计学意义(χ2 = 1.197,P = 0.274)。2014年麻疹发病呈冬春季分布,2015 - 2018年演变为3 - 6 月的单峰型;确诊病例主要分布在主城区的西山区45.38%（59/130）,官渡区44.62%（58/130）,五华区8.46%（11/130）;男女确诊病例比为1.60∶1, 确诊病例中8～23月龄组最多65例（50.00%）,其次是＜8月龄组32例（24.62%）、＞18岁组19例（14.62%）。结论 昆明市应加强麻疹重点地区和易感人群的监测,努力减少和消除免疫空白人群;进一步提高麻疹病例咽拭子标本采集质量,为努力实现消除麻疹目标提供实验室依据。     

鹿城区2011年-2017年麻疹监测结果及流行特征分析

目的分析温州市鹿城区2011年-2017年麻疹流行病学特征。方法对温州市鹿城区2011年-2017年麻疹监测数据用描述性流行病学方法进行分析。结果2011年-2017年鹿城区共报告麻疹117例,年均发病率为2.10/10万;<8月龄儿童和≥15岁成人分别占全部病例的37.61%和29.06%。8月龄~14岁麻疹病例(39例)和排除病例(85例)中有免疫史者分别占28.21%和78.82%,排除病例免疫史明显高于麻疹病例免疫史,差异有统计学意义(χ^2=29.35,P<0.01)。血清标本采集率、3 d内送达率由2011年48.52%和52.41%提高至2012年80%以上。结论2011年-2017年鹿城区麻疹病例呈现明显下降趋势,但仍需提高适龄儿童含麻疹成分疫苗覆盖率和及时接种率,及早监测和有效处置麻疹疫情,并进一步提高监测的敏感性、特异性和及时性。     

安徽省2011―2020年麻疹流行特征及消除麻疹策略探讨

目的  分析2011-2020年安徽省麻疹流行特征, 探讨消除麻疹策略。方法  采用描述流行病学方法分析2011-2020年安徽省麻疹流行特征。结果  安徽省2011-2020年共报告麻疹病例8 892例, 年均发病率为1.48/10万, 整体呈现下降趋势(X²_趋势=1 794.80, P<0.001)。病例主要集中在2-6月, 低发病年份无明显季节聚集性。皖北、皖中和皖南地区年平均发病率分别为1.82/10万、1.12/10万和1.24/10万, 差异有统计学意义(X²=44.95, P<0.001)。病例主要集中在不足2岁和15岁以上人群, 占总发病数的90.25%。56.94%的病例无明确含麻疹成分疫苗(measles containing vaccine, MCV)接种史, 30.40%的病例接种史不详。758例麻疹病例有基因型鉴定结果, 其中737例均为本土H1基因型, 16例为疫苗株A基因型, B3基因型2例, D8基因型3例。共报告突发公共卫生事件相关信息5起, 暴发疫情76起。结论  2011-2020年安徽省麻疹发病呈现下降趋势, 近年来保持低发病水平。应继续提高适龄儿童MCV的及时、全程接种率, 必要时对重点人群开展补充免疫, 同时加强流行病学监测和病原学监测, 进一步阻断麻疹病毒传播。     

湖北省健康人群麻疹、风疹、腮腺炎人群免疫水平分析

目的:了解湖北省人群麻疹、风疹和腮腺炎抗体水平,制定免疫对策。方法:抽取咸宁市和黄石市两个地区部分健康人群,采集0岁～50岁健康人群标本共700份,使用ELISA法定量检测正常人血清中麻疹IgG、风疹IgG和腮腺炎IgG抗体水平。结果:麻疹、风疹和腮腺炎IgG抗体阳性率分别为87.14%、55.43%和61.86%。结论:抽取的湖北省两个地区健康人群风疹IgG和腮腺炎IgG抗体阳性率均比较低;控制麻疹重点人群为小于2岁年龄组;需要对风疹强化免疫以及对2岁以下儿童进行腮腺炎强化免疫。     

湛江市2006-2007年麻疹与风疹监测结果分析

目的 分析湛江市麻疹疑似病例的血清学实验室诊断符合率和风疹检测结果,完善麻疹监测网络实验室检测工作,为进一步提高麻疹、风疹的病例诊断提供依据.方法 应用ELISA法检测全市送检的血清样本中麻疹和风疹IgM抗体,对检测结果和病例资料进行分析.结果 实验室检测麻疹疑似病例血清样本747份,检出麻疹IgM抗体阳性502例,实验室诊断符合率为67.20%;在麻疹IgM抗体阴性血清样本中榆测风疹IgM抗体245份,阳性48例,阳性检出率为19.59%.麻疹发病高峰时间主要集中在3-7月,占病例总数的78.29%,风疹发病时间主要在4月和12月;麻疹发病年龄以0～9岁居多,占病例总数的73.31%,风疹发病年龄集中在15～24岁;麻疹、风疹病例的户籍分布均以本市户口为主,占病例总数的99%以上;麻疹男女比例为1.55:1,风疹男女比例为1.09:1;无免疫接种史或接种史不详的麻疹病例占95.02%,风疹病例占97.92%.结论 近两年,我市麻疹疫情上升较快,说明我市目前还没有形成足够保护易感人群的免疫屏障,全市计划免疫工作有待进一步加强;同时也应加强对风疹的控制.     

江苏省2006年-2008年健康人群麻疹抗体监测分析

目的：了解江苏省健康人群麻疹血凝抑制抗体水平免疫状况。方法：采用麻疹血凝抑制（HI）试验对监测人群进行麻疹抗体测定并对结果进行分析。结果：麻疹血凝抑制抗体总阳性率为92．44％,GMT为1：22．84。2006年-2008年麻疹抗体阳性率范围波动在89．15％～96．71％之间,抗体效价在1：7．52～1：32．22之间。不同年份之间有显著性差异（χ^2=52．03,P〈0.01）。结论：江苏省麻疹血凝抑制抗体除0岁组偏低外,其余人群均有保护作用,提示应加强对0岁组人群的保护。