光子嫩肤治疗面部皮肤光老化100例疗效观察

为观察光子嫩肤技术治疗面部皮肤光老化的疗效，用光子嫩肤仪治疗100例有面部皮肤光老化患者，每位患者治疗5次，每次间隔3—4周。治疗结束后，色素沉着、毛细血管扩张、细小皱纹和皮肤质地的改盖有效率分别为79．8％、82．4％、79．6％和85．0％。光子嫩肤仪是一种无创性治疗面部光老化的有效方法。     

应用强脉冲光治疗面部皮肤色斑并改善皮肤整体状况

目的探讨应用强脉冲光治疗面部皮肤色斑及改善皮肤整体状况的疗效。方法对474例面部色斑患者采用强脉冲光子嫩肤仪进行治疗，共5次，每次间隔3～4周。治疗前拍照对比，医患双方分别填写疗效观察表进行评估。结果色斑治疗有效率，患者评价为89．0％，医生评价为89．7％，医患双方评价合并后为89．3％；面部皮肤状况整体改善率，患者评价为94．7％，医生评价为95．0％，医患双方评价合并后为94．8％。疗效肯定，并发症发生率低（1．5％）。结论应用强脉冲光技术治疗面部皮肤色斑及改善皮肤状况，效果满意，治疗过程无创伤，无痛苦，无结痂，无色素沉着，不需休假，是一种安全、有效和方便的治疗方法。     

强脉冲光子治疗某些皮肤病的临床观察

为评价应用强脉冲光子嫩肤仪治疗皮肤色素性、血管扩张性及光老化性疾病的疗效及安全性,采用560nm的IPLQuantumSR光子嫩肤治疗仪,治疗77例雀斑、12例文身、21例黄褐斑、27例红血丝、14例酒渣鼻、15例毛孔扩大患者,5次为一疗程,两次间隔3~4周,观察临床疗效和复发率。结果:色素性疾病总有效率为78.05%,血管扩张性疾病总有效率为93.33%,光老化性疾病总有效率为75.75%。使用强脉冲光子嫩肤仪治疗皮肤色素性、血管扩张性及光老化性疾病,具有非介入、无创伤、无需休息、疗效明显和复发率低的优点。     

强脉冲光子嫩肤机治疗面部雀斑40例临床研究

<正>强脉冲光子嫩肤机,脉冲波长560~1 200nm。选取面部雀斑患者40例,共治疗3~5次,每次治疗间隔3周。结果:痊愈15例,显效20例,好转2例,无效3例,有效率92.5%,愈显率77.5%。认为强脉冲光子嫩肤机对雀斑的选择性治疗,效果明显、复发率低、无创伤,优于传统方法,值得临床应用。参4     

光子脱毛的临床疗效与分析

目的为了评价光子（强脉冲光）脱毛技术的疗效，以及疗效与治疗次数、治疗间隔时间、治疗参数、毛发形态的关系。方法使用武汉奇致激光公司生产的DPL系列Princess光子嫩肤仪对57例多毛患者共176个部位（均为治疗2次以上）进行治疗。结果57例患者的176个治疗部位取得了满意的疗效，71％的治疗部位脱毛率达痊愈标准，21％的治疗部位脱毛率达到了有效的标准，最低脱毛率也高于50％以上。总有效率达到了92％以上。治疗期间共有3例5个治疗部位发生热损害。结论光子脱毛技术是一种方便快捷，安全，高效的治疗多毛的办法。     

光子嫩肤技术治疗92例面部色素性皮肤病的临床观察

目的研究光子嫩肤技术对面部色素性皮肤病治疗效果。方法应用光子多功能治疗仪治疗92例面部色素性皮肤病,并进行临床观察。结果雀斑47例,有效率95.7%;痤疮后色素沉着22例,有效率95.5%;黄褐斑11例,有效率18.2%;脂溢性角化12例,有效率58.3%。结论光子嫩肤技术适合治疗雀斑和痤疮后色素沉着。     

光子嫩肤252例疗效观察

目的观察光子嫩肤技术对患者面部皮肤美容的综合临床效果。方法采用光子嫩肤仪(飞顿Ⅱ号)宽光谱(420nm~950nm)治疗混合性色斑、毛细血管扩张、细小皱纹、毛孔粗大等共252例。结果应用光子嫩肤技术作用皮肤色基产生综合生物疗效,达到皮肤美容的目的,总有效率达到90%以上。结论光子嫩肤技术疗效确切、安全省时,是具有一定治疗范围的高新技术。     

光子嫩肤治疗面部皮肤问题的临床观察

目的观察光子嫩肤对面部皮肤问题的治疗效果。方法应用光子嫩肤治疗仪及皮肤测试仪治疗及检测117例面部皮肤问题,进行临床观察。结果雀斑23例,有效率86.96%,痤疮后色素沉着斑28例,有效率85.71%,毛孔粗大18例,有效率83.33%,黄褐斑21例,有效率28.57%,酒糟鼻15例,有效率73.33%,红血丝12例有效率16.67%。面部皮肤测试情况:皮肤弹性增加,黑色素水平下降,水份增加,油份减少。结论光子嫩肤技术适合座疮后色素沉着斑、雀斑、毛孔粗大。     

国产光子脱毛仪治疗多毛症疗效观察

目的观察国产光子脱毛仪治疗多毛症的临床疗效。方法采用国产的光子脱毛系统对148例患者各部位多余毛发治疗，反复2～7次，每次间隔4～6周。疗程结束随访6个月。治疗前后进行对比，记录效果并让病人对满意度打分。结果所有患者均能耐受治疗。脱毛总有效率为91．9％。病人满意度为83．1％，副反应发生率为4．1％。结论国产光子脱毛仪疗效满意，操作简单，治疗费用明显低于进口机，对多毛症患者是一个很好的选择。     

光子嫩肤技术联合复方木尼孜其颗粒治疗面部黄褐斑的临床观察

<正>54例黄褐斑患者随机分为两组。对照组27例行光子嫩肤技术治疗,治疗组27例行光子嫩肤技术联合复方木尼孜其颗粒治疗,观测两组患者临床治疗效果。结果:治疗组有效率为77.78%,对照组为55.56%,两组有效率差异有统计学意义(P0.05)。认为光子嫩肤技术联合复方木尼     

Photorejuvenation using long-pulsed alexandrite and long-pulsed neodymium:yttrium-aluminum-garnet lasers: a pilot study of clinical outcome and patients' satisfaction in Koreans

Long-pulsed 755-nm alexandrite and long-pulsed 1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) lasers have been used for photorejuvenation of the face. The aim of this study was to investigate the safety and efficacy of long-pulsed alexandrite and long-pulsed Nd:YAG lasers for photorejuvenation in Korea. One hundred and sixteen Korean patients with photo-aged facial skin were enrolled. Sixty-two patients with facial pigmentation underwent long-pulsed alexandrite laser treatment. Eleven patients that wanted to improve facial pigmentation with minimal pain had quasi-long-pulsed alexandrite laser treatment. Forty three patients had long-pulsed Nd:YAG laser therapy. Outcome assessments included standard photographs and global evaluation by blinded investigators. The self-assessment grade was provided in questionnaires. Forty-four percent of patients reported excellent or good improvement of their pigmentary lesions (>50% improvement) using a long-pulsed alexandrite laser. Of patients who underwent long-pulsed Nd:YAG laser treatment, 36% reported excellent or good improvement in skin tightening, 50% in facial flushing and 45% in pigmentary lesions. We conclude that long-pulsed alexandrite and long-pulsed Nd:YAG lasers are safe and effective for facial photorejuvenation in Koreans.     

Comparative split-face study of 5-aminolevulinic acid photodynamic therapy with intense pulsed light for photorejuvenation of Asian skin

Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) (ALA-PDT) using intense pulsed light (IPL) as a light source (IPL-ALA-PDT) has been used for photorejuvenation, but it is unclear if this protocol can be applied to darker skin types. We performed this study to assess our IPL-ALA-PDT protocol for photorejuvenation in Asian skin. To determine an appropriate dose, ALA ointment (0-20%) was applied to the upper arm of five healthy volunteers and the fluorescence intensity (FI) was measured using a spectrofluorometer. Non-linear regression analysis of FI 2 h after ALA application with global fitting gave a typical sigmoid dose-response curve with R2 = 0.9705 and saturation after 5% ALA. The entire faces of 16 Japanese women with photodamage were then treated with IPL (500-670 and 870-1400 nm, 23-30 J/cm2) 2 h after application of 5% ALA to one side of the face. Three treatments were delivered at 4-week intervals with follow-up visits. Comparative analysis of photorejuvenation showed noticeable improvements on both sides of the face, although the reduction in the photoaging score from baseline did not differ significantly between the two sides in all subjects. Despite this finding, 75% of the patients felt that the IPL-ALA-PDT-treated side of the face showed greater improvement than the IPL-treated side. However, all IPL-ALA-PDT-treated sides showed adverse effects such as erythema and pain. Therefore, we conclude that the IPL-ALA-PDT protocol requires optimization for photorejuvenation in Asians.     

Photodynamic therapy for skin rejuvenation: treatment options – results of a consensus conference of an expert group for aesthetic photodynamic therapy

In addition to providing effective treatment for non‐melanoma skin cancers or their precursors, photodynamic therapy (PDT) has also attracted considerable attention for its use on aesthetic dermatology. In a first consensus publication the mechanisms of action of its photorejuvenation effects and recent studies were presented; in this paper treatment protocols for the different anatomical regions exposed to chronic sun damage like face, neck, décolleté and the back of the hands are given and suitable procedures for pre‐ and after‐care are discussed.     

What is nonablative photorejuvenation of human skin?

Nonablative photorejuvenation has become an integral procedure in the emerging discipline of laser dermatologic surgery. The objective is to confine selectively, without any epidermal damage, thermal injury to the papillary, and upper reticular dermis leading to fibroblast activation and synthesis of new collagen and extracellular matrix material. The procedure results in minimal patient morbidity, no interference with lifestyle, and a low risk of complications, while providing a satisfying degree of rhytides reduction. Multiple devices have been studied and marketed for nonablative photorejuvenation of human skin. However, currently, nonablative photorejuvenation should not be considered an alternative to laser skin resurfacing. The skin surface is not removed or modified. What really occurs may be more accurately referred to as dermal "remodeling" or "toning" as a wound healing response is initiated and collagen regenerated. The narrow "therapeutic window" of laser-induced dermal heating and epidermal cooling must still be optimized so that effective treatments can be obtained routinely. Clinical verification of effective treatment parameters (irradiation wavelength, pulse structure, radiant exposure, cooling time) will be obtained through further human studies. Most importantly, understanding the relationship between the degree of dermal thermal injury and synthesis of new collagen and extracellular matrix material will be fundamental to predicting the clinical efficacy and limitations of nonablative photorejuvenation.     

Ultrastructural changes seen after ALA-IPL photorejuvenation: a pilot study.

BACKGROUND: Intense pulse light (IPL) treatment currently represents one of the most popular non-ablative photodamage skin treatments. Recent anecdotal evidence suggests that aminolevulonic acid (ALA) photodynamic therapy using IPL as a light source is superior to IPL alone for photorejuvenation. METHODS: Seven adult subjects (six women, one man) with minimal photodamage were treated with full face IPL treatment. Half of the face was pre-treated with topical ALA. Pre-and post-treatment biopsies were analyzed for changes in collagen by electron microscopic ultrastructural analysis. RESULTS: An increase in type I collagen fibers was seen after treatment in all subjects. There was a greater increase in type I collagen formation in those subjects who were pre-treated with topical ALA. CONCLUSION: This small pilot study is the first to focus on the ultrastructural changes seen after ALA-IPL photorejuvenation. We found a greater shift toward type I collagen synthesis in the ALA-IPL group compared to the IPL group. The addition of ALA to IPL treatment for photorejuvenation may be superior to IPL alone.     

Clinical efficacy of devices for nonablative photorejuvenation

OBJECTIVE: To evaluate the scientific evidence for the efficacy of devices for nonablative photorejuvenation of the skin. DATA SOURCES: All studies published between January 1996 and June 2002 in the dermatology literature listed in the MEDLINE database. Search terms included nonablative and photoaging or skin aging. STUDY SELECTION: All studies that presented data on human clinical trials that were designed to test the efficacy of nonablative light sources in reducing fine lines and wrinkles due to photodamage. DATA EXTRACTION: Data presented in the studies were reviewed and evaluated from the perspective of study design and validity of conclusions. DATA SYNTHESIS: Eleven studies were reviewed. Five different light sources were used, each with varying parameters. Ten different clinical end point scales and methodologies were used. No 2 studies used the same clinical end point standards. The majority of the studies provided no statistical analysis of data. CONCLUSIONS: The studies reviewed failed to present consistent data on the efficacy of nonablative photorejuvenation to improve or eliminate rhytids. The field is early in development, and continued improvement and standardization of study design are needed to determine the efficacy of these interventions.     

Long‐term clinical results of IPL photorejuvenation

BACKGROUND: Non‐ablative photorejuvenation is characterized by the reduction of intrinsic and extrinsic changes in photodamaged skin. Only short‐term improvement has been documented previously.

OBJECTIVE: To evaluate quantitatively the short‐term and long‐term clinical effectiveness of multiple full‐face IPL treatments for non‐ablative facial photorejuvenation.

METHODS: A total of 47 patients with varying degrees of photodamaged skin and rosaceal dermatitis underwent a series of four to five IPL treatments with a Vasculight (Lumenis Corp). Treatments were conducted every 3–4 weeks. Photographs were taken at baseline and after the treatment series was completed at both 6 weeks and 6 months. Adverse effects and clinical improvement were documented. A patient satisfaction questionnaire was completed and reviewed at the 6‐month evaluation period.

RESULTS: Standardized evaluation of rhytids showed a statistically significant improvement in wrinkles at both evaluation endpoints. Some degradation occurred over time. Facial vascularity, dyschromia, and large pore size progressively improved from the 6‐week measurement to the 6‐month measurement.

CONCLUSION: This clinical study demonstrates that non‐ablative facial rejuvenation is associated with long‐term clinical improvement of facial rhytids, abnormal vascularity and pigmentary disorders with minimal risks and side effects to the patient.     

Investigation of irradiation by different nonablative lasers on primary cultured skin fibroblasts

Background. A variety of lasers with different wavelengths and biological effects are widely used for nonablative skin rejuvenation, but the underlying mechanisms have not been fully investigated. Aim. To investigate the effects of irradiation by different nonablative lasers on collagen synthesis and the antioxidant status of cultured fibroblasts to identify a possible mechanism for laser photorejuvenation. Methods. Cultured skin fibroblasts were irradiated with three different lasers: 532 nm potassium–titanyl phosphate (KTP), 1064 nm Q‐switched neodymium:yttrium–aluminium–garnet (Nd:Yag) and 1064 nm long‐pulse Nd:YAG, and production of collagen and changes in lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px) were assayed. Results. Irradiation by all three lasers led to a marked increase in collagen production. Two major antioxidant enzymes, SOD and GSH, were significantly increased, whereas MDA was markedly reduced after laser irradiation. No change in LDH activity was found between nonirradiated and irradiated fibroblasts. Conclusion. This study indicates that the increased collagen synthesis by fibroblasts after laser treatment may be partly due to improved antioxidant capacity, which reduces oxidative stress and thus stimulates new collagen production.