应用冷宁康敷料治疗烧伤和整形供皮区创面42例

目的通过使用新型烧伤敷料治疗二度烧伤和整形供皮区创面，旨在减少病人的痛苦，加快创面的愈合。方法在烧伤二度创面和整形供皮区创面应用冷宁康敷料42例，对照组分别用磺胺嘧啶银或油纱布，然后观察创面的愈合时间和质量。结果冷宁康组创面愈合时间缩短，愈合质量优于对照组。结果冷宁康敷料是一种安全可靠、使用方便的外用烧伤敷料。     

冷宁康敷料应用于儿童植皮术前创面准备的临床观察

目的通过使用新型水凝胶敷料为延迟手术植皮的创面提供有效的治疗环境，促进新鲜肉芽生长，消除水肿肉芽，清洁创面。达到符合植皮标准的创面，加快愈合时间。方法在17例采用融痂方式治疗超过三周的儿童三度烧伤创面应用冷宁康敷料做术前创面准备，与以往传统应用油纱布敷料创面做对照，观察创面的植皮时间和一般情况。结果冷宁康组创面植皮准备时间、一般状况优于油纱布对照组。结论冷宁康敷料具有良好的封闭保湿性能，明显减少创面渗出，促进新鲜肉芽生长，提升创面的清洁程度，从而达到加快创面愈合的目的。     

冷宁康敷料应用于供皮区创面的体会

传统的供皮区处理方法，多为暴露或半暴露疗法。在给病人带来较大痛苦的同时，也不利于创面的上皮生长。随着临床界对创面湿性愈合理论的广泛认同，以该理论为基础的水凝胶类敷料在临床上得以日益广泛的应用。许多临床研究表明：与传统的纱布敷料相比，水凝胶敷料缩短了创面愈合的时间、降低了感染率、减轻了病人的痛苦，并且减少了医疗费用。[第一段]     

天年素医用功能敷料对烧伤创面的疗效观察

我院于１９９７年１０月～１２月对３０例烧伤病人创面使用天年素医用功能敷料进行临床观察，现报告如下。１资料与方法病例选择：男２３例、女７例，年龄４～５８岁。烧伤面积１％～５％，均为Ⅱ度创面，新鲜创面２８例，感染创面２例。使用方法：所有创面按换药操作常规...     

纳米银敷料治疗烧伤创面的疗效与安全研究进展

纳米银敷料作为一种新型抗菌材料近年来被广泛用于烧伤创面的治疗,其在促进烧伤创面愈合方面有较好的效果,有着控制创面感染、缓解换药疼痛及减少换药次数等优点。本文对其促进烧伤创面愈合的原理、疗效及安全性3个方面的研究进展进行综述,并对新型纳米银敷料的研制方向进行了展望。     

小面积烫伤创面早期外用HD系列医用水凝胶创伤敷料的临床研究

目的研究小面积烫伤创面早期外用HD系列医用水凝胶创伤敷料治疗后的疗效。 方法回顾性分析2016年5月至2018年5月在伤后3 h内入苏州科技城医院烧伤整形科门诊就诊的120例小面积热液烫伤患者,根据患者及其家属的经济接受程度,采用2种方法处理创面,对应分为2组,各60例,对照组伤后均使用复方磺胺嘧啶锌凝胶治疗,试验组伤后前3 d使用HD系列医用水凝胶创伤敷料治疗,3 d后同对照组处理。观察两组患者创面疼痛情况、次日创面转浅情况及创面治疗时间。对数据进行t检验及卡方检验。 结果试验组创面疼痛情况明显好于对照组,差异有统计学意义(χ²＝96.356, P<0.05);试验组次日创面转浅情况明显好于对照组,差异有统计学意义(χ²＝66.473, P<0.05);试验组创面治疗时间短于对照组,差异有统计学意义(t＝4.113, P<0.05)。 结论小面积烫伤创面早期外用HD系列医用水凝胶创伤敷料不仅可以有效缓解烫伤后创面疼痛,还能促使创面转浅,缩短创面治疗所需时间,值得临床推广使用。     

软聚硅酮银离子敷料应用于烧伤创面的效果评价

文题释义：软聚硅酮银离子敷料：是一种运用Safetac技术制成的高分子有机化合物,从内到外由一层具有自黏性软聚硅酮伤口接触内层,一层包括聚氨酯泡沫、无纺布和高吸收性聚丙烯混合纤维的吸收垫,以及一层透气并防水的外覆薄膜组成,具有抗感染、吸渗性好、透气性好等特性,容易黏附于干燥完整的皮肤表面而不紧贴在湿润创面,能在创面表面形成湿润环境。 烧伤：指由于高温、电流、强辐射或者腐蚀性物质引起的不同程度组织损害,主要指皮肤和/或黏膜,导致组织的缺血缺氧或其他组织器官的免疫功能紊乱,炎症递质释放,最终导致其他组织器官功能的衰竭。 背景：软聚硅酮银离子敷料是一种运用Safetac技术制成的高分子有机化合物,具有抗感染、吸渗性好、透气性好等特性,能为创面愈合提供良好的湿润环境。 目的：评价软聚硅酮银离子敷料修复深Ⅱ度及以下程度烧伤创面的有效性。 方法：应用计算机全面检索知网、维普、万方、中国生物医学文献数据库和PubMed、Embase、Web of Science数据库,选择软聚硅酮银离子敷料修复深Ⅱ度及以下程度烧伤创面的随机对照试验,治疗组为单独软聚硅酮银离子敷料治疗,或软聚硅酮银离子敷料联合常规治疗,或联合其他治疗;对照组为常规治疗,或其他治疗,或安慰剂治疗。对文献进行筛选、信息提取和质量评价后,利用Review Manager 5.3软件进行Meta分析。 结果与结论：①共纳入11篇文献,784例患者,治疗组381例,对照组403例;②Meta分析结果显示：治疗组在第7,14,21天及最后一次测量的烧伤创面愈合率均高于对照组[OR=11.56,95%CI(9.60,13.53),      P < 0.000 01;OR=13.29,95%CI(7.54,19.04),P < 0.000 01;OR=4.10,95%CI(2.28,5.93),P < 0.000 1;OR=1.17,95%CI(0.42,1.93),P =0.002],烧伤创面愈合时间短于对照组[OR=-2.81,95%CI(-3.49,-2.12),P < 0.000 01],烧伤创面疼痛程度低于对照组[OR=-0.38,95%CI(-0.53,-0.24),P < 0.000 01];两组烧伤创面细菌培养阳性率、伤口感染、换药次数、创面治疗费用、不良反应等比较差异均无显著性意义[OR=1.16,95%CI(0.47,2.85),P=0.74;OR=1.44,95%CI(0.47,4.41),P=0.52;OR=-8.04,95%CI(-18.82,2.74),P=0.14;OR=-98.26,95%CI(-272.91,76.40),P=0.27;OR=0.61,95%CI(0.31,1.20),P=0.15];③结果表明,软聚硅酮银离子敷料应用于深Ⅱ度及以下程度的烧伤创面能提高创面愈合率,缩短创面愈合时间,减轻疼痛。 ORCID: 0000-0003-3340-2201(钟淑贤) 中国组织工程研究杂志出版内容重点：生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程     

传导型敷料Drawtex管理深Ⅱ度烧伤创面的临床疗效

目的:观察传导型敷料Drawtex在深Ⅱ度烧伤创面治疗中的临床疗效。方法:纳入2018年1月至2020年1月北京积水潭医院烧伤科收治的烧伤面积为5%~20%体表总面积（TBSA）的深Ⅱ度烧伤患者200例,随机分为观察组（ n=100）和对照组（ n=100）。两组均给予创面清创换药处理和凡士林油...     

胶原敷料治疗烧伤创面愈合后色素沉着298例

目的探讨烧伤创面愈合后遗留色素沉着应用胶原敷料治疗的效果。方法选择2005年至2008年烧伤创面愈合后遗留色素沉着的患者298例,分为观察组和对照组,观察组148例,对照组150例。观察组的患者应用胶原敷料,而对照组采用避光治疗作对照研究。两组均连续治疗6周,在1、2、3、4、5、6周分别观察各组创面色素沉着改变的情况。结果采用胶原敷料的观察组有效例数130例,有效率为88％;对照组有效例数为24例,有效率为16％,两组比较差异有统计学意义（P〈0．05）。结论胶原敷料对于烧伤创面愈合后遗留的早期色素沉着,有一定的治疗效果。     

水胶体敷料治疗肛周烧伤溃疡创面1例

对于小面积烧伤创面，采用油纱覆盖、外涂龙胆紫等是经典的治疗方法，但其创面愈合不甚理想，而水胶体敷料的使用更接近Ⅱ度以下烧伤创面愈合的需要。作者采用水胶体敷料成功治愈肛周烧伤溃疡创面1例，取得了满意的效果。现报告如下。     

Electrospun mupirocin loaded polyurethane fiber mats for anti-infection burn wound dressing application

Wound care treatment is a serious issue faced by the medical staffs due to its variety and complexity. Wound dressings are typically used to manage the various types of wounds. In this study, polyurethane (PU) fibers containing mupirocin (Mu), a commonly used antibiotic in wound care, were fabricated via electrospinning technique. The aim of this study was to develop biomedical electrospun fiber scaffolds for preventing wound infections with good compatibility and to demonstrate their applications as anti-infective burn wound dressings. The surface morphology of fibers was obtained by scanning electron microscopy. FT-IR spectra, water vapor transmission rate, and drug release study in vitro were tested to demonstrate the fiber scaffold characteristic. The prepared PU/Mu composite scaffolds had satisfactory antibacterial activity especially against Staphylococcus aureus. The cell studies revealed that the scaffolds were biocompatible and safe for cell attachment. Histological and immunohistochemical examinations were performed in rats, and the results indicated the histological analysis of tissue stained with H&E showed no obvious inflammation reaction. The results indicated that the electrospun scaffolds were capable of loading and delivering drugs, and could be potentially used as novel antibacterial burn wound dressings.     

Development of a functional wound dressing composed of hyaluronic acid spongy sheet containing bioactive components: evaluation of wound healing potential in animal tests

This study aimed to develop a novel wound dressing composed of hyaluronic acid (HA) spongy sheet containing bioactive components. The wound dressing prepared by the freeze-drying method has a two-layered structure: an upper layer composed of cross-linked high-molecular-weight HA (HMW-HA) and a lower layer composed of low-molecular-weight HA (LMW-HA) containing arginine (Arg), magnesium ascorbyl phosphate (vitamin C derivative: VC), and epidermal growth factor (EGF) (referred to as EGF-dressing). A wound dressing containing only Arg and VC was prepared in a similar manner (referred to as EGF-free-dressing). The potential of each wound dressing was evaluated in animal tests using Sprague Dawley (SD) rats and diabetic mice. In the first experiment, each wound dressing was applied to a full-thickness skin defect in the abdominal region of SD rats. Wound conditions after 1?week and 2?weeks of treatment were evaluated based on macroscopic and histological appearance. A commercially available non-woven alginate wound dressing (Alg-dressing) was used in a control group. Both EGF-free-dressing and EGF-dressing decreased wound size and promoted granulation tissue formation associated with angiogenesis more effectively when compared with Alg-dressing. In particular, EGF-dressing promoted re-epithelialization. In the second experiment, each wound dressing was applied to a full-thickness skin defect in the dorsal region of diabetic mice. Wound conditions after 1?week and 2?weeks of treatment were evaluated based on macroscopic and histological appearance. A commercially available Alg-dressing was used in a control group. Both EGF-free-dressing and EGF-dressing decreased wound size and promoted granulation tissue formation associated with angiogenesis more effectively when compared with Alg-dressing. These findings indicate that EGF-free-dressing and EGF-dressing have the potential for more effective wound healing when compared with Alg-dressing. In particular, EGF-dressing has a higher potential for wound healing when compared with EGF-free-dressing.     

烧伤创面覆盖物研究进展

创面覆盖物的开发和应用是烧伤创面修复研究中的重点。多年来 ,已开发应用了多种生物覆盖物和合成覆盖物用于烧伤创面的暂时性或永久性封密。本文综述了常用覆盖物的特点、临床应用情况及发展前景 ,并对尚存在的问题作了介绍     

Chitosan nanoparticle/PCL nanofiber composite for wound dressing and drug delivery

Many investigations of wound dressings equipped with drug delivery systems have recently been conducted. Chitosan is widely used not only as a material for wound dressing by the efficacy of its own, but also as a nanoparticle for drug delivery. In this study, an electrospun polycaprolactone nanofiber composite with chitosan nanoparticles (ChiNP–PCLNF) was fabricated and then evaluated for its drug release and biocompatibility to skin fibroblasts. ChiNP–PCLNF complexes showed no cytotoxicity and nanoparticles adsorbed by van der Waals force were released into aquatic environments and then penetrated into rat primary fibroblasts. Our studies demonstrate the potential for application of ChiNP–PCLNF as a wound dressing system with drug delivery for skin wound healing without side effects.     

The use of bioactive wound dressing,stimulating epithelial regeneration of IIIa-degree burn wounds

Clinical and morphological comparison of wound healing after transplantation of living cultured allofibroblast on days 1–2 after the injury, collagen-1-based dressing with PDGF-BB, and traditional dressing with levomecol ointment showed that bioactive dressing accelerated wound epithelialization (5–7 days vs. 20–22 days with gauze dressing); the incidence of suppurative complications decreased, no crust formed, and epithelialization was not associated with the formation of a hypertrophic cicatrix. Biological dressing based on living cultured allofibroblasts and collagen-1 with PDGF-BB exhibited equal stimulatory effects on burn wound healing. Translated from Kletochnye Tehnologii v Biologii i Medicine, No. 3, pp. 166–170, August, 2008     

Effects of new wound dressings on healing of thermal burns of the skin in acute radiation disease

Effects of new wound dressing bacterial cellulose impregnated with SOD and poviargol (Procel-Super and Procel-PA) and Inerpan hydrogel dressing on the reparative processes in deep dermal burns (IIIa–IIIb degree) in rats exposed to total even irradiation in a dose of 4 Gy were studied. Inerpan and Procel-Super dressings proved to be the most effective under these conditions: they accelerated healing of burn wounds by 17.0 and 5.5%, respectively. Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 9, pp. 351–355, September, 2004     

Effects of new wound dressings on healing of thermal burns of the skin in acute radiation disease

Effects of new wound dressing bacterial cellulose impregnated with SOD and poviargol (Procel-Super and Procel-PA) and Inerpan hydrogel dressing on the reparative processes in deep dermal burns (IIIa–IIIb degree) in rats exposed to total even irradiation in a dose of 4 Gy were studied. Inerpan and Procel-Super dressings proved to be the most effective under these conditions: they accelerated healing of burn wounds by 17.0 and 5.5%, respectively.Translated from Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 138, No. 9, pp. 351–355, September, 2004     

Sodium carboxymethyl cellulose hydrogels containing reduced graphene oxide (rGO) as a functional antibiofilm wound dressing

Biofilms comprise bacteria attached to wound surfaces and are major contributors to non-healing wounds. It was found that the increased resistance of biofilms to antibiotics allows wound infections to persist chronically in spite of antibiotic therapy. In this study, the reduced form of graphene oxide (rGO) was explored as plausible antibiofilm agents. The rGO was synthesized via reducing the functional groups of GO. Then, rGO were characterized using zetasizer, X-ray photoelectron spectroscopy, UV–Vis spectroscopy and FESEM. The rGO were then formulated into sodium carboxymethyl cellulose (NaCMC) hydrogels to form rGO hydrogel and tested for antibiofilm activities in vitro using XTT test, and in vivo biofilm formation assay using nematodes C. elegans. Reduced GO hydrogel was successfully formed by reducing the functional groups of GO, and a reduction of up to 95% of functional groups was confirmed with X-ray photoelectron spectroscopy analysis. XTT tests confirmed that rGO hydrogels reduced biofilm formation by S. aureus (81–84%) and P. aeruginosa (50–62%). Fluorescence intensity also confirmed that rGO hydrogel can inhibit biofilm bacteria in C. elegans experiments. This study implied that rGO hydrogel is an effective antibiofilm agent for infected wounds.     

Development of new wound dressing composed of spongy collagen sheet containing dibutyryl cyclic AMP

Al though cyclic AMP has been considered to regulate cell proliferation, the mechanism of this function is largely unknown. Recent studies suggest that cyclic AMP promotes the proliferation of skin cells in a dose-dependent manner. An ointment containing dibutyryl cyclic AMP has been used in the treatment of skin ulcers and found to be effective in promoting tissue repair. To search more efficacious wound management, the authors developed a new wound dressing composed of a spongy atelo-collagen sheet containing dibutyryl cyclic AMP. This wound dressing was evaluated in two types of animal tests. One is the application of the wound dressing to a full-thickness skin defect in order to evaluate the granulation tissue formation and the wound size reduction. The wound dressing was found to promote the granulation tissue formation and naturally reduce the wound size. The other test was the application of the wound dressing to the full-thickness skin defect, leaving behind a skin island in a central portion, in order to evaluate the epithelialization. This skin island left in a full-thickness skin defect was extremely enlarged. The enlargement of the skin island seems to be related to the epithelialization from the margin of the skin island as well as by the expansion of a skin island induced by contraction of the developed granulation tissue in the surrounding wound area. These results suggest that an atelo-collagen spongy sheet containing dibutyryl cyclic AMP is effective in promoting the granulation tissue formation and epithelialization.