儿童血清胃泌素正常值初探

为探讨儿童空腹血清胃泌素的正常值 ,将312例正常儿童(年龄6岁～12岁)分为A组(6岁～)、B组(7岁～)、C组 (8岁～)、D组(9岁～)、E组(10岁～)、F组(11岁～12岁)等6组 ,用放射免疫分析法测定空腹血清胃泌素。结果 :正常儿童空腹血清胃泌素最低值为33.47pg/ml,最高值为147.62pg/ml,均值为(67.01±20.40)pg/ml,男女间无明显差异(P>0.05)。各年龄组均值分别为(68.52±26.08)pg/ml,(66.53±19.32)pg/ml,(70.28±22.40)pg/ml,(69.83±20.55)pg/ml,(68.10±19.22)pg/ml和(61.03±15.54)pg/ml,经方差分析 ,组间无明显差异 (P>0.05) ,各组男女间亦无显著差异 (P>0.05)。提示正常儿童空腹血清胃泌素均值 (67.01±20.40)pg/ml,与国内相关报道中正常对照组均值接近 ,结果可靠 ,可作为正常值供有关科研工作者参考     

短肠综合征血清胃泌素水平动态变化的动物实验研究

观察大鼠短肠综合征血清胃泌素动态变化规律，发现术后１４天内血清胃泌素水平低于正常对照组，其中以第４天为最低点，以后缓慢上升，至第１４天时基本恢复正常。这种降低与正常对照组相比，血清胃泌素变化差异无显著性意义（Ｐ〉０．０５）。术后第１４天开始血清胃泌素升高加快，至第２１天时差异已有显著性意义（Ｐ〈０．０５），第２８天时差异有非常显著著性意义（Ｐ〈０．０１）。认为高胃泌素血症可能与短肠综合征残留肠管…     

缺铁性贫血患儿血清胃泌素水平测定及间断补铁疗效观察

研究缺铁性贫血儿童胃泌素水平的变化;观察间断补铁治疗儿童ＩＤＡ的疗效。方法：４９例ＩＤＡ患儿每周口服一次铁制剂（元素铁２ｍｇ／ｋｇ）,共１２周。在治疗前后测查Ｈｂ、ＺＰＰ、ＳＦ及血汪必素。结果：经补铁治疗,Ｈｂ、ＳＦ均极显著性升高,ＺＰＰ则明显下降,ＩＤＡ患儿血清胃泌素水平明显升高,与对照组比较差异显著,治疗后恢复正常。结论（１）每周一次间断补铁治疗儿童ＩＤＡ效果显著。②患儿胃泌素的异常分泌可能与     

儿童呼吸道疾病流行病学调查分析

为了解儿童常见呼吸道疾病的发病情况,为防治提供依据,以随机、分层、不等比、整群抽样方法,调查温州市4个街道内0～14岁儿童10293名。结果:实际接受调查人数9947名。毛细支气管炎(简称毛支)、哮喘、反复呼吸道感染(RRI)、慢性咳嗽的患病率及饲养宠物猫或狗的比例分别为6.00％、1.24％、8.16％、3.31％与10.93％,其中16.08％的毛支患儿发展为哮喘;既往被诊断为哮喘或喘息性支气管炎的比例为4.51％,与本次调查确诊的患病率差异有显著性(X2=191.30,P<0.01);哮喘、RRI、慢性咳嗽在各年龄组患病率差异均有显著性(X2=60.45～148.64,P<0.01),以幼儿组、学龄前组为高(P<0.0045)。提示毛支与哮喘有密切相关性,诊断哮喘要严格掌握诊断标准,防止扩大化。呼吸道疾病流行情况的资料为今后群防群治和相关研究提供依据。     

上海市杨浦区4—12岁部份儿童单纯性肥胖症流行病学调查

单纯性肥胖儿童逐年增加是儿保工作者面临的一个严峻课题,为了解上海市单纯性肥胖症(简称肥胖症)发病情况,及时进行科学指导,我们将杨浦区部份学校肥胖症流行病学调查报告如下。     

窒息新生儿血清胃泌素与胃酸分泌的动态观察

为探讨不同程度窒息对新生儿胃酸分泌及胃泌素水平的影响。对25例轻度窒息新生儿、20例重度窒息的新生儿于出生后1、3、7天检测血清胃泌素和胃液基础酸排量(BAO)。结果显示重度窒息组第1、3天的血清胃泌素水平明显低于轻度窒息组，而第1天胃液基础酸排量则高于轻度窒息组。结论重度窒息新生儿血清胃泌素水平较轻度窒息新生儿明显降低，而胃液基础酸排量增高，这可能是导致新生儿喂养不耐受、易致消化道出血的原因。     

缺铁性贫血患儿血清胃泌素水平测定及间断补铁疗效观察

研究缺铁性贫血 (IDA)儿童胃泌素水平的变化 ;观察间断补铁治疗儿童IDA的疗效。方法 :49例 IDA患儿每周口服一次铁制剂 (元素铁 2 mg/kg) ,共 1 2周。在治疗前后测查 Hb、ZPP、SF及血清胃泌素。结果 :经补铁治疗 ,Hb、SF均极显著性升高 (P<0 .0 1 ) ,ZPP则明显下降 (P<0 .0 1 ) ;IDA患儿血清胃泌素水平明显升高 ,与对照组比较差异显著 ,治疗后恢复正常。结论 :1每周一次间断补铁治疗儿童 IDA效果显著。 2 IDA患儿胃泌素的异常分泌可能与缺铁所致的胃粘膜萎缩有关     

危重症患儿血中胃泌素、胃动素水平的变化及临床意义

目的 研究血中胃泌素(GAS)、胃动素(MTL)水平在危重症及并发胃肠功能障碍患儿中的变化及意义.方法 将75例患儿分为极危重组、危重组、非危重组,检测其急性期、恢复期及25例对照组血中GAS、MTL水平,分析GAS和MTL水平与病情危重程度、胃肠功能障碍的关系.结果 极危重组、危重组、非危重组GAS分别为(227.41±62.80)、(154.25±38.84)、(84.01±17.10)ng/L,差异有非常显著性(P＜0.01);MTL分别为(413.53±59.80)、(368.36±43.64)、(279.97±33.51)ng/L,差异有非常显著性(P＜0.01).有胃肠功能障碍组血清GAS、血浆MTL水平明显高于无胃肠功能障碍组(P＜0.01).极危重组、危重组患儿恢复期GAS、MTL水平低于急性期,差异有显著性(P＜0.01).非危重组恢复期GAS、MTL水平与急性期比较,差异无显著性(P＞0.05).结论 血液GAS和MTL水平可作为检测胃肠功能障碍的实验室指标.     

新生儿窒息血中胃泌素水平改变及其临床意义的探讨

目的：探讨新生儿窒息血中胃泌素水平的改变及其临床意义。方法：对36例窒息足月新生儿血中胃泌素浓度进行了放免测试,并与38例正常足月新生儿相比较,同时探讨了与其它临床因素间的关系。结果：窒息足月新生儿血清胃泌素浓度(115±5) ng/L明显低于正常足月新生儿对照组(t=2.854,P<0.01),窒息后患儿开奶前胃泌素浓度与1分钟Apgar评分、采血时日龄(h)、第7日龄时进奶量(ml/日)因素影响呈正相关(r=0.82)。结论：窒息新生儿血清胃泌素浓度明显低于正常;1分钟Apgar评分对窒息后新生儿生后胃泌素水平影响最大且呈正相关;胃泌素对新生儿消化道成熟起促进作用。     

沪港儿童血脂水平和营养状况的研究

为改进儿童膳食,预防肥胖的发生提供科学依据,分析比较沪港两地儿童的血脂水平与体格生长、膳食状况、活动情况的关系,对上海儿童140名(男66名,女74名:平均年龄7.4岁±0.12岁)进行体格测量、膳食调查以及血脂测定,并与在香港随机选择的125名儿童(男70名,女55名:平均年龄7.0岁±0.10岁)的相关资料作比较。另外,记录上海儿童每天的各项活动情况,分析儿童血脂与体格生长、膳食、运动的关系。结果发现香港儿童的总胆固醇水平(4.59±0.91)mmol/L已超过美国推荐的儿童正常水平标准,其总胆固醇、甘油三脂、低密度脂蛋白均高于上海儿童,尤其是香港男童的总胆固醇和低密度脂蛋白显著高于上海男童。上海儿童的体块指数(Body Mass Index,BMI)高于香港儿童,香港女童的BMI(14.7±2.7)明显低下。两地儿童都存在着膳食中蛋白质、脂肪所产热能占总热能偏高以及碳水化合物热能偏低的问题。上海儿童中,血清总胆固醇水平高的儿童,脂肪尤其是饱和脂肪酸的摄入较高而活动水平则相对较低。提示应加强健康宣教,注意避免儿童形成高蛋白、高脂肪、低碳水化合物的膳食结构,注重儿童的运动锻炼,必要时应对部分超重、肥胖儿童的血脂水平进行监测。     

胃泌素水平与小儿急性肠套叠病因关系的研究

为探讨胃泌素水平、病毒性肠炎与小儿急性肠套叠病因的关系,对30例小儿急性肠套叠、30例病毒性肠炎患者治疗前后和30例正常同龄婴幼儿,用放射免疫分析法测定其血清胃泌素值和胰高血糖素值。结果:与正常对照组比较,病毒性肠炎治疗前的血清胃泌素值无显著差异(P>0.05),治疗后的血清胃泌素值有显著差异(P<0.05);而肠套叠患者治疗前后的血清胃泌素值和对照组比较有显著差异(P<0.05)。病毒性肠炎和肠套叠治疗前后的血清胰高糖素值有显著差异(P<0.05)。结论:高胃泌素血症、病毒性肠炎可能是小儿急性肠套叠的发病原因之一。     

Epidemiologic study of sports injuries in children

From 1981 to 1982, within a one year period, all medically treated childrens' accidents were recorded in the public and private medical facilities of a French health care district near Paris. Sports injuries represented 11% of all injuries, and in children aged 12 years and over, sports areas were the leading site of accidents (24%). Seven hundred thirty-eight sports injuries to children aged 6 years and over were analysed and compared to other types of accidental injuries (home, school and traffic accidents). The overall incidence of sports injuries was estimated to be 1.1% in children aged 6 to 14 years. Out-of-school sports accidents were more frequent among boys, but boys and girls had similar injury rates in school physical education. Most lesions were benign but the fracture rate was 22%. A majority of lesions were located on the upper limb. Most commonly, the mechanism of accident was a forward fall and children were injured without any participation of sports equipment. The hospitalization rate was 11%. Repeated hospital admissions and a long time elapsing between the accident and full recovery were significantly more often observed than in other types of accidents. This might be explained by a higher rate of epiphyseal fractures and internal fixations. Eighteen months after the accident, musculo-skeletal sequelae were observed in 12% of the inpatient children.     

Epidemiologic study of multihandicapped children in the north of France]

PATIENTS AND METHODS: The files of 440 severely handicapped children in the north of France were studied. These children had severe mental retardation and very poor motricity development. The methods of care and nursing were studied. RESULTS: Amounts these patients, 40.4% were in medico-social centers, 30% in non-medico-social centers, and 29.4% lived at home with their parents. Only 6% were unknown by the departmental commission of specialized education (CDES). The rate of prevalence of the severely handicapped children from 5 to 19 years in the north of France was 0.7 per thousand. CONCLUSIONS: Results are compared with those from an INSERM study about handicap patients in 14 French counties.