人类博卡病毒感染与急性胃肠炎发生风险的Meta分析

目的探讨人类博卡病毒（HBoV）感染与急性胃肠炎的关系。方法计算机检索CNKI、Ovid、PubMed等数据库,纳入关于人类博卡病毒感染与急性胃肠炎发生的病例一对照研究。应用Stata11．0和RevMan5．0软件对人类博卡病毒与急性胃肠炎发生的关系进行Meta分析,根据异质性结果有固定效应模型或随机效应模型计算合并比值比（oR）及95％可信区间（C1）。结果共纳入8篇文献9个研究,其中HBoVs与急性胃肠炎存在相关关系（X^2=6．53,P=0．59,P=0％,OR=2．16,95％CI：1．61～2．92）。亚组分析：HBoV1感染与急性胃肠炎发病合并OR值为1．83（X^2=4．11,P=0．66,I^2=0％,95％CI：1．16～2．90）;HBoV2与急性胃肠炎合并OR值为2．00（x。=2．27,P=0．69,／2=0％,95％CI：1．37～2．92）;HBoV3与急性胃肠炎之间可能无疾病相关性（OR=I．24,95％CI：0．46-3．31）。结论HBoVs感染与急性胃肠炎发病存在相关关系．其中HBoV1和HBoV2感染是急性胃肠炎发生的危险因素。     

2型糖尿病患者焦虑抑郁情绪与社会心理因素的关系

目的：探讨2型糖尿病患者焦虑、抑郁情绪与心理压力、应对方式和社会支持的关系。方法：采用自填式问卷，对172名2型糖尿病患者进行调查，了解患者的一般情况、心理压力来源、病人应对措施、社会支持等社会心理因素，同时用医院焦虑抑郁量表（HAD）测量其焦虑与抑郁情况。结果：焦虑得分≥9分者35人，占20．3％；抑郁得分≥9分者33人，占19．2％。控制性别、年龄、婚姻状况、学历、经济收入等潜在的混杂因素后的多因素logistic回归分析表明，感受“担心疾病可能造成的伤害”（OR=1．76，95％CI=1．12-2．77）、“疾病造成的社会／家庭危机感”（OR=1．85，95％CI=1．18-2．92）、“担心身体／生理功能下降”（OR=2．16，95％CI=1．28～3．67）和“担心经济条件降低”（OR=2．03，95％CI=1．27～3．26）的压力越大，对疾病越多采取“消极应对”的措施（OR=1．94，95％CI=1．26-2．97），越容易出现焦虑情绪：感受“疾病造成的社会／家庭危机感”（OR=1．79，95％CI=1．09～2．96）、“担心身体／生理功能下降”（OR=2．89，95％CI=1．59-5．24）的压力越大，对疾病越多采取“消极应对”的措施（OR=1．95，95％CI=1．23～3．11），越容易出现抑郁情绪，较多采取“逃避”的应对措施者较少出现抑郁情绪（OR=0．52，95％CI=0．30-0．90）。结论：2型糖尿病人的焦虑、抑郁情绪与疾病引起的心理紧张和病人采取的应对方式有关。     

抑郁症复发危险因素回归分析

目的 探讨抑郁症复发的危险因素,为抑郁症的防治提供依据。方法 采用队列研究和非条件Logistic回归分析,探讨抑郁症惠者复发危险因素。结果 多因素Logistic回归分析显示患者服药依从性（OR=0．143,95％CI：0．046～0．439）、精神障碍家族史（OR=3．861,95％CI：1．362～10．943）和负性生活事件（OR=3．453,95％CI：1．149～10．370）为抑郁症复发的重要危险因素。结论 抑郁症复发与生物遗传因素、环境因素、行为因素和社会心理因素关系密切,提高抑郁症患者服药依从性,减少患者负性生活事件的影响和实施心理干预,是防治抑郁症复发积极而有效的措施。     

CD14启动子-159位点基因多态性与冠状动脉粥样硬化性心脏病的相关性研究

目的研究湖北地区汉族人群CD14启动予-159（C→T）多态性分布，探讨该多态性与冠状动脉粥样硬化性心脏病（冠心病）的相关性。方法应用聚合酶链反应-限制性片段长度多态性技术对湖北地区汉族162例冠心病患者及196名正常对照组者CD14基因启动子-159位点进行基因型分析。结果CD14启动子-159位点基因型频率和等位基因频率在冠心病组和对照组间比较差异有统计学意义，（基因型：X^2=0．654，P〈0．05，CT vs CC，OR=1．245，95％CI：1．001～1．473，TT vs CC，OR=2．374，95％CI：2．012～2．649；等位基因：X^2=0．547，P〈0．05，TvsC，X^2=0、547，P〈0、05，OR=3．105，95 ％CI：2．493～3．539）：CD14启动子-159位点基因型频率和等位基因频率在非心肌梗塞组和心肌梗塞组间比较差异有统计学意义（基因型：X^2=0．782，P〈0．05，CF vs CC，OR=2．375，95％CI：2．017～2．689，TT vs CC．OR=3．459，95％CI：3．003～3．846；等位基因：X^2=2．374，P〈0．05，T vs C，X^2=2．374，P〈0．05，OR=4．011，95％CI：3．814～4．279），然而，我们没有发现往冠心病狭窄血管支数之间存存差异。结论CD14启动子-159（C→T）基因多态性中的T等位基因可能是心肌梗塞的遗传学风险因素。     

乙肝后肝硬化患者HLA-A、DRB1等位基因多态性研究

目的：了解乙肝后肝硬化患者的HIA-A、DRB1等位基因多态性。方法：用基因芯片分型方法分析比较61例慢性乙肝后肝硬化患者与146例正常人HLA-A、DRB1等位基因的多态性。结果：HLA-A位点中的HIA-A02、11、24与HLA-DRB1位点中的HIA-DRB1*12、09、04为正常人群常见等位基因。乙肝后肝硬化患者组HnA02(43．4％vs29．1％，OR：1．87，P=0．005，95％CI：1．21-2．89)与HLA-DRB1*07(13．9％vs5．1％，OR：3．00，P=0．002，95％CI：1．48-6．07)、HIA-DRB1*08(16．4％vs6．8％，OR：2．67，P=0．003，95％CI：1．40L5．08)、HLA-DRB1*11(12．3％vs5．8％，OR：2．27，P=0．025，95％CI：1．11-4．64)的出现频率较正常对照组明显升高。在HIA-A位点中，乙肝后肝硬化患者组的纯合子比例较正常组有升高趋势，但无统计学意义。结论：HLA-A02与HLA-DRBl*07、08、11可能是乙肝后肝硬化的易感基因。     

非麻疹疫苗免疫目标人群麻疹发病相关危险因素配对病例对照研究

目的探讨非麻疹疫苗免疫目标人群麻疹发病相关危险因素,为预防控制该人群麻疹发病提供依据。方法对2008—2009年广州市白云区的麻疹病例进行1：1配对,配对因素为性别、年龄和居住地,对相关危险因素进行条件Logistic回归分析及多因素非条件Logistic回归分析。结果调查病例中71．43％的病例为流动人口;28．57％的病例或其监护人为初中以下文化程度;32．80％的病例或其监护人月均收入低于1000元;15岁以上病例既往有麻疹疫苗接种史的仅占4．65％;24．87％的病例病前3周曾与麻疹病人有过接触;32．80％患者病前3周曾去医院就诊．就诊医院级别中省市级、区县级、卫生院分别占62．29％、20．97％和17．74％,就诊科别中以儿科、内科为主,分别占70．97％和25．81％;38．10％的病例病前3周内曾乘坐公共交通工具。单因素分析显示。经济水平低（OR=0．59,OR95%CI=0．37～0．94）、未种麻疹疫苗（OR=0．32,OR95%CI=0．19～0．52）、有麻疹病例接触史（OR=0．22,OR95%CI=0．13—0．36）、流动人口（OR=0．22,OR95%CI=0．13-0．36）、就诊史（OR=0．30,OR95%CI=0．18-0．51）、就诊医院类型（OR=0．33,OR95%CI=0．18～0．51）和就诊科别（OR=0．34,OR95%CI=0．22—0．52）等因素与麻疹发病有明显的相关性。多因素Logistic分析显示,经济水平低（OR=0．49,OR95%CI=0．28-0．87）、未接种麻疹疫苗（OR=0．67,OR95%CI=0．52～0．86）、有麻疹病例接触史（OR=0．14,OR95%CI=0．08-0．25）、流动人口（OR=0．25,OR95％CI=0．15-0．43）、就诊史（OR=8．51,OR95%CI=2．65～27．30）、就诊科别（OR=0．15,OR95%CI=0．05～0．46）等因素与麻疹的发病密切相关。结论经济水平低、未接种麻疹疫苗、病前3周内有麻疹病例接触史、流动人口、病前3周内有就诊史和就诊科别等因素可能是影响非麻疹疫苗免疫目标人群麻疹发病的主要危险因素。     

β1肾上腺素能受体基因389A/G多态性与急性心肌梗死的关系

目的探讨βl肾上腺素能受体基因389A／G多态性与急性心肌梗死（acute myocardial infarcfion，AMI）的关系。方法应用聚合酶链反应-限制性片段长度多态性分析技术检测150例急性心肌梗死患者和150例性别和年龄匹配的对照者的基因型，同时采集相关的临床资料，进行病例．对照统计学分析和多因素参与的回归分析。结果AMI组和对照组在基因型和等位基因频率分布上的差异均有统计学意义（P均〈0．01），A等位基因在AMI组明显高于对照组。在多因素参与的回归分析中，389A／G多态性（OR：2．88，95％CI：1．70—4．88，P〈0．01）、吸烟（OR：2．72，95％CI：1．52—4．88，P〈0．01）、高脂血症（OR：2．85，95％CI：1．68—4．86，P〈0．01）、糖尿病（OR：2．38，95％CI：1．27—4．47，P〈0．01）和高血压（OR：2．00，95％CI：1．62—3．45，P〈0．05）均为AMI的独立危险因素。结论β1肾上腺素能受体基因389A／G多态性与AMI明显相关，为AMI的独立危险因素。     

阿奇霉素对比阿莫西林/克拉维酸治疗儿童急性中耳炎疗效和安全性的Meta分析

目的采用Meta分析方法比较阿奇霉素与阿莫西林／克拉维酸治疗儿童急性中耳炎疗效和安全性。方法电子检索中国生物医学文献数据库、中文科技期刊数据库、中国知网、万方数据库、中国医学会数字化期刊、PubMed、Cochrane Library和EMBASE数据库,检索起止时间均从建库至2013年8月。纳入阿奇霉素对比阿莫西林／克拉维酸治疗儿童急性中耳炎的RCT文献,对文献进行质量评价。评估临床治愈率、治疗失败率和不良反应。采用RevMan5．0软件进行数据分析,二分类变量采用OR及其95％CI表示。结果共纳入13篇RCT文献（5081例患儿）。Meta分析结果显示,阿奇霉素组与阿莫西St,／克拉维酸组在〈10d临床治愈率（OR=0．69,95％CI：0．46～1．02）、-19d临床治愈率（OR=0．88,95％CI：0．68～1．13）、～29d临床治愈率（OR=0．99,95％CI：0．83—1．19）、t〉30d临床治愈率（OR=1．00,95％CI：0．72～1．39）和治疗失败率（OR=0．87,95％CI：0．65～1．17）差异均无统计学意义。阿奇霉素组恶心（OR=0．44,95％CI：0．20～0．97）、皮疹（OR=0．48,95％CI：0．31～0．75）、腹泻（OR=0．38,95％CI：0．25～0．57）和稀便（OR=0．41,95％CI：0．20—0．81）的发生率显著低于阿莫西林／克拉维酸组。结论阿奇霉素与阿莫西林／克拉维酸治疗儿童中耳炎疗效相当且不良反应少。     

IL-6-174G／C多态性与肺癌无相关性：基于2901例肺癌患者和3234例对照的Meta分析

目的为准确评估IL-6-174G／C多态性与肺癌危险度的关系。我们采用了Meta分析的方法。通过检索Medline、EMBASE、OVID和中国生物医学数据库中至2012年12月为止发表的所有病例对照研究文献,筛选数据,计算合并的OR值和95％可信区间（95％CI）。最终纳人5篇文献,包括病例2901例,对照3234例。meta分析后发现,IL-6-174C等位基因并不能明显升高肺癌危险度（CCvs．GG：OR=1.06,95％CI=0．92-1．23;GCVS．GG：OR=1．05,95％CI=0．83～1．32;CC＋GCVS．GG：OR=1．01,95％CI=1．90-1．13;CCVS．GC＋GG：OR=1．08,95％CI=0．95～1．23）。漏斗图和Egger＇s检验没有发现发表偏倚,肺癌病理学和吸烟状态亚组分析示：IL-6-174G／C多态性与肺癌危险度无明显相关性。尽管存在一些局限,确切评估IL-6-174G／C与肺癌的危险度,有待于今后设计更好,样本量更大的研究。     

影响颞叶癫癎预后的危险因素分析

目的：探讨影响颞叶癫癎预后的危险因素,为临床合理治疗颞叶癫癎和判断预后提供依据。方法：采用病例对照研究,回顾性分析两组颞叶癫癎患者即药物难治组102例,药物控制良好组166例的临床资料,采用单因素分析和多因素Logistic回归模型分析影响颞叶癫癎预后的相关因素。结果：单因素分析表明合理药物治疗前病程长、初期发作频繁（〉4次／月）、围产期损伤、服药依从性差、具有神经系统疾患和有影像学异常等6个因素对颞叶癫癎的预后有不利影响（均P〈0．05）,进一步进行多因素Logistic回归分析,筛选出合理治疗前病程长（OR=1．989,95％CI：1．071～3．692）、初期发作频率高（OR=10．393,95％CI：5．355～20．170）、服药依从性差（OR=5．151,95％CI：2．916～8．615）、具有神经系统疾患（OR=1．113,95％CI：0．564-4．448）和有影像学异常（OR=4．032,95％CI：2．160～7．526）是影响颞叶癫癎预后的独立危险因素。结论：合理药物治疗前病程长、初期发作频繁（〉4次／月）、患者服药依从性差、具有神经系统疾患和影像学异常是药物治疗颞叶癫癎的重要危险因素,具有这些因素的患者易发展成难治性癫癎。     

脊柱术后发生手术部位感染独立危险因素的Meta分析

文题释义：手术部位感染：术后30 d内(或者置入内固定装置1年内)发生的浅表、深部或者器官的感染。浅部感染指术后30 d内发生感染，感染只涉及切口皮肤或皮下组织。深部感染指若无植入物留在原位，感染发生在术后30 d内；若植入物在原位，感染发生在1年内，并且感染可能与手术有关，深部感染涉及深部软组织。当感染涉及解剖的任何部分(如器官或空间)而非手术操作的切口感染即为器官感染。 背景：脊柱术后手术部位感染的危险因素多样且复杂，目前国内外对于脊柱术后手术部位感染相关危险因素的研究仍然存在较大的争议。 目的：系统评价脊柱术后手术部位感染的独立危险因素，为手术部位感染的防治提供理论依据。 方法：检索2004年1月至2019年6月中外数据库，按照拟定的文献纳入与排除标准获得有关脊柱术后手术部位感染独立危险因素的病例-对照研究和队列研究，提取有效数据，分别采用固定效应模型和随机效应模型计算各独立危险因素(高血压、糖尿病、肥胖、吸烟、手术史)的合并OR值和95%CI进行Meta分析，比较其结果的一致性，分析合并结果的可靠性。 结果与结论：①共纳入19篇文献，共包括脊柱术后发生手术部位感染的病例1 008例，对照组7 527例；②各独立危险因素合并OR值(95%CI)由高到低依次为：糖尿病(OR=3.24，95%CI：2.09-5.02)、肥胖(OR=2.99，95%CI：1.77-5.05)、手术史(OR=2.12，95%CI：1.79-2.50)、高血压(OR=1.90，95%CI：1.34-2.69)、吸烟(OR=1.85，95%CI：1.39-2.48)；③提示糖尿病、高血压、肥胖、吸烟、手术史均为脊柱术后发生手术部位感染的独立危险因素，各独立危险因素与脊柱术后发生手术部位感染的概率均呈正相关。 ORCID: 0000-0002-4963-6988(覃作恒) 中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程     

HSP90B1基因多态性与系统性红斑狼疮易感性的关联研究

目的：探讨HSP90B1基因多态性与中国汉族人群系统性红斑狼疮(SLE)易感性的关系。方法：从医院收集360例对照和360例SLE患者,按照年龄和性别进行匹配。利用Multiplex SNaPshot分型技术对SNP位点分型。采用基于错误发现率 (FDR) 标准的本杰明-汉伯格 (BH) 法进行多重检验校正。结果：显性模型分析发现rs1165681的基因型频率分布在对照组和SLE组之间存在统计学差异(Crude OR = 0.621, 95%CI = 0.450-0.856, P=0.004; Adjusted OR = 0.619, 95%CI = 0.449-0.855, P=0.004);隐性模型分析发现rs10778306 (Crude OR = 0.568, 95%CI = 0.328-0.984,P = 0.044; Adjusted OR = 0.570, 95%CI = 0.329-0.988, P = 0.045)、rs2722188(Crude OR = 0.227, 95%CI = 0.076-0.681, P = 0.008; Adjusted OR = 0.227, 95%CI=0.076-0.682, P=0.008) 的基因型分布在两组之间存在统计学差异。BH法校正后,rs1165681基因型分布在两组之间有统计学差异 (P_BH = 0.044)。单倍型分析后CCATTAGGCAT(OR=0.323, 95%CI=0.154-0.680, P = 0.002)、CCCTTAGGCAC (OR = 1.324, 95%CI = 1.014-1.729, P =0.039)、TCCCTAGTCGC(OR = 0.465, 95%CI = 0.221-0.979, P = 0.039)和TTCTCGGGCAT(OR=0.443, 95%CI = 0.224-0.875, P = 0.016) 与SLE的发病风险有关;BH法校正后,CCATTAGGCAT在两组之间的分布有统计学差异(P_BH = 0.028),其他单倍型均无统计学差异 (P>0.05)。结论：HP90B1基因多态性可能与中国汉族人群的SLE发病有关。     

A case-control study of 92 cases of in-patient suicides

BACKGROUND: A significant number of patients committed suicide while receiving in-patient treatment in psychiatric hospitals. Most previous studies on psychiatric in-patient suicides were conducted in the West. This study aimed to describe the characteristics and identify risk factors of suicides occurring during psychiatric in-patient care in Hong Kong. METHOD: The case record data of suicide cases (Coroner's verdicts of suicides and undetermined deaths) from all public psychiatric hospitals in the entire region within a 3 years' period (N=93) were compared with matched controls. RESULTS: In-patient suicide rate was 269/100,000 admissions. Majority had schizophrenia. Suicide usually occurred after the first month of admission, during leave, and by jump from heights. There were little case-control differences in treatment received. Multiple conditional logistic regression found 5 risk factors: previous history of deliberate self-harm (OR=4.60, 95% CI=1.57-13.5); admitted because of suicidal behaviour (OR=3.92, 95% CI=1.3-11.9); depressive symptoms at time of suicide (OR=8.53, 95% CI=1.4-52); away without leave at anytime during index admission (OR=17, 95% CI=1.76-163); and extrapyramidal side effects/akathisia at time of suicide (OR=10.8, 95% CI=1.75-66.7). LIMITATIONS: Retrospective case record review depended on non-standardized and variable quality of case notes entry. Matching for hospitals in this study would make the comparison between hospitals impossible. Although this is the second largest case-control study of psychiatric in-patient suicide, the estimated power suggested subtle risk factors would be missed. CONCLUSION: Majority of in-patient suicides occurred at a time of perceived low risk. A high sensitivity to the risk of suicide and vigorous treatment of depressive symptoms were indicated. The care processes during the index admission could bear strong influences on the risk of in-patient suicides.     

Life events and psychosocial factors in elderly suicides--a case-control study.

BACKGROUND: Stressful life events, such as family conflicts, separation, bereavement, somatic illness and financial problems are common antecedents of suicide. Studies on suicide among younger persons dominate the literature, despite the fact that a large proportion of suicides occur among elderly persons. METHODS: The occurrence of stressful life events was investigated among elderly suicide cases and population controls. The study was conducted in the southwestern part of Sweden and included 85 persons (46 males and 39 females) 65 years and above who had committed suicide from January 1994 to May 1996. Population controls (84 males and 69 females) were randomly selected. Interviews were carried out with the controls and with informants for the suicide cases. Questions on sociodemographic background, mental and somatic health status, and life events (0-6, 7-12 and 13-24 months preceding suicide/interview) were included in the interviews. RESULTS: Somatic illness, family discord and financial trouble were significant risk factors during all three time periods. Other risk factors were mental disorder, lower education, feelings of loneliness and previous suicide in the family. Factors associated with a decreased risk included active participation in organizations and having a hobby. Variables that remained in the multivariate logistic regression model were mental disorder (men, odds ratio (OR) = 62.4, 95% CI 17.9-217.5; women, OR = 55.9, 95% CI 14.1-222.3) and family discord (men, OR = 10.0. 95% CI 1.7-59.8; women, OR = 9.2, 95% CI 1.9-44.8). CONCLUSIONS: Mental disorder and family discord were the two major risk factors for suicide among elderly men and women.     

Current psychiatric morbidity, aggression/impulsivity, and personality dimensions in child and adolescent suicide: a case-control study

OBJECTIVE: The present study was designed to evaluate psychiatric risk factors for child and adolescent suicide, and to determine the association between impulsive-aggressive and other personality traits, and suicide completion in this population. METHOD: Psychiatric diagnoses, impulsive-aggressive and other personality traits were assessed in 55 child and adolescent suicide victims and 55 community controls using semi-structured proxy-based interviews and questionnaires. RESULTS: The most significant psychiatric risk factors associated with child and adolescent suicide were depressive disorders (OR=48.414, 95% CI 6.247-375.185), substance/alcohol abuse disorder (OR=5.365, 95% CI 1.434-20.076), and disruptive disorders (OR=13.643, 95% CI 2.292-23.16). Additionally, suicide victims showed higher scores on lifetime aggression/impulsivity, and harm avoidance. However, after logistic regression, the only independent significant predictors of suicide in this age group were the presence of depressive disorders (Adjusted OR (AOR)=39.652, 95% CI 4.501-349.345), substance/alcohol abuse disorders (AOR=7.325, 95% CI 1.127-47.62), and disruptive disorders (AOR=6.464, 95% CI 1.422-29.38). LIMITATIONS: Relatively small sample size, and cross-sectional design. CONCLUSIONS: Our findings confirm the existence of a particular clinical profile of children and adolescents at high risk for suicide. Additionally, our results reinforce the need for improved understanding of the interrelationships between stressors, depression, substance/alcohol abuse disorders, disruptive disorders and personality traits/dimensions in youth suicidal behavior.     

Polymorphisms of TNF microsatellite marker a and HLA-DR-DQ in diabetes mellitus-a study in 609 Swedish subjects

We explored the importance of the genetic markers microsatellite TNFa, HLA-DR3-DQ2, and DR4-DQ8 in diabetes mellitus. The studied groups comprised autoimmune type 1 (n = 63), nonautoimmune type 1 (n = 35), latent autoimmune diabetes in adults (LADA; n = 54), and nonautoimmune type 2 (n = 340) and these patients were compared to 117 healthy controls. HLA genotyping was done with polymerase chain reaction and sequence-specific oligonucleotides. TNFa microsatellites were determined with polymerase chain reaction and fragment size determination. Univariate analysis of these genetic risk factors demonstrated that homozygosity for TNFa2/2 was a significant risk factor for autoimmune type 1 diabetes (odds ratio (OR) = 5.82; 95% confidence interval (95%CI) 1.97-17.2), for autoimmune negative type 1 diabetes (OR = 4.63; 95%CI 1.32-16.2), and for LADA (OR = 3.90; 95%CI 1.21-12.5). Moreover, heterozygosity for HLA-DR3-DQ2/DR4-DQ8 was an important risk factor for autoimmune type 1 diabetes (OR = 16.4; 95%CI 3.60-75) as was DR4-DQ8/x (OR = 2.52; 95%CI 1.27-4.98). Heterozygosity for HLA-DR3-DQ2/DR4-DQ8 was a risk factor also for LADA (OR = 10.0; 95%CI 2.05-48.9). Neither HLA-DR3-DQ2 nor DR4-DQ8 were risk factors for nonautoimmune type 1 or type 2 diabetes. We concluded that heterozygosity for DR3-DQ2/DR4-DQ8 and to some extent homozygosity for TNFa2/2 were risk factors for autoimmune diabetes irrespective of the clinical classification.     

Risk factors for ventilator dependency following coronary artery bypass grafting

Background: Ventilator dependency following coronary artery bypass grafting (CABG) is often associated with significant morbidity and mortality. However, few reports have focused on the independent risk factors for ventilator dependency following CABG. This study aimed to evaluate the independent risk factors for ventilator dependency following coronary artery bypass grafting (CABG). Methods: The relevant pre-, intra- and post-operative data of patients without a history of chronic obstructive pulmonary disease undergoing isolated CABG from January 2003 to December 2008 in our center were retrospectively analyzed. Elapsed time between CABG and extubation of more than 48 hours was defined as postoperative ventilator dependency (PVD). Results: The incidence of PVD was 13.8% (81/588). The in-hospital mortality in the PVD group was significantly higher than that in the non-PVD group (8.6% versus 2.4%, p=0.0092). Besides the length of ICU and hospital stay, PVD correlated with negative respiratory outcomes. The independent risk factors for PVD were preoperative congestive heart failure (OR=2.456, 95%CI 1.426-6.879), preoperative hypoalbuminemia (OR=1.353, 95%CI 1.125-3.232), preoperative arterial oxygen partial pressure (PO₂) (OR=0.462, 95%CI 0.235-0.783) and postoperative anaemia (OR=1.541, 95%CI 1.231-3.783). Conclusions: Preoperative congestive heart failure, preoperative hypoalbuminemia, low preoperative PO₂ and postoperative anaemia were identified as four independent risk factors for ventilator dependency following CABG.