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Antibiotic prophylaxis for percutaneous endoscopic gastrostomy. A prospective, randomized, double-blind clinical trial 总被引:3,自引:0,他引:3
N K Jain D E Larson K W Schroeder D D Burton K P Cannon R L Thompson E P DiMagno 《Annals of internal medicine》1987,107(6):824-828
Study Objective. To determine if prophylactic use of cefazolin reduces peristomal wound infection associated with percutaneous endoscopic gastrostomy. Design. Prospective, randomized, double-blind, placebo-controlled clinical trial. Setting. Academic medical center, referral-based, gastroenterology service. Patients. One hundred thirty hospitalized patients, 23 of whom were excluded. Of the remaining 107 patients, 52 (group I) were already using antibiotics at the time of randomization for gastrostomy, whereas 55 (group II) were not. Interventions. Patients received either intravenous saline as a placebo or intravenous cefazolin (1 g) 30 minutes before gastrostomy. Measurements and Main Results. For 1 week after gastrostomy, the peristomal area was evaluated and a score assigned each day for erythema (0 to 4), induration (0 to 3), and exudate (0 to 4). A maximum combined score of 8 or more or the development of pus was a criterion for infection. None of the patients in group I developed a wound infection. Only 2 of 27 group II patients given prophylaxis developed a wound infection, compared with 9 of 28 patients not given prophylaxis, a difference of 25% (95% confidence interval, 4.8 to 44.6%; p less than 0.025). The number of patients who developed a wound infection was 0 of 52 in group I and 2 of 27 in group II patients who received cefazolin, a difference of 7.4% (95% confidence interval, -2.5 to 17.3%; p = 0.07). Conclusion. Cefazolin prophylaxis significantly reduces the risk for peristomal wound infection associated with percutaneous endoscopic gastrostomy. It is needed, however, only for patients not already receiving antibiotic treatment at the time of gastrostomy. 相似文献
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Yi Chen Yu-Ting Duan Qin Xie Xian-Peng Qin Bo Chen Lin Xia Yong Zhou Ning-Ning Li Xiao-Ting Wu 《World journal of gastroenterology : WJG》2013,19(41):7197-7204
AIM:To assess the theoretical advantages of magnetic endoscope imaging(MEI)over standard colonoscopies(SCs)and to compare their efficacies.METHODS:Electronic databases,including PubMed,EMBASE,the Cochrane library and the Science Citation Index,were searched to retrieve relevant trials.In addition,abstracts from papers presented at professional meetings and the reference lists of retrieved articles were reviewed to identify additional studies.The metaanalyses were performed using RevMan 5.1.A random effect model with the Mantel-Haenszel method was used for pooling dichotomous and continuous data.A sensitivity analysis was performed by excluding the trials with a small number of patients and by excluding the trials performed by inexperienced providers.RESULTS:Eight randomized controlled trials(RCTs),including 2967 patients,were included in the metaanalysis to compare cecal intubation rates and times,sedation dose,abdominal pain scores and the use of ancillary maneuvers between MEI and SC.The overall OR was 1.92(95%CI:1.13-3.27,eight RCTs),as indicated by the cecal intubation rate of MEI compared with SC,but MEI did not have any distinct advantage over SC for cecal intubation time(MD=-0.07,95%CI:-0.16-0.02;three RCTs).MEI did not generally result in lower pain scores.Outcomes were also analyzed for the two subgroups based on the endoscopists’experience level to evaluate cecal intubation rates.MEI presented better outcomes for non-experienced colonoscopists than experienced colonoscopists.CONCLUSION:The real-time magnetic imaging system is of benefit in training and educating inexperienced endoscopists and improves the cecal intubation rate for experienced and inexperienced endoscopists. 相似文献
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Dormann AJ Wigginghaus B Risius H Kleimann F Kloppenborg A Rosemann J Padel Y Pohl R Baum HH Lübbesmeier A Schwab J Kühlkamp V Gutjahr W Lindenburger W Schütz H Huchzermeyer H 《Zeitschrift für Gastroenterologie》2000,38(3):229-234
OBJECTIVE: To determine the efficacy of antibiotic prophylaxis in percutaneous endoscopic gastrostomy (PEG) as a part of a standardized regimen. METHODS: An open prospective randomised multicenter study in 216 patients. 106 received ceftriaxone 1 g i.v. 30 min preinterventionally and 110 no study medication. A standardized protocol was followed for PEG preparation, insertion, and aftercare; all patients received a 15 French gastrostomy tube. Follow-up of local and systemic infection and clinical course was continued to postintervention day 10. An aggregate erythema and exudation score > 3 or the presence of pus was taken as indicative of peristomal infection. The pharmacoeconomics of antibiotic use were also examined. RESULTS: In no-prophylaxis patients, wound infection rates were 23.6% on day 4 and 24.5% on day 10 vs. 7.6% (p < 0.05) and 11.4% (p < 0.05), respectively, in prophylaxis patients. Results were disproportionally better in tumor patients in comparison with neurological patients. Patients systemic infection rates were 11.8% vs. 1.9% in noprophylaxis vs. prophylaxis (p < 0.05), and overall infection rates 36.3% vs. 13.3%, respectively (p < 0.05). Pneumonia was more frequent in patients with underlying neurological disease and reduced in the prophylaxis group. Antibiotic and application costs were similar in both groups (p = 0.400). CONCLUSIONS: Single-dose ceftriaxone 1 g is a effective prophylaxis against local and systemic infection after PEG and should be a part of a standard regimen. 相似文献
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Jan Peveling-Oberhag Florian Michael Andrea Tal Christoph Welsch Johannes Vermehren Harald Farnik Georgios Grammatikos Christian Lange Dirk Walter Irina Blumenstein Natalie Filmann Eva Herrmann Jörg Albert Stefan Zeuzem Jörg Bojunga Mireen Friedrich-Rust 《Journal of gastroenterology and hepatology》2020,35(3):401-407
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《Best Practice & Research: Clinical Gastroenterology》2016,30(5):769-781
Percutaneous endoscopic gastrostomy (PEG) has become the method of choice for mid-to long-term enteral feeding. The majority of complications that occur are minor, but the rare major complications may be life threatening. Some complications occur soon after tube placement, others develop later, when the gastrostomy tract has matured. Older patients with comorbidities and infections appear to be at a greater risk of developing complications. Apart from being aware of indications and contraindications, proper technique of PEG placement, including correct positioning of the external fixation device, and daily tube care are important preventive measures. Adequate management of anticoagulation and antithrombotic agents is important to prevent bleeding, and administration of broad spectrum antibiotics prior to the procedure helps prevent infectious complications. Early recognition of complications enables prompt diagnosis and effective therapy. 相似文献
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Radhakrishnan NV Shenoy AH Cartmill I Sharma RK George R Foster DN Quest L 《European journal of gastroenterology & hepatology》2006,18(12):1279-1284
OBJECTIVE: To study the effectiveness of local antiseptic spray with or without a three-dose antibiotic regimen in the prevention of stomal infection following percutaneous endoscopic gastrostomy. METHODS: Ninety-six patients were randomized into three groups: A, intravenous cefuroxime 750 mg just before the procedure followed by two further doses every 8 h; B, single application of povidone-iodine (Betadine) antiseptic spray; C, combination of A and B. The stomal site was examined at midweek and at the end of week 1 for evidence of infection using a validated scoring system. Fisher's exact test was used for analysis of primary end point, namely, stomal infection at midweek and at the end of week 1. Logistic regression models were used for secondary analysis to consider the effects of diabetes, acid suppressants, steroids, age and sex on outcome. RESULTS: Group A had 34 patients, group B had 28 and group C had 34. Age, sex and indications in groups A, B and C are broadly comparable. Stomal infection was 32% in group B vs. groups A (6%) and C (9%) (P = 0.0114) at midweek, and 3% in group C vs. 32% each in groups A and B (P = 0.0013) at the end of week 1. Cumulative infections (n) at the end of week 1 were lower in group C (3) (9%) than in groups A (11) (32%) and B (12) (43%) (P = 0.003). No significant difference was observed between the three groups in terms of the number of patients who were given antibiotics for other indications (P = 0.363). By logistic regression only diabetes, but not other covariates, seems to have a significant effect on stomal infection (odds ratio, 33.34; 95% CI, 4.33-256.7). CONCLUSION: A combination of cefuroxime and Betadine spray significantly reduces stomal infection following percutaneous endoscopic gastrostomy at the end of week 1. Both the antibiotic group (A) and the combined group (C) did well compared with the Betadine only group (B) at midweek. 相似文献
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Sandra Baile-Maxía Lucía Medina-Prado Maryana Bozhychko Carolina Mangas-Sanjuan Francisco Ruiz Luis Compañy Juan Martínez Juan Antonio Casellas José Ramón Aparicio 《Digestive endoscopy》2020,32(6):984-988
Percutaneous endoscopic gastrostomy (PEG) is the method of choice for feeding and nutritional support in patients with a normal gastrointestinal function who require long-term enteral nutrition. We report our experience regarding an alternative endoscopic ultrasound (EUS)-guided PEG technique. A retrospective clinical experience case series study was conducted from January 2019 to November 2019 at a tertiary center. Adult patients deemed unfit for conventional PEG due to absence of transillumination or previous gastric surgery were enrolled. An EUS target was created by filling a glove with saline and placing it in the abdomen. EUS was performed and the target identified from the stomach. The abdominal wall was punctured from the stomach and a guidewire was advanced. The guidewire was knotted to a string, which was passed into the stomach and drawn back through the mouth. The procedure was continued following the traditional technique. Four patients underwent EUS-PEG in our center during the study period. Mean age was 65 years and 50% were male. Two patients (50%) had a body mass index over 30. PEG indications were tongue malignancies (50%), cerebrovascular disease (25%) and dementia (25%). One patient had a Roux-en-Y gastric bypass and percutaneous endoscopic jejunostomy was performed. Technical success rate was 100% and no complications occurred. This case series shows that the EUS-guided PEG technique is a safe alternative in patients deemed unfit for conventional PEG. 相似文献
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Barrera Torres EH 《Revista de gastroenterologia de Mexico》2005,70(Z1):42-47
Trans-endoscopic gastrostomy (TEG), after 25 years since it's introduction, is at present the most utilized method to gain access to the upper digestive tract, to place an enteral feeding tube. There are different modalities that must be known to be able to decide which alternative is the best according to our judgment and experience. The endoscopist is one more member of a multidisciplinary team caring for the patient who must have a pro-active role in the clinical management of each case. We must not forget that a good result is based on an adequate patient selection, keeping in mind the limitations, the complications and very importantly, the final care of each procedure. 相似文献
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胃镜下经皮胃造瘘的临床应用 总被引:4,自引:0,他引:4
许乐 《世界华人消化杂志》2009,17(33):3377-3380
1980 年非手术经皮内镜下胃造瘘术(percutaneous endoscopic gastrostomy, PEG)被介绍应用于临床, 其优点是操作简便、并发症少. 近30年来, PEG临床应用的范围不断扩展,越来越受到重视. 该项技术已在欧美、日本等国家替代外科胃造瘘. 目前PEG已经成为需要长期肠内营养支持患者的首选方法. 本文介绍了PEG技术, PEG的适应证、禁忌证、并发症以及处理方法. 相似文献
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BACKGROUND: We developed a new method of endoscope holder-assisted percutaneous endoscopic gastrostomy (PEG) placement requiring only a single physician. OBJECTIVE: This study compared the feasibility and safety of the new method with the conventional pull method of PEG performed by 2 physicians. DESIGN: Prospective, randomized comparison study. SETTING: Rural municipal hospital. PATIENTS: Eighty consecutive patients with dysphagia. INTERVENTIONS: Patients were randomized to receive PEG placement by a single physician using the endoscope holder (40 patients) or by 2 physicians using the conventional pull method (40 patients). MAIN OUTCOME MEASUREMENTS: The success rate, duration, and complications of both methods were scored. RESULTS: The success rate of PEG by either method was similar (98%) using the endoscope holder compared with 100% with the conventional method. The duration of both endoscopic procedures was also similar (12.9 +/- 2 and 11.5 +/- 2 minutes) (P = .43). No major complication occurred with either procedure. There was 1 death within 30 days (of aspiration pneumonia) 3 days after conventional PEG placement. LIMITATIONS: The number of patients evaluated is small. CONCLUSIONS: Endoscope holder-assisted PEG placement allows a single physician to perform all the important aspects of pull PEG placement under direct vision without assistance from another specially trained individual. The method appears to be as feasible and safe as the conventional pull method. 相似文献
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目的:探讨经皮内镜胃造瘘临床上常见问题,并为患者制定合理的治疗方案,以控制患者症状,降低死亡率.方法:在充分评估患者的情况后,提出临床问题,从Cochrane图书馆(1995-2010)、MEDLINE(1990-12/2010)、EMBase (1990-12/2010)、SCIE(1990-12/2010)、中国知... 相似文献
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