Cimetidine in the treatment of duodenal ulcer.

In a double-blind trial performed in two centres, 67 outpatients with endoscopically confirmed duodenal (55) or pyloric canal (12) ulcers received cimetidine (34 patients) or placebo (33 patients) for six weeks. At 6 weeks complete healing of ulcers was significantly increased in patients receiving cimetidine (82%) compared with those receiving placebo (39%) (chi2=11-27; P less than 0-0008). Patients receiving cimetidine had significantly less daytime pain and required less antacid than those receiving placebo. Gastric acid secretion measured one week after cessation of treatment demonstrated that there was no rebound hypersecretion of acid in patients who had received cimetidine. The pretrial basal acid output of those patients whose ulcers failed to heal during cimetidine therapy was significantly greater than that of those whose ulcers healed during treatment with the drug (P less than 0-001). No side effects were encountered.     

艾普拉唑在幽门螺旋杆菌阳性十二指肠溃疡患者治疗中的应用研究

目的:探究艾普拉唑在幽门螺旋杆菌阳性十二指肠溃疡患者治疗中的应用。方法:选取我院急诊内科收治的幽门螺旋杆菌阳性十二指肠溃疡85例患者为研究对象,随机分为对照组(30例)与试验组(55例)。对照组患者前两周给予奥美拉唑片、阿莫西林、呋喃唑酮口服,两周后仅服用奥美拉唑片。试验组前两周予以艾普拉唑肠溶片、阿莫西林、呋喃唑酮口服,两周后仅服艾普拉唑肠溶片。两组均治疗4周。治疗结束后比较两组临床疗效、Hp根除率以及不良反应发生率。结果:治疗后与对照组相比,试验组临床总有效率、Hp根除率以及疼痛缓解率较高,差异有统计学意义(P<0.05);两组不良反应相比差异无统计学意义(P>0.05)。结论:艾普拉唑治疗幽门螺旋杆菌阳性十二指肠溃疡患者能够提高疗效,安全性较高。     

奥美拉唑联合呋喃唑酮治疗十二指肠活动性溃疡

目的　探讨幽门螺杆菌 (HP)与活动性十二指肠溃疡治愈及复发的关系。方法　将活动性十二指肠溃疡患者随机分为观察组 46例和对照组 40例 ,分别采用奥美拉唑联合呋喃唑酮治疗和单用奥美拉唑治疗进行效果对比。结果　观察组和对照组的治愈率分别为 95 .6 %和 80 % (P <0 .0 5 ) ,HP根除率分别为 97.72 %和 2 8.12 % (P <0 .0 1) ,未复发率分别为 95 .45 %和 2 1.87% (P <0 .0 1)。结论　根除HP是治愈溃疡及防止复发的有力措施 ,奥美拉唑和呋喃唑酮合用根除HP是很有效的方法之一。     

洛赛克治疗十二指肠溃疡106例分析

0引言 十二指肠溃疡的发生和胃酸分泌过多有密切关系.十二指肠溃疡患者,其平均基础酸分泌量和最大酸分泌量,都较正常人高出1～2倍.造成胃酸过多的原因是壁细胞多,迷走神经亢进和胃排空过速.     

Highly selective vagotomy in the treatment of complicated duodenal ulcer

Highly selective vagotomy has been utilized urgently in 33 patients with bleeding duodenal ulcer, 16 patients with pyloric stenosis and six patients presenting with perforated ulcer. Five patients died after surgery for bleeding duodenal ulcer, and two patients rebled after surgery. Forty-eight patients were reviewed at a mean of 28 months with an excellent outcome being obtained in 45 patients. Two of the three patients with poor results had proven ulcer recurrence while the third patient required reoperation for recurrent pyloric stenosis. No patient has suffered diarrhoea after vagotomy. Highly selective vagotomy is an effective treatment for urgent management of complicated duodenal ulceration and is without troublesome post-vagotomy symptoms.     

A case of duodenal anisakiasis with duodenal ulcer

Humans can be incidentally parasitized by third-stage larvae of Anisakis species following the ingestion of raw or undercooked seafood. Acute gastric anisakiasis is one of the most frequently encountered complaints in Korea. However, duodenal anisakiasis with duodenal ulcer had not been reported in Korea, despite the habit of eating raw fish. In this case, a 47-year-old man was hospitalized because of sharp epigastric pain and repeated vomiting after eating raw fish 3 days previously. On admission, esophagogastroduodenoscopic examination revealed an active duodenal bulb ulcer. At 5 mm away from the ulcer margin, a whitish linear worm was found with half of its body penetrating the duodenal mucosa. Herein, we report this case of duodenal anisakiasis accompanied by duodenal ulcer.     

埃索美拉唑与奥美拉唑治疗十二指肠溃疡疗效比较

目的：评估埃索美拉唑治疗十二指肠溃疡（duodenal ulcer,DU）的临床疗效和安全性。方法70例DU患者,分别用埃索美拉唑片剂40 mg,qd和奥美拉唑胶囊40 mg,qd进行治疗,胃镜观察溃疡愈合程度。结果4周后埃索美拉唑组和奥美拉唑组溃疡愈合率分别为91.4%和88.6%,总有效率分别为97.1%和94.2%。但埃索美拉唑比奥美拉唑缓解DU疼痛更为快速,埃索美拉唑组1 d内的疼痛消失率为42.9%,而奥美拉唑组为14.3%。结论埃索美拉唑治疗DU具有较好的疗效,且无明显不良反应,值得临床推广。     

3种方案治疗Hp阳性十二指肠球部溃疡的临床分析

近年来，幽门螺杆菌（Hp）是消化性溃疡的主要病因已被公认，对Hp阳性消化性溃疡进行Hp根除治疗，防止溃疡复发的作用也得到肯定，但在根除Hp的多种药物配伍方案中，以何种配伍最佳，观点不一。本文采用3种三联方案治疗Hp阳性十二指肠球部溃疡患者，对其疗效及费用进行比较，以寻找一个价廉高效、安全可行的治疗方案。