1089例老年及老年前期男性血脂现状分析

目的 研究本市１０８９例老年和老年前期男性的血脂现状。方法 采用标准化方法测定血清总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）、低密度脂蛋胆固醇（ＬＤＬ－Ｃ）水平。结果 ＴＣ、ＴＧ、ＬＤＬ－Ｃ在６０￣６４岁时达到高峰。８０岁以上高龄男性ＴＧ下降,ＨＤＬ－Ｃ增高。老年前期和老年期男性ＴＣ、ＴＧ、ＨＤＬ－Ｃ、ＬＤＬ－Ｃ均值分别为４．８２和４．９８ｍｍｏｌ／Ｌ、１．５５和１．５０     

郑州市区146例老年男性血液脂类水平调查

为了解老年男性的血脂水平，对郑州市１４６例离退休干部进行了血糖（Ｇｌｕ）、总胆固醇（ＴＣ），甘油三酯（ＴＧ）、载脂蛋白ＡⅠ（ＡｐｏＡⅠ）及载脂蛋白Ｂ（ＡｐｏＢ）的检测，并对这些指标之间的关系进行相关分析，报道如下。１对象与方法１．１调查对象老年组１４...     

老年男女脑血管病400例血脂分析比较

已知人体脂质代谢紊乱是引起动脉粥样硬化的主要因素之一 ,是老年脑血管病的危险因素之一 ,但对男女性别之间、脑梗死与脑出血之间血脂代谢有无差别的看法不同。本文对 40 0例老年脑血管病患者进行血脂的测定 ,比较男女性别间、脑梗死与脑出血间的血脂水平 ,旨在探讨其临床意义。1　对象与方法1 1　对象　在 1997年 1月～ 1999年 6月住院脑血管病中随机抽取老年病例40 0例 ,分成男、女 2组 ,男性组 2 0 0例 ,其中脑梗死与脑出血各 10 0例 (年龄 6 0～ 88岁 ,平均 70 15岁 ,合并糖尿病 2 0例、肾病 2例、冠心病 2 4例 ) ;女性组 2 0 0例 ,脑…     

老年男性外周血白细胞计数与血脂异常相关性分析

白细胞计数被一些研究认为是冠心病的预测因子〔1〕,作为冠心病的重要危险因素血脂异常是否与白细胞计数有关系已经引起关注〔2〕。中青年的代谢异常与白细胞计数间的相关性研究提示白细胞数与血压、血脂、血糖有关联〔3〕。此次调查旨在分析老年男性白细胞与血脂异常的关系。1     

老年男性患者血清抵抗素与血脂水平的相关性研究

目的观察老年男性患者血清抵抗素与血脂水平的关系。方法选择老年(≥80岁)男性患者220例,根据血脂水平分为血脂异常组(80例)和血脂正常组(140例),使用酶联免疫法测定空腹血清抵抗素浓度,并分析两者关联。结果血脂异常组患者空腹血清抵抗素浓度较血脂正常组高[(7.16±0.77)ng/ml比(6.21±0.63)ng/ml,P<0.05],血清抵抗素浓度与总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平呈负相关(γ=-0.231,-0.254,-0.243,均为P<0.01),与三酰甘油水平呈正相关(γ=0.127,P<0.01),在控制了年龄、病史和相关用药后,高密度脂蛋白胆固醇与抵抗素水平独立相关(P=0.017)。结论老年男性血脂异常患者空腹血清抵抗素浓度升高,可能与脂代谢紊乱有关。     

老年及老年前期冠心病病人血脂,载脂蛋白水平变化及其临床意义的研究

测定１０３例老年及老年前期冠心病人和１００例正常人的血浆脂质、载脂蛋白水平，结果表明冠心病人血浆总胆固醇、甘油三酯、低密度蛋白胆固醇、载脂蛋白Ｂ和脂蛋白水平明显增高，高密度脂蛋白胆固醇水平明显降低，载脂蛋白ＡＩ水平与正常人差别不明显，多因素逐步判别分析，ＨＤＬ－Ｃ、ＴＣ、ＡｐｏＢ，ＨＤＬ－Ｃ／ＬＤＬ－Ｃ，ＬＤＬ－Ｃ对冠心病具有独立差别不明显，多因素逐步判别分析中，ＨＤＬ－Ｃ、ＴＣ、ＡｐｏＢ，ＨＤＬ     

老年男性血脂紊乱患者的血清瘦素水平观察

瘦素 (ＬＰ)是脂肪组织合成和分泌的一种激素蛋白 ,通过对下丘脑摄食中枢的负反馈作用 ,抑制食欲 ,减少能量摄入 ,兴奋交感神经活性 ,使产热、能耗增加 ,体重减轻。ＬＰ水平能反映体脂含量的多少 ,而血清ＬＰ水平与血脂之间的关系目前尚无定论 ,本文主要探讨老年人血脂正常及血脂紊乱者的血清ＬＰ水平观察情况。1　资料和方法1 1　一般资料　老年患者 73例 ,均为男性 ,年龄 60～ 10 1岁 ,病情控制平稳 ,无明显并发症。均伴有血脂紊乱 ,已经经调脂治疗。根据血脂控制情况分为血脂(控制 )正常组及血脂紊乱组 ,血脂正常组血脂标准为 :总胆固醇 …     

250例男性衰老和老年人性功能调查分析

为了解男性初老和老年人性功能情况，对250例初老老年男性进行了调查。     

121例老年妇女5种性激素和血脂测定分析

对121例60岁以上的老年妇女测定了血清促卵泡成熟激素(FSH)、黄体生成激素(LH)、催乳素(PRL)、雌二醇(E_2)、睾酮(T)5种性激素和胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),结果表明老年妇女TC与LDL-C和性激中FSH、LH均明显升高,而E_2极度低落。但在75岁以上组E_2值有上升趋势,HDL-C亦有明显升高,与其他组相比P<0.01,有显著差异。提示HDL-C与E_2值上升是一致的。而HDL-C升高对冠心病的发生具有保护作用,故建议绝经后妇女宜尽早补充适量雌激素。     

上海黄浦区离休干部血脂知识-态度-行为调查

目的调查上海黄浦区离休干部血脂知识-态度-行为(KAP)现况及影响因素,为老年人群血脂异常的防治工作提供依据。方法从黄浦区离休干部中完全随机抽取410例进行血脂检查及KAP问卷调查,根据血脂检查结果分为血脂正常组(对照组)和血脂异常组(研究组)。其中对照组120例,男性72例,女性48例。研究组290例,男性169例,女性121例。比较两组KAP得分及分析得分的影响因素。根据数据类型分别采用t检验、χ~2检验或方差分析比较组间差异。多元线性逐步回归分析影响KAP得分的因素。结果研究组女性的行为得分高于男性,差异有统计学意义[(9.74±1.80)vs(7.65±2.98)分;P0.05]。研究组中大专及以上学历人群的血脂知识、态度得分高于对照组[(21.02±8.56)vs(17.50±8.77)分,(7.27±1.69)vs(6.82±1.81)分;P0.05],合并高血压人群的态度得分明显高于对照组[(7.75±1.75)vs(6.86±1.65)分;P0.05],合并冠心病人群的血脂知识、态度和行为得分明显低于对照组,差异有统计学意义(P0.05)。多重线性逐步回归分析结果表明知识得分主要受态度得分、年龄、文化程度3个因素影响;态度得分主要受行为得分、知识得分、年龄、收缩压(SBP)4个因素影响;行为得分主要受态度得分、体质量、空腹血糖(FBG)、尿酸(UA)4个因素影响。结论应在老年人尤其是血脂异常的男性、高龄、低文化程度,以及合并高血压、冠心病、高血糖、高尿酸人群中,普及血脂健康教育,提高血脂知识水平,倡导科学的饮食结构、运动方法和生活习惯,降低血脂异常及心脑血管疾病的风险。     

Plasma lipids and lipoproteins in elderly Japanese-American men

Knowledge about blood lipids in older individuals is limited. In the Lipoprotein Study of the Honolulu Heart Program, plasma cholesterol, triglyceride, and high-density lipoprotein (HDL) were measured during 1980 and 1981 in Japanese-American men over 60 years of age. In addition, low-density lipoprotein cholesterol (LDL-C) was estimated via a regression model. Age-related differences in mean lipid levels between the youngest (60 to 64 years) and the oldest (75 years and older) groups included a decrease in total cholesterol from 214 to 207 mg/dL and plasma triglyceride from 188 to 144 mg/dL. High density lipoprotein cholesterol rose from 47 to 49 mg/dL and LDL was relatively stable (137 and 135 mg/dL, respectively). Age-adjusted total cholesterol tended to significantly increase with increasing body mass index and hematocrit but was not significantly related with systolic blood pressure, physical activity index, cigarettes per day, or alcohol intake. Among those variables HDL-C decreased significantly with increasing body mass index and hematocrit and increased significantly with increasing alcohol intake. Compared with elderly white men in the Lipid Research Clinic Program, total cholesterol values tended to be slightly higher and triglyceride values were substantially higher, whereas HDL and LDL values were appreciably lower. Both cholesterol and triglyceride values were substantially higher than values reported from Japan from men in these age groups.     

Plasma lipids, lipoproteins and atherogenic index in men and women administered vitamin C.

The aim of the study was to establish whether it is possible, in a group of deliberately selected subjects with hyperlipidaemia, to modulate cholesterol levels by ascorbic acid administered at a dose of 500 mg/day. The authors assessed the levels of vitamin C, total and HDL cholesterol, triacylglycerols in the blood serum of 140 probands assigned to an 83-member experimental group, and to a 57-member control group. The experimental group was provided Celaskon effervescens Spofa at a dose of 500 mg/day/person. The experiment lasted for 18 months. Blood collections were made in the whole cohort at six-month intervals. Administration of L-ascorbic acid led to a highly significant decrease in the levels of total and LDL cholesterol. After 12 months of study, a highly significant decrease in atherogenic index and an increase in HDL cholesterol levels were found persisting until the end of the experiment.     

Influence of bezafibrate on plasma lipoproteins, biliary lipids and fecal sterols in healthy men

The effect of a 4-week treatment with 600 mg/day of bezafibrate in addition to a low-cholesterol, fat-modified diet on plasma lipids and lipoproteins and on biliary lipids and fecal sterols was investigated in 12 healthy men aged 25-39, and compared to the effect of the diet plus placebo, using a double-blind crossover design. The comparison of placebo and treatment values indicated that bezafibrate, beyond the effect of the diet, significantly lowered concentrations of circulating triglycerides (-25.5%), total cholesterol (-25.8%), LDL cholesterol (-19.5%), and apolipoprotein B (-19.9%), and increased apolipoprotein A-II concentrations in serum (+15.0%). There was a tendency towards lower biliary bile acid and cholesterol secretion rates with bezafibrate; lithogenic indices in fasting and stimulated bile were similar with the drug and placebo. Fecal bile acid excretion rate with diet plus bezafibrate was significantly less than with diet plus placebo. The data obtained are in accord with the hypothesis that bezafibrate exerts its effects on cholesterol and bile acid metabolism predominantly by decreasing VLDL secretion, possibly through an enhancement of fatty acid beta-oxidation in the liver.     

Plasma lipids and lipoproteins in juvenile chronic arthritis

Summary Altered levels of high density lipoprotein (HDL), low density lipoprotein (LDL), and very-low density lipoprotein (VLDL), as well as apolipoproteins have been previously described in rheumatoid arthritis patients. We have attempted to evaluate the serum triglyceride, total cholesterol, cholesterol in DHL, LDL, apolipoprotein A1 (apo-A1) and apolipoprotein B (apo-B) levels in juvenile chronic arthritis (JCA) and to correlate them with CRP and ESR in the active and non-active stages of JCA. A total of 37 children who fulfilled ARA criteria for the diagnosis of JCA were studied. There were 18 girls and 19 boys. Age range was 2.5–16 years with a mean of 9.5. The mean duration of disease was 1.8 years. Nineteen patients were accepted to have active disease. Eighteen age and sex matched healty children served as controls. Apo-A1 was significantly lower in the active JCA group when compared to inactive patients and healthy controls (both p<0.05). There were significant inverse correlations between apo-A1 and both ESR and CRP levels in these patients (r=0.67, p<0.05 and r=–0.61, p<0.–05, respectively). Although mean LDL levels were numerically lower in the JCA patients (67.2 mg/dl in the active and 68.6 mg/dl in the inactive patients) the difference with healthy controls (91.7 mg/dl) was not statistically significant. There was no significant differences in regard to triglyceride, total cholesterol, cholesterol in HDL, and apo-B levels between neither of the groups. We conclude that JCA patients have a dyslipoproteinaemic state with already altered metabolism of lipids at different stages of the chronic inflammation from active to inactive disease.     

Plasma lipids and lipoproteins in liver disease.

There are many changes in the plasma, lipids, and lipoproteins in patients with liver disease. They have proved difficult to study but our understanding of these changes has increased greatly during recent years. In obstructive jaundice hyperlipidaemia is a fairly constant finding and this appears to be due to the regurgitation of phospholipid from the obstructed biliary tree. The plasma lipids tend to fall with parenchymal liver disease. The composition of the lipoproteins depends on the activity of the plasma enzyme lecithin: cholesterol acyl transferase. When LCAT activity is high the individual lipoprotein fractions are normal. When it is reduced all of the lipoprotein fractions are affected but the pattern found with obstruction is quite different from that found with parenchymal disease. The changes in plasma lipoproteins appear to be associated with change in the lipid composition of cellular membranes and this may have important functional implications.     

Plasma lipids and lipoproteins pattern in beta-thalassemia major

We studied serum lipids and lipoproteins in 20 patients with beta-thalassemia major, under high transfusion programme and regular chelation therapy, and in 20 control subjects. Total cholesterol, HDL-cholesterol, HDL2-and HDL3-cholesterol, apolipoprotein A and B levels were significantly lower in patients with Cooley's anemia, whereas free cholesterol, triglycerides and the HDL-/HDL3-cholesterol ratio did not differ in the two groups. We think that liver damage plays an important role in determining the altered lipoprotein pattern in beta-thalassemia major. However, other factors may contribute to cause such lipid changes.     

Plasma lipids, lipoproteins and apolipoproteins in two kindreds of hypobetalipoproteinemia

Plasma lipids and apolipoproteins were quantified in two kindreds of hypobetalipoproteinemia. All affected members were asymptomatic but showed a decrease of 75% in apolipoprotein B and of 69% in LDL-cholesterol. There were no major changes in apo A-I and A-II but all affected family members had reduced levels of apo C-II (by 58%) and C-III (by 59%) without significant decrease in apo C-I and no specific decrease of apo C-III1. Apolipoprotein E is decreased in SDS-PAGE. The plasma level and phenotype of Lp(a) are not affected by HBL, suggesting that a catabolic rather than a synthetic mechanism is responsible for the disease. As shown by density gradient ultracentrifugation, HDL2 particles that contain essentially apolipoprotein A-I, cholesterol and phospholipids represent in affected subjects the major part of HDL. Due to the net reduction of apolipoprotein B-containing particles (VLDL and LDL) as acceptors of lipids in HBL, there is an accumulation of large particles rich in cholesteryl esters.