Are probiotics and other functional foods the medicines of the future?

Many health benefits are being claimed on behalf of so-called 'functional foods', and they are becoming more popular among consumers. But do they really help to prevent and treat disease? This paper discusses their potential uses and looks at current research and opinion, focusing on probiotics, prebiotics and synbiotics, which can be added to foods such as yoghurt.     

Are eosinophils crucial for the development of bronchial asthma?]

Genetically-engineered agents have been developed for the treatment of immunological diseases. Anti-IL-5 neutralizing antibody was applied for chronic asthma. A single intravenous infusion of anti-Il-5 did decrease blood and sputum eosinophils, but did not affect LAR after allergen provocation or BHA. The result suggests several possibilities including that 1) local eosinophils were not diminished enough by this dosage of the treatment, or 2) asthma symptoms are not related to eosinophils at least once the disease has started. Prolonged administration of the antibody or IL-5 inhibitors that can easily penetrate into the mucosal tissue will answer the question.     

Are both the sensory and the affective dimensions of pain encoded in the face?

The facial expression of pain plays a crucial role in pain communication and pain diagnostics. Despite its importance, it has remained unknown which dimensions of pain (sensory and/or affective) are encoded in the face. To answer this question, we used a well-established cognitive strategy (suggestions) to differentially modulate the sensory and affective dimensions of pain and investigate the effect of this manipulation on facial responses to experimental pain. Twenty-two subjects participated in the study. Their facial expressions, pain intensity, and unpleasantness ratings as well as skin conductance responses to tonic and phasic heat pain were assessed before and after suggestions directed toward increase in affective and sensory qualities of pain, respectively, were provided. Facial expressions were analyzed with the Facial Action Coding system. As expected, suggestions designed to increase the sensory dimension produced a selective increase in pain intensity ratings, whereas suggestions designed to increase pain affect produced increased unpleasantness ratings and elevated skin conductance responses. Furthermore, suggestions for either increased pain affect or pain sensation produced selective modulations in facial response patterns, with facial movements around the eyes mostly encoding sensory aspects, whereas movements of the eyebrows and of the upper lip were closely associated with the affective pain dimension. The facial expression of pain is a multidimensional response system that differentially encodes affective and sensory pain qualities. This differential encoding might have evolved to guarantee that the specific characteristics of one’s pain experience are facially communicated, thereby ensuring adequate help and support from others.     

Are you in control of the method or is the method in control of you?

The starting point for this article is the concept that there is a risk in slavishly adhering to one particular method in nursing education. With this approach in mind, the aim was to examine the use of an educational model with drama in relation to Gadamer's idea of method, as well as to discuss the conditions for lifeworld dialogues in learning encounters.     

Are multiple markers the future of prostate cancer diagnostics?

Prostate specific antigen (PSA) is the most successful and widely employed cancer serum marker in use today. There is growing evidence that the introduction of wide PSA screening and earlier detection can result in decreased cancer mortality associated with a decline in metastatic disease. PSA circulates in a number of distinct forms. Measurement of these in addition to total PSA significantly increases diagnostic utility. Diagnostic utility is likely to be further increased by adding kallikreins, cytokines, growth factors, receptors and cellular adhesion factors to the biomarker panel. The need for multiple markers reflects the multidimensional nature of prostate disease which ranges from metastatic cancer to indolent cancer to benign hyperplasia and inflammation, all of which require distinct treatments and medical interventions.     

Are the 2-isomers of the drug rimantadine active anti-influenza A agents?

There is a lack of information in the medical chemistry literature concerning the anti-influenza A activity of the drug rimantadine's 2-isomer (2-rimantadine). We now present results showing that, although 2-adamantanamine (2-amantadine) 3 is only moderately active, some 2-rimantadine analogues are effective anti-influenza A virus agents in vitro. The 2-rimantadine analogues and their spirocyclobutane and spirocyclopentane congeners were synthesized through interesting routes. The 2-rimantadine analogues were 2-4 times more potent than rimantadine 2 against influenza virus A H2N2 strain; their spirocyclobutane congeners proved equally active to rimantadine 2. Two compounds exhibited a similar activity and one of the compounds was was fourfold more potent than rimantadine 2 against H3N2 strain.