Reliability of the international knee documentation committee radiographic grading system

BACKGROUND: The International Knee Documentation Committee (IKDC) forms are commonly used to measure outcomes after anterior cruciate ligament (ACL) reconstruction. The knee examination portion of the IKDC forms includes a radiographic grading system to grade degenerative changes. The interrater and intrarater reliability of this radiographic grading system remain unknown. HYPOTHESIS: We hypothesize that the IKDC radiographic grading system will have acceptable interrater and intrarater reliability. STUDY DESIGN: Case series (diagnosis); Level of evidence, 4. METHODS: Radiographs of 205 ACL-reconstructed knees were obtained at 5-year follow-up. Specifically, weightbearing posteroanterior radiographs of the operative knee in 35 degrees to 45 degrees of flexion and a lateral radiograph in 30 degrees of flexion were used. The radiographs were independently graded by 2 sports medicine fellowship-trained orthopaedic surgeons using the IKDC 2000 standard instructions. One surgeon graded the same radiographs 6 months apart, blinded to patient and prior IKDC grades. The percentage agreement was calculated for each of the 5 knee compartments as defined by the IKDC. Interrater reliability was evaluated using the intraclass correlation coefficient (ICC) 2-way mixed effect model with absolute agreement. The Spearman rank-order correlation coefficient (r(s)) was applied to evaluate intrarater reliability. RESULTS: The interrater agreement between the 2 surgeons was 59% for the medial joint space (ICC = 0.46; 95% confidence interval [CI] = 0.35-0.56), 54% for the lateral joint space (ICC = 0.45; 95% CI = 0.27-0.58), 49% for the patellofemoral joint (ICC = 0.40; 95% CI = 0.26-0.52), 63% for the anterior joint space (ICC = 0.20; 95% CI = 0.05-0.34), and 44% for the posterior joint space (ICC = 0.28; 95% CI = 0.15-0.40). The intrarater agreement was 83% for the medial joint space (r(s) = .77, P < .001), 86% for the lateral joint space (r(s) = .76, P < .001), 81% for the patellofemoral joint (r(s) = .79, P < .001), 91% for the anterior joint space (r(s) = .48, P < .001), and 69% for the posterior joint space (r(s) = .64, P < .001). CONCLUSIONS: While intrarater reliability was acceptable, interrater reliability was poor. These findings suggest that multiple raters may score the same radiographs differently using the IKDC radiographic grading system. The use of a single rater to grade all radiographs when using the IKDC radiographic grading system maximizes reliability.     

Visual analogue scores in assessment of acute mountain sickness

Acute mountain sickness (AMS) is common on ascent to high altitude, with self assessment being the current method used to assess symptoms. The Lake Louise Self-Report Score (LLSRS) and the Environmental Symptoms Questionnaire (ESQ) are widely used and validated. A Visual Analogue Scale (VAS) may be used as a simpler alternative for AMS assessment. Our aims were to compare a VAS using lines of length 100 mm, for both individual symptoms of AMS and self-assessed overall AMS with both LLSRS and a shortened Environmental Symptoms Questionnaire (ESQc) on ascent to 4392 m. We set out to suggest a specific score as a cut off point for diagnosis of AMS when using the VAS. There were significant positive correlations (p<0.01), between VAS and both LLSRS and ESQc scores for overall AMS and a composite AMS score derived from the individual symptom scores at 4392 m. The sensitivity and specificity of the VAS were calculated as 0.67 and 0.98, respectively, when using the LLSRS as the standard test for comparison, and 0.91 and 0.96, respectively, when using the ESQc for comparison. The cut off point for diagnosis of AMS was calculated to be 22 mm or above when using a VAS for overall AMS or 15 mm or above when using the VAS composite score, when using LLSRS as the comparative test. Our results show significant correlations between the VAS and the LLSRS and ESQc, when assessing AMS at 4392 m. Our study suggests that a VAS could provide a simple alternative method of assessing AMS at high altitude.     

Exploring Australian high-performance athletes’ perceptions and experiences of sport participation during pregnancy and post-pregnancy: Development and test-retest reliability of the Mum-Alete Survey

ObjectivesTo develop and assess the test-retest reliability of a survey exploring high-performance athletes’ perceptions and experiences during and post-pregnancy.DesignCross-sectional mixed-methods survey.MethodsA three-phase approach was employed to develop the Mum-Alete survey. Relevant domains and questions were identified through a review of the literature and gap analysis (Phase 1). The face and content validity were assessed during Phase 2. The survey was modified, and the final survey included 113 questions. The test-retest reliability was assessed during Phase 3. Seven athletes aged ≥18 years who were currently pregnant and/or given birth since 1 July 2016 were recruited. The survey was administered via Qualtrics and completed on two occasions. Intraclass correlation coefficient (ICC) were determined to assess test-retest reliability (excellent, good, moderate, and poor).ResultsThe average ICC of all items was 0.962 (95% CI 0.957–0.966) demonstrating excellent test-retest reliability. The test-retest reliability was excellent for the demographic and general questions domain (ICC = 0.967 95% CI 0.955–0.977) and good for the exercise (ICC 0.762 95% CI 0.707–0.811), physical health (ICC 0.841 95% CI 0.810–0.868) and well-being (ICC 0.827 95% CI 0.784–0.865) domains.ConclusionsThe high test-retest reliability of the survey indicates excellent consistency of measures between the two time-points.     

Reliability of a measure of prediagnosis physical activity for cancer survivors

PURPOSE: This study was conducted to examine the test-retest reliability of a measure of prediagnosis physical activity participation administered to colorectal cancer survivors recruited from a population-based state cancer registry. METHODS: A total of 112 participants completed two telephone interviews, 1 month apart, reporting usual weekly physical activity in the year before their cancer diagnosis. Intraclass correlation coefficients (ICC) and standard error of measurement (SEM) were used to describe the test-retest reliability of the measure across the sample; the Bland-Altman approach was used to describe reliability at the individual level. The test-retest reliability for categorized total physical activity (active, insufficiently active, sedentary) was assessed using the kappa statistic. RESULTS: When the complete sample was considered, the ICC ranged from 0.40 (95% CI: 0.24, 0.55) for vigorous gardening to 0.77 (95% CI: 0.68, 0.84) for moderate physical activity. The SEM, however, were large, indicating high measurement error. The Bland-Altman plots indicated that the reproducibility of data decreases as the amount of physical activity reported each week increases. The kappa coefficient for the categorized data was 0.62 (95% CI: 0.48, 0.76). CONCLUSION: Overall, the results indicated low levels of repeatability for this measure of historical physical activity. Categorizing participants as active, insufficiently active, or sedentary provides a higher level of test-retest reliability.     

Determining knee joint alignment using digital photographs

The objective of this work is to find out how reliably knee joint alignment can be measured from a standardized photograph and what influence changes in the standing position have on the angles measured. The interrater, intrarater, and test-retest reliability were evaluated. The influence of image-object distance, the distance between the legs and leg rotation on the measured angles was evaluated. In addition to the digital photographs, 10 full-length radiographs were obtained in an upright position to determine whether the measured angles represent the anatomic axis or mechanical axis. There was high correlation between the interrater (ICC 0.997), intrarater (ICC 0.989) and test-retest reliability (ICC 0.904). Only slight deviation was found with the changes in radiograph-object distance (0 degrees -1.8 degrees ). With feet together varus malalignment was greater. Leg rotation showed a strong influence on the measured results (ICC 0.658). The angle measured in the digital photographs reflects the mechanical axis with only slight deviation (0.12 degrees -1.9 degrees ). The measurement of the clinical axis using standardized radiography is highly reliable and can be used for individual follow-up of varus and valgus malalignments.     

Reliability and validity of the occupational physical activity questionnaire

INTRODUCTION: Few questionnaires have been designed for wide-scale, population-based surveillance of occupational physical activity (PA) behaviors. PURPOSE: This study was conducted to determine the test-retest reliability and validity of the Occupational Physical Activity Questionnaire (OPAQ) designed to assess the usual weekly duration of occupational sitting or standing, walking, and heavy labor activities. METHODS: Analyses were based on a convenience sample of 41 adults (13 men, 28 women) (mean+/- SD, 38.8+/- 9.9 yr) who worked in a broad range of occupations. Intraclass correlation coefficients (ICC) were used to evaluate the 2-wk test-retest reliability of the OPAQ. Spearman correlations were used to assess criterion (occupational PA record, Actigraph) and construct (cardiorespiratory fitness, percent body fat) related validity. Convergent validity with the current Behavioral Risk Factor Surveillance System (BRFSS) occupational PA question was evaluated with the kappa coefficient. RESULTS: The 2-wk test-retest reliability coefficients for the OPAQ hours per week ranged from an ICC of 0.55 to 0.91. Fair-to-substantial criterion validity was observed for like activities on the OPAQ and a detailed 7-d occupational PA record for sitting or standing (r=0.37), walking (r=0.74), and heavy labor activity (r=0.31). OPAQ walking was related to PA record moderate-intensity PA (r=0.41), Actigraph occupational light-intensity counts (r=0.41), and Actigraph total counts (r=0.44). Associations observed between the OPAQ and submaximal exercise heart rate or percent body fat were low (r=-0.17 to 0.32). Convergent validity displaying the ability of the OPAQ to correctly identify participants who performed mostly sitting or standing, mostly walking, or mostly heavy labor at work was substantial [kappa=0.71 (95% CI=0.49, 0.94)]. CONCLUSIONS: The test-retest reliability and validity of the OPAQ are similar to other established occupational PA questionnaires. This preliminary study supports the use of the OPAQ in research and surveillance settings.     

Excellent reliability of toe strength measurements in children aged ten to twelve years achieved with a novel fixed dynamometer

BackgroundStronger toe flexor muscles improve performance outcomes in children, including balance, sprinting, jumping and side stepping. Toe flexor strength (TFS) is recommended as part of the clinical assessment of foot function in children. Fixed dynamometry, rather than handheld, is the gold standard of measurement; however, it can be prohibitively costly. No fixed dynamometer reliability studies on toe flexion have been conducted in children to date.Research questionsDoes the novel fixed hand-held dynamometer (HHD) protocol provide reliable intra-rater and test-retest measurements of toe flexor strength in children aged 10 to 12?MethodsTwo trials were recorded from 14 healthy children (10–12 years), 7–14 days apart by the same rater. A Lafayette HHD (model 01163) measured peak force. The HHD was secured in a mobile custom mould below a step with a strap, which secured the foot of the participant. The receptor pads of the HHD were level with the upper surface of the step, maintaining neutral toe joints at rest. The participant was seated on an adjustable stool to ensure the hip, knee and ankle were each at 90° flexion, with the testing foot flat on the upper surface of the step. The averages of three maximal five second efforts were used for data analysis using a two-way mixed effects model with repeated measures ANOVA (intraclass correlation coefficient ICC 3,3). Standard error of measurement (SEM) was calculated to determine the absolute between trial variability.ResultsThe novel fixed HHD protocol provided excellent test-retest reliability with small measurement error for hallux (ICC 3,3 = 0.93, 95 % CI 0.78−0.98, SEM = 4.31 N) and lesser toe flexor strength testing (ICC 3,3 = 0.96, 95 % CI 0.87−0.99, SEM = 1.86 N).SignificanceThe fixed HHD protocol described in this study has excellent reliability for the test-retest evaluation of children’s toe flexor strength.     

Validity and reliability of functional performance tests in meniscectomized patients with or without knee osteoarthritis

AIMS: Reduced functional performance and muscular dysfunction after knee injury and in knee osteoarthritis (OA) is suggested to be a factor in OA development. Validated functional performance tests applicable in the clinic and large-scale studies are lacking. The aim was to study the reliability and validity of 10 functional performance tests. METHODS: Two hundred and eighty-five subjects, 15-22 years post-meniscectomy, performed 10 functional performance tests. The mean age was 54 years (SD+/-11.2) and 79% were men; 52% had radiographic OA, and 48% were categorized as symptomatic. The tests were evaluated for test-retest reliability, discriminative ability (younger vs older age, men vs women, symptom-free vs symptomatic) and floor and ceiling effects. RESULTS: Two of the 10 tests, maximum number of knee bendings in 30 s and one-leg hop for distance, had good test-retest reliability (ICC 0.92, 95% CI 0.86-0.96 and 0.93, 95% CI 0.87-0.97) and were able to discriminate with regard to age, gender and symptoms, and had acceptable floor effects (9% and 3%, respectively). CONCLUSION: This study suggests the use of two functional performance tests: knee bendings/30 s and one-leg hop for distance, easy to use for evaluation of interventions due to knee injury and knee OA and when attaining long-term data of natural disease history.     

A multicenter study to determine the efficacy and safety of strontium (89Sr) chloride for palliation of painful bony metastases in cancer patients

PURPOSE: A multicenter study was conducted to evaluate the efficacy of strontium chloride (89SrCl2) for palliation of painful bony metastases using the Visual Analogue Scale (VAS), Brief Pain Inventory (BPI) and Functional Assessment for Cancer Therapy-General (FACT-G). METHODS: Ninety patients received a single injection of 2.0 MBq/kg and were classified as responders if VAS scores decreased without increased use of analgesics or if analgesic consumption decreased without an increase in the VAS. RESULTS: In the 69 subjects that could be evaluated, mean VAS values decreased significantly from 48.0 +/- 20.8 mm at baseline to 24.1 +/- 22.3 mm at last visit(Week 12) (p < 0.0001). VAS decreased more than 10 mm in 58.0% of these subjects, and analgesic consumption was reduced more than 10% in 39.1% of subjects. The response rates were 46.4% (95% confidence interval (CI) 34.3-58.8%) in the 69 subjects that could be evaluated and 43.3% (95% CI 32.9-54.2%) in all subjects. The scoring in BPI for interference in daily life improved together with improvement in its pain scores. Total FACT-G score showed significant improvement, as did its score in the subsection of physical well-being. Both platelets and leucocytes decreased by 22% at nadir (week 8), and such profiles of myelosuppression by 89SrCl2 were similar to those in the previous clinical studies. CONCLUSION: These results suggest the clinical utility of 89SrCl2 for pain palliation, which leads to QOL improvement in patients with painful generalized bone metastases.     

Test-retest reliability of center of pressure measures for postural control assessment in older cardiac patients

BackgroundElderly patients are a growing population in cardiac rehabilitation (CR). As postural control declines with age, assessment of impaired balance is important in older CR patients in order to predict fall risk and to initiate counteracting steps. Functional balance tests are subjective and lack adequate sensitivity to small differences, and are further subject to ceiling effects. A quantitative approach to measure postural control on a continuous scale is therefore desirable. Force plates are already used for this purpose in other clinical contexts, therefore could be a promising tool also for older CR patients. However, in this population the reliability of the assessment is not fully known.Research questionAnalysis of test-retest reliability of center of pressure (CoP) measures for the assessment of postural control using a force plate in older CR patients.Methods156 CR patients (≥75 years) were enrolled. CoP measures (path length (PL), mean velocity (MV), and 95% confidence ellipse area (95CEA)) were analyzed twice with an interval of two days in between (bipedal narrow stance, eyes open (EO) and closed (EC), three trials for each condition, 30 s per trial), using a force plate. For test-retest reliability estimation absolute differences (Δ: T0-T1), intraclass correlation coefficients (ICC) with 95% confidence intervals, standard error of measurement and minimal detectable change were calculated.ResultsUnder EO condition ICC were excellent for PL and MV (0.95) and good for 95CEA (0.88) with Δ of 10.1 cm (PL), 0.3 cm/sec (MV) and 1.5 cm² (95CEA) respectively. Under EC condition ICC were excellent (≥ 0.95) for all variables with larger Δ (PL: 21.7 cm; MV: 0.7 cm/sec; 95CEA: 2.4 cm²).SignificanceIn older CR patients, the assessment of CoP measures using a force plate shows good to excellent test-retest reliability.     

Translation and validation of the Danish Foot Function Index (FFI‐DK)

The objective of this study was to translate the Foot Function Index (FFI) for use in Danish‐speaking patients with foot complaints. The FFI consists of 23 items scored on a numeric rating scale from 0 to 10. The 23 items are grouped into three subscales: pain (nine items), activity limitation (five items), and disability (nine items). The Danish FFI was developed according to the recommended forward/backward translation protocol. The data analysis included reliability [intraclass correlation coefficient (ICC) 2.1] and internal consistency (Cronbach's alpha). Excellent internal consistency was shown for the three subscales: pain (0.99), disability (0.98), and activity limitation (0.98), as for the total score (0.97). The test‐retest reliability was excellent: pain subscale: ICC 0.98 [95% confidence interval (CI): 0.97–0.99]; activity limitation subscale: ICC: 0.95 (95% CI: 0.91–0.98); disability subscale: ICC 0.97 (95% CI: 0.95–0.98); total score: ICC: 0.95 (95% CI: 0.91 to 0.98). The mean difference between test and retest was below 1 point and P > 0.08. Bland–Altman plots showed no significant or clinically relevant differences from test to retest in any of the subscales or in the total score. The Danish version of the FFI was found to be valid and reliable and therefore acceptable for use in the Danish population.     

123I-5-IA-85380 SPECT measurement of nicotinic acetylcholine receptors in human brain by the constant infusion paradigm: feasibility and reproducibility.

(123)I-5-IA-85380 ((123)I-5-IA; [(123)I]-5-iodo-3-[2(S)-azetidinylmethoxy]pyridine) is a promising SPECT radiotracer for imaging beta(2)-containing nicotinic acetylcholine receptors (beta(2)-nAChRs) in brain. Beta(2)-nAChRs are the initial site of action of nicotine and are implicated in various neuropsychiatric disorders. The feasibility and reproducibility of the bolus-plus-constant-infusion paradigm for equilibrium modeling of (123)I-5-IA using SPECT in healthy nonsmokers was studied. METHODS: Ten healthy nonsmokers (mean age +/- SD, 43.7 +/- 9.9 y) underwent two (123)I-5-IA SPECT scans within 4 wk. (123)I-5-IA was administered as a bolus (125.8 +/- 14.6 MBq) plus constant infusion (18.1 +/- 1.5 MBq/h). SPECT acquisitions (30 min) and venous blood sampling were performed every 60 min throughout the infusion (10-14 h). The test-retest variability and reliability of plasma activity (kBq/mL), the regional brain activity reflected by units of kBq/mL and %ID/mL (injected dose/mL brain tissue), and the equilibrium outcome measures V(T)' (ratio of total uptake to total plasma parent concentration) and V(T) (ratio of total uptake to free plasma parent concentration) were evaluated in 4 brain areas, including thalamus, striatum, cortex, and cerebellum. RESULTS: Linear regression analysis revealed that time-activity curves for both plasma and brain (123)I-5-IA activity stabilized by 5 h, with an average change of [2.5%/h between 6 and 8 h of infusion, permitting equilibrium modeling. The plasma free fraction (f(1)), total parent, and clearance demonstrated good test-retest variability (mean, 10.9%-12.5%), whereas the variability of free parent was greater (mean, 24.3%). Regional brain activity (kBq/mL) demonstrated good test-retest variability (11.1%-16.4%) that improved when corrected for infusion rate (mean, 8.2%-9.9%) or for injected dose (mean, 9.5%-13.3%). V(T)' demonstrated better test-retest variability (mean, 7.0%-8.9%) than V(T) (mean, 12.9%-14.6%). Reliability assessed by the intraclass correlation coefficient (ICC) was superior for kBq/mL (ICC = 0.83-0.90) and %ID/mL (ICC = 0.93-0.96) compared with V(T)' (ICC = 0.30-0.64) and V(T) (ICC = 0.28-0.60). The lower reliability of V(T) was attributed to the poor reliability of the free fraction (ICC = 0.35) and free parent (ICC = 0.68). CONCLUSION: These results support the feasibility and reproducibility of equilibrium imaging with (123)I-5-IA for measurement of beta(2)-nAChRs in human brain.     

The reliability of physical performance measures in peripheral neuropathy

The purpose of this study was to evaluate the test-retest reliability of select physical performance measures among people with peripheral neuropathy (PN). METHODS: 20 PN patients (12 women, 8 men, mean age=68.4+/-12.5 years) were assessed on two separate occasions. Plantar pressure sensitivity was determined with a monofilament of known strength. Functional capacity and mobility were measured by the 6-min walk (6MW) and timed up-and-go (TUG) tests, respectively. Standing balance was evaluated by computing the average velocity (VEL) and area enclosing 95% of the body COP (A95) while participants stood quietly with eyes closed for multiple trials of varying length. Isokinetic knee extensor and flexor peak torque (KEPT, KFPT) were measured with an dynamometer during five maximal voluntary contractions. RESULTS: Plantar sensitivity and all measures of physical function demonstrated significant reliability. High reliability was observed for the 6MW (ICC=0.94) and the two-trial average TUG (ICC=0.99). Similarly, KEPT and KFPT were highly reliable whether using the top trial, or averaging the three best trials (ICCs>0.96). Averaging multiple standing balance trials generally increased ICC values, with 30s trials appearing to possess the highest reliability. DISCUSSION: Despite the heterogeneity of the PN population, select measures of physical performance are highly reliable and therefore recommended for use when examining physical function in these patients.     

U-turn speed is a valid and reliable smartphone-based measure of multiple sclerosis-related gait and balance impairment

BackgroundPeople living with multiple sclerosis (MS) experience impairments in gait and mobility, that are not fully captured with manually timed walking tests or rating scales administered during periodic clinical visits. We have developed a smartphone-based assessment of ambulation performance, the 5 U-Turn Test (5UTT), a quantitative self-administered test of U-turn ability while walking, for people with MS (PwMS).Research questionWhat is the test-retest reliability and concurrent validity of U-turn speed, an unsupervised self-assessment of gait and balance impairment, measured using a body-worn smartphone during the 5UTT?Methods76 PwMS and 25 healthy controls (HCs) participated in a cross-sectional non-randomised interventional feasibility study. The 5UTT was self-administered daily and the median U-turn speed, measured during a 14-day session, was compared against existing validated in-clinic measures of MS-related disability.ResultsU-turn speed, measured during a 14-day session from the 5UTT, demonstrated good-to-excellent test-retest reliability in PwMS alone and combined with HCs (intraclass correlation coefficient [ICC] = 0.87 [95 % CI: 0.80–0.92]) and moderate-to-excellent reliability in HCs alone (ICC = 0.88 [95 % CI: 0.69–0.96]). U-turn speed was significantly correlated with in-clinic measures of walking speed, physical fatigue, ambulation impairment, overall MS-related disability and patients’ self-perception of quality of life, at baseline, Week 12 and Week 24. The minimal detectable change of the U-turn speed from the 5UTT was low (19.42 %) in PwMS and indicates a good precision of this measurement tool when compared with conventional in-clinic measures of walking performance.SignificanceThe frequent self-assessment of turn speed, as an outcome measure from a smartphone-based U-turn test, may represent an ecologically valid digital solution to remotely and reliably monitor gait and balance impairment in a home environment during MS clinical trials and practice.     

Distribution characteristics, reproducibility, and precision of region of interest-based hippocampal diffusion tensor imaging measures

BACKGROUND AND PURPOSE: For adequate interpretation of diffusion tensor imaging (DTI) parameters empirical distribution characteristics, precision, and reproducibility should be known. The present study investigated distribution and reliability parameters of hippocampal fractional anisotropy (FA) and mean diffusivity (MD). METHODS: FA and MD values were averaged in hippocampal regions of interest in 20 subjects (10 women and 10 men; age range, 25-69 years). Regions of interest were manually placed bilaterally by one investigator at 2 occasions, and by a second independent investigator. Sample distributions of FA and MD values were compared with normal distributions. Intraclass coefficients (ICCs), standard errors of measurement (SEMs), and coefficients of variation (CVs) with confidence intervals (CI95s) were computed. RESULTS: The results did not show any deviation of averaged FA (0.237 +/- 0.017) and MD (775 +/- 28 microm2/s) values from normal distribution. Intraobserver reliability (ICC > or = 0.90) and precision (CV < or = 3.5%) were high for all measures. Interobserver reliability reached values of ICC > or = 0.84 and CV < or = 4.1%. FA yielded lower precision (CV 2.2-4.1%) than MD (CV 1.3-2.5%), CI95s were around +/-0.015-0.020 and +/-25-30 microm2/s for FA and MD, respectively. FA differences of 0.020-0.030 and MD differences of 40-50 microm2/s can be assumed to reflect reliably distinct values in hippocampal regions. CONCLUSION: The results are in line with previous reports on reliability of DTI measures by using different designs and methodology. Notwithstanding the difficulties associated with region of interest-derived DTI measurements in hippocampal regions, the present approach provides estimates of distribution characteristics and precision applicable to routine assessments of DTI parameters in clinical and research context.     

Measurement properties of the CHAMPS physical activity questionnaire in a sample of older Australians.

BACKGROUND: The effective evaluation of physical activity interventions for older adults requires measurement instruments with acceptable psychometric properties that are sufficiently sensitive to detect changes in this population. AIM: To assess the measurement properties (reliability and validity) of the Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire in a sample of older Australians. METHODS: CHAMPS data were collected from 167 older adults (mean age 79.1 S.D. 6.3 years) and validated with tests of physical ability and the SF-12 measures of physical and mental health. Responses from a sub-sample of 43 older adults were used to assess 1-week test-retest reliability. RESULTS: Approximately 25% of participants needed assistance to complete the CHAMPS questionnaire. There were low but significant correlations between the CHAMPS scores and the physical performance measures (rho=0.14-0.32) and the physical health scale of the SF-12 (rho=0.12-0.24). Reliability coefficients were highest for moderate-intensity (ICC=0.81-0.88) and lowest for vigorous-intensity physical activity (ICC=0.34-0.45). Agreement between test-retest estimates of sufficient physical activity for health benefits (> or =150min and > or =5 sessions per week) was high (percent agreement=88% and Cohen's kappa=0.68). CONCLUSION: These findings suggest that the CHAMPS questionnaire has acceptable measurement properties, and is therefore suitable for use among older Australian adults, as long as adequate assistance is provided during administration.     

Functional movement screen test: A reliable screening test for young elite ice hockey players

ObjectivesTo determine inter-rater and intra-rater reliability of the Functional Movement Screen (FMS) test among young elite hockey players.DesignReliability study.SettingInter-rater reliability was evaluated by two raters in the field. All performances were videotaped. Two other raters evaluated the videos once and then again 6 weeks later to determine intra-rater reliability. A weighted kappa statistic was used to analyze intra-rater and inter-rater reliability of each FMS sub-test, while an intra-class correlation coefficient (ICC) was calculated for the total score.ParticipantsTwenty-eight male hockey players aged 13–16.Main OutcomeFMS total and sub-tests scores.ResultsThe video raters demonstrated excellent intra-rater reliability for the total score, with an ICC of 0.96 (95% CI; 0.92–0.98) and 0.96 (95% CI; 0.91–0.98). The field raters achieved excellent inter-rater reliability for the total score, with an ICC of 0.96 (95% CI; 0.92–0.98). Sub-test analysis showed good agreement among all four raters for five of the seven main sub-tests.ConclusionFMS is a reliable test for young elite hockey players. Further research should be done to assess the predictive validity of the FMS test within this population so that physiotherapists may eventually use it as an injury prevention tool.     

SPECT of serotonin transporters using 123I-ADAM: optimal imaging time after bolus injection and long-term test-retest in healthy volunteers.

(123)I-ADAM (2-([2-([dimethylamino]methyl)phenyl]thio)-5-(123)I-iodophenylamine) has been recently proposed as a new serotonin transporter (SERT) ligand for SPECT. The objective of this study was to characterize (123)I-ADAM in healthy volunteers. (123)I-ADAM distribution in the normal brain, pseudoequilibrium interval after a single injection, normal specific uptake values, and long-term test-retest variability and reliability were investigated. METHODS: Ten healthy volunteers underwent 2 SPECT sessions under the same conditions 47.6 +/- 24.0 d apart. Scans were sequentially acquired from the time of (123)I-ADAM intravenous injection up to 12 h after injection. Regions of interest (ROIs) for cerebellum (C), midbrain, thalamus, striatum, mesial temporal region, and cortex were drawn on MR images and pasted to corresponding SPECT slices after coregistration. Specific uptake ratios (SURs) at pseudoequilibrium and the simplified reference tissue model (SRTM) methods were used for quantification. SURs were obtained as ([region - C]/C) at each time point. Test-retest variability and reliability (intraclass correlation coefficient [ICC]) were calculated. RESULTS: The highest (123)I-ADAM specific uptake was found in the midbrain and thalamus, followed by the striatum and mesial temporal region. Quantification results using SUR and SRTM were correlated with R = 0.93 (test) and R = 0.94 (retest). SURs remained stable in all regions from 4 to 6 h after injection. Using SUR, test-retest variability/ICC were 13% +/- 11%/0.74 in midbrain, 16% +/- 13%/0.63 in thalamus, 19% +/- 18%/0.62 in striatum, and 22% +/- 19%/0.05 in mesial temporal region. CONCLUSION: (123)I-ADAM accumulates in cerebral regions with high known SERT density. The optimal imaging time for (123)I-ADAM SPECT quantification is suggested to be from 4 to 6 h after a single injection. Long-term test-retest variability and reliability found in the midbrain are comparable to that reported with other (123)I-labeled SPECT ligands. These results support the use of (123)I-ADAM SPECT for SERT imaging after a single injection in humans.     

Language used in Lake Louise Scoring System underestimates symptoms of acute mountain sickness in 4- to 11-year-old children

The Lake Louise Scoring System (LLSS) was designed to evaluate adults for symptoms of acute mountain sickness (AMS). The language used in the LLSS may be too complex for young children to comprehend. This study evaluates if age-appropriate language alters the results of AMS diagnostic scores in 4- to 11-yr-old children. With parental help, subjects completed the LLSS and an equivalent Lake Louise Age-Adjusted Symptom Score (LLAASS) daily for 3 days. Measurements were made at 1605 m, in the subjects' homes, without any altitude change. Equivalent questions between the two surveys were assessed for agreement on the day when the most symptoms were recorded for each question. Thirty-seven children (19 girls), ages 4 to 11 yr (mean age 7.4 +/- 2.3 yr) completed the study. Kappa values: headache (kappa = 0.22), gastrointestinal (kappa = 0.34), fatigue (kappa = 0.88), dizziness (kappa = 0.65), and sleep (kappa = 0.88) ranged from fair to very good. The LLAASS resulted in higher mean symptom scores (1.14 +/- 0.98) compared to LLSS questions (0.61 +/- 0.82) (p < 0.01). The AMS diagnostic threshold was reached in 9% (95% CI, 4-16) of measurements using the LLAASS and 4.5% (95% CI, 1.5-10) with the LLSS. The LLSS results in reporting of fewer AMS symptoms in this population when compared with a diagnostic tool using age-appropriate language and/or visual representations. Age-appropriate communication must be used to assess AMS, particularly for headache (the key symptom of AMS) and gastrointestinal symptoms. Young children report symptoms of AMS at baseline without altitude gain; therefore, the AMS diagnostic threshold in this population may require modification.     

The interrater and intrarater reliability of the functional movement screen: A systematic review with meta-analysis

ObjectiveTo synthesize the literature and perform a meta-analysis for both the interrater and intrarater reliability of the FMS™.MethodsAcademic Search Complete, CINAHL, Medline and SportsDiscus databases were systematically searched from inception to March 2015. Studies were included if the primary purpose was to determine the interrater or intrarater reliability of the FMS™, assessed and scored all 7-items using the standard scoring criteria, provided a composite score and employed intraclass correlation coefficients (ICCs). Studies were excluded if reliability was not the primary aim, participants were injured at data collection, or a modified FMS™ or scoring system was utilized.ResultsSeven papers were included; 6 assessing interrater and 6 assessing intrarater reliability. There was moderate evidence in good interrater reliability with a summary ICC of 0.843 (95% CI = 0.640, 0.936; Q₇ = 84.915, p < 0.0001). There was moderate evidence in good intrarater reliability with a summary ICC of 0.869 (95% CI = 0.785, 0.921; Q₁₂ = 60.763, p < 0.0001).ConclusionThere was moderate evidence for both forms of reliability. The sensitivity assessments revealed this interpretation is stable and not influenced by any one study. Overall, the FMS™ is a reliable tool for clinical practice.