不同种类骨移植在青少年特发性脊柱侧凸后路矫形术中的中长期疗效评价

背景:脊柱侧凸矫正术中植骨融合技术是决定矫形治疗结果的关键因素之一。因自体骨应用受限,同种异体骨移植已广泛应用于临床。但同种异体皮质骨颗粒与同种异体松质骨颗粒在脊柱矫形患者中应用的实际效果是否一致?目的:比较不同种类骨移植在青少年特发性脊柱侧凸后路矫形植骨融合术中的应用效果。方法:2004年1月至2007年1月107例青少年特发性脊柱侧凸患者接受经后路脊柱侧凸矫形植骨融合手术。根据植骨材料不同分为A组(同种异体松质骨植骨,57例)和B组(同种异体皮质骨植骨,50例),比较两组患者随访第6、9、12、18、24、36个月的植骨融合情况、术后Cobb角变化情况及并发症等。结果:两组患者年龄、性别、主弯Cobb角、融合节段数及植骨量均无明显差异。平均随访时间为39.8个月。所有病例畸形明显矫正,术后1周总体矫正率为74.2%,最终随访总体矫正率72.1%。术后1周Cobb角及畸形矫形率,最终随访Cobb角、畸形矫形率及矫形度数丢失方面,两组相比均无明显统计学差异(P>0.05)。所有病例最终达到植骨骨性融合,A组平均融合时间15.0个月(6～36个月),B组平均融合时间15.9个月(6～36个月)。术后第6、9、12、18、24、36个月,两组骨性融合率均无明显统计学差异(P>0.05)。两组均未发生螺钉松动、断裂、断棒、假关节等并发症。术后A组4例(7.0%)、B组3例(6.0%)患者出现脑脊液漏,A组1例(1.8%)患者出现切口局部愈合障碍,均得到合理处理。结论:同种异体松质骨或皮质骨骨移植是脊柱侧凸后路矫形植骨融合术中较为理想的植骨方法之一,尤其是后者更是具有来源广泛、骨量大的优点。但在使用时,需根据同种异体骨骨愈合机制来制定术后治疗和康复计划,确保发挥复合骨移植在脊柱矫形术中的优势。     

骨移植在青少年特发性脊柱侧凸后路矫形术的应用研究

[目的]通过不同植骨在青少年特发性脊柱侧凸后路矫形植骨融合术中的应用比较,探讨其临床应用效果.[方法]回顾性分析2000年～2005年行后路钉-棒系统矫形手术的71例青少年特发性脊柱侧凸患者,其中自体骨移植21例(A组),同种异体骨移植23例(B组),自体骨混合同种异体骨移植27例(C组),比较随访第3、9、15、36个月的融合率、Cobb's角丢失率及假关节发生率.[结果]A组平均融合节段7个,B组平均融合节段7.6个,C组平均融合节段8个.随访的第3个月,融合率、Cobb's角丢失率及假关节发牛率A组、B组、C组无显著性差异(P＞0.05).第9个月,A组融合率高于B、C两组,A组与B、C组有显著性差异(P＜0.05),B、C组间无显著性差异(P＞0.05),Cobb's角丢失率及假关节发生率A、B、C组无显著性差异(P＞0.05).第15、36个月,融合率、Cobb's角丢失率及假关节发牛率A、B、C组无显著性差异(P＞0.05).[结论]同种异体骨移植、自体骨混合同种异体骨移植与自体骨移植在青少年特发性脊柱侧凸后路矫形手术中对维持矫形效果可取得相近的近远期临床效果.     

同种异体与自体骨移植治疗脊柱侧凸的前瞻性研究

目的探讨同种异体骨移植在脊柱侧凸后路融合术中的使用效果。方法自1995年3月～2000年3月,前瞻性对60例脊柱侧凸患者行同种异体骨或自体骨移植后路矫形融合术,男19例,女41例。将其随机分为A组(30例)单纯使用同种异体骨移植和B组(30例)采用自体髂骨移植。A组中先天性脊柱侧凸16例、特发性脊柱侧凸12例、神经纤维瘤病和马凡氏综合征各1例。手术时平均年龄14.5岁(6～32岁),术前胸弯平均86.6°(47°～116°),平均融合节段8个(4～10个)。B组中先天性脊柱侧凸15例、特发性脊柱侧凸9例、神经纤维瘤病5例、马凡氏综合征1例。手术时平均年龄13.7岁(11～21岁),术前胸弯平均77.8°(42°～101°),平均融合节段7个(5～10个)。对两组患者的平均手术时间、失血量、并发症、矫形丢失进行对比分析。结果术后随访2~6年,平均4年5个月。与B组相比,A组患者手术时间明显缩短,失血量大大减少。最终随访时,A组平均Cobb角为44°(31°～73°),平均丢失8°;B组平均Cobb角为41°(24°～68°),平均丢失6°。A组和B组中分别有3例和2例患者出现了假关节。A组有1例患者出现伤口浅表感染。在平均矫形丢失和并发症发生率方面两组之间差异无显著性意义(P >0.05),但B组中有6例出现了供骨部位疼痛。结论在脊柱后路融合术中,尤其需要大量骨移植     

同种异体骨加自体肋骨治疗特发性胸椎侧凸的疗效分析

目的通过与自体髂骨植骨融合术进行比较,探讨以同种异体骨加用自体肋骨取代自体髂骨在特发性胸椎侧凸后路矫形术中的应用效果。方法对1999～2000年间收治的有完整资料的84例特发性胸椎侧凸患者进行回顾性分析。A组(自体髂骨融合组)34例,年龄12～20岁,平均14.5岁;Cobb角40°～82°(平均56°),未行胸廓成形术,King分型Ⅱ型8例,Ⅲ型22例,Ⅴ型4例。B组(同种异体骨加自体肋骨融合组)50例,年龄13～19岁,平均15.4岁;Cobb角38°～80°(平均54°),King Ⅱ型14例,Ⅲ型30例,Ⅴ型6例。均采用后路CD、CDH 或TSRH固定。术后定期随访并进行影像学和临床融合状态评估。结果术后随访2～5年,平均3.4年。A组患者术后Cobb角平均矫形率为73.2%。随访2年时矫形丢失率为10%,假关节发生率为3%。取骨处的总体并发症发生率为26%,包括取髂骨处深部感染、血肿,伤口浅层愈合不佳,取髂骨处疼痛等。B组术后Cobb角矫形率为70.4%,随访2年时矫形丢失率为9%,假关节发生率为2%,TSRH钩-棒固定松动2例。胸廓成形术取肋骨的总体并发症发生率为20%,包括术中胸膜破裂,术后局部反常呼吸,渗出性胸膜炎,深吸气性疼痛等。结论同种异体骨加自体肋骨植骨若适应证选择恰当是一种安全、可靠、有效、经济的植骨方法,从融合率、矫形丢失、术后并发症等因素考     

同种异体骨与自体骨移植治疗青少年脊柱侧凸的比较研究

[目的]观察同种异体骨移植与自体骨移植治疗青少年脊柱侧凸的临床效果.[方法]对1996～2006年本科收治的63例青少年脊柱侧凸患者的临床资料,采用回顾性"病例-对照"研究方法进行分析,A组(同种异体骨移植组)32例,10～15岁,平均12.2岁;Cobb's角38°～113°,平均62°;B组(自体髂骨移植组)31例,年龄9～14岁,平均12.4岁;Cobb's角41°～105°,平均54°.所有患者均选择中华长城椎弓根内固定系统经后路矫正,术后定期随访并对临床效果进行评估.[结果]出院后2个月即开始随访,随访时间18～24个月,平均26个月;亦无严重并发症发生;A组的手术时间、失血量较B组患者减少,组间具有统计学意义(P＜0.01).[结论]两组患者具有相似的临床效果,在严格掌握适应证,充分术前准备、正确手术操作、及时术后处理的前提下,同种异体骨移植能够有效替代自体髂骨移植治疗青少年脊柱侧凸.     

同种异体骨融合技术在脊柱侧凸手术治疗中的应用

目的　观察同种异体骨在治疗脊柱侧凸时的有效性和安全性。方法　对 5 4例脊柱侧凸患者采用同种异体骨植骨融合 ,随访 4 1例 ,平均随访 16个月。观察同种异体骨的临床反应及脊柱融合情况。结果　术后存在一定的排斥反应 ,但没有明显的临床意义 ;1例出现急性深层感染 ,无晚期感染者。均未因同种异体骨移植发生疾病感染。X线观察发现术后 4个月 ,开始出现新骨 ,最后随访时 ,矫正角度平均丢失 3 4°,最小者为 - 1°,最大者为 6°。内置物无脱位、折断。结论　在治疗脊柱侧凸植骨融合时 ,采用同种异体骨移植是安全、有效的。     

前后路异体植骨在有症状的胸腰椎畸形治疗中的应用

该研究对各种前后路自体、异体骨联合治疗有症状的胸腰段脊柱侧弯和后凸畸形的效果进行了分析。105例有症状的胸腰段畸形患者,根据其手术途径和植骨的类型分成7组。其中三组为自体植骨组(对照组):前路自体肋骨或髂骨移植、后路自体肋骨或髂骨移植、前后联合自体碎块骨移植;四组为异体植骨组:后路碎块异体骨、前路椎间柱状异体骨加后路混合碎块自体及异体骨、前路碎块     

肋骨结构性支撑植骨在脊柱侧凸前路矫形手术中应用的长期随访

[目的]评价肋骨结构性支撑植骨在青少年特发性脊柱侧凸前路矫形融合手术中应用的长期随访结果.[方法]回顾性分析术后随访时间超过4年的青少年特发性脊柱侧凸前路矫形手术病例30例,男3例,女27例;年龄12～ 17.5岁,平均14.3岁.侧凸类型包括PUMC Ⅰ b型5例、Ⅰc型5例、Ⅱd1型20例.全部病例均行前路矫形融合手术,植骨方式采用自体肋骨结构性支撑植骨.术前、术后及随访时摄脊柱站立位X线片,测量冠状面及矢状面Cobb角,并观察植骨融合情况,有无假关节形成及内置物并发症.[结果]随访4～10.2年,平均6.3年.融合弯冠状面矫形率术后平均为75.1％,末次随访时矫形丢失平均4.6°;固定融合节段冠状面矫形率术后平均为93.2％,末次随访时丢失平均2.1°;固定融合节段矢状面Cobb角术前与术后比较无显著性差异,末次随访时矫形丢失平均3.1°.13例胸腰段后凸患者术前后凸平均8.3°,术后矫正为前凸平均5.6°,末次随访时保持前凸平均3.7°.全部病例末次随访时均未见假关节形成或内置物并发症.[结论]肋骨结构性支撑植骨在青少年特发性脊柱侧凸前路矫形融合手术中能获得并维持良好的冠状面及矢状面矫形,且融合率高、远期矫形丢失少,是一种可靠、有效的植骨方法.     

Lenke 5型脊柱侧凸前路单棒矫形术中放置钛网对术后矢状面重建的影响

目的 探讨放置钛网对Lenke 5型青少年特发性脊柱侧凸(adolescent idiopathic scoliosis, AIS)行选择性前路单棒矫形加植骨融合术后矢状面重建的影响.方法 40例Lenke 5型AIS患者,根据术中植骨方式分为两组,均接受选择性前路单棒矫形术.术中椎间融合植骨时,A组患者放置钛网,B组则单纯以剪碎的自体肋骨和髂骨骨粒植骨.A组女19例,男1例;年龄12～18岁.B组女17例,男3例;年龄13～20岁.两组患者获得1.5年以上的随访.对术前、术后和末次随访时的冠状面矫形与矢状面重建指标进行分析.结果 在术后和随访中,两组患者主弯的矫正率大于70%,继发弯也获得较满意的自发性纠正.无内固定相关和假关节形成等并发症发生.两组患者术后和随访中也获得较满意的矢状面重建.其中,术后和随访中胸椎后凸增加,胸腰交界性后凸轻微变化,腰椎前凸无明显丢失,内固定近端后凸成角轻度增大,内固定区成角前凸轻度减小,这些指标在两组间差别无统计学意义.末次随访时,A组患者SVA和L1到C7PL线的距离平明显小于其术前和术后的测量值,而这些指标在B组均无显著变化.结论 选择性前路单棒矫形加椎间植骨融合术是治疗Lenke 5型脊柱侧凸的有效方法.与自体植骨相比,钛网植骨可较好地改善矢状面的整体平衡.     

胸腰椎爆裂性骨折前路手术植骨融合方式初探

目的通过对胸腰椎骨折前路手术治疗中植骨融合方法效果进行回顾性分析,探讨胸腰椎骨折前路手术中各种植骨方法对疗效的影响。方法对2000年1月～2005年5月胸腰椎爆裂性骨折施行前路手术的65例患者进行随访,其中自体肋骨植骨8例,自体髂骨植骨16例,单独钛网内颗粒骨植骨28例,钛网内、外髂骨条植骨13例。结果术后伤椎高度均基本恢复正常。65例患者均获得3～48个月(平均20个月)随访,术后椎体高度丢失和后凸畸形角增大多发生于单纯髂骨植骨者,肋骨植骨融合时间长。钛网结合髂骨条植骨融合率高,融合时间最短。结论前路三维生物固定是治疗胸腰椎骨折的有效方法,钛网联合髂骨条植骨是脊柱融合方式的最佳选择之一。     

Recombinant human bone morphogenetic protein-2 enhances anterior spinal fusion in a thoracoscopically instrumented animal model

BACKGROUND: Thoracoscopically assisted anterior spinal arthrodesis and instrumentation is being used more widely to treat idiopathic scoliosis. However, harvesting autologous bone increases operative time and morbidity. The purpose of this study was to compare autologous iliac crest and rib graft with recombinant human bone morphogenetic protein-2 (rhBMP-2) in thoracoscopically assisted anterior spinal arthrodesis and instrumentation in an animal model. METHODS: Twenty-two pigs underwent thoracoscopically assisted anterior spinal arthrodesis. Each animal had five contiguous thoracic discectomies followed by anterior instrumentation. The animals were randomly assigned to five treatment groups. Group I consisted of control animals that received no graft material; group II, animals treated with autologous rib graft; group III, animals treated with autologous iliac crest graft; group IV, animals treated with an rhBMP-2-composite sponge (collagen-hydroxyapatite-tricalcium phosphate carrier); and group V, animals treated with a composite sponge carrier alone. The animals were killed four months after the procedure, and the spines were harvested. The fusion mass was assessed with use of axial and sagittal computed tomography scans. The spines were tested biomechanically with incremental loads applied in the frontal and axial planes to achieve bending moments of up to 6.0 N-m. Angular motion at each segment was recorded with use of a three-dimensional motion analysis system. Histomorphometric analysis of each undecalcified disc segment was also performed. RESULTS: The fusion grades, according to computed tomography analysis with use of a 4-point grading system in which scores of 3 and 4 indicated a solid fusion, were 0.6 point for group I, 2.1 points for group II, 2.3 points for group III, 3.8 points for group IV, and 0.4 point for group V. Group IV (the rhBMP-2-treated animals) had a higher grade than all of the other groups. Group II (rib graft) and group III (iliac crest) had similar grades, and both were greater than group I (the untreated controls) and group V (composite sponge alone) (p < 0.05). In axial rotation, lateral bending, and flexion-extension, the spines in group IV were stiffer than those in the four other groups (p < 0.05); the spines in groups II and III were similar, and the spines in both of those groups were stiffer than those in groups I and V (the control groups). Histologic analysis demonstrated that the total new-bone area, expressed as a percentage of the total disc space area, was 23.2% in group I, 37.1% in group II, 37.2% in group III, 48.5% in group IV, and 5.9% in group V. Group IV had significantly greater bone formation than all of the other groups (p < 0.001). The animals treated with rib graft (group II) and iliac crest (group III) had a similar amount of bone formation, and it was greater than that in both control groups (p < 0.001). CONCLUSIONS: The rhBMP-2 significantly increased the prevalence and quality of the spinal fusion after thoracoscopically assisted anterior arthrodesis and instrumentation in an animal model compared with that in the other treatment groups and in the controls.     

Allograft versus autograft bone in scoliosis surgery

The results of a study of the use of autograft versus allograft bone in the surgery of idiopathic adolescent scoliosis are presented. Two groups of patients, matched for age, sex, level and angle of curve, received bone grafts, 20 patients having autogenous bone from the iliac crest and the other 20 having donor bone from a bone bank. Both groups had otherwise identical posterior fusions and Harrington instrumentation. There was no difference between the two groups in a blind, radiographic assessment of bone graft mass at six months, nor in maintenance of the curve correction over the same period. No major operative complications nor failures of instrumentation were encountered. There was, however, a marked reduction in operative time and blood loss in the patients receiving donor bone and also a much lower incidence of late symptoms relating to the operative sites. We conclude that, even in the presence of adequate iliac crest, the use of bank bone is superior for grafting in idiopathic scoliosis surgery.     

外源性重组人骨形态发生蛋白-2应用于兔腰椎植骨融合中细胞增殖的实验研究

目的 探讨外源性重组人骨形态发生蛋白-2(rhBMP-2)应用于兔腰椎后路横突植骨融合中的促成骨效应细胞增殖作用及其成骨机制. 方法 45只新西兰大白兔随机分为三组(n=15),建立腰椎后路横突间植骨融合模型,分别植入rhBMP-2/异体骨复合骨条(复合骨组)、自体髂骨条(自体骨组)、单纯异体髂骨条(异体骨组).用流式细胞仪检测2、7、14、28、35 d具有成骨效应的骨髓基质细胞(MSCs)、成骨细胞、血管内皮细胞的增殖量. 结果复合骨组MSCs增殖量在术后2、7、35 d均比自体骨组和异体骨组高,差异均有统计学意义(P<0.05).复合骨组成骨细胞增殖量除在术后2 d高于自体骨组,差异有统计学意义(P=0.028)外,在其他时间点差异均无统计学意义(P>0.05),但复合骨组成骨细胞增殖量在术后2、7、14、28、35 d时均高于异体骨组,差异有统计学意义(P<0.05).复合骨组血管内皮细胞增殖量在术后2、7、28 d均高于自体骨组和异体骨组,差异有统计学意义(P<0.05).结论 在脊柱融合的不同时间段,外源性rhBMP-2能有效地促进MSCs、成骨细胞、血管内皮细胞增殖.     

Cancellous allograft versus autologous bone grafting for repair of comminuted distal radius fractures: a prospective, randomized trial

BACKGROUND: Distal radius fractures with a large metaphyseal defect often need defect filling. We assessed the reliability of a new allogenic transplant as a bone-graft substitute in comparison to autologous iliac crest bone-grafting. METHODS: This prospective, randomized study included 90 patients. Fracture-osteosynthesis was done with 2.7 mm quarter-tube plates. Tutoplast-cancellous-chips were used as allografts. Clinical and radiologic parameters were determined at three and 12 months after surgery. RESULTS: Overall outcomes were assessed according to the Demerit Point System: There were 71% good-to-excellent results in the "Tutoplast"; group and 75% good-to-excellent in the "iliac crest" group. Radiologic parameters were comparable and within normal range. Complications deriving from iliac bone harvesting were notably more frequent in the iliac crest group. Operation time was significantly shorter in the Tutoplast group. CONCLUSION: By the use of the investigated allograft no adverse effects were detected on the outcome of the treated radius fractures. Therefore, this new allograft could be a desirable alternative to autologous bone grafting from the iliac crest, as operating and anesthetics times are shortened and complications of iliac crest bone grafting avoided.     

Bone morphogenetic protein-2 compared to autologous iliac crest bone graft in the treatment of long bone nonunion

This retrospective study investigated the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) mixed with cancellous allograft on fracture healing compared to iliac crest autograft in the treatment of long bone nonunion. Eighty-nine patients with 93 established long bone nonunions treated between January 2002 and June 2004 at a single academic Level I trauma center were evaluated. Patients with clinical and radiographic evidence of failed fracture union underwent nonunion debridement, revision of fixation, and implantation at the nonunion site of either rhBMP-2 or the standard treatment autologous iliac crest bone graft. Union rate, operative time, estimated intraoperative blood loss, hospital length of stay, and postoperative infections were recorded. Nineteen nonunions received rhBMP-2 on a specialized carrier matrix (an absorbable collagen sponge) mixed with cancellous allograft, and 74 nonunions were treated with autologous iliac crest bone graft. There was no statistical difference in the rate of healing between treatment groups (68.4% vs 85.1%, respectively; P=.09). Incidence of postoperative infection was 16.2% after autologous iliac crest bone graft and 5.3% after rhBMP-2/absorbable collagen sponge (P=.22). Iliac crest autograft was associated with longer operative procedures (257.9±93.0 vs 168.9±86.5 minutes; P=.0007) and greater intraoperative blood loss (554.6±447.8 vs 331.6±357.2 mL; P=.01). These outcomes suggest that rhBMP-2 may provide a suitable alternative to autologous iliac bone graft, with the possible advantages of shorter operative time and reduced intraoperative blood loss, and may be considered as part of the orthopedic surgeon's treatment options.     

Freeze-dried allograft versus autograft bone in scoliosis surgery

Summary Two groups of 36 patients who underwent posterior vertebral fusion for scoliosis were compared retrospectively; the postoperative follow-up was 2 years. Autogenous bone taken from the iliac crest was used in group A, whereas the patients in group B received freeze-dried allograft from our bone bank. There was no significant difference between the two groups in maintenance of the curve correction after the same delay, nor in incidence of complications. A reduction of blood loss or operating time, however, could not be demonstrated in our study.     

脊柱结核病灶清除并椎间支撑植骨术后并发症的防治

目的 探讨脊柱结核病灶清除并椎间支撑植骨术后并发症的防治方法.方法 2000年1月—2015年12月,宁夏医科大学总医院采用病灶清除并椎间支撑植骨术治疗脊柱结核患者326例.通过术后X线片、MRI及CT分析植骨融合情况及植骨相关并发症发生情况.结果 所有患者术后化疗3～36(7.89±5.92)个月,结核灶全部治愈、植骨融合后停药,无新的结核灶形成.共使用348个植骨材料,其中髂骨290个,多根肋骨捆绑20个,肋髂骨捆绑26个,钛网12个.术后植骨融合过程中发生植骨倾斜9例(2.8％),植骨骨折8例(2.5％)、植骨吸收4例(1.2％)、植骨下沉3例(0.9％)、植骨移位1例(0.3％)、假关节形成1例(0.3％),相应给予延长制动时间、辅助外固定、再次手术彻底清除病灶或硬化骨、延长用药时间等措施,直至植骨融合、病灶治愈.结论 脊柱结核病灶清除并椎间支撑植骨术后植骨融合过程中可能出现植骨块倾斜、骨折、吸收、下沉、移位及假关节形成等并发症,应注意预防并给予相应处理,促进病灶治愈和植骨融合.     

A level-1 pilot study to evaluate of ultraporous β-tricalcium phosphate as a graft extender in the posterior correction of adolescent idiopathic scoliosis

The objective of this study is to compare the clinical and radiographic results of ultraporous β-tricalcium phosphate (β-TCP) versus autogenous iliac crest bone graft (ICBG), through prospective randomized pilot study (EBM-Level 1), as graft extenders in scoliosis surgery. In the posterior correction of scoliosis, local bone resected as part of the procedure is used as the base bone graft material. Supplemental grafting from the iliac crest is considered the gold-standard in posterior spinal fusion. However, autograft is not available in unlimited quantities, and bone harvesting is a source of significant morbidity. Ultraporous β-TCP might be a substitute for ICBG in these patients and thus eliminate donor site morbidity. A total of 40 patients with adolescent idiopathic scoliosis (AIS) were randomized into two treatment groups and underwent corrective posterior instrumentation. In 20 patients, ICBG harvesting was performed whereas the other half received β-TCP (VITOSS^®) to augment the local bone graft. If thoracoplasty was performed, the resected rib bone was added in both groups. Patients were observed clinically and radiographically for a minimum of 20 months postoperatively, with a mean follow-up of 4 years. Overall pain and pain specific to the back and donor site were assessed using a visual analog scale (VAS). As a result, both groups were comparable with respect to the age at the time of surgery, gender ratio, preoperative deformity, and hence length of instrumentation. There was no significant difference in blood loss and operative time. In nine patients of the β-TCP group and eight patients of the ICBG group, thoracoplasty was performed resulting in a rib graft of on average 7.9 g in both groups. Average curve correction was 61.7% in the β-TCP group and 61.2% in the ICBG group at hospital discharge (P = 0.313) and 57.2 and 54.3%, respectively, at follow-up (P = 0.109). Loss of curve correction amounted on average 2.6° in the β-TCP group and 4.2° in the comparison group (P = 0.033). In the ICBG group, four patients still reported donor site pain of on average 2/10 on the VAS at last follow-up. One patient in the β-TCP group was diagnosed with a pseudarthrosis at the caudal end of the instrumentation. Revision surgery demonstrated solid bone formation directly above the pseudarthrosis with no histological evidence of β-TCP in the biopsy taken. In conclusion, the use of β-TCP instead of ICBG as extenders of local bone graft yielded equivalent results in the posterior correction of AIS. The promising early results of this pilot study support that β-TCP appears to be an effective bone substitute in scoliosis surgery avoiding harvesting of pelvic bone and the associated morbidity.     

前路一期病灶清除植骨内固定治疗胸腰椎结核

目的探讨经前路一期病灶清除植骨融合内固定治疗胸腰椎结核的临床疗效。方法2004年10月-2009年3月,采用前路一期病灶清除椎间植骨融合内固定的手术方式治疗胸腰椎结核31例。术前正规抗结核化疗3-5周,术中彻底的清除病灶,对于骨缺损采用自体髂骨或多根肋骨支撑植骨修复,同时行前路钉板或钉棒系统内固定,术后卧床4-6周,继续正规化疗12个月左右。结果所有患者均获得6-37个月的随访,结核病灶顺利愈合,植骨稳定、融合,内固定无失效,脊柱后凸畸形得到矫正和预防,术前伴有神经症状者神经症状基本消失。结论对胸腰椎结核行前路一期病灶清除植骨融合内固定可有效地重建脊柱稳定性、矫正和预防脊柱后凸畸形,获得良好的骨性融合,临床疗效可靠。     

Cortical allografts in spinal tuberculosis

One-hundred-twenty-three patients with neurological deficit due to spinal tuberculosis underwent anterior spinal decompression and anterior column reconstruction with fresh-frozen femoral allograft. Fifty-two patients with a follow-up of more than 5 years were evaluated to assess the incorporation and the efficacy of allograft in maintaining correction. The allograft was incorporated in 49 patients at a mean follow-up of 6.5 (5.3-8.2) years. Complete neurological recovery occurred in 39 patients. The mean pre-operative kyphosis of 37 degrees (15 degrees -67 degrees ) was corrected to 18 degrees (5 degrees -45 degrees ). Fresh-frozen allografts are a suitable alternative to autologous rib and iliac crest grafts in the treatment of spinal tuberculosis.