The effect of serotonin interaction with cells

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 115, N ^o 4, pp. 396–399, April, 1993     

Thrombolytic and antithrombotic effects of the low-molecular-weight heparin-serotonin complex

Thrombolytic activity of the low-molecular-weight heparin-serotonin complex is tested in rats. Thrombi are formed in the left jugular vein. The complex, its components, or normal saline is injected in the right jugular vein 5 min after thrombosis. The complex exhibits high thrombolytic activity in comparison with the control (normal saline) and similar to that of heparin. Antithrombotic activity of the complex is higher than that of heparin, normal saline, and serotonin. Thrombolytic and antithrombotic activities of the complex may be associated with its non-enzyme fibrinolytic activity. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 11, pp. 530–532, November, 1996     

New arguments for positive inotropic vagal influence on cardiac contractility in cats

Vagal influences on the heart were studied in narcotized cats, in which the cardiotripic effects of sympathetic nerves, heart rate, and pre- and afterload were excluded. Under these conditions vagus nerve exerted only a positive inotropic effect probably mediated by an unknown humoral factor. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 396–398, April, 2000     

Effect of cyclic GABA derivative TZ-146 on the content of neurotransmitters in rat brain stem

The effect of cyclic GABA derivative TZ-146 on the content of catecholamines, serotonin, their metabolites, and neurotransmitter amino acids in rat hypothalamus and brain stem was studied by high-performance liquid chromatography with electrochemical detection. Opposite changes in the content of homovanillic acid, aspartate, glutamate, and glycine in the examined structures were accompanied by inhibition of dopamine metabolism. Possible participation of cerebral glutamatergic system in the effect of TZ-146 is discussed. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 5, pp. 544–546, May, 2000     

Antioxidant and immunomodulating effects of ceruloplasmin in experimental influenza infection

Exogenous ceruloplasmin is shown to increase the resistance of mice to influenza virus, reduce the immunodepressive effect of the virus, and improve the biochemical parameters in the acute period of experimental infection. A possible positive effect of ceruloplasmin on delayed complications of influenza is discussed. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 9, pp. 285–287, September, 1994 Presented by T. T. Berezov, Member of the Russian Academy of Medical Sciences     

New property of the heparin-serotonin complex

The antihypoxic activity of the heparin-serotonin complex was studied under conditions of acute hypobaric hypoxia. Rats were given an intraperitoneal injection of the complex in a dose of 300 μg/kg and “lifted” on a height of 12,000 m. In these rats, the intervals before the posture loss and the second agonal inhalation were 9.6- and 8.8-fold as long as those in control rats. The survival of the complex-treated rats was 90%, 70% in rats injected with heparin or serotonin, and 50% in the control group. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 10. pp. 425–427, October, 1998     

The costimulating effect of chorionic gonadotropin on lymphokine-activated splenocytes. New aspects of the immunomodulating effect of the pregnancy hormone

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, No 8, pp. 163–165, August, 1993     

Antiarrhythmic effects of allapinin in neurogenic atrial fibrillation

Antiarrhythmic effect of allapinin under conditions of neurogenic atrial fibrillation includes a vagolytic effect, which consists in inhibition of the synchronizing and tonic components of the vagal chronotropic influence. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, N 2, pp. 174–176, February 1999     

Asymmetrical effects of vagus nerves on functional parameters of rat heart in postnatal ontogeny

Significant age-related peculiarities in the dynamics of stroke volume and parameters of variational pulsogram are revealed in bilaterally vagotomized in rats. Asymmetry in vagal influences on cardiac function appear during puberty. Right-sided vagotomy predominantly affects variability of the cardiac rhythm, while left-sided vagotomy mostly affects the force of heart contractions. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 10–13, July, 2000     

Asymmetrical effects of vagus nerves on functional parameters of rat heart in postnatal ontogeny

Significant age-related peculiarities in the dynamics of stroke volume and parameters of variational pulsogram are revealed in bilaterally vagotomized in rats. Asymmetry in vagal influences on cardiac function appear during puberty. Right-sided vagotomy predominantly affects variability of the cardiac rhythm, while left-sided vagotomy mostly affects the force of heart contractions. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 10–13, July, 2000     

Wenckebach arrhythmia produced in cats by vagal stimulation with volleys of electric pulses

A model permitting second-degree atrioventricular block (Wenckebach arrhythmia) to be reproducibly elicited in experimental animals (cats) by vagus nerve stimulation with volleys of electric pulses is described. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 7, pp. 13–15, July, 1995 Presented by B. I. Tkachenko, Member of the Russian Academy of Medical Sciences     

Effect of neurotensin and epinephrine on sinus arrhythmia caused by burst stimulation of the vagus nerve

Administration of neurotensin against the background of sinus arrhythmia caused by burst stimulation of the vagus nerve in cats restores synchronization of the cardiac and vagal rhythms or modulates the proportion between them. This either stops the arrhythmia or changes its parameters. The effects of the peptide are similar to those of epinephrine and are abolished by β-adrenoreceptor blockage. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 5, pp. 494–497, May, 1997     

Comparative study of antiarrhythmic effects of methacizin and its components under conditions of neurogenic atrial fibrillation

Antifibrillatory effect of methacizin under conditions of neurogenic atrial fibrillation in cats was due to its vagolytic rather than cardiotropic activity. The immediate antifibrillatory effect of methacizin surpassed that of its components (ethacizin and ethmozin). However, 30 min after administration the antiarrhythmic effect of methacizin did not differ from that of ethacizin alone. Translated fromByulleten's Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 9, pp. 291–293, September, 1999     

Effect of transection of various branches of the vagus nerve on lipopolysaccharide-induced synthesis of corticotropin-releasing hormone mRNA in the paraventricular nuclei of rat hypothalamus

Effects of selective transection of the gastric, celiac, and hepatic branches of the vagus nerve on expression of corticotropin-releasing hormone mRNA in small cell neurons of the hypothalamic paraventricular nuclei in rats administered with bacterial lipopolysaccharide were studied usingin situ hybridization technique. Low doses of lipopolysaccharide stimulated expression of corticotropin-releasing hormone mRNA in rats subjected to axotomy of the gastric or celiac branches of the vagus nerve, but did not change the intensity of autoradiographic labeling in animals with transected hepatic branches. High doses of lipopolysaccharide enhanced expression of corticotropin-releasing hormone mRNA in vagotomized rats of all groups, which indicated the existence of a vagus-independent mechanism responsible for activation of paraventricular neurons mediating the effect of this hormone. The data suggest that the inflammation-dependent activation of stress-regulating neurons in the hypothalamus is controlled by several mechanisms, whose activation depends on the severity of inflammatory processes. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 106–109, July, 2000     

Effect of transection of various branches of the vagus nerve on lipopolysaccharide-induced synthesis of corticotropin-releasing hormone mRNA in the paraventricular nuclei of rat hypothalamus

Effects of selective transection of the gastric, celiac, and hepatic branches of the vagus nerve on expression of corticotropin-releasing hormone mRNA in small cell neurons of the hypothalamic paraventricular nuclei in rats administered with bacterial lipopolysaccharide were studied usingin situ hybridization technique. Low doses of lipopolysaccharide stimulated expression of corticotropin-releasing hormone mRNA in rats subjected to axotomy of the gastric or celiac branches of the vagus nerve, but did not change the intensity of autoradiographic labeling in animals with transected hepatic branches. High doses of lipopolysaccharide enhanced expression of corticotropin-releasing hormone mRNA in vagotomized rats of all groups, which indicated the existence of a vagus-independent mechanism responsible for activation of paraventricular neurons mediating the effect of this hormone. The data suggest that the inflammation-dependent activation of stress-regulating neurons in the hypothalamus is controlled by several mechanisms, whose activation depends on the severity of inflammatory processes. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 106–109, July, 2000     

Age-specific vagus regulation of the chronotropic function of the heart in desympathized and intact rats

Comparison of the effects of stimulation of vagus nerves in intact and desympathized rats showed differences in the variation pulsogram parameters in different age groups. A similar time course of variation pulsogram parameters in response to vagus nerve stimulation was observed in normal and experimental rats. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 6, pp. 703–706, June, 1997     

Estimation fast-reversible of effects of ethanol and pharmacokinetic forecast

The alternative and graduated methods for estimation of fast-reversible effects of ethanol are compared. Estimation of the myorelaxing and anticonvulsive effects of ethanol by the alternative method can be used with some limitations for the effector analysis of ethanol pharmacokinetics. It is shown that the effector expectation of pharmacokinetic profile for ethanol based on the minimal effective doses of bicuculline inducing clonic convulsions and tonic extension is comparable to experimentally determined brain contents of¹⁴C-ethanol. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 6, pp. 673–676, June, 1997     

Effect of fractionated administration of antigen on rosette formation in mice

Rosette formation is shown to be stimulated by administration of the same antigen dose in several injections at short intervals. The effect of fractionated administration of the antigen is mainly due to T lymphocytes, is selectively directed to antigen-binding structures containing disulfide groups, and is realized via the vagus nerve. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 7, pp. 71–74, July, 1995 Presented by V. P. Kaznacheev, Member of the Russian Academy of Medical Sciences