Primary squamous cell carcinoma of the stomach: a case report and review of the literature

Primary squamous cell carcinoma of the stomach is extremely rare. To date, only 80 cases have been reported. A 65-year-old man with complaints of epigastric pain and cachexia for the past year is presented. He had a tumour with infiltration of the corpus and antrum of the stomach. The tumour was unresectable, and the patient died within 3 months.     

Primary squamous cell carcinoma of the stomach: a case report

Primary squamous cell carcinoma (SCC) of the stomach is a very rare tumour. We report a case of SCC of the stomach in a 56-year old woman who had metastases to the liver and abdominal lymph nodes.     

Primary squamous cell carcinoma of the stomach. Report of a case and review of literature

Primary squamous cell carcinomas of the stomach represent a rare entity. Since the first report in 1895 by R?rig et al. (1) only 80 cases have been published. These reports show a peak incidence in the sixth decade of life and preference of male gender (5:1). We report the case of a 61-year-old patient who presented with anemia and weight loss due to a large tumor of the gastric wall with adhesion to the pancreatic tail. After radical regional "en bloc" gastrectomy, splenectomy and pancreatic tail resection, the diagnosis of primary gastric squamous cell carcinoma could be confirmed, since the esophageal wall and the pancreatic tail were not infiltrated and extragastric squamous cell primaries could be excluded. After postoperative irradiation of the upper abdominal area, the patient developed a single liver metastasis in the left hepatic lobe that decreased with polychemotherapy. It was resected half a year later. Due mainly to advanced tumor stages, survival after surgical resection is poor. However, adjuvant radio and chemotherapy have resulted in survival rates of more than 3 years in reported cases, as in the present case. Five years after the diagnosis was established the patient is free of recurrence and without any complaint. Pathophysiological features, therapy and outcome are discussed by reviewing the cases reported in world literature.     

原发性肺鳞癌回盲部转移1例报道并文献复习

目的 提高对原发性肺癌消化道转移的认识。方法 报道1例原发性肺鳞癌回肓部转移的病例，并对肺癌胃肠道转移相关文献进行复习。结果56岁男性，突发右下腹疼痛伴咳嗽、咯痰，发现头顶部肿物1个月。以“急腹症”为首症就诊，手术病理证实为回盲部鳞癌、癌性穿孔，经支气管镜活检确诊为肺鳞癌,同时合并多部位转移。结论肺癌胃肠道转移较为少见...     

Primary squamous cell carcinoma of the stomach: a case report with immunohistochemical and molecular biologic studies

Primary squamous cell carcinoma (SCC) of the stomach is an extremely rare tumor and its pathogenesis is still unknown. We report a case of SCC of the stomach in a 69-year-old man. The patient's stomach contained an area of SCC surrounded by squamous metaplasia. To our knowledge, this is the first reported study to have investigated the pathogenesis of this tumor type by immunohistochemistry, liquid hybridization assay for human papilloma virus (HPV) infection, and polymerase chain reaction for Epstein-Barr virus (EBV) infection. These tests yielded proof of EBV infection in surgical specimens of the tumor. Therefore, we suggest that EBV infection may be involved in the pathogenesis of SCC arising in the stomach.     

原发性肺印戒细胞癌1例并文献复习

病例介绍 林某,女,62岁,以“咳嗽伴气短半个月,加重1周”入院。入院前半个月,患者无诱因出现咳嗽,夜间明显,无咳痰,无咯血,无发热。伴气短,无胸痛,无声音嘶哑及饮水呛咳等。曾在大连市第三人民医院行胸部CT检查提示：左肺上叶占位肿块,大小约2．8cm×1．8cm;双肺多发结节;肺门淋巴结肿大,左侧胸腔积液,心包积液。     

原发性肝脏鳞状细胞癌1例

患者男性,68岁,因腹胀2年,发现上腹部包块2个月入院.患者2年前开始出现进食后腹胀、早饱,间断发生,未经诊治.2个月前无意中发现上腹部包块就诊.3个月来体质量减轻5kg.既往健康,否认病毒性肝炎病史.嗜烟20年,每日香烟30根.查体:明显消瘦,全身浅表淋巴结未触及肿大.双肺呼吸音清,心界不大,心率70次/min,心律齐,腹部凹陷,剑突下偏左可见明显异常隆起,质韧,无压痛,边界不明显,大小约6cmx6cm,活动欠佳,全腹无压痛,反跳痛及肌紧张,脾未触及;移动性浊音阴性,肠鸣音4次/min.     

Primary advanced gastric small cell carcinoma: a case report and review of the literature

We report a 73-yr-old man with primary advanced gastric small cell carcinoma, pure type. A large, Borrman type I tumor was located from the cardia to the entire gastric fundus and upper body. Atypical cells showed a round nucleus, small nucleolus, dense to granular chromatin, and scant cytoplasm. The histological findings indicates an advanced stage and exposure to the gastric serosa. Mitotic figures were observed. There was a proliferation of a sheet-like, solid pattern, but no rosette-like, sqamoid, or glandular patterns. The neoplastic cells were positive for Leu-7 (CD57) and 123C3 (CD56, neural cell adhesion molecule, NCAM) on the surface membrane. We diagnosed this case as primary advanced gastric small cell carcinoma, pure type, and report that Leu-7 and 123C3 monoclonal antibodies are useful markers for gastric small cell carcinoma. The 32 previously reported cases of gastric small cell carcinoma are also reviewed.     

Laryngeal sarcocystosis accompanying laryngeal squamous cell carcinoma: case report and literature review

Laryngeal sarcocystosis is an uncommon zoonotic coccidian protozoal infestation of human beings. The authors reviewed the pathology of 1,063 laryngeal biopsies over the past 10 years (2000 to 2009). Only one case of laryngeal sarcocystosis accompanying laryngeal squamous cell carcinoma was identified. The overall prevalence of laryngeal sarcocystosis was 0.094%. The case was a 66-year-old man who presented with voice hoarseness for six months. Physical examination and computed tomography revealed an ulcerative exophytic mass on the right true vocal cord, suggestive of laryngeal carcinoma. He underwent a right frontolateral partial laryngectomy. Histopathology showed a nonkeratinizing squamous cell carcinoma with Sarcocystis spp in the vocalis muscle. He was followed up and enrolled in speech therapy. The authors briefly review the clinicopathologic features and pathogenesis of muscular sarcocystosis and concurrent laryngeal sarcocystosis and squamous cell carcinoma.     

肺鳞癌结肠黏膜转移一例报告和文献复习

肺癌患者发生结肠转移非常罕见，患者一般无典型症状，晚期可出现腹痛、消化道出血、梗阻、穿孔等症状，并发症和死亡率较高，短期预后差。本中心报道一位63岁男性患者，以"间断咳嗽和右下腹隐痛"就诊，诊断肺鳞状细胞癌并纵隔淋巴结转移和结肠寡转移，经过PD-1免疫治疗，症状改善明显，目前仍在治疗和随访中。     

Hepatocellular carcinoma with extrahepatic growth: a case report and review of the Japanese literature

A case of extrahepatically growing hepatocellular carcinoma is reported, and the Japanese literature is reviewed. A 42-year-old man was admitted to our hospital on December 27, 1985 complaining of epigastralgia and nausea. Ultrasonography and computerized tomography showed a large tumor in the right hepatic lobe. This Was removed surgically and examined histologically.     

Hepatocellular carcinoma with extrahepatic growth: a case report and review of the Japanese literature

A case of extrahepatically growing hepatocellular carcinoma is reported, and the Japanese literature is reviewed. A 42-year-old man was admitted to our hospital on December 27,1985 complaining of epigastralgia and nausea. Ultrasonography and computerized tomography showed a large tumor in the right hepatic lobe. This Was removed surgically and examined histologically.     

胃原发性恶性黑色素瘤1例并文献复习

胃原发性恶性黑色素瘤是一种罕见的高度恶性肿瘤,应该与转移性胃恶性黑色素瘤、胃低分化腺癌、胃其他原发性肿瘤及转移瘤等相鉴别。该肿瘤位于胃底部,呈浸润性生长。镜下可见肿瘤细胞弥漫性片状分布,细胞呈多形性,细胞核呈空泡状,核仁明显,核分裂象易见,肿瘤细胞内见少量黑色素颗粒。免疫组织学检查发现肿瘤细胞中HMB45、S-100蛋白呈强阳性表达,而不表达Cytokeratin、EMA、CEA。我们通过对1例胃原发性恶性黑色素瘤患者的报道并文献复习,提高对该病的认识。     

Primary micropapillary carcinoma of the colon: a case report and literature review

We report a case of micropapillary carcinoma (MPC) of the transverse colon. A 56-year-old woman was admitted to our hospital with hematochezia. A lower gastrointestinal examination revealed an irregular ulcerative tumor of approximately 60 mm diameter with marginal elevation in the transverse colon. Abdominal computed tomography showed multiple swollen lymph nodes. A histological examination of the resected specimen revealed that cancer cells had invaded the subserosa. Microscopically, small papillary cells proliferated with lacuna spaces and the cribriform glandular configuration was observed. Immunohistochemically, the basal surface of the neoplastic cell clusters was diffusely positive for MUC1. No primary tumor was observed except for the colon. Therefore, this tumor was diagnosed as a primary MPC of the colon. Since a colorectal MPC was first reported in 2005, seven case reports and three pathological reviews have been presented in the English literature. MPC has an aggressive behavior with a high incidence of lymphovascular invasion and nodal metastases. We should take intensive chemotherapy for colorectal MPC into account, even if surgical resection is curative.     

Granular cell tumor of stomach： A case report and review of literature

Granular cell tumor (GCT) was described for the first time by Abrikosoff in 1926. It is a relatively rare neoplasm that may occur at many sites, but most commonly in the skin or soft tissues. The occurrence of GCT in the gastrointestinal tract is rare, accounting approximately for 8% of all tumors, among which the most common site is the esophagus, whereas gastric localization is very rare. Gastric GCTs can be solitary or, more frequently, associated with other gastrointestinal localization. Although GCTs are usually clinically and histologically benign, some malignant cases have been reported. Histologically, these tumors consist of polygonal and fusiform cells disposed in compact "nests" and immunohistochemical staining for S-100 protein supports the proposed derivation from Schwann cells. A correct preoperative diagnosis of this tumor can only be made in 50% of all patients and it is always based on endoscopic biopsy. Laparoscopic or conventional wedge resection represents the treatment of choice. In this study, the authors reported a case of a 49-year-old woman with a solitary granular cell tumor of the stomach with infiltrative pattern, successfully treated with surgical resection. A review of literature is also presented with emphasis on diagnostic criteria concerning the malignant form.     

Alpha-fetoprotein-producing pancreatic carcinoma: case report and review of the Japanese literature

An autopsy was performed of a patient who succumbed to pancreatic carcinoma and in whom an unusually high level of serum alpha-fetoprotein (AFP) (84,000 ng/ml) was obtained. An immunohistochemical approach, utilizing the peroxidase-antiperoxidase method, proved that AFP was confined within pancreatic carcinomatous cells of the primary lesion and liver metastases. No AFP-positive cells were ever observed in the hepatocytes adjacent to the metastatic lesions in the liver. It may be inferred that, in this particular case, the carcinomatous cells themselves synthesize AFP. The sites of production of AFP in AFP-positive pancreatic carcinoma were discussed in a review of the literature.     

Primary cholesterol hepatolithiasis associated with cholangiocellular carcinoma: a case report and literature review

Hepatolithiasis associated with cholangiocellular carcinoma is occasionally a calcium bilirubinate stone. Primary cholesterol hepatolithiasis associated with cholangiocellular carcinoma is rare; only 6 cases have been reported in the literature. A 55-year-old man was admitted to our hospital because of an elevated level of carbohydrate antigen 19-9. Various imaging studies demonstrated a mass in the segment VII of the liver. The patient underwent a curative surgical operation. Histopathological examination revealed that it was cholangiocellular carcinoma located in the periphery of the liver. A cholesterol stone was present, encircled by the cholangiocellular carcinoma. Minor inflammatory changes were observed around the stone.