深圳市2002～2004年集体性食物中毒分析

目的 为给深圳市的食物中毒预防工作提供借鉴，对深圳市2002～2004年的食物中毒情况进行了分析。方法 对深圳市及各区卫生监督部门上报的集体性食物中毒报告资料进行统计学、流行病学分析。结果3年中深圳市共发生食物中毒94起，平均每年31．3起，1666人中毒，平均每年555人。2003年有1人死亡。中毒主要发生季节为每年第二、第三季度。宝安和南山为高发区域，共占53．2％，集体食堂引起的食物中毒起数和发病人数最多。分别为71起1429人。引起中毒的食品主要为动物性食品。食物中毒的致病因素60，6％为细菌性食物中毒，细菌性食物中毒中40．3％是由副溶血性弧菌引起，占细菌性食物中毒的第一位。结论 深圳市食物中毒的好发季节都在夏、秋季节，大多集中在集体食堂，以细菌性食物中毒为主，预防食物中毒今后的工作重点首先应是加强集体食堂卫生管理问题。     

江阴市2004-2006年食物中毒分析及预防对策探讨

目的：为掌握江阴市食物中毒流行病学特点及其流行原因，为采取针对性防治对策提供科学依据。方法：对2004—2006年江阴全市食物中毒报表与专题调查报告进行统计分析。结果：2004—2006年间江阴市集体性食物中毒发生率维持在较低水平，集体食堂引起的食物中毒起数和发病人数最多，分别为12起、215人。引起中毒的食品主要为肉类及其制品。食物中毒的致病因素为细菌性食物中毒，细菌性食物中毒中主要是由副溶血性弧菌引起，占细菌性食物中毒的第一位。每年7、8、9月份为高发，但以有机磷农药污染蔬菜造成的化学性食物中毒有所上升。结论：江阴市食物中毒好发在夏、秋季节，大多集中在集体食堂，以细菌性食物中毒为主。各级卫生部门应加大对食品卫生的监督检查力度，严格控制中毒发生，加强卫生宣传教育，减少误食有毒化学物中毒而死亡的病例。     

深圳市南山区2000～2007年食物中毒流行特征分析

目的了解和掌握深圳市南山区食物中毒发生的规律和特点，为制定食物中毒预防控制措施和策略提供科学依据。方法对深圳市南山区2000～2007年发生的食物中毒资料进行统计学、流行病学分析。结果2000～2007年全区共发生食物中毒53起，中毒703人，无死亡病例；中毒发生高峰为第三季度，占总起数的58．49％；中毒类型以细菌性食物中毒为主占总起数的94．34％；致病因素主要是副溶血性弧菌，共发生26起，中毒323人，分别占中毒总起数和人数的49．06％和45．95％；食物中毒多发生在集体食堂，餐饮业次之，发生中毒33起及19起，分别占总起数的62．26％、35．85％。结论南山区食物中毒主要发生在集体食堂及餐饮业服务单位，以细菌性中毒占绝大多数。加强食品卫生监督执法力度和食品卫生安全知识宣传教育工作是预防食物中毒的关键措施。     

深圳市某中心区2006～2012年食物中毒情况分析

目的：了解深圳市某中心区食物中毒发病现状,为采取有效预防控制措施提供科学依据。方法：对某中心区2006～2012年食物中毒发生情况进行统计分析。结果：2006～2012年共处理确诊食物中毒36起,中毒319人,无重大食物中毒,无死亡。食物中毒场所分布主要分布在集体食堂、餐饮服务单位,中毒起数占总起数86.11%,家庭、商场、食品摊档次之。36起食物中毒中,细菌性食物中毒占总中毒起数63.88%,化学性食物中毒占19.44%,动植物性食物中毒占8.33%。主要发生在第二、三季度的中毒起数占总起数的69.44%,中毒人数占总中毒人数的65.20%。结论：某中心区食物中毒主要为细菌性食物中毒,食物中毒发生的起数和中毒人数总体呈逐年下降趋势,但近年化学性食物中毒比例有上升趋势。加强卫生监测和宣传食品安全教育是预防食物中毒的关键措施。     

青海省1990—1995年食物中毒情况分析

自《食品卫生法》颁布以来，虽然不断加强食品卫生的监督管理，但食物中毒时有发生。为了解和掌握青海省食物中毒的发生情况、防止食物中毒、制定食品卫生对策，对青海省1990～1995年各地报告的食物中毒案例进行了．整理分析。基本情况1历年发生食物中毒47起，中毒3646人，死亡17人。其中1990～1992年和1995年发生起数较多，分别占中毒总起数的66％和17％，1994年中毒人数较多。1992年和1995年死亡人数占总死亡人数的76．5％，见表1。2食物中毒季节分布，除细菌性食物中毒外，其它类型食物中毒无明显季节变化。细菌性食物中毒特别是由沙门氏…     

梅州市2003-2007年食物中毒情况分析与建议

目的了解梅州市食物中毒发生的规律和特点，为食物中毒预防控制工作提供科学依据。方法采用描述性流行病学方法，对2003-2007年梅州市食物中毒调查报告和检测资料进行整理、分析。结果2003-2007年梅州市共发生47宗食物中毒事件，其中中毒829人，死亡9人，病死率1．08％；中毒原因以细菌性食物中毒最多，占34．04％；中毒人数占54．16％；中毒场所以家庭为多，占44．68％；中毒人数以集体食堂为多，占总人数的36．31％。结论食物中毒主要发生在家庭，中毒人数以集体食堂为多，以细菌性食物中毒为主，应加强食物中毒预防控制知识宣传，提高群众的防患意识。     

梅州市2002～2004年食物中毒情况分析

目的探索梅州市食物中毒发生规律和流行特点，为预防和控制食物中毒提供科学依据。方法对2002-2004年梅州市食物中毒情况进行分析。结果3年来全市共发生食物中毒41起，中毒人数904人，死亡4人。微生物污染引起食物中毒，发生14起，占总中毒起数的34．1％；中毒人数亦为最多，共440人，占中毒人数的48．7％。中毒行业分布多发于家庭，共发生26起，占总中毒起数的63．4％。结论2002-2004年梅州市食物中毒发生呈上升的趋势，必须加大食品卫生监管力度，加强知识宣传，提高社会群众的防患意识，最大限度地降低食物中毒的发生。     

2002-2008年常州市新北区集体性食物中毒调查分析

目的了解新兴城市地区集体性食物中毒的特征和影响因素,为政府制定食品安全监督管理措施提供科学依据。方法收集整理常州市新北区2002-2008年集体性食物中毒资料并进行统计分析。结果7年间共发生17起集体性食物中毒事件,中毒391人,其中细菌性食物中毒14起(82.4%),化学性食物中毒3起(17.6%);副溶血性弧菌是细菌性食物中毒的主要致病原(78.6%);6~9月为细菌性食物中毒发生的高峰季节(85.7%);交叉污染是细菌性食物中毒发生的主要原因(57.1%);发生场所以集体食堂为主(47.1%)。结论常州市新北区集体性食物中毒以细菌性为主,而食品安全监管队伍薄弱,强化队伍和监管力度是该地区控制食物中毒发生的主要对策。     

集体食物中毒97例救治与调查分析

近１年来，邹平县各医疗单位收治数百例食物中毒，有９７人属于集体性食物中毒。含４起化学性食物中毒事故和１起细菌性食物中毒事故，死亡３人，严重危害了人民群众的生命安全和身体健康。１流行病学调查与临床资料１．１暴发调查见表１。１．２甲拌磷与亚硝酸盐复合中毒...     

海南省1999～2002年食物中毒情况分析

目的：对1999～2002年海南省食物中毒情况进行分析，并提出预防控制建议。方法：采用国家标准检验方法进行检验和食物中毒诊断标准及技术处理原则对中毒进行流行病学分析原因判定。结果：海南省4年来春季发生食物中毒起数较多，冬季发生食物中毒较少；农村发生的食物中毒高于城市，占65．5％；群体性食物中毒起数占75．9％，中毒人数占94．0％，但是，所有死亡事件均为散发中毒造成；发生在集体食堂(主要是学校学生食堂)的中毒人数最多，占中毒总人数的63．9％；微生物食物中毒发生起数占总中毒起数的41．5％，其中毒人数占总中毒人数49．3％。结论：必须根据海南省食物中毒的特点、食物中毒高发场所、人群、主要中毒食品、中毒原因等，提出预防控制食物中毒的措施和策略。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.