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Kristiina Vuolukka Päivi Auvinen Jan-Erik Palmgren Tuuli Voutilainen Sirpa Aaltomaa Vesa Kataja 《Brachytherapy》2019,18(5):583-588
PurposeThe purpose of this study was to evaluate the incidence of late severe (≥Grade 3) urinary toxicity and the long-term efficacy after low-dose-rate brachytherapy (LDR-BT) in patients with localized prostate cancer (PCa).Methods and MaterialsDuring the years 1999–2008, 241 patients with PCa who underwent LDR-BT with I125 and were followed up in Kuopio University Hospital were included to this analysis. The incidence of late severe (Grade 3) urinary toxicity and the long-term efficacy results were analyzed.ResultsAll D'Amico risk groups were represented, as 58.9%, 35.3%, and 5.8% of the patients were classified as low-, intermediate-, and high-risk patients, respectively. With a median followup of 11.4 years after implantation, the incidence of severe urinary toxicity increased throughout the followup period. The risk of Grade 3 urinary toxicity was highest among patients with higher Gleason scores (p = 0.016) and higher initial urine residual volumes (p = 0.017) and the cumulative incidence of severe urinary toxicity was 10.0%. The crude rate for transurethral prostatic resection was 5.8%. The relapse-free survival, the cause-specific survival, and the overall survival were 79.3%, 95.0%, and 66.4%, respectively.ConclusionsThe treatment was well tolerated as 90% of patients avoided any Grade 3 urinary toxicity. LDR-BT for localized PCa achieved high and durable efficacy. These results support the role of LDR-BT monotherapy as one of the valid primary treatment options for low-risk and favorable intermediate-risk patients. 相似文献
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N. Fujima K. Hirata T. Shiga R. Li K. Yasuda R. Onimaru K. Tsuchiya S. Kano T. Mizumachi A. Homma K. Kudo H. Shirato 《Clinical radiology》2018,73(12):1059.e1-1059.e8
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L. Lenga R. Czwikla J.L. Wichmann D. Leithner M.H. Albrecht T. DAngelo C.T. Arendt C. Booz R. Hammerstingl T.J. Vogl S.S. Martin 《Clinical radiology》2018,73(9):833.e19-833.e27
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