纳络酮治疗急性酒精中毒117例与常规治疗方法比较分析

目的：筛选救治急性酒精中毒更有效药物;方法：分纳络酮治疗组１１７例,应用纳络酮０．８ｍｇ～１．２ｍｇ溶于５％葡萄糖２５０ｍｌ,一次性持续常速静脉滴注;与常规治疗为对照组２２３例,应用５％葡萄糖 ５００ｍｌ～１０００ｍｌ加正规胰岛素８ｕ～１２ｕ、１０％氯化钾注射液１０ｍｌ、维生素Ｃ注射液２．０ｇ、ＡＴＰ注射剂４０ｍｇ、辅酶Ａ注射剂１００ｕ、维生素Ｂ６１００ｍｇ～２００ｍｇ溶液,持续常速静脉滴注比较,     

葛根素治疗冠心病心绞痛的临床观察

目的：评价葛根素注射液对冠心病心绞痛的疗效。方法：将１１５例冠心病心绞痛患随机分为葛根素治疗组与对照组。治疗组５８例,５％葡萄糖注射液５００ｍｌ＋葛根素注射液３００ｍｇ,每天一次静滴,１０次为一疗程。对照组５７例,５％葡萄糖注射液５００ｍｌ＋硝酸甘油注射液１０ｍｇ,每天一次静滴,１０次为一疗程,或口服硝酸异山梨醇酯,并根据病情调节剂量。比较两组有效率、血压、心率、心肌耗氧的结果。结果：总有效率两     

硝酸异山梨酯与硝酸甘油治疗不稳定性心绞痛疗效比较

目的：比较进口硝酸异山梨酯注射液与国产硝酸甘油静脉制剂治疗不稳定性心绞痛的疗效。方法：不稳定性心绞痛病人５０例，其中治疗组３０例以进口硝酸异山梨酯注射液２０ｍｇ加入５％葡萄糖液５００ｍｌ中静脉滴注，ｑｄ，连用１４ｄ，２０例应用硝酸甘油静脉制剂１０ｍｇ加入５％葡萄糖液５００ｍｌ中静脉滴注，ｇｄ，连用１４ｄ作为对照组。结果：治疗组总有效率８６．６７％，心电图总有效率５６．６７％，而对照组则分别为７５％与４０％。组间比较，Ｐ值均小于０．０５。结论：进口硝酸异山梨酯注射液疗效优于硝酸甘油静脉制剂。     

苯海拉明注射液静滴治疗眩晕急性发作的临床观察

目的：观察苯海拉明注射液静滴治疗眩晕急性发作的疗效。方法：２２０例各种病因的晕病人为治疗组１２０例和对照组１００例,治疗组给予苯海拉明注射２０ｍｇ加入５％葡萄糖注射液中２５０ｍｌ静滴,每天１次。对照组给予５０％葡萄糖４０ｍｌ加入维生素Ｃｌｇ,维生素Ｂ６０１ｇ灌注,每天１次,均７天为一疗程。     

地尔硫静脉滴注治疗冠心病心绞痛

目的：观察地尔硫Ｚｈｕｏ注射液静脉滴注治疗冠心病心绞痛的疗效。方法：８６例心绞痛患者分为两组，其中治疗组４６例，用地尔硫Ｚｈｕｏ５０ｍｇ加入５％葡萄糖液２５０ｍｌ中静滴，１次／ｄ，连续１０ｄ；对照组４０例用丹参液１６ｍｌ加入５％葡萄糖液２５０ｍｌ中静滴，１次／ｄ，连续１０ｄ。结果：治疗组症状控制总有效率９８％，患者心电图改善率６１％，明显高于对照组的３７％和２８％，地尔硫Ｚｈｕｏ改善心功能效果明显     

头孢噻肟与环丙沙星治疗细胞菌性痢疾疗效比较

比较头孢噻肟和环丙沙星对细菌性痢疾的疗效。方法用头孢噻肟治疗性痢疾２２例,剂量２０００ｍｇ／ｄ,加入１０％葡萄糖溶液２５０ｍｌ中静脉滴注,每天１次。别用环丙沙星注射液１００ｍｌ静脉滴注,每天２次,治疗３０例作为对照。结果头孢噻肟组临床有效率为９５．５％,细菌转阴率为８１．８％;对照组分别为９３．３％和８３．３％,     

黄芪注射液与丹参注射液联用治疗慢性肺心病心衰

目的：观察黄芪注射液与丹参注射液联用治疗慢性肺心病心衰的疗效,共观察６０例,并设对照组６０例进行对照比较,方法：对照组采用低流量吸氧、抗感染、强心甙、利尿剂、纠正酸碱失衡和电解质紊乱等规治疗;治疗组在上述常规综合治疗基础上加用黄芪注射液与丹参注射液各２０ｍｌ一起加入５％葡萄糖液５００ｍｌ中静脉滴注,每日１次,２周为１疗程。结果：治疗组有效率为９３％,对照组有效率为７０％,治疗组疗效明显高于对照组,     

尼莫能治疗急性脑梗死40例临床疗效观察

观察尼莫通对急性脑梗死的治疗效果。方法：选择诊断明确的急性脑梗死病人，随机分为二组，治疗组４０例，尼莫通１０ｍｇ／５０ｍｌ静脉滴注，每日一次，连用７天。对照组４０例，生理盐水５００ｍｌ加丹参注射液１６ｍｌ静脉滴注，每日一次，连用１４天。结果：治疗组总有效率９２．５０％，显效率７０．００％，明显优于对照组７０．００％，此外，尼莫通还可降低血糖粘稠度。治疗中未见明显不良反应，结论：尼莫通对急性脑梗死治     

心脉龙治疗慢性充血性心力衰竭的临床研究

为观察心脉龙治疗慢性充血性心力衰竭的临床疗效,从祖国医学出发,为治疗该病提供一安全有效的方法。共观察充血性心力衰竭患者病例60例,随机分为治疗组(心脉龙注射液)30例及对照组(多巴酚丁胺加速尿)30例,疗程5天。结果治疗组总有效率86.67％,矍效率40％,对照组总有效率73.33％,显效率3.33％,治疗组疗效优于对胛,组,经统计学处理有显著差异(P<0.05)。同时安全性观察显示用药期间无明显毒副反应。结果提示心脉龙注射液对充血性心力衰竭有治疗作用,其疗效确切、安全可靠。     

头孢噻肟与环丙沙星治疗细菌性痢疾疗效比较

目的：比较头孢噻肟和环丙沙星对细菌性痢疾的疗效。方法：用头孢噻肟治疗细菌性痢疾２２例,剂量２０００ｍｇ／ｄ,加入１０％葡萄糖溶液２５０ｍｌ中静脉滴注,每天１次。另用环丙沙星注射液１００ｍｌ静脉滴注,每天２次,治疗３０例作为对照。两组用药天数均为５±２ｄ（２～８ｄ）。结果：头孢噻肟组临床有效率为９５．５％,细菌转阴率为８１．８％;对照组分别为９３．３％和８３．３％,两组差异均无显著性（Ｐ＞０．０５）,且均未见不良反应。结论：头孢噻肟与环丙沙星治疗细菌性痢疾疗效无差别,二者均为抗痢疾杆菌的高效药物     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.