两种脱敏药物治疗牙周手术后牙本质敏感症的临床疗效

目的:评价氟保护漆和精氨酸磷酸钙用于牙周根向复位瓣术后早期对根面牙本质敏感症的临床疗效。方法:选择90例重度牙周炎行牙周手术后发生根面牙本质敏感症的病人,共357个患牙,随机分为A、B、C 3组,每组各119个。A组:氟保护漆涂擦法脱敏;B组:精氨酸磷酸钙脱敏抛光膏脱敏;C组(空白对照):不用任何药物。在治疗后即刻和1周后进行脱敏疗效比较。结果:与空白对照组比较,氟保护漆和脱敏抛光膏均有良好的脱敏效果(P<0.05);而两种脱敏药物之间比较无统计学意义(P﹥0.05)。结论:氟保护漆和高露洁脱敏抛光膏在行牙周根向复位瓣术后局部早期应用均能有效减少根面牙本质敏感症的发生,两者均值得临床推广应用。     

极固宁治疗超声龈下刮治所致根面牙本质敏感症的疗效

目的:观察极固宁治疗超声龈下刮治所致根面牙本质敏感症的临床疗效,探讨其作用机制。方法:将66例龈下刮冶术所致的516个根面牙本质敏感症的患牙随机分为2组,即极固宁脱敏组和氟化钠甘油脱敏组,分别使用极固宁或750g/L氟化钠甘油进行脱敏治疗,观察即刻、1个月疼痛的VAS值。结果:极固宁组脱敏组即刻有效率为94.32%,明显高于氟化钠甘油脱敏组71.83%,统计学分析两者有显著性差异(P<0.01)。而脱敏后l个月,两组无显著性差异(P>0.05)。结论:极固宁对治疗龈下刮治后产生的牙本质敏感症有着较为理想的疗效,其操作简单,值得推广应用。     

3种脱敏剂治疗超声龈下刮治所致根面牙本质敏感症的疗效观察

目的:评价极固宁、Gluma脱敏剂、75%氟化钠甘油治疗超声龈下刮治所致根面牙本质敏感症的临床疗效,探讨其作用机制.方法:将99例龈下刮冶术所致的774颗根面牙本质过敏症患牙随机分为3组,即极固宁脱敏组、Gluma脱敏剂组和氟化钠甘油脱敏组,分别进行脱敏治疗,观察即刻、1个月疼痛的VAS值.结果:极固宁脱敏组和Gluma脱敏剂的即刻有效率分别为94.32%、93.41%,显著优于氟化钠甘油脱敏组(71.83%),而脱敏后1个月,3组间无显著性差异.结论:极固宁、Gluma脱敏剂对治疗龈下刮治后产生的牙本质过敏有着较为理想疗效.     

高露洁脱敏抛光膏即刻改善牙本质敏感的疗效观察

目的评估临床应用高露洁脱敏抛光膏后牙本质敏感的即刻改善效果。方法牙本质敏感患者122例患牙215颗,洁治术后应用高露洁脱敏抛光膏,分别于抛光前、抛光后即刻采用冷空气喷吹法检测患牙的敏感程度,记录视觉模拟疼痛评分（visual analogue scale,VAS）值。结果 122例受试者,男性61例,女性61例,平均年龄（44.20±13.20）岁。患牙215颗,其中前牙86颗,前磨牙63颗,磨牙66颗。应用脱敏抛光膏后,73.95%的患牙敏感症状即刻完全缓解或部分缓解,所有患牙抛光前VAS值为56.52±19.68,抛光后VAS值下降为33.07±22.75,抛光前后差异有统计学意义（P〈0.001）。结论洁治术后应用高露洁抛光膏对即刻改善牙本质敏感有一定的疗效。     

口腔脱敏糊剂治疗龈下刮治和根面平整术后根面牙本质过敏疗效观察

目的观察口腔脱敏糊剂治疗龈下刮治和根面平整术后根面牙本质过敏的临床疗效。方法将52例接受龈下刮治及根面平整术后出现根面牙本质过敏症的慢性牙周炎患者的368颗患牙随机分为2组,分别采用口腔脱敏糊剂和不含脱敏成分的普通牙膏刷牙,评估使用1周、4周后牙齿敏感情况和安全性。结果脱敏1周后,口腔脱敏糊剂组和普通牙膏组的有效率分别为66.7%、20.0%;脱敏4周后,有效率分别为96.2%、78.9%。两者疗效有显著性差异。试验期间未出现不良反应。结论口腔脱敏糊剂对治疗龈下刮治和根面平整术后产生的根面牙本质过敏有着较为理想疗效,且使用方便。     

牙周非手术治疗对根面牙本质敏感症形成的影响

目的：观察牙周非手术治疗对导致根面牙本质敏感症的影响，并探讨其机理。方法：对52例慢性牙周炎患者的1453颗牙进行龈下刮冶及根面平整术，随访3个月。总结冶疗后患者根面牙本质敏感症的发生情况。结果：52例患者中，39例共432颗牙发生了不同程度的根面牙本质敏感症，给予积极治疗后症状大多消失。龈下刮治术和根面平整术可使部分牙本质小管敞开暴露于口腔环境中，使外来刺激遵循液体动力学原理激发痛觉。结论：脱敏治疗应纳入牙周治疗计划中。     

呀可宁脱敏凝胶治疗牙本质敏感症的临床观察

目的 观察呀可宁脱敏凝胶治疗牙周炎患者龈上洁治、龈下刮治后牙本质敏感症的临床疗效.方法 将呀可宁脱敏凝胶用软毛刷涂擦敏感部位,使其均匀渗透,并在口腔内滞留3～5 min.结果 呀可宁脱敏凝胶治疗这种牙本质敏感症的有效率达到99.69%.结论 呀可宁脱敏凝胶治疗牙周炎患牙洁、刮治后牙本质敏感症可取得较好的临床效果.     

呀可宁脱敏凝胶治疗洁刮治术后牙本质敏感的临床观察

目的观察呀可宁脱敏凝胶治疗洁刮治术后牙本质敏感的效果。方法85例洁刮治后牙本质敏感的患者随机分成2组,试验组43例330颗患牙,呀可宁脱敏凝胶脱敏;对照组42例352颗患牙,75%氟化钠甘油脱敏。比较脱敏后即刻和1个月后有效率的差异。结果脱敏后即刻有效率：试验组为96.4%（显效215颗,有效103颗,无效12颗）,对照组为79.5%（显效206颗,有效74颗,无效72颗）,2组脱敏效果的差异有统计学意义（χ^2=44.609,P〈0.0001）。脱敏1个月后,试验组有效率为97.9%（显效241颗,有效82颗,无效7颗）,对照组有效率为95.5%（显效269颗,有效67颗,无效16颗）,2组脱敏效果的差异无统计学意义（χ^2=3.072,P=0.08）。结论呀可宁脱敏凝胶对洁刮治术后牙本质敏感的即刻疗效较好。     

精氨酸脱敏牙膏治疗牙本质敏感的Meta分析

目的：采用Meta分析方法进行系统评价并比较精氨酸脱敏牙膏与常用脱敏牙膏治疗牙本质敏感的疗效。方法计算机检索万方、PubMed、Web of Science和Cochrane图书馆等数据库,并辅以手工检索,搜集精氨酸脱敏牙膏治疗牙本质敏感的随机对照试验（randomized controlled trial ,RCT）,数据的提取和质量评价由两个评价者独立完成。采用RevMan 5.3软件进行Meta分析。结果共纳入7项RCT,所有的结果通过触压敏感测试及冷空气喷吹检测评估,使用随机效应模型分析各治疗组的均数和标准差。Meta分析结果显示,精氨酸脱敏牙膏与含钾脱敏牙膏的疗效差异有统计学意义（触压评估：SMD=1.83,95％CI[1.07,2.58],P<0.05;冷空气评估：SMD=?1.19,95％CI[?1.69,?0.69],P<0.05）;精氨酸脱敏牙膏与含锶脱敏牙膏的疗效差异无统计学意义（触压评估：SMD=0.68,95％CI[?1.59,2.96],P>0.05;冷空气评估：SMD=?0.94,95％CI[?2.28,0.40],P>0.05）。结论精氨酸脱敏牙膏治疗牙本质敏感的效果优于含钾脱敏牙膏,但与含锶脱敏牙膏无明显差异。     

两种脱敏剂用于牙周非手术治疗术后牙本质过敏的临床研究

目的探讨两种脱敏剂治疗牙周非手术治疗后根面牙本质过敏的临床疗效。方法选择慢性牙周病患者120例(患牙468颗),随机分为4组,在行常规龈下刮治术和根面平整术后,分别采用A组多乐氟、B组多乐氟加氟保护剂、C组氟保护剂、D组碘甘油(安慰剂)进行脱敏治疗,在治疗后即刻、1周、4周,观察评价脱敏疗效,并采用视觉模拟评分(VAS)对患牙的敏感程度进行评估。结果经药物治疗后,A、B、C三组患牙脱敏疗效均明显优于D组(χ2=173.42,P=0.000),B组疗效优于A、C组(χ2=11.379,P=0.003),A、C组间差异则无统计学意义(χ2=0.026,P=0.872)。结论牙周非手术治疗后,联合应用多乐氟和氟保护剂治疗根面牙本质过敏可以取得较为理想的临床效果。     

柠檬精油对牙周致病菌抑制作用及其安全性初步研究

目的:探讨柠檬精油对牙周致病菌的体外抗菌活性及对细胞增殖的影响。方法:采用微量液体稀释法测定柠檬精油对Pg、Fn、Aa、Pi的最小抑菌浓度(minimal inhibitory concentration,MIC)及最小杀菌浓度(minimum bactericidal concentration,MBC);以较低浓度的MIC为标准稀释LEO作为实验组,采用MTT法测定柠檬精油对HUVECs的毒性作用,明确抑菌浓度下LEO的安全性。结果:柠檬精油对牙周主要致病菌均有抑菌作用,Pg、Fn、Aa、Pi的MIC分别是9.0 g/L、4.5 g/L、4.5 g/L、9.0 g/L,Aa、Fn的 MBC是9.0 g/L,Pg、Pi的MBC未测得。1/2MIC、1/20MIC浓度的LEO能够抑制人脐静脉内皮细胞的生长,而低于1/200MIC浓度的LEO则对人脐静脉内皮细胞的生长没有影响,其中1/200MIC浓度的LEO作用明显优于0.02%的CHX。结论:体外环境中,柠檬精油对牙周致病菌Pg、Fn、Aa、Pi具有抗菌活性,低浓度应用对机体相对安全。     

Oral cancer: molecular technologies for risk assessment and diagnosis

Purpose: The effective biomarkers related to diagnosis, metastasis, drug resistance and irradiation sensitivity of oral cancers will help the pathologist and oncologist to determine the molecular taxonomy diagnosis and design the individualization treatment for the patients with oral cancers.     

Computer-assisted planning for maxillofacial prosthodontic rehabilitation

Computerized tomography (CT) planning and the use of CT derived surgical templates for implant placement have shown promise for restoring function within months after surgical reconstruction of acquired post-oncologic defects.     

Stimulated whole saliva components in children with Down syndrome

The authors report on the components of stimulated whole saliva from children with Down syndrome—including pH, flow rate, sialic acid and protein concentrations, and amylase and peroxidase activity. Saliva samples were collected from 35 children aged 6–10 years. Of the participants, 17 had Down syndrome and 18 did not. To stimulate saliva production, the children chewed a piece of parafilm for 10 minutes before the sample was collected. Soon after collecting the saliva sample, the authors measured pH using a portable pH-meter. Sialic acid levels were determined with a thiobarbituric acid assay. Protein content was determined with Folin's phenol reagent. Amylase was assayed and the authors measured the maltose produced by the breakdown of starch and peroxidase using ortho-dianisidine.
No statistically significant difference was observed in levels of sialic acid (free and total) between the two groups. Protein concentration was about 36% higher in the group with Down syndrome. However, the salivary flow rate, pH, and amylase and peroxidase activities were lower among the children with Down syndrome.     

Effect of Pingyangmycin on human venous malformation endothelial cells

Purpose: Venous malformations are common vascular anomalies with a propensity of the head and neck. Intralesional injection of Pingyangmycin (PYM, bleomycin A5 hydrochloride) is a widely used sclerotherapy method for the treatment of venous malformation.     

牙髓再生的研究现状

目前,根管治疗术在临床上已得到了广泛的应用并成功的保存了患牙,但其仍有许多术后并发症。随着组织工程技术在口腔领域的应用,构建一种组织工程化牙髓进行牙髓-牙本质复合体的再生治疗成为可能。近年来国内外已有很多关于牙髓再生的研究,并且已经取得了一定成果。本文将对目前国内外牙髓再生的研究进展现状作一综述。     

Oropharyngeal dysphagia in amyotrophic lateral sclerosis alters quality of life

Dysphagia is one of the most important complications encountered in amyotrophic lateral sclerosis (ALS). Our aim was to determine whether oropharyngeal dysphagia impacted the quality of life (QoL) of patients with ALS. Thirty consecutive patients were recruited (31–82 years, 18 men). Swallowing function was evaluated using a standardised videofluoroscopic barium swallow. All the patients completed a specific questionnaire on quality of life in dysphagia (SWAL‐QoL) immediately after the videofluoroscopy. The results of dysphagia outcome severity scale separated 14 patients with oropharyngeal dysphagia and 16 with normal swallowing function. There was no difference in the average age, weight and body mass index of the two groups (dysphagic patients: 68 ± 11 kg versus non‐dysphagic patients: 69 ± 14 kg). Most of the dysphagic patients had a bulbar affection based on their Norris scores which determine the importance of cranial nerves illness (20 ± 8), significantly lower than those of the non‐dysphagic patients (35 ± 5) (P < 0·0001). There was no difference in the neurological peripheral symptoms evaluated by Amyotrophic Lateral Sclerosis Functional Rating Scale scores (dysphagic patients: 26 ± 7 versus non‐dysphagic patients: 27 ± 8) (ns). The swallowing quality of life questionnaire revealed that the dysphagic patients had significant burden (P < 0·001). They were affected by the necessity to applied a food selection (P < 0·01), by the increase in eating duration (P < 0·05) and described a decrease in eating desire (P < 0·05). They complained of fear regarding the risk of dysphagia (P < 0·05). They also described difficulties with oral communication (P < 0·001). All of those complained about dysphagia which impacted directly mental health (P < 0·05) and social life (P < 0·05). In conclusion, oropharyngeal dysphagia is a common symptom accompanying ALS, which alters the patient's QoL, especially social health.     

替牙期骨性Ⅲ类错牙合患者颞下颌关节特征的锥形束CT研究

目的:采用锥形束CT(CBCT)研究替牙期骨性Ⅲ类错牙合患者颞下颌关节的影像学特征,探讨Ⅲ类功能状态下,颞下颌关节的生长、改建机制。方法:从就诊于昆明医科大学附属口腔医院正畸科的患者中选取符合纳入标准的替牙期骨性Ⅲ类错牙合患者及骨性Ⅰ类错牙合患者各20名,使用NNT viewer 5.3图像处理软件进行三维重建及线距和角度的测量,并进行统计学分析。结果:替牙期骨性Ⅲ类错牙合患者组和替牙期骨性Ⅰ类错牙合患者组对比结果为:矢状面双侧关节前间隙偏小、双侧关节上间隙偏小、双侧关节结节斜度偏小;冠状面双侧关节内间隙偏小,双侧关节上间隙偏小,双侧关节外间隙偏小,右侧髁状突角度偏小;横截面右侧髁状突前后径偏小。结论:替牙期骨性Ⅲ类错牙合患者颞下颌关节发育不充分,呈现髁状突,关节窝深度,关节结节斜度;冠状面关节内、外间隙均较小的特征。骨性Ⅲ类错牙合患者髁状突在关节窝中处于前置近关节窝顶位置。骨性Ⅲ类错牙合患者颞下颌关节影像学特征与其功能状态相适应。     

拔牙位点保存用复合温敏凝胶的构建及体外表征

目的:制备多壁碳纳米管/羟基磷灰石/壳聚糖复合温敏凝胶,探讨其作为拔牙位点保存材料的理化性能。方法:采用原位沉积方法制备多壁碳纳米管/羟基磷灰石(MWNT/ HA简称HAC)复合无机材料,将其分散至壳聚糖温敏凝胶中,制备壳聚糖/多壁碳纳米管/羟基磷灰石(CS /MWNT/HA简称CS/HAC)复合温敏凝胶,以成胶时间、孔径、孔隙率、机械强度及降解性能为指标优化配方设计,并表征复合温敏凝胶的微观形貌及理化性能。结果:以10 g/L的HAC作为补强成分加入到壳聚糖溶液中,能够在不影响成胶并保证一定孔隙率(84%)的前提下,提高材料的机械性能(抗压强度0.441 MPa),所获复合温敏凝胶具有适宜的临床操作时间(12 min),并具有可控的降解速率。结论:负载HAC的复合温敏凝胶具有良好的成型性,并具有较好的机械性能,在拔牙位点保存领域具有良好的应用前景。