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EB病毒重叠感染肝炎病毒的研究 总被引:1,自引:0,他引:1
EB病毒(EBV)在世界范围内广泛存在,是传染性单核细胞增多症的原因。也与伯基特氏淋巴瘤、鼻咽癌、淋巴增殖综合征、淋巴瘤及口腔绒毛苦历有关’‘-”,也可引起病毒性食道炎’“。EBV与肝炎病毒(ITV)重叠感染的报道不多。我们于1990年5月至1996年4月对此作了研究,以探讨两者重叠感染的状况及其结果。1材料和方法1.1病例和血清随机抽取160例病毒性肝炎住院患者血清,包括56例急性病毒性肝炎(AVH),20例慢性轻度肝炎(CLH),30例慢性中度肝炎(CMH),22例肝炎肝硬化(I。C),10例慢性重型肝炎(CHF)和22例原发性肝癌(… 相似文献
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目的探讨广西地区壮族患者EB病毒各年龄段EBNA1/IgA、EA/IgG及EA/IgA抗体的rA值和阳性率与年龄的关系。方法收集140例未经治疗的壮族鼻咽癌患者和280例健康人的血清,用ELISA检测EBNA1/IgA、EA/IgG及EA/IgA抗体,分别计算各年龄段的抗体水平及阳性率并进行统计学分析。结果鼻咽癌患者各年龄段EBNA1/IgA、EA/IgA及EA/IgG抗体rA值均有统计学差异(P<0.05)。在50岁以后的年龄段病人与健康人EA/IgG、EA/IgA、EBNA1/IgA抗体阳性率无显著差异。结论壮族鼻咽癌患者EB病毒EBNA1/IgA、EA/IgA及EA/IgG抗体水平存在年龄上的差异。在鼻咽癌的临床诊断和高危人群筛查中有必要根据不同年龄段的人群界定不同的阳性临界值。 相似文献
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目的 通过分析HIV/AIDS患者EB病毒(EBV)潜伏感染的临床特点和免疫特征,探讨EBV潜伏感染对HIV/AIDS患者的影响。方法 收集确诊HIV/AIDS患者的血液标本进行检测,并回顾性分析患者的临床资料。EBV DNA的检测分别采用全血标本和血清标本进行实时定量PCR检测,血清EBV抗体的检测采用酶联免疫吸附法,淋巴细胞亚群的检测采用流式细胞分析,EB病毒编码RNA(Epstein-Barr virus-encoded RNA,EBERs)检测采用原位杂交的方法。结果 共收集168例患者的血清和全血标本,所有患者的血清EBV DNA载量均<400 copies/mL,但HIV RNA≥20copies/mL的患者全血EBV DNA阳性率显著高于HIV RNA<20copies/mL的患者(71.79%vs. 28.21%,χ2=15.986,P<0.01)。血清EBV抗体检测发现全部患者EBV-CA-IgG均为阳性,但只有血清EBV-EA-IgG抗体的阳性率在全血EBV DNA阳性患者和阴性患者中表现出显著性差异(25.64%vs. 3.92%,χ2=10.8... 相似文献
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目的 :研究黑龙江地区多发性骨髓瘤 (MM )患者EB病毒 (EBV)、人类疱疹病毒 6 (HHV 6 )的感染情况 ,以探究MM的病因及发病机制。方法 :用多聚酶链反应 (PCR)技术检测MM患者EBV、HHV 6感染情况 ,每批试验均设阳性质粒对照及无模板阴性对照 ,同时检测了 2 6例正常人。结果 :MM患者总的病毒感染率为83.3% ,EBV DNA阳性率为 5 0 .0 % ,正常对照组EBV DNA阳性率为 3.8% ;MM患者HHV 6DNA阳性率为33.3% ,正常对照组HHV 6DNA为 0。MM患者EBV、HHV 6感染与正常对照组差异有极显著性意义 (P <0 .0 1)。结论 :黑龙江地区一些MM患者存在EBV、HHV 6感染 ,但两种病毒致病的确切机制尚不清楚。 相似文献
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许多研究表明Epstein-Barr病毒(EBV)感染与鼻咽癌、Burkitt淋巴瘤等恶性肿瘤的发生密切相关,而且新近发现EB病毒与唾液腺的肿瘤、胃癌也有关系。我们应用双温循环多聚酶链反应(PCR)和斑点杂交(Dot Blot)技术,对胃癌和邻近癌旁组织及胃良仕疾病的活检标本中的EB病毒进行检测和比较,以探讨EB病毒与胃癌发生的关系。 相似文献
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目的探讨成人EB病毒性肝炎的临床特征、治疗及预后。方法 23例患者采用更昔洛韦粉针250 mg加入5%葡萄糖100 ml静脉滴注,每12 h静脉滴注1次,每次静脉滴注时间1 h,连用7~10 d。同时采用舒肝宁、异甘草酸镁等药物常规护肝、降酶等综合治疗。结果患者治疗后显效17例(73.9%),有效6例(26.1%),总有效率100%。结论采用更昔洛韦抗病毒,舒肝宁、异甘草酸镁等药物常规护肝、降酶等综合治疗EB病毒性肝炎有较好的疗效。 相似文献
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聚合酶链反应方法检测EB病毒在鉴别韦格纳肉芽肿病和鼻T/NK细胞淋巴瘤中的应用 总被引:3,自引:0,他引:3
目的:探讨通过聚合酶链反应(PCR)方法检测上呼吸道病变组织中的EB病毒(EBV)感染情况在韦格纳肉芽肿病(WG)和鼻T/NK细胞淋巴瘤鉴别诊断中的价值。方法:提取11例WG、16例鼻T/NK细胞淋巴瘤和15例慢性鼻窦炎或鼻腔息肉患者的上呼吸道病变活检组织石蜡包埋标本的DNA,应用PCR方法检测其中是否存在EBV—DNA。结果:各组的EBV—DNA阳性率分别为:WG组10.0%,鼻T/NK细胞淋巴瘤组60.0%,慢性鼻窦炎或鼻腔息肉组9.1%。WG组和鼻T/NK细胞淋巴瘤组的阳性率比较差异具有统计学意义(P=0.018)。结论:WG与EBV感染无关,检测上呼吸道病变组织的EBV—DNA有助于鉴别诊断WG和鼻T/NK细胞淋巴瘤。 相似文献
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目的探讨低分子肝素抗凝治疗对老年重症肺炎预后的影响。方法选取2018年1月至2019年1月入住北京世纪坛医院呼吸与危重症医学科重症监护病房(RICU)的年龄≥65岁的重症肺炎患者100例,利用随机数字表分为两组,对照组给予常规治疗,试验组在常规治疗基础上加用低分子肝素4000 U皮下注射,每日1次,治疗14 d。分别于治疗前及治疗第3、7、14天比较两组患者急性生理和慢性健康状况评分系统Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)评分、血气分析、凝血指标、D二聚体、血常规、C反应蛋白、降钙素原,以及28天死亡率、出血率、深静脉血栓形成率。结果治疗前,两组患者的基本资料和APACHEⅡ评分差异无统计学差异(P>0.05)。治疗第3天,两组患者的APACHEⅡ评分、D二聚体、白细胞、中性粒细胞百分比和C反应蛋白水平无显著差异。治疗第7天、14天,试验组的上述指标显著低于对照组(P<0.05)。血气分析显示,仅在治疗第14天,试验组乳酸水平显著低于对照组(P<0.05)。治疗期间,两组患者凝血指标和降钙素原差异均无统计学意义(P>0.05)。试验组的28天平均死亡率为8%,显著低于对照组(24%,P<0.05)。两组患者出血发生率无显著差异(P>0.05)。试验组深静脉血栓形成率显著低于对照组(P<0.05)。结论临床上对老年重症肺炎患者应用低分子肝素辅助治疗,可减少APACHEⅡ评分,降低28天死亡率,减少医院内深静脉血栓的发生。 相似文献
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Savolainen-Kopra C Blomqvist S Kaijalainen S Jounio U Juvonen R Peitso A Saukkoriipi A Vainio O Hovi T Roivainen M 《Viruses》2009,1(3):1178-1189
Human rhinoviruses (HRV) are known to cause common cold as well as more complicated respiratory infections. HRV species -A, -B and -C have all been associated with lower respiratory infections and exacerbations of asthma. However, the type distribution of strains connected to different kinds of lower respiratory conditions is not clearly known. We have analysed the presence of HRV in sputum specimens derived from military recruits with and without pre-diagnosed asthma at times of acute respiratory infection (CIAS Study, 2004-2005). The analysis was performed with HRV and HEV real-time RT-PCR assays. Subsequently we studied type distribution of HRV strains by genetic typing in the VP4/VP2 genomic region. In total 146 (38.8%) specimens were HRV-positive and 36 (9.3%) HEV-positive. No difference was found in HRV detection between the asthmatic vs. non-asthmatic patients. Most of the genetically typed strains, 18 (62.1%), belonged to HRV-A, while HRV-B strains constituted five (17.2%) of the HRV-positive strains. HRV-C strain was typed four times from the HRV-positive cases and a HEV-D strain twice. We further typed six HEV positive strains in the partial VP1 region. Three of these belonged to HRV-A and three to HEV-D. HRV-A strains were discovered throughout the study period, while HRV-C strains originated from winter and spring specimens. Interestingly, four out of five typed HRV-B strains originated from the summer season specimens. 相似文献
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Acute fibrinous and organizing pneumonia (AFOP) is a disease of the small airways that is characterized by deposition of fibrin within the alveolar spaces. The histological pattern is described as a variant of cryptogenic organizing pneumonia (COP). Although COP has been occasionally described in patients with HIV infection, the variant form, AFOP, has not been previously reported in such patients. This report describes an intriguing case of AFOP in a patient with HIV infection and Pneumocystis jiroveci pneumonia. AFOP was diagnosed after tapering of corticosteroid therapy. This case illustrates that non-infectious pulmonary infiltrates should be considered in the differential diagnosis of lung disease in patients with HIV infection. 相似文献
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目的探讨人免疫球蛋白联合酚妥拉明治疗小儿重症肺炎的临床疗效。方法选择我院收治的重症肺炎患儿120例,将其分为观察组67例和对照组53例,对照组给予常规对症治疗,观察组在对照组基础上给予酚妥拉明以及人免疫球蛋白。结果观察组总有效率为95.52%显著高于对照组83.02%(P0.05);观察组患儿气促消失时间、咳嗽消失时间、肺部啰音消失时间以及住院时间均显著短于对照组(P0.05);治疗后,观察组Ig G水平较治疗前显著升高(P0.05),且显著高于对照组(P0.05);两组治疗期间均无明显不良反应。结论人免疫球蛋白联合酚妥拉明治疗小儿重症肺炎其临床疗效显著。 相似文献
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目的 探讨分析重度烧伤合并气道损伤患者,发生重症肺炎时耶氏肺孢子虫感染的临床特点,总结诊断经验,减少误诊和漏诊.方法 回顾分析近2年因合并重症肺炎收入我院ICU的12例重度烧伤患者的诊治及转归情况,入住ICU的第1天和第7天分别送检BALF的细菌及真菌培养.结果 转入ICU的12例患者中有4例患者BALF涂片中耶氏肺孢子虫阳性,经BALF发现还合并有鲍曼不动杆菌的有3例,肺孢子菌4例,白色念珠菌4例,铜绿假单胞菌3例,病原学检出率高.结论 重度烧伤合并气道损伤患者在治疗过程中极易出现各种院内二重机会性感染,例如肺孢子虫肺炎;经BALF检查可以提高病原菌检出率,应注重对此类重症患者肺部感染病原学的早期筛查及治疗. 相似文献
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亚胺培南西司他丁治疗重症肺炎患者的观察 总被引:2,自引:2,他引:2
目的评价亚胺培南西司他丁治疗重症肺炎患者的临床疗效及安全性。方法以42例重症肺炎患者为研究对象,给予亚胺培南西司他丁0.5或1 g,q8 h静滴,观察重症肺炎患者的临床和不良反应。结果应用亚胺培南西司他丁治疗重症肺炎患者的疗效明显胜于治疗前;痰液病原体的清除率为87.5%;胸部CT肺部炎性渗出病灶较前明显吸收;34例存活的重症肺炎患者未见不良反应。结论亚胺培南西司他丁对重症肺炎患者有良好的治疗效果。 相似文献
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目的分析研究纤维支气管镜技术在ICU重症肺炎患者中的临床应用。方法选择我院ICU收治的120例重症肺炎患者为研究对象,将其随机分成治疗组和对照组各60例,治疗组采用纤支镜治疗,对照组采用常规的抗感染和机械通气等支持治疗,比较两组患者的疗效。结果治疗组与对照组的总有效率分别为86.67%和66.67%,两组之间具有显著差异,P0.05。结论使用纤支镜对患者进行吸痰以及灌洗治疗,可有效改善重症肺炎症状,并缩短患者的住院时间,安全性好,值得在临床推广应用。 相似文献
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目的:探讨降钙素原(Procalcitonin,PCT)及C反应蛋白水平(C-reactionprotein,CRP)在重症肺炎患者预后判断及转归中的作用 方法:2012年2月-2014年12月,回顾性分析我科收治重症肺炎患者65例,按照预后情况分为死亡组和存活组,对比分析两组间的临床一般特征、入院治疗前、48h、72h、出院前或死亡前PCT、CRP水平及APACHEⅡ评分 结果:两组患者PCT、CRP水平均较正常值明显升高,其中死亡组PCT 、CRP水平较存活组明显提高(P<0.01)。通过连续监测PCT、CRP水平发现抗生素使用有效时PCT水平明显降低,而CRP水平下降速度较PCT明显降低。血清 PCT 水平与APACHEⅡ评分的相关系数为 0.689,其相关性均高于CRP。PCT、CRP水平的升高与患者死亡具有相关性,OR值( 95% CI)分别为 2.9 (1.2- 7.8 )、7.4( 3.5 ~ 18.7) (P=0.003,0.001 )。结论:PCT、CRP水平在重症肺炎患者预后判断及转归中具有较好的作用,其中PCT水平监测效果优于CRP水平。 相似文献
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Dzekedzeke K Siziya S Fylkesnes K 《Tropical medicine & international health : TM & IH》2008,13(2):152-161
Objective To examine the contribution of human immunodeficiency virus (HIV) to adult death rates between 1995/1996 and 1998/1999 in some urban and rural populations in Zambia.
Method A cohort of 2592 out of 3013 adults aged 15–49 years enrolled in a baseline survey in 1995/1996 in areas of Chelston Township (HIV prevalence 26.2%) and Kapiri Mposhi district (HIV prevalence 15.6%) were followed up in 1998/1999. Person years of observation (PYO) were calculated for those known to have been alive, dead and migrated between the surveys. Fixed covariates Cox proportional hazard models were fitted to assess survival prospects.
Results Death rates per 1000 PYO in the rural cohort were 38.1 among those with HIV, 4.8 among those without HIV and 9.8 for all; the population attributable fraction of deaths among those with HIV was 52.3%. Respective estimates in the urban cohort were 53.8, 4.6, 17.2 and 73.6%. The hazard rate (HR) ratio of death for persons infected with HIV was 8.7 times [HR 8.65; 95% confidence interval (CI) 5.28–14.15] higher than for the uninfected after adjusting for age, area of residence, marital status, self-rated health and years spent on education. HR among those who rated their health good/excellent was 40% less, i.e. HR 0.60 (95% CI: 0.40–0.91) than those who rated it to be poor/fair.
Conclusions HIV infection was the most important factor accounting for adult deaths in the communities. 相似文献
Method A cohort of 2592 out of 3013 adults aged 15–49 years enrolled in a baseline survey in 1995/1996 in areas of Chelston Township (HIV prevalence 26.2%) and Kapiri Mposhi district (HIV prevalence 15.6%) were followed up in 1998/1999. Person years of observation (PYO) were calculated for those known to have been alive, dead and migrated between the surveys. Fixed covariates Cox proportional hazard models were fitted to assess survival prospects.
Results Death rates per 1000 PYO in the rural cohort were 38.1 among those with HIV, 4.8 among those without HIV and 9.8 for all; the population attributable fraction of deaths among those with HIV was 52.3%. Respective estimates in the urban cohort were 53.8, 4.6, 17.2 and 73.6%. The hazard rate (HR) ratio of death for persons infected with HIV was 8.7 times [HR 8.65; 95% confidence interval (CI) 5.28–14.15] higher than for the uninfected after adjusting for age, area of residence, marital status, self-rated health and years spent on education. HR among those who rated their health good/excellent was 40% less, i.e. HR 0.60 (95% CI: 0.40–0.91) than those who rated it to be poor/fair.
Conclusions HIV infection was the most important factor accounting for adult deaths in the communities. 相似文献