急性低频感音神经性耳聋的临床观察

目的探讨急性低频感音神经性耳聋(acute low-tone sensorineural hearing loss,ALHL)的临床特点和疗效,提高对该疾病的诊断和认识。方法回顾性分析62例ALHL患者的临床表现、听力学检查和治疗情况,总结其临床发展规律。结果发病年龄以青中年为主,女性明显多于男性,多为单耳发病,表现为耳闷或伴耳鸣,听力下降,不伴眩晕,所有患者纯音听阈均表现为轻中度低频感音神经性耳聋,治疗前后分别为(38.71±6.82)dB和(20.56±9.44)dB,两者比较差异具有统计学意义(P<0.05)。鼓室图"A"型,49例(80.9%)镫骨肌反射引出,40例(64.5%)Metz试验阳性,62例ABR均正常。62例患者治疗前DPOAE在0.5～1 kHz的引出率仅为18.7%,反应幅值明显降低,治疗后DPOAE在0.5～1 kHz的引出率提高至43.8%,幅值亦有所提高。结论 ALHL以突发的耳闷和(或)伴耳鸣为主要表现,常单耳发病,青中年女性为主,听力学定位诊断为蜗性聋,仅累及低频区,皮质类固醇激素治疗有较好的疗效。     

60例急性低频感音神经性聋临床疗效分析

目的 探讨急性低频下降型感音神经性听力损失(ALHL)的良好治疗方法.方法 60例急性低频下降型感音神经性耳聋患者,随机分为两组,即对照组和地塞米松组,各30例.对照组患者均给予金钠多注射液等常规治疗10天,地塞米松组患者在对照组用药的基础上加用地塞米松,同样治疗10天,观察两组患者的临床疗效.结果 对照组和地塞米松组治疗后低频平均听阈均有显著改善(均P<0.05),而高频平均听阈治疗前后均明显变化(P>0.05),地塞米松组治疗后高频平均听阈优于对照组(P<0.05).地塞米松组总有效率高于对照组(P<0.05).结论 地塞米松联合金钠多治疗急性低频感音神经性聋临床疗效良好,建议临床推广.     

急性低频感音神经性聋的临床研究

目的探讨急性低频感音神经性聋（acute low-frequency sensorineural hearing loss,ALHL）的临床特征和疗效,提高对该疾病的认识和鉴别能力。方法回顾性分析42例（42耳）ALHL的临床表现、听力学检测结果和2～5年的随访情况,总结ALHL的临床发病特征。结果本组42例（42耳）ALHL呈急性发病,年龄27～44岁。男16例（38.10%）,女26例（61.90%）。20例（20耳）伴低调耳鸣,17例（17耳）伴耳部堵闷,11例（11耳）伴听觉过敏现象,6例（6耳）伴有头昏。0.125～1kHz平均听阈为（38.74&#177;4.62）dBHL,2～8kHz平均听阈为（13.52&#177;3.86）dBHL,治疗后上述平均听阈分别为（21.05&#177;9.74）dBHL和（19.85&#177;9.44）dBHL。所有病人的听性脑干反应（auditory brainstem response,ABR）各波潜伏期及波间期正常。畸变产物耳声发射（distortion product otoacoustic emissions,DPOAE）在低频区引出率为16.67%,高频区引出率为85.71%。结论ALHL以单侧发病为主,常伴低调耳鸣、耳部堵闷及胀满感。该病多见于青年女性。纯音听阈以低频听阈升高为特征,ABR正常。病变可能位于耳蜗顶周。     

类固醇治疗急性低频性感音神经性聋的短期疗效和预后

不伴眩晕的急性低频性感音神经性聋 (acute low-tone sensorineural hearing loss,ALHL)属梅尼埃病听力障碍的典型类别 ,起因于内耳内淋巴积水 ,与免疫反应有关。本文应用类固醇治疗 4 0例 AL HL患者 ,以观察其结果和预后。患者入选标准 :1突发性感音神经性聋 ,鼓膜正常 ;2纯音测听 12 5、2 5 0和 5 0 0 Hz等三个低频率点的听力损失总和≥ 10 0 d B,而在 2、4和8k Hz等三个高频率点的听力损失总和≤ 6 0 d B;3患者无眩晕、自发性眼震及其它致聋病因。听力测试方法 :自患者就诊日开始连续进行纯音测听。所选 4 0例中 ,男 8例 ,女 32例 ,…     

甘露醇治疗急性低频感音神经性聋临床观察

目的观察甘露醇对急性低频性感音神经性聋(acute low-tone sensorineural hearingloss,ALHL)的治疗效果。方法随机将60例(68耳)ALHL患者分为甘露醇组30例(35耳)和对照组30例(33耳),对照组应用常规治疗,甘露醇组除常规治疗外加用甘露醇。结果经过1~2个疗程治疗,对照组33耳治愈3耳,显效11耳,有效12耳,无效7耳,总有效率78.79%;甘露醇组35耳治愈8耳,显效13耳,有效13耳,无效1耳,总有效率97.14%,两组间差异有显著统计学意义(P<0.05)。结论ALHL除常规治疗外,加用甘露醇疗效更显著。     

急性低频感音神经性听力损失临床分析

目的探讨急性低频感音神经性听力损失(acute low-frequency sensorineural hearing loss,ALHL)的发病特点、听力学特征及治疗方法。方法回顾性分析47例ALHL患者的临床症状、体征、听力学检查及随访结果。结果 47例ALHL患者平均发病年龄为36.91±10.18岁,女性24例(51.06%),男性23例(48.94%)。单耳发病43例(91.49%,43/47),31例(65.96%)患者伴耳鸣,10例(21.28%)伴耳闷。全部患者纯音听阈均表现为低频听力下降,鼓室导抗图均为A型,ABR均正常。经脱水剂或利尿剂及类固醇激素等治疗后总有效率为85.11%(40/47),1例自愈。随访4～25个月,37例无复发(90.24%,37/41),4例复发(9.76%,4/41)。结论 ALHL一般单耳发病,中青年居多,伴随症状以耳鸣最为常见,其次是耳闷;听力学检测主要提示耳蜗受累;脱水剂或利尿剂及类固醇激素疗效显著;该病有复发的可能,应加强随访。     

急性低频感音神经性聋的临床分析

目的:评估急性低频感音神经性聋的临床疗效以及相关因素对预后的影响.方法:从398例突发性聋患者中筛选出41例急性低频听力下降者,分析经糖皮质激素等综合治疗后的效果,探讨患者的性别、病程和发病年龄与疗效的相关性.结果:急性低频感音神经性聋占突发性聋的10.30%,其中女性患者占70.73%,明显高于男性.初诊时3个低频和...     

急性低频感音神经性聋76例临床分析

目的探讨急性低频感音神经性聋(acute low-frequeacy hearing loss,ALHL)的临床特点及疗效。方法回顾性分析76例急性低频感音神经性聋患者的临床特征、听功能检查情况及以皮质类固醇激素、扩血管药物、神经营养药及高压氧治疗的疗效。结果 76例患者均以耳闷为主要症状,纯音听力曲线表现为低频下降型,中高频正常,单耳多发,女性多见,不伴眩晕且预后良好;治疗前后平均听阈值(125、250、500Hz)分别为30.5和14.7dB HL,治疗后较治疗前下降15.8dB;治愈率87.50%(70/80),有效率95.00%(76/80),仅2例(4耳)无效。结论 ALHL患者主要表现为耳闷,纯音听阈曲线为低频下降型,皮质类固醇激素及扩血管药物、神经营养药治疗有效。     

急性低频感音神经性聋

急性低顿感音神经性聋是临床一种常见疾病,临床特点、诊断标准、病因及发病机制、治疗方案有其特点.该病近年来逐渐引起国内外学者重视,本文综述了该病近年来的国内外研究进展.     

单侧低频感音神经性聋：附40例分析

文中对40例单侧低频感音神经性聋患者进行分析,发现患者主诉中有耳鸣的最多(87.5%)、耳聋次(75%)、眩晕和耳闷者各为35%及25%.纯音测听均为低频感音神经性聋,其低频与高频听阈均值之差为26.32 dB.40例中36例听性脑干反应正常.并讨论了产生低频感音神经性聋可能的原因,耳鸣、低频听力损害与内淋巴积水的关系,并提出对低频感音神经性自应有统一的划定标准.     

An electrocochleographic study of acute low-tone sensorineural hearing loss

Summary Twenty-four patients with acute low-tone sensorineural hearing loss (ALHL) were examined using electrocochleography. The negative summating potential (SP) amplitude and the summating potential/action potential (AP) ratio were significantly greater in the ALHL patients than in normals. The SP/AP ratio was smaller in the ALHL patients than in patients with known Meniere's disease and moderate hearing loss, although the SP amplitude was somewhat greater in the former. An abnormal increase in the SP amplitude following click stimuli was found in 54% of the ALHL patients, while the SP/AP ratio was increased abnormally in 63% of these patients. These findings suggest that the pathophysiology of ALHL may be similar to that for endolymphatic hydrops.     

急性低频感音神经性听力损失的听力学检查特征及意义

目的明确各项听力学检查在急性低频感音神经性听力损失诊断及研究中的意义,以指导该病的诊断和治疗。方法对2008年7月至2010年5月在本科就诊的急性低频感音神经性听力损失患者的临床听力学检查进行了回顾性分析。结果在所有15例患者中有9人(60.0%)有明显诱发因素。在随访期间,有8例(53.3%)出现复发。男女两性无诱发因素和复发率差异。8例患者进行了耳蜗电图的检查,有5例(62.5%)-SP/AP(总合电位/动作电位)检查异常。结论纯音测听、耳蜗电图、DPOAE(畸变产物耳声发射)、ABR(听性脑干电位)在急性低频感音神经性听力损失诊断及研究中意义较大。其发病很可能与生活压力事件相关,病因可能是膜迷路积水、自身免疫性机制和自主神经功能紊乱等因素的综合作用。     

Epidemiological survey of acute low-tone sensorineural hearing loss

Abstract

Objectives: A nationwide epidemiological survey involving 23 hospitals in Japan was conducted and the predictive values of demographic data were examined statistically.

Methods: A total of 642 patients from 23 hospitals, including 20 university hospitals, in Japan were enrolled in the study. Age ranged from 8 to 87 years, and all were diagnosed with acute low-tone sensorineural hearing loss (ALHL) between 1994 and 2016. Demographic data for the patients, such as symptoms, gender, mean age, and distribution of ALHL grading, were collected and analyzed in relation to prognosis using Student’s t-test, χ² test and logistic regression.

Results: Female gender (p?<?.013), younger age (p?<?.001), low-grade hearing loss (p?<?.001), and shorter interval between onset and initial visit (p?<?.004) were significantly predictive of a good prognosis. The prognosis for definite ALHL was significantly better than that for probable ALHL (p?<?.007).

Conclusions: The severity of initial hearing loss, interval between onset and initial visit and age were important prognostic indicators for ALHL, while female gender was an important prognostic indicator peculiar to ALHL.     

Sudden sensorineural hearing loss after heroin injection

Sudden sensorineural hearing loss is a symptom of cochlear injury. Potential aetiologies are vascular diseases, viral infections, allergic reactions, autoimmune disorders, and traumatic rupture of the intralabyrinthe membrane. Unlike in unilateral cases bilateral sensorineural hearing loss is often associated with specific disease entities. We report a case of sudden bilateral deafness after intravenous heroin abuse. The putative pathophysiological mechanisms are discussed.     

聪耳熄鸣丸治疗感音神经性耳聋、耳鸣的疗效观察

目的 研究聪耳熄鸣丸治疗感音神经耳聋、耳鸣的临床疗效。方法 随机选取来我院就治的感音神经性聋、伴耳鸣病人120例,分治疗组和对照组进行对比。结果 治疗组和对照组对耳鸣的疗效,分别为68％和40％;治疗组和对照组对耳聋的疗效分别为68％和50％,有显著性差异。结论 聪耳熄鸣丸是治疗感音神经性耳聋,耳鸣的有效药物。     

Idiopathic sudden sensorineural hearing loss and acute low-tone sensorineural hearing loss: a comparison of the results of a nationwide epidemiological survey in Japan

Abstract

Objectives: The aim of this study was to investigate the differences between idiopathic sudden sensorineural hearing loss (SSNHL), and acute low-tone sensorineural hearing loss (ALHL) using the results of a nationwide survey database in Japan and to analyze the variables associated with their clinical features and the severity of hearing impairment, treatment, and prognosis.

Methods: Participants were patients registered between April 2014 and March 2016 in a multicenter epidemiological survey database involving 30 university hospitals and medical centers across Japan. Statistical analysis was performed to clarify the factors associated with their clinical characteristics and the severity of hearing impairment, treatment, and prognosis.

Results: Idiopathic SSNHL and ALHL differed significantly in terms of male-to-female ratio, age distribution, and time from onset to start of treatment. The treatment methods and hearing prognosis also differed markedly between the two diseases. A majority (92%) of idiopathic SSNHL patients were administered some type of corticosteroid, while half of the ALHL patients received corticosteroids and a diuretic agent.

Conclusion: The results suggested that idiopathic SSNHL and ALHL belonged to different categories of inner ear disease.     

急性低频下降型感音神经性听力损失的临床研究

目的：研究急性低频下降型感音神经性听力损失（ALHL）的病因、诊断和治疗方法。方法：选择55例ALHL患者为研究对象,经详细询问病史和耳专科检查后,行纯音测听,声导抗测听和听性脑干反应（ABR）,随机分为泼尼松组和对照组治疗,疗程结束后随访6个月。结果：两组患者多以青年为主,主要症状为耳闷,低音调耳鸣和听力减退,耳科检查无殊。所有患者（55例58耳）纯音听阈示轻到中度低频感音神经性聋,鼓室导抗图“A”型,49耳镫骨肌反射引出,其中40耳Metz试验阳性。受检的45耳中ABR均正常。治疗后泼尼松组效果优于对照组（P〈O．05）。结论：ALHL以突发的低音调耳鸣,听力减退和耳闷为主要表现,常单耳发病,听力学定位诊断提示为蜗性病变,仅累及低频区。本病对皮质类固醇激素有一定的治疗效果。