骨髓血窦结构与实质细胞的关系

本文对6.25戈瑞全身照射后大鼠的骨髓有核细胞,外周血白细胞总数和股骨骨髓组织形态学进行了平行观察。结果表明,实质细胞的损伤和恢复与骨髓血窦结构的破坏和修复有密切的依赖关系,照后3天,血窦结构严重破坏,骨髓有核细胞和外周血白细胞数亦降到最低值。照后7天,大部分血窦结构已修复,髓腔内出现了再生的造血细胞灶,骨髓有核细胞和外周血白细胞数也开始回升。骨髓血窦修复较再生的造血细胞灶的出现早4天,骨髓有核细胞和外周血白细胞数恢复到照前水平分别在血窦完全修复后7和14天。骨髓血窦结构的破坏和修复是加重实质细胞的损伤和促进其恢复的重要因素之一。     

溴丁基东莨菪碱对骨髓损伤影响的电镜观察

用⁶⁰Coγ线一次全身照射l0Gy。造成骨髓严重损伤。于照射后邵捌,6、24、72小对腹腔注射溴丁基东蓖菪碱5mg／kg体重,进行治疗,对照动物和治疗动物骨髓的电镜观察结果证明。溴丁基东茛菪碱治疗可以减轻血窦壁的退变、断裂,破坏,促进血窦损伤的修复’早期降低网状吞噬细胞吞噬活动,减少出血,减少纤维,基质的退变,破坏’造血细胞周围基地比较。清洁”,促进造血细胞的再生,     

糖化血红蛋白与糖尿病视网膜病变的关系

目的探讨老年Ⅱ型糖尿病患者糖化血红蛋白（HbA1c）、空腹血糖（FBG）、餐后2小时血糖（PBG2h）与视网膜病变的关系。方法对158例Ⅱ型糖尿病患者进行HbA1c、FBG及PBG2h检测并作眼底检查。其中糖尿病正常眼底（NDR）组83例,其中男性45例,女性38例;糖尿病视网膜病变（DR）组75例,男性35例,女性40例;年龄60-78岁,平均（69±9）岁。结果DR组HbA1c、FBG、PBG2h值明显高于NDR组（P〈0.01）,而两组间性别、年龄差异无统计学意义（P〉0.05）。结论HbA1c、可作为糖尿病患者发现DR的指标,与FBG、PBG2h三者结合考虑更有助于DR的发现。     

介入法岩下窦静脉取血的插管体会

采用介入法岩下窦静脉取血测促肾上腺皮质激素(ACTH),是区分垂体来源或异位来源的库兴综合症(Cushing综合征)最可靠的检查手段,其诊断的阳性率明显高于垂体影像学检查,为指导手术治疗提供重要的依据,是一项值得推广的技术。但由于该检测有创,价格昂贵及技术复杂,国内医院开展较少。我院介入放射科自2003年已采用该技术     

颈内动脉硬脑膜支供血的自发性颈动脉海绵窦瘘长期随访研究

颈动脉海绵窦瘘(CCF)可自发产生或外伤引起,按解剖结构不同可细分为A、B、C、D共4型,A型为海绵窦(CS)和颈内动脉(ICA)直接形成瘘,B型为CS和ICA硬膜支形成瘘,C型为CS和颈外动脉(ECA)的硬膜支形成瘘,D型为CS和ICA、ECA硬膜支均形成瘘。大部分B、C、D型CCF为自发性,自发性CCF多为良性稳定性病变,除非有皮层静脉引流,很少引起颅内出血或非出血性神经缺陷。D型     

超声检查在胎盘血窦中的诊断效果及与围生儿结局的相关性

目的 探讨超声检查在胎盘血窦中的诊断效果及与围生儿结局的关系。方法 选取我院于28周以后分娩的孕妇9451例,行超声检查,并以临床胎盘病理结果作为“金标准”,分析超声检查在胎盘血窦中的效果并计算诊断效能。根据病理结果将孕妇分为血窦组和对照组,对两组孕妇进行随访(随访到胎儿娩出截止),比较两组围生儿结局;采用Pearson相关性分析软件对孕妇胎盘血窦发生率与围生儿结局进行相关性分析。结果 9451例孕妇经病理检查确诊胎盘血窦28例,确诊率为0.30%。超声检查最终确诊25例,检查准确率为89.29%(25/28)(P> 0.05),诊断灵敏度为82.14%(23/28)、特异度为99.98%(9421/9423);血窦组剖宫产率、产前出血率、新生儿窒息率、胎儿宫内生长受限率高于对照组(P <0.05); Pearson相关性分析结果表明:胎盘超声诊断胎盘血窦检出率与剖宫产率、产前出血率、新生儿窒息率、胎儿宫内生长受限率呈正相关性(P <0.05)。结论 超声检查用于胎盘血窦中检出率及诊断灵敏度、特异度较高,且与围生儿结局存在强相关性,加强孕妇超声检查,能改善胎盘血窦孕妇...     

高原地区红细胞增多人群血红蛋白与HbA1c关系的初步研究

目的：探讨高原地区红细胞增多人群血红蛋白（HGB）与糖化血红蛋白（HbAlc）的关系。方法：观察组57例，对照组14例，同时静脉抽血测定血红蛋白（HGB），糖化血红蛋白（HbAlc）；按血红蛋白含量分组，研究血红蛋白（HGB）与糖化血红蛋白（HbAlc）关系。结果：高原地区红细胞增多人群的糖化血红蛋白（HbAlc）随血红蛋白（HGB）含量升高而升高（P〈0．01）。结论：高原地区红细胞增多人群的血红蛋白（HGB）与糖化血红蛋白（HbAlc）有显著的相关性。     

高原地区红细胞增多人群血红蛋白与HbA1c关系的初步研究

目的:探讨高原地区红细胞增多人群血红蛋白(HGB)与糖化血红蛋白(HbA1c)的关系。方法:观察组57例,对照组14例,同时静脉抽血测定血红蛋白(HGB),糖化血红蛋白(HbA1c);按血红蛋白含量分组,研究血红蛋白(HGB)与糖化血红蛋白(HbA1c)关系。结果:高原地区红细胞增多人群的糖化血红蛋白(HbA1c)随血红蛋白(HGB)含量升高而升高(P<0.01)。结论:高原地区红细胞增多人群的血红蛋白(HGB)与糖化血红蛋白(HbA1c)有显著的相关性。     

健康成人骨盆骨髓扩散加权成像性别、年龄间差异及相关性研究

目的 探讨健康成人骨盆骨髓扩散加权成像(DWI)性别、年龄间差异及相关性.方法 回顾性分析230名健康成人骨盆DWI检查资料.将骨盆骨髓扩散信号分为3大型并测量ADC值,分析骨盆骨髓扩散分型及ADC值年龄、性别间差异及相关性.结果 男性30岁前后、女性50岁前后骨盆扩散分型变化明显,20 ～ 50岁间男女骨盆扩散分型差异明显,50岁以后差异不显著.20～50岁间,女性髂骨、坐骨ADC值高于男性,50岁以后女性耻骨ADC值高于男性,且骨盆扩散信号、ADC值与年龄存在一定负相关.结论 骨盆DWI可用来反映骨髓年龄、性别间差异.     

多发性骨髓瘤MRI表现与骨髓瘤细胞比值关系研究

目的　探讨多发性骨髓瘤(multiplemyeloma, MM)MRI表现与骨髓瘤细胞比值的关系。方法　对经骨髓涂片或活检确诊的 15例MM病人的脊柱MRI表现分型,分析各型与骨髓瘤细胞所占百分比、血红蛋白值的关系。结果　局灶型病变 7例,弥漫型 4例,“盐和胡椒面”型 4例。MRI表现分型不同,骨髓瘤细胞所占百分比值之间存在显著性差异 (Ρ=0. 008);血红蛋白值之间亦存在显著性差异(Ρ= 0. 03)。MM的脊柱弥漫型侵犯与高的骨髓瘤细胞比值及低的血红蛋白值相关。结论　脊柱MRI可反映MM的骨髓受累情况,其MRI表现与骨髓瘤细胞所占百分比值、血红蛋白值之间存在相关性。     

尾悬吊大鼠骨和骨髓中骨钙素的变化

目的研究模拟失重骨质和骨髓内骨钙素 (OC)以及骨和软骨钙盐代谢的形态学变化。方法选用2 0只SD大鼠 ,随机配对分为 1 4d和 2 8d尾悬吊组及相应的 2个自由活动组 ,每组 5只。组织标本行原位杂交及三色染色。结果尾吊组大鼠骨质和骨髓内OC的表达明显弱于对照组 (P <0 .0 5 ) ;尾吊组1 4dOC的表达明显强于 2 8d(P <0 .0 5 )。模拟失重导致股骨和软骨基质钙化障碍 ,原有钙化基质内钙盐脱钙明显 ,2 8d脱钙明显加重。结论大鼠后肢去负荷导致骨和骨髓OC含量的降低 ,骨和软骨钙盐代谢障碍 ,去负荷时间越长越显著     

Transplantation of Chimeric Bone Marrow

Retransplantation of bone marrow was studied in an attempt to understand why foetal liver was superior to adult bone marrow in the treatment of lethally-irradiated mice.

Presensitization experiments, in which recipients were immunized against cells of the future donor-strain, were performed. In this system foetal-liver-chimeric spleen-cells were as effective antigenically as those taken from adult-bone-marrow chimeras.

Foetal-liver-chimeric bone-marrow, used to protect irradiated mice that had been presensitized to normal homologous donor-type cells, was as ineffective as that from normal mice of comparable strain. From these results an unaltered sensitivity of the foetally-derived chimeric cells to specific isoantibodies was deduced.

The findings are discussed in relation to several postulates offered to explain the ameliorating effect of foetal liver on homologous disease in radiation chimeras. Investigations presented here test, but the results fail to support, a loss of either isoantigenicity or sensitivity to specific antibodies on the part of chimeric cells of foetal origin. The superiority of chimeric cells of foetal origin over those of adult-marrow origin in retransplantation bone-marrow experiments is consistent with a tolerant state of foetally-derived donor cells to the host strain.     

中轴骨骨髓MR成像研究

目的：分析不同年龄正常中轴骨的MR表现以探讨MRI上中轴骨骨髓转化的规律及特点。资料与方法：共搜集460例不同年龄正常中轴骨骨髓MR图像。其中颅骨156例，男，87例，女69例，年龄0－25岁；腰椎231例，男136例，女95例，年龄0－78岁；骨盆及股骨上段73例，男43例，女30例，年龄0－70岁。结果：MRI上不同年龄中轴骨骨髓信号不同，主要表现在信号强度与均匀性两方面，总体上说，随年龄增长，信号强度逐渐增高，不均匀性逐渐显著。结论：中轴骨骨髓转化以局灶不均匀转化为主,不同年龄中轴骨骨髓MRI表面不同，在进行相关疾病诊断时一定要结合患者年龄。     

Stem Cells in Bone and Bone Marrow after Contamination with Bone-seeking Radionuclides

Summary

The effects of time, mass and oxidation state on plutonium gastrointestinal absorption and tooth adsorption were studied during and after chronic ingestion of plutonium-238 (IV) or (VI) (1·55–15·60 kBq/ml) in 6·5 mm bicarbonate medium by fed rats via drinking water for 8 days to 3 months. Animals were killed during the ingestion to follow the kinetics of whole-body storage and clearance of plutonium. At 1·55 kBq/ml the amount of plutonium retained in the skeleton increased continuously during the 85 days of ingestion and reached a plateau thereafter. This plutonium retention was therefore dependent on the total mass administered but not proportional to this mass, as the fraction of administered plutonium retained decreased during the first 22 days of ingestion and then stabilized. This is reflected by the gastrointestinal transfer (f₁), which had risen to (3·80 ± 0·82) × 10^?5 on Day 3 of ingestion and then decreased to a stabilized value of (1·07 ± 0·06) × 10^?5 from Day 30 to the end of the ingestion period. In the liver, the amount of plutonium retained reached a plateau, which lasted from Day 30 to the end of ingestion. The kidneys and spleen were also found to be retention sites. By Day 3 of ingestion, for a mass ingested of 5 × 10^?7 g/kg of body mass, the maximum mean value of f₁ we found was smaller than the 10^?4 recommended by ICRP Report 30. The oxidation state had no effect on f₁. Large plutonium deposition was observed on the teeth. For both oxidation states (IV) and (VI), about 0·10% of the administered dose was deposited on the teeth after 3 days of ingestion, whatever the plutonium concentration administered. However, whereas the amount of plutonium (IV) deposited did not change throughout the ingestion period, tooth deposition of plutonium (VI) decreased.