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1.
Natalie Nanayakkara Sanjeeva Ranasinha Adelle Gadowski Stephane Heritier Jeff R. Flack Natalie Wischer Jencia Wong Sophia Zoungas 《Journal of diabetes and its complications》2018,32(3):279-290
Background
Type 2 diabetes (T2DM) is increasingly diagnosed in younger patients. The trajectory of complications in patients diagnosed at a younger or older age is not well understood. We examine the associations between age, age at diagnosis and diabetes duration and vascular complications in patients with T2DM.Methods
A cross-sectional study of pre-specified demographic and clinical data, from 3419 adults with T2DM participating in the Australian National Diabetes Audit (2015). Factors associated with diabetes complications were analysed using logistic regression.Results
Mean (± SD) current age was 62.9 ± 12.5 years, age at diagnosis was 49.4 ± 12.3 years and mean diabetes duration was 13.5 ± 9.4 years. Macrovascular complications were more prevalent in patients who were older at diabetes diagnosis whereas microvascular complications were more prevalent in patients who were younger at diabetes diagnosis. Age, age at diagnosis and diabetes duration were all independently associated with increased risk of macrovascular complications after adjustment for sex, smoking, BMI and microvascular complications (all p < 0.001). In contrast, only diabetes duration was independently associated with microvascular complications after adjustment for sex, smoking, BMI and macrovascular complications (p < 0.001).Conclusions
Age, age at diagnosis, and diabetes duration were all independently associated with macrovascular complications whereas only diabetes duration was independently associated with microvascular complications. 相似文献2.
S. Kou J.Y. Cao S. Yeo D.J. Holmes-Walker S.L. Lau J.E. Gunton 《Journal of diabetes and its complications》2018,32(2):144-149
Aim
To determine whether cardiovascular outcomes in type 2 diabetes (T2D) differ according to ethnicity, and whether ethnicity influences the effect of gender on these outcomes in Caucasians, East-Southeast-Asians, Middle-Easterners, South-Asians and Pacific-Islanders.Methods
We compared demographics, HbA1c, lipid profile, renal function markers, and prevalence of macrovascular and microvascular complications between ethnic groups. Cross-sectional data was prospectively collected from 204 consecutive patients at Westmead Hospital's T2D clinic from April–October 2015. Univariate analysis was performed using chi-squared test for categorical data, and Mann-Whitney-U or Kruskal-Wallis test for continuous data.Results
Compared to Caucasians, South-Asians were diagnosed younger, were currently younger, had lower body-mass-index (BMI) and better renal function but higher rates of non-ST-elevation myocardial infarction (STEMI, 21.7% versus 3.5%, p < 0.05). East-Southeast-Asians had lower BMI but more nephropathy than Caucasians (59% versus 39%, p < 0.05). East-Southeast-Asian males had fewer CVD than Caucasians, but this protection was absent in East-Southeast-Asian females. Middle-Easterners had more non-STEMI than Caucasians (5.3% vs 3.5%, p < 0.05). Middle-Eastern females were not at lower CVD risk than males. Caucasians had most PVD (20% versus 6%, p < 0.05).Conclusions
Ethnicity influences rates of diabetes-related complications. Female CVD protection is altered in some groups. Ethnicity should be considered in assessing CVD and complications risk. 相似文献3.
Victor W. Zhong Juhaeri Juhaeri Stephen R. Cole Christina M. Shay Penny Gordon-Larsen Evangelos Kontopantelis Elizabeth J. Mayer-Davis 《Journal of diabetes and its complications》2018,32(2):203-209
Aims
To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).Methods
Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥ 3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.Results
In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P < 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).Conclusions
HbA1C variability is a strong predictor for HH in T1D and T2D. 相似文献4.
Rula Ghandour Nahed Mikki Niveen M.E. Abu Rmeileh Lars Jerdén Margareta Norberg Jan W. Eriksson Abdullatif Husseini 《Primary Care Diabetes》2018,12(6):547-557
Background
Type 2 diabetes mellitus (T2DM) is a growing pandemic that will lead, if not managed and controlled, to frequent complications, poor quality of life, and high rates of disability and death. Little is known about T2DM complications in Palestine. The aim of this study is to estimate the prevalence of T2DM complications in Ramallah and al-Bireh governorate of Palestine.Methods
The study was conducted in eleven primary healthcare clinics offering services for persons with T2DM. Macrovascular complications were assessed using the Diabetes complication index. Microvascular complications were measured by physical examinations and laboratory tests. Questionnaires, laboratory tests, and physical examinations were used to assess socio-demographic characteristics, co-morbidities and other risk factors.Results
517 adult men and nonpregnant women participated in the study (166 men, 351 women). The response rate was 84%. Mean age and mean duration of diabetes were 58.1 and 9.4 years respectively. Prevalence of diagnosed microvascular and macrovascular complications was 67.2% and 28.6% respectively. 78.2% of the participants had poor glycemic control (HbA1c ≥ 7.0%).Conclusion
Significant proportions of persons with T2DM had macro- and microvascular complications and poor metabolic control. These findings are important for policy development and the planning of health services. 相似文献5.
You-Cheol Hwang Ji Eun Jun Won-Jung Hong Sang-Man Jin Ji Cheol Bae Kyu Yeon Hur Moon-Kyu Lee Jae Hyeon Kim 《Journal of diabetes and its complications》2018,32(1):61-66
Aims
We aimed to determine whether baseline level and change in serum albumin concentration are predictive of future development of type 2 diabetes (T2D).Methods
A total of 15,428 subjects (8764 men and 6664 women) without diabetes at baseline, aged 21–88 years (mean age of 51.0 years), were enrolled from a health screening program.Results
During the 5-year follow-up period, a total of 599 incident cases (3.9%) of T2D developed. Higher baseline serum albumin concentration was associated with increased T2D risk, independent of age, sex, or body mass index; however, this association was confounded and was not significant after further adjustment for other T2D risk factors. Compared with subjects in the lowest tertile of change in serum albumin concentration, subjects in the highest tertile showed a lower risk for T2D development, independent of risk factors for T2D and baseline serum albumin concentration [OR (95% CI), 0.30 (0.21–0.43), p for trend < 0.001].Conclusion
Higher baseline serum albumin concentration was not an independent risk factor of future T2D, whereas an increase in serum albumin concentration was independently associated with a lower diabetes risk. 相似文献6.
Georgia Davis Maya Fayfman David Reyes-Umpierrez Shahzeena Hafeez Francisco J. Pasquel Priyathama Vellanki J. Sonya Haw Limin Peng Sol Jacobs Guillermo E. Umpierrez 《Journal of diabetes and its complications》2018,32(3):305-309
Aims
To determine the frequency of increasing levels of stress hyperglycemia and its associated complications in surgery patients without a history of diabetes.Methods
We reviewed hospital outcomes in 1971 general surgery patients with documented preoperative normoglycemia [blood glucose (BG) < 140 mg/dL] who developed stress hyperglycemia (BG > 140 mg/dL or > 180 mg/dL) within 48 h after surgery between 1/1/2010 and 10/31/2015.Results
A total of 415 patients (21%) had ≥ 1 episode of BG between 140 and 180 mg/dL and 206 patients (10.5%) had BG > 180 mg/dL. The median length of hospital stay (LOS) was 9 days [interquartile range (IQR) 5,15] for BG between 140 and 180 mg/dL and 12 days (IQR 6,18) for BG > 180 mg/dL compared to normoglycemia at 6 days (IQR 4,11), both p < 0.001. Patients with BG 140–180 mg/dL had higher rates of complications with an odds ratio (OR) of 1.68 [95% confidence interval (95% CI) 1.15–2.44], and those with BG > 180 mg/dL had more complications [OR 3.46 (95% CI 2.24–5.36)] and higher mortality [OR 6.56 (95% CI 2.12–20.27)] compared to normoglycemia.Conclusion
Increasing levels of stress hyperglycemia are associated with higher rates of perioperative complications and hospital mortality in surgical patients without diabetes. 相似文献7.
J. Mortensen A.J. Clark T. Lange G.S. Andersen M. Goldberg C.H. Ramlau-Hansen J. Head M. Kivimäki I.E.H. Madsen C. Leineweber R. Lund R. Rugulies M. Zins H. Westerlund N.H. Rod 《Diabetes & metabolism》2018,44(1):38-44
Aim
To examine whether informal caregiving is associated with increased risk of type 2 diabetes (T2D), and whether job strain and social support at work modify the association.Methods
Individual participant's data were pooled from three cohort studies—the French GAZEL study, the Swedish Longitudinal Occupational Survey of Health (SLOSH) and the British Whitehall II study—a total of 21,243 study subjects. Informal caregiving was defined as unpaid care for a closely related person. Job strain was assessed using the demand-control model, and questions on co-worker and supervisor support were combined in a measure of social support at work. Incident T2D was ascertained using registry-based, clinically assessed and self-reported data.Results
A total of 1058 participants developed T2D during the up to 10 years of follow-up. Neither informal caregiving (OR: 1.09, 95% CI: 0.92–1.30) nor high job strain (OR: 1.04, 95% CI: 0.86–1.26) were associated with T2D risk, whereas low social support at work was a risk factor for T2D (OR: 1.18, 95% CI: 1.02–1.37). Also, informal caregivers who were also exposed to low social support at work were at higher risk of T2D (OR: 1.40, 95% CI: 1.08–1.82) compared with those who were not informal caregivers and had high social support at work (multiplicative test for interaction, P = 0.04; additive test for interaction, synergy index = 10).Conclusion
Informal caregiving was not independently associated with T2D risk. However, low social support at work was a risk factor, and informal caregivers with low social support at work had even higher risks of T2D. 相似文献8.
Chia-Lin Lee Wayne Huey-Herng Sheu I-Te Lee Shih-Yi Lin Wen-Miin Liang Jun-Sing Wang Yu-Fen Li 《Diabetes & metabolism》2018,44(2):121-128
Aim
To investigate the effect of changes in fasting plasma glucose (FPG) variability, as assessed by 2-year trajectories of FPG variability, on mortality risk in patients with type 2 diabetes (T2D).Methods
From 2009 to 2012, outpatients with T2D, aged > 18 years, were enrolled from a medical centre. FPG was measured every 3 months for 2 years in 3569 people. For each of the eight 3-month intervals, FPG variability and means were calculated, with variability defined as the coefficient of variation of FPG. Also, trajectories of FPG variability and means were determined separately, using group-based trajectory analysis with latent class growth models. These models were fitted using the SAS Proc Traj procedure. The primary outcome was all-cause mortality, which was followed-up to the end of 2014.Results
Five distinct trajectories of FPG variability (low, increasing, fluctuating, decreasing and high) and means (well controlled, stable control, worsening control, improving control and poor control) were established. The five trajectories of mean FPG were all associated with the same mortality risk. In contrast, in comparison to the low FPG variability trajectory, the fluctuating, decreasing and high variability trajectories all had significantly higher risks of mortality, with respective hazards ratios of 2.63 (95% CI: 1.40–4.93; P = 0.003), 2.78 (95% CI: 1.33–5.80; P = 0.007) and 4.44 (95% CI: 1.78–11.06; P = 0.001) after multivariable adjustment.Conclusion
Changes in FPG variability were independently associated with increased mortality risk in patients with T2D. 相似文献9.
Cardiovascular benefits of combined interval training and post-exercise nutrition in type 2 diabetes
Monique E. Francois Kevin J. Pistawka Frank A. Halperin Jonathan P. Little 《Journal of diabetes and its complications》2018,32(2):226-233
Aim
The purpose of this study was to examine whether the combination of high-intensity interval training (HIIT) and post-exercise protein supplementation would improve cardiovascular outcomes in individuals with T2D.Methods
In a double-blind controlled trial, fifty-three adults with T2D (free of CVD and not on exogenous insulin) were randomized to 12 weeks of cardio and resistance-based HIIT (4-10 × 1 min at 90% maximal heart rate) with post-exercise milk, milk-protein, or placebo supplementation, thrice weekly. Before and after, carotid and femoral artery intima media thickness (IMT) and femoral flow profiles were assessed using high-resolution ultrasound. Central and peripheral arterial stiffness were assessed by pulse wave velocity (PWV), and resting and maximal heart rate rates were measured.Results
After 12 weeks of HIIT femoral IMT (Pre: 0.84 ± 0.21 mm vs. Post: 0.81 ± 0.16 mm, p = 0.03), carotid-femoral PWV (Pre: 10.1 ± 3.2 m/s vs. Post: 8.6 ± 1.8 m/s, p < 0.01) and resting heart rate (Pre: 70.4 ± 10.8 bpm vs. Post: 67.8 ± 8.6 bpm, p = 0.01) were all significantly lower. There were no differences between nutrition groups (all significant main effects of time) for all outcomes.Conclusion
HIIT reduces femoral IMT, arterial stiffness and resting heart rate in individuals with T2D. The addition of post-exercise milk or protein to HIIT did not have additive effects for improving cardiovascular outcomes in the present study. Taken together, HIIT alone may be an effective means to reduce the burden of cardiovascular complications in T2D. 相似文献10.
Yanbo Li Suhang Shang Yulang Fei Chen Chen Yu Jiang Liangjun Dang Jie Liu Louyan Ma Meng Wei Qiumin Qu 《Journal of diabetes and its complications》2018,32(1):48-55
Aims
Type 2 diabetes and obesity, which are frequently comorbid, have been associated with cognitive impairment. We aim to examine the potential modulating effect between obesity and diabetes on cognitive impairment.Methods
We recruited 865 adults (aged ≥ 55 years) lived in a village of Xi'an in China from October 2014 to March 2015. All participants underwent biomedical and neuropsychological assessment. Relations of diabetes and abdominal obesity to cognitive impairment were examined in multiple regression models.Results
A total of 155 participants (17.9%) presented with the diagnosis of cognitive impairment. Diabetes or obesity alone wasn't significantly associated with cognitive impairment. Interaction analysis showed a significant interaction between abdominal obesity and diabetes on cognitive impairment. Stratified multivariate analysis revealed that the association between diabetes and cognitive impairment was positive in participants with abdominal obesity (OR 2.436, 95% CI 1.345–4.411, p = 0.003, in diabetics with high WC, and OR 2.348, 95% CI 1.373–4.014, p = 0.002, in diabetics with high WHR), but negative in those without abdominal obesity.Conclusions
Type 2 diabetes interacts with abdominal obesity to be associated with an increased risk of cognitive impairment by more than two times. 相似文献11.
Razieh Anari Reza Amani Seyed Mahmoud Latifi Masoud Veissi Hajieh Shahbazian 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2017,11(1):37-41
Aim
Obesity and diabetes are contributed to cardiovascular disease risk. The current study was performed to evaluate the association of central and general obesity and cardio-metabolic risk factors, including dyslipidemia and hypertension in T2DM patients.Methods
This was a cross-sectional study in T2DM adults. Body mass index (BMI) was used to identify general obesity and waist circumference (WC) was measured to define abdominal obesity (based on ATP III). Biochemical analyses, and anthropometric and blood pressure measurements were done for all participants.Results
Participants with central obesity showed significantly higher systolic (132.5 mmHg vs. 125.4 mmHg, p = 0.024) and diastolic blood pressures (84.9 mmHg vs. 80 mmHg, p = 0.007) than participants without obesity. Dyslipidemia was more prevalent in all participants either by BMI (98.3% vs. 97%, 95% CI: 0.18–17.53) or by WC (97.2% vs. 98%, 95% CI: 0.07–7.19). Abdominal adiposity in diabetic subjects showed significant reverse association with high level of physical activity (OR = 0.22, 95% CI: 0.06–0.85). Hypertriglyceridemia rate was increased with both central (OR = 2.11; p = 0.040) and general obesity (OR = 2.68; p = 0.021). After adjustment for energy intake and age, females had higher risk of general (OR = 4.57, 95% CI = 1.88–11.11) and central obesity (OR = 7.93, 95% CI = 3.48–18.08).Conclusions
Females were more susceptible to obesity. Hypertension was associated with both obesity measures. Dyslipidemia, except for hypertriglyceridemia, was correlated to neither abdominal nor general obesity. 相似文献12.
13.
Aims
rs5219 is in Potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) E23K gene, located at 11p15.1. Researches on the association between rs5219 gene polymorphism with type 2 diabetes mellitus (T2DM) were performed extensively, but the results remain controversial. To investigate the relationship, a meta-analysis involving 21,464 individuals was conducted.Methods
Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of this association. Publication bias was evaluated with Begg’s test. Our research includes three gene models: allelic genetic model (K-allele vs. E-allele), recessive genetic model (KK vs. EK + EE) and dominant genetic model (EE vs. EK + KK).Results
In allelic genetic model, subgroup analysis demonstrated rs5219 K-allele was relevant to T2DM risk in Caucasian (OR: 1.16, 95% CI: 1.09–1.24, P = 0.000) and East Asian (OR: 1.19, 95% CI: 1.13–1.26, P = 0.000), recessive genetic model indicated rs5219 KK genotype was related to T2DM risk in Caucasian, East Asian, South Asian, and North African (OR: 1.27, 95% CI: 1.17–1.38, P = 0.000), dominant genetic model pointed out rs5219 EE genotype was an opposite association with T2DM risk in Caucasian (OR: 0.86, 95% CI: 0.78–0.94, P = 0.001). No obvious evidence of publication bias was found.Conclusions
There was a believable evidence to verify that rs5219 variation was associated with T2DM. 相似文献14.
Nada A. Abualula Margaret F. Rodan Renee A. Milligan Kathryn H. Jacobsen 《Journal of diabetes and its complications》2018,32(1):83-88
Background
The goal of this study was to examine the self-rated health (SRH) of adolescents with type 1 diabetes (T1D).Methods
A logistic regression analysis of baseline data from adolescents in the United States included in the T1D Exchange Clinic Registry in 2010–2012 was conducted. Participants were 13–18 years old at the time of enrollment in the registry and had been diagnosed with T1D at least one year before enrollment (n = 5799).Results
Half (49.0%) of the participants were female, 46.3% were ages 16–18 years, 22.5% were non-white, 35.7% did not have private/military health insurance, and 78.8% had HbA1c levels > 7.5%, indicating poor T1D management, 20.7% reported having diabetes-related stress often or very often, and 46.4% used insulin injections or pens rather than a pump. In total, 10.3% (n = 600) of the participants rated their health as poor or fair and 59.3% (n = 3439) rated their health as very good or excellent. Participants with poor or fair SRH were more likely than those with very good or excellent SRH to be female (adjusted OR = 1.7(1.4, 2.1)), 16 to 18 years old (OR = 2.1(1.7, 2.5)), and non-white (OR = 2.7(2.2, 3.4)), to be without private or military insurance (OR = 2.4(2.1, 3.0)), to have HbA1c levels > 7.5% (OR = 3.3(2.4, 4.7)), to report having diabetes-related stress often or very often (OR = 6.1(5.1, 7.2)), and to use an injection or pen rather than a pump (OR = 2.1(1.6, 2.4)).Conclusions
Because adolescents with T1D who report lower SRH are more likely to have uncontrolled blood glucose and frequent diabetes-related stress, use of pumps and stress-reduction strategies may improve SRH among adolescents with T1D. 相似文献15.
B. Rasouli E. Ahlqvist L. Alfredsson T. Andersson P.-O. Carlsson L. Groop J.E. Löfvenborg M. Martinell A. Rosengren T. Tuomi A. Wolk S. Carlsson 《Diabetes & metabolism》2018,44(4):354-360
Aim
Coffee consumption is inversely related to risk of type 2 diabetes (T2D). In contrast, an increased risk of latent autoimmune diabetes in adults (LADA) has been reported in heavy coffee consumers, primarily in a subgroup with stronger autoimmune characteristics. Our study aimed to investigate whether coffee consumption interacts with HLA genotypes in relation to risk of LADA.Methods
This population-based study comprised incident cases of LADA (n = 484) and T2D (n = 1609), and also 885 healthy controls. Information on coffee consumption was collected by food frequency questionnaire. Odds ratios (ORs) with 95% CIs of diabetes were calculated and adjusted for age, gender, BMI, education level, smoking and alcohol intake. Potential interactions between coffee consumption and high-risk HLA genotypes were calculated by attributable proportion (AP) due to interaction.Results
Coffee intake was positively associated with LADA in carriers of high-risk HLA genotypes (OR: 1.14 per cup/day, 95% CI: 1.02–1.28), whereas no association was observed in non-carriers (OR: 1.04, 95% CI: 0.93–1.17). Subjects with both heavy coffee consumption (≥ 4 cups/day) and high-risk HLA genotypes had an OR of 5.74 (95% CI: 3.34–9.88) with an estimated AP of 0.36 (95% CI: 0.01–0.71; P = 0.04370).Conclusion
Our findings suggest that coffee consumption interacts with HLA to promote LADA. 相似文献16.
H. Kahal A. Aburima B. Spurgeon K.S. Wraith A.S. Rigby T. Sathyapalan E.S. Kilpatrick K.M. Naseem S.L. Atkin 《Diabetes & metabolism》2018,44(5):431-436
Aim
Strict glycaemic control has been associated with an increased mortality rate in subjects with type 2 diabetes (T2DM). Here we examined platelet function immediately and 24 hours following induced hypoglycaemia in people with type 2 diabetes compared to healthy age-matched controls.Methods
Hyperinsulinaemic clamps reduced blood glucose to 2.8 mmol/L (50 mg/dl) for 1 hour. Sampling at baseline; euglycaemia 5 mmol/L (90 mg/dl); hypoglycaemia; and at 24 post clamp were undertaken. Platelet function was measured by whole blood flow cytometry.Results
10 subjects with T2DM and 8 controls were recruited. Platelets from people with T2DM showed reduced sensitivity to prostacyclin (PGI2, 1 nM) following hypoglycaemia. The ability of PGI2 to inhibit platelet activation was significantly impaired at 24 hours compared to baseline in the T2DM group. Here, inhibition of fibrinogen binding was 29.5% (10.3–43.8) compared to 50.8% (36.8–61.1), (P < 0.05), while inhibition of P-selectin expression was 32% (16.1–47.6) vs. 54.4% (42.5–67.5) (P < 0.05). No significant changes in platelet function were noted in controls.Conclusion
Induced hypoglycaemia in T2DM enhances platelet hyperactivity through impaired sensitivity to prostacyclin at 24 hours. 相似文献17.
Objective
The aim of this study was to test the serum concentrations of fatty acid-binding protein 4(FABP4) in children with type 1 diabetes mellitus (T1DM) and to determine the relationship between patients with good and poor glycaemic control who were classified according to their glycated hemoglobin A1c (HbA1c) levels.Methods
Children with T1DM were selected consecutively from our department from May 2016 to May 2017. For comparison, the same non-diabetic, age, sex, BMI and pubertal stage-matched healthy children were selected consecutively among non-diabetic children. Serum levels of FABP4 were batch analyzed using a commercially available ELISA assay. Patients were categorized into two groups according to their glycaemic control (Poor glycaemic control is HbA1c > 7.0% and good is ≤7.0%).Results
In this study, 118 children with T1DM and 118 control cases were included. The mean serum FABP4 concentrations were significantly (P < .001) higher in T1DM as compared to controls. There was a modest correlation between serum concentrations of FABP4 and duration of diabetes (r = 0.484, P < .001). Fifty-two patients were defined as poor glycaemic control (HbA1c > 7.0%). The mean serum FABP4 concentrations were significantly (P = .002) higher in the poor glycaemic control as compared to the good glycaemic control. After adjusting for all other predictors, FABP4 remained an independent poor glycaemic control indictor with an adjusted OR of 1.07 (95% CI, 1.01–1.13; P = .03).Conclusions
The present results indicated that FABP4 concentrations were increased and independently associated with the poor glycaemic control in Chinese children with T1DM. 相似文献18.
M.L. Tanenbaum R.N. Adams J.S. Gonzalez S.J. Hanes K.K. Hood 《Journal of diabetes and its complications》2018,32(2):196-202
Aims
Self-compassion (SC), or treating oneself with kindness when dealing with personal challenges, has not been rigorously examined in people with T1D. SC has been shown to buffer against negative emotions and to be linked to improved health outcomes, but diabetes-specific SC has not been studied. This study aimed to adapt the Self-Compassion Scale and validate it for a diabetes-specific population.Methods
We developed and validated a diabetes-specific version of the Self-Compassion Scale (Neff, 2003) in a sample of adults with T1D (N = 542; 65% female; 97% non-Hispanic White; M age 41, SD = 15.7; M A1c = 7.3, SD = 1; 72% insulin pump users; 50% continuous glucose monitoring [CGM] users). Confirmatory factor analyses (CFA), and reliability and construct validity analyses were conducted. Validity measures included diabetes distress, diabetes empowerment, diabetes numeracy, and A1c.Results
A two-factor bi-factor structure showed best fit, providing support for use of the adapted scale (SCS-D) as a unitary construct. The 19-item unidimensional SCS-D demonstrated excellent internal consistency (ɑ = 0.94; range of item-total correlations: 0.52–0.71) and construct validity. As hypothesized, higher SCS-D was associated with less distress, greater empowerment, and lower A1c, and was not associated with numeracy.Conclusions
The SCS-D is a reliable and valid measure of diabetes-specific self-compassion in adults with T1D. 相似文献19.
Ahmed Abdelwahed Markku Eskola Petteri Kosonen Heikki Mäkynen Jari Laurikka Heini Huhtala Jaakko Inkovaara Yochai Birnbaum Kjell Nikus 《Journal of electrocardiology》2017,50(1):102-110
Background
Acute left circumflex coronary artery (LCx) occlusion is not easily detected by the standard 12-lead electrocardiogram (ECG).Methods
In 16 patients continuous ECG recording was performed during balloon occlusion. The treated lesions were divided into proximal and distal based on the location of the ischemic segments with respect to the left obtuse margin of the heart.Results
Mean ΔST (=ST amplitude during inflation - pre-inflation ST) ≥0.5 mm in both leads I and aVL predicted a proximal occlusion site with sensitivity of 62.5% (95% confidence interval [CI] 24.9–91.5%), specificity 100% (95% CI 63.1–100%), positive predictive value 100% (95% CI 47.8–100%), and negative predictive value 72.7% (95% CI 39–94%). In lead III, mean ΔST was +0.3 mm in the distal and ?0.2 mm in the proximal group, respectively (p = 0.036).Conclusions
ST elevation in leads I and aVL is associated with myocardial ischemia at or proximal to the left obtuse margin. 相似文献20.
Arttu Holkeri Antti Eranti Tuomas V. Kenttä Kai Noponen M. Anette E. Haukilahti Tapio Seppänen M. Juhani Junttila Tuomas Kerola Harri Rissanen Markku Heliövaara Paul Knekt Aapo L. Aro Heikki V. Huikuri 《Journal of electrocardiology》2018,51(1):74-81