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1.
Anne Gedebjerg Thomas Peter Almdal Klara Berencsi Jørgen Rungby Jens Steen Nielsen Daniel R. Witte Søren Friborg Ivan Brandslund Allan Vaag Henning Beck-Nielsen Henrik Toft Sørensen Reimar Wernich Thomsen 《Journal of diabetes and its complications》2018,32(1):34-40
Aims
To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis.Methods
We examined the prevalence of complications and associated clinical characteristics among 6958 newly diagnosed T2D patients enrolled in the prospective Danish Center for Strategic Research in T2D cohort during 2010–2016. We calculated age- and gender-adjusted prevalence ratios (aPRs) of complications using log-binomial and Poisson regression.Results
In total, 35% (n = 2456) T2D patients had diabetic complications around diagnosis; 12% (n = 828) had microvascular complications, 17% (n = 1186) macrovascular complications, and 6% (n = 442) had both. HbA1c levels of ≥ 7% were associated with microvascular complications [HbA1c 7%–8%; aPR: 1.35, 95% confidence interval (CI): 1.12–1.62] but not macrovascular complications [aPR: 0.91, 95% CI: 0.76–1.08]. High C-peptide ≥ 800 pmol/L was associated with macrovascular [aPR 1.34, 95% CI: 1.00–1.80] but not microvascular [aPR 0.97, 95% CI: 0.71–1.33] complications. Macrovascular complications were associated with male sex, age > 50 years, obesity, hypertriglyceridemia, low HDL cholesterol, smoking, elevated CRP levels, and anti-hypertensive therapy. Microvascular complications were associated with high blood pressure, hypertriglyceridemia, and absence of lipid-lowering therapy.Conclusions
One-third of patients with T2D had diabetes complications around time of diagnosis. Our findings suggest different pathophysiological mechanisms behind micro- and macrovascular complications. 相似文献2.
Rula Ghandour Nahed Mikki Niveen M.E. Abu Rmeileh Lars Jerdén Margareta Norberg Jan W. Eriksson Abdullatif Husseini 《Primary Care Diabetes》2018,12(6):547-557
Background
Type 2 diabetes mellitus (T2DM) is a growing pandemic that will lead, if not managed and controlled, to frequent complications, poor quality of life, and high rates of disability and death. Little is known about T2DM complications in Palestine. The aim of this study is to estimate the prevalence of T2DM complications in Ramallah and al-Bireh governorate of Palestine.Methods
The study was conducted in eleven primary healthcare clinics offering services for persons with T2DM. Macrovascular complications were assessed using the Diabetes complication index. Microvascular complications were measured by physical examinations and laboratory tests. Questionnaires, laboratory tests, and physical examinations were used to assess socio-demographic characteristics, co-morbidities and other risk factors.Results
517 adult men and nonpregnant women participated in the study (166 men, 351 women). The response rate was 84%. Mean age and mean duration of diabetes were 58.1 and 9.4 years respectively. Prevalence of diagnosed microvascular and macrovascular complications was 67.2% and 28.6% respectively. 78.2% of the participants had poor glycemic control (HbA1c ≥ 7.0%).Conclusion
Significant proportions of persons with T2DM had macro- and microvascular complications and poor metabolic control. These findings are important for policy development and the planning of health services. 相似文献3.
Sneha Jakhotia Mudili Sivaprasad Tattari Shalini Paduru Yadagiri Reddy Kalluru Viswanath Khubchand Jakhotia Rakesh Sahay Manisha Sahay Geereddy Bhanuprakash Reddy 《Journal of diabetes and its complications》2018,32(2):221-225
Aim
Heat shock protein 27 (Hsp27) is a small heat shock protein known to protect the cells from apoptosis under stress. In the present study, we determined the plasma Hsp27 levels in type 2 diabetes subjects without and with microvascular complications- diabetic retinopathy (DRe), diabetic nephropathy (DNe), and diabetic neuropathy (DNu) to understand if it could serve as a marker for these complications.Methods
This is a hospital-based case-control study with 754 subjects including 247 controls, 195 subjects with diabetes, 123 with DRe, 80 with DNe and 109 with DNu. Plasma Hsp27 levels were measured by ELISA.Results
The mean plasma Hsp27 was higher in the DNe group (631.5 ± 355.2) compared to the control (496.55 ± 308.54), diabetes (523.41 ± 371.01), DRe (494.60 ± 391.48) and DNu (455.21 ± 319.74) groups with a p-value of 0.018. Receiver operating characteristic (ROC) curve analysis of Hsp27 in DNe group showed an area under the curve (AUC) of 0.617. Spearman correlation analysis shows a positive correlation of plasma Hsp27 with serum creatinine (p = 0.053, r-value 0.083). Gender, age and BMI did not affect the plasma Hsp27 levels.Conclusion
The plasma Hsp27 levels in the DNe group are higher compared to the control and other complications, thereby it could be explored to be used as a potential biomarker of DNe. 相似文献4.
B.K. Mishra P. Shukla M. Aslam A.A. Siddiqui S.V. Madhu 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):839-842
Background
It is being increasingly reported that some of the youth onset diabetes patients cannot be classified clearly as type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) based on usual criteria and the term double diabetes (DD) coined for these cases.Aim
The objective of the study was to find out the prevalence of DD in youth onset diabetes patients from east Delhi and neighboring NCR region.Methods
A total of 200 patients with youth onset diabetes below 25 years of age were recruited from a tertiary care hospital in East Delhi. Clinical history, family history of diabetes and anthropometry of patients were recorded. Fasting serum C-peptide, Anti-IA2-antibody and Anti-GAD-antibody were measured in all patients. Patients positive for Anti-GAD-antibody (>1.05 U/ml) and C-peptide level >0.3 nmol/l were characterized as DD patients. Patients negative for Anti-GAD-antibody and C-peptide >0.3 nmol/l were kept under the category of T2DM. Patients with low C-peptide level along with one of the following, positive Anti-GAD-antibody, positive Anti-IA2-antibody and diabetic ketoacidosis (DKA) were considered as T1DM. Remaining patients were kept under the unknown category.Results
Mean age of study subjects was 18.2 ± 7.1 years. Seven percent (7%) of the subjects were classified as DD, 51% as T1DM, 13% as T2DM and 29% were kept under the unknown category. Mean age of subjects with 22.2 ± 9.7, 16.9 ± 6.7, 20.6 ± 7.7 and 19.4 ± 7.4 years in DD, T1DM, T2DM and unknown category respectively. Mean BMI of subjects with DD, T1DM, T2DM and unknown category was 19.8 ± 5.7, 16.6 ± 3.7, 19.3 ± 4.1 and 18.0 ± 4.6 kg/m2 respectively.Conclusion
Double diabetes is an important occurrence among youth onset diabetes subjects. Only half of the subjects with youth onset of diabetes had T1DM. 相似文献5.
Sophia Zoungas Mark Woodward Qiang Li Mark E. Cooper Pavel Hamet Stephen Harrap Simon Heller Michel Marre Anushka Patel Neil Poulter Bryan Williams John Chalmers for the ADVANCE Collaborative group 《Diabetologia》2014,57(12):2465-2474
Aims/hypothesis
Data are inconsistent regarding the associations between age, age at diagnosis of diabetes, diabetes duration and subsequent vascular complications.Methods
The associations between age (or age at diagnosis), diabetes duration and major macrovascular events, all-cause death and major microvascular events were examined in 11,140 patients with type 2 diabetes randomly allocated to intensive or standard glucose control in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial. Rates were calculated by 5 year baseline age (or age at diagnosis) and diabetes duration strata. Risks were estimated using Cox models adjusted for treatment assignment and HbA1c.Results
The mean age (±SD) was 65.8?±?6.4 years, age at diagnosis was 57.8?±?8.7 years and diabetes duration was 7.9?±?6.4 years. Diabetes duration was associated with the risk of macrovascular events (HR 1.13 [95% CI 1.08, 1.17]), microvascular events (1.28 [1.23, 1.33]) and death (1.15 [1.10, 1.20]) whereas age (or age at diagnosis) was only associated with the risk of macrovascular events (1.33 [1.27, 1.39]) and death (1.56 [1.48, 1.64]). No interaction was observed between diabetes duration, age and the risk of macrovascular events or death (both p?>?0.4). However, an interaction was observed between diabetes duration, age and the risk of microvascular events (p?=?0.002), such that the effects of increasing diabetes duration were greatest at younger rather than older age.Conclusions/interpretation
In patients with type 2 diabetes, age or age at diagnosis and diabetes duration are independently associated with macrovascular events and death whereas only diabetes duration is independently associated with microvascular events and this effect is greater in the youngest patients. 相似文献6.
7.
S. Kou J.Y. Cao S. Yeo D.J. Holmes-Walker S.L. Lau J.E. Gunton 《Journal of diabetes and its complications》2018,32(2):144-149
Aim
To determine whether cardiovascular outcomes in type 2 diabetes (T2D) differ according to ethnicity, and whether ethnicity influences the effect of gender on these outcomes in Caucasians, East-Southeast-Asians, Middle-Easterners, South-Asians and Pacific-Islanders.Methods
We compared demographics, HbA1c, lipid profile, renal function markers, and prevalence of macrovascular and microvascular complications between ethnic groups. Cross-sectional data was prospectively collected from 204 consecutive patients at Westmead Hospital's T2D clinic from April–October 2015. Univariate analysis was performed using chi-squared test for categorical data, and Mann-Whitney-U or Kruskal-Wallis test for continuous data.Results
Compared to Caucasians, South-Asians were diagnosed younger, were currently younger, had lower body-mass-index (BMI) and better renal function but higher rates of non-ST-elevation myocardial infarction (STEMI, 21.7% versus 3.5%, p < 0.05). East-Southeast-Asians had lower BMI but more nephropathy than Caucasians (59% versus 39%, p < 0.05). East-Southeast-Asian males had fewer CVD than Caucasians, but this protection was absent in East-Southeast-Asian females. Middle-Easterners had more non-STEMI than Caucasians (5.3% vs 3.5%, p < 0.05). Middle-Eastern females were not at lower CVD risk than males. Caucasians had most PVD (20% versus 6%, p < 0.05).Conclusions
Ethnicity influences rates of diabetes-related complications. Female CVD protection is altered in some groups. Ethnicity should be considered in assessing CVD and complications risk. 相似文献8.
Objective
The aim of this study was to test the serum concentrations of fatty acid-binding protein 4(FABP4) in children with type 1 diabetes mellitus (T1DM) and to determine the relationship between patients with good and poor glycaemic control who were classified according to their glycated hemoglobin A1c (HbA1c) levels.Methods
Children with T1DM were selected consecutively from our department from May 2016 to May 2017. For comparison, the same non-diabetic, age, sex, BMI and pubertal stage-matched healthy children were selected consecutively among non-diabetic children. Serum levels of FABP4 were batch analyzed using a commercially available ELISA assay. Patients were categorized into two groups according to their glycaemic control (Poor glycaemic control is HbA1c > 7.0% and good is ≤7.0%).Results
In this study, 118 children with T1DM and 118 control cases were included. The mean serum FABP4 concentrations were significantly (P < .001) higher in T1DM as compared to controls. There was a modest correlation between serum concentrations of FABP4 and duration of diabetes (r = 0.484, P < .001). Fifty-two patients were defined as poor glycaemic control (HbA1c > 7.0%). The mean serum FABP4 concentrations were significantly (P = .002) higher in the poor glycaemic control as compared to the good glycaemic control. After adjusting for all other predictors, FABP4 remained an independent poor glycaemic control indictor with an adjusted OR of 1.07 (95% CI, 1.01–1.13; P = .03).Conclusions
The present results indicated that FABP4 concentrations were increased and independently associated with the poor glycaemic control in Chinese children with T1DM. 相似文献9.
Jennifer J. Salinas Jennifer M. Reingle Gonzalez Soham Al Snih 《Journal of diabetes and its complications》2018,32(1):75-82
Aims
To evaluate how depression and diabetes severity impact disability progression among Mexican Americans over a 15-year period.Methods
We used seven waves of the Hispanic Established Population for the Epidemiologic Study of the Elderly (H-EPESE). Primary disability outcomes included the Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) scales. Explanatory variables included time since diagnosis with diabetes (no type 2 diabetes, 1–10, 11–20, 21 +), an indicator of disease severity, and depression. Longitudinal generalized estimating equation models were used to estimate the relationship between time since diabetes diagnosis, depressive symptoms and ADL and IADL disability progression over a 15-year time period.Results
Years since diabetes diagnosis was associated with more rapid ADL and IADL disability progression compared to those without type 2 diabetes. Depression accelerated the disabling process in participants who were diagnosed with diabetes 11 years or more years ago.Conclusions
Longer duration of diabetes and greater symptoms of depression increase vulnerability for disability among older Mexican American adults. 相似文献10.
Alfred Gatt Kevin Cassar Owen Falzon Christian Ellul Kenneth P. Camilleri Jean Gauci Stephen Mizzi Anabelle Mizzi Cassandra Sturgeon Nachiappan Chockalingam Cynthia Formosa 《Primary Care Diabetes》2018,12(4):312-318
Aims
The purpose of this study was to investigate whether heat emitted from the feet of patients with type 2 diabetes (DM) and peripheral arterial disease (PAD) differed from those with type 2 diabetes without complications (DM).Methods
A non-experimental, comparative prospective study design was employed in a tertiary referral hospital. Out of 223 randomly selected participants (430 limbs) who were initially tested, 62 limbs were categorized as DM + PAD and 22 limbs as DM without PAD. Subjects with evidence of peripheral neuropathy were excluded. Participants underwent thermographic imaging. Automatic segmentation of regions of interest extracted the temperature data.Results
A significant difference in temperature in all the toes between the two groups was found (p = 0.005, p = 0.033, p = 0.015, p = 0.038 and p = 0.02 for toes 1–5 respectively). The mean forefoot temperature in DM + PAD was significantly higher than that in DM (p = .019), with DM + PAD having a higher mean temperature (28.3 °C) compared to DM (26.2 °C). Similarly, the toes of subjects with DM + PAD were significantly warmer than those of subjects with DM only.Conclusions
Contrary to expectations the mean toe and forefoot temperatures in DM patients with PAD is higher than in those with DM only. This unexpected result could be attributed to disruption of noradrenergic vasoconstrictor thermoregulatory mechanisms with resulting increased flow through cutaneous vessels and subsequent increased heat emissivity. These results demonstrate that thermography may have potential in detecting PAD and associated temperature differences. 相似文献11.
Michael Quartuccio Eleanor M. Simonsick Susan Langan Tamara Harris Rebecca L. Sudore Roland Thorpe Caterina Rosano Felicia Hill-Briggs Sherita Golden Rita R. Kalyani 《Journal of diabetes and its complications》2018,32(4):368-372
Objective
Lower health literacy is associated with higher rates of mortality and chronic disease. It remains unclear whether health literacy is associated with diabetes and/or hyperglycemia in older adults, and if this relationship differs by sex.Research design and methods
We performed a cross-sectional analysis of 2510 older adults in the Health, Aging and Body Composition (Health ABC) Study who had both a Rapid Estimate of Adult Literacy in Medicine (REALM) measurement and diabetes status available. Sex-stratified logistic regression models were used to analyze the relationship of health literacy categories (low, medium, and high) to diabetes status, adjusting for key covariates. Secondary analyses examined the relationship of health literacy to glycemic markers (A1C, fasting blood glucose).Results
Among participants in the Health ABC cohort, 429 had diabetes. Mean age was 76 years old and 45% were female. Men with diabetes more commonly had low health literacy levels than men without diabetes (10.1% versus 9.3%, p = 0.02). Similar results were seen among women (14.7% versus 6.1%, p < 0.01). In a model adjusting for age, race, income, education, BMI, smoking, and alcohol use, women with low versus high health literacy had a two-fold higher likelihood of diabetes (OR = 2.2; 95% CI 1.1–4.3). No significant relationship was observed in men. Progressively lower categories of health literacy were associated with higher age-adjusted mean A1C and fasting blood glucose levels in women (both p for trend < 0.01) but not men.Conclusions
In this large, ethnically diverse sample of community-dwelling older adults, lower health literacy level is related to a greater likelihood of diabetes and higher A1C and fasting blood glucose levels in women–but not in men–after adjusting for age, race, and other demographic and lifestyle factors. Future studies are needed to assess mechanisms underlying this relationship and if interventions to improve health literacy are effective in reducing the burden of diabetes, particularly in women. 相似文献12.
Osama B. Albasheer Mohammed S. Mahfouz Yahia Solan Duaa A. Khan Mohammed A. Muqri Haneen A. Almutairi Ali M. Alelyani Hussain A. Alahmed 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(2):117-121
Purpose
To determine the prevalence of depression and related risk factors among type 2 diabetes mellitus patients (T2DM) in Jazan area, Saudi Arabia.Method
A cross sectional, self-administered questionnaire study was conducted among T2DM patients in Jazan area, Saudi Arabia. A total of 385 patients were selected at randomly. The Patient Health Questionnaire (PHQ-9) was utilized to measure symptoms and signs of depression.Results
The overall prevalence of depression among T2DM patients was 37.6%. Of them, 24.2% were mildly depressed, 9.6% were moderately severely depressed, and 4.2% were severely depression. Significant predictors of depression include the presence of diabetic foot (P = 0.000), cardio-vascular diseases (P = 0.000), eye complication (P = 0.073), and erectile dysfunction (P = 0.090). The prevalence of depression was not significantly associated with the age (P = 0.375) and gender (P = 0.374). Similarly no association was found with duration of diabetes (P = 0.475) and HbA1c (P = 0.555).Conclusion
The study revealed that diabetes complications are strong predictors of the rate of depression among T2DM patients. Therefore, early depression screening is needed to improve the quality of life of diabetic patients. 相似文献13.
Kazuo Eguchi Takahiro Komori Toshinobu Saito Satoshi Hoshide Kazuomi Kario 《Journal of electrocardiology》2018,51(1):21-26
Background
We tested the hypothesis that an alpha-glucosidase inhibitor (α-GI), miglitol, is effective in protecting the cardiovascular system in type 2 diabetes mellitus (T2DM).Methods
We studied 19 hospitalized heart disease patients with T2DM in whom we performed continuous glucose monitoring, Holter electrocardiogram, and ambulatory blood pressure (BP) monitoring simultaneously for 48 h. The α-GI miglitol was administered for half of the study period by a cross-over fashion. T-wave alternans (TWA), a marker of future fatal arrhythmic events, was also analyzed by Holter ECG.Results
Of the 19 patients, the measures of glucose variability were significantly lower during miglitol therapy than in control period. BP variability was similar with/without miglitol. However, TWA was significantly lower during the miglitol period compared to control period (63 ± 4.8 vs. 75.8 ± 5.1 μV, p = 0.032).Conclusion
An α-GI, miglitol, can reduce TWA by reducing the fluctuation of glucose in heart disease patients with T2DM. 相似文献14.
Meghan B. Brennan Elbert S. Huang Jennifer M. Lobo Hyojung Kang Marylou Guihan Anirban Basu Min-Woong Sohn 《Journal of diabetes and its complications》2018,32(1):27-33
Aim
Statins reduce morbidity and mortality among patients with diabetes, but their use remains suboptimal. Understanding trends in statin use may inform strategies for improvement.Methods
We enrolled a national, retrospective cohort of 899,664 veterans aged ≥ 40 years with diabetes in 2003. We followed them through 2011, dividing the nine-year follow-up into 90-day periods. For each period, we determined statin use, defined as possession of ≥ 30-day supply. We examine factors associated with statin uptake among baseline non-users with a multivariate model.Results
Baseline prevalence of statin use was 43%, increased by 1.8% per period (p for trend < 0.001), and reached a maximum of ~ 59%. Statin use among non-Hispanic racial/ethnic minorities lagged behind their white counterparts. Among baseline non-users, statin use was 9% after Year 1 and reached 36% by Year 9. Factors associated with statin uptake included use of hypoglycemic agents, HbA1c between 7 and 8.9% (53–74 mmol/mol), hypertension, heart failure, peripheral vascular disease, and Hispanic ethnicity.Conclusion
Statin use is slowly increasing among patients with diabetes, and at varying rates within subgroups of this population. Policies that prioritize these subgroups for statin promotion may help guide future, intervention-based research to increase compliance with current guidelines. 相似文献15.
Ghada Al-Humaidi Ismet Sarikaya Abdelhamid H. Elgazzar Azu Owunwanne 《Journal of the Saudi Heart Association》2018,30(1):3-8
Objective
The prevalence of coronary artery disease (CAD) is high in patients with diabetes. Because ischemia and infarction are often silent in diabetic patients, diagnosis of CAD occurs inevitably late. It is essential to identify the presence of CAD in diabetic patients to start early treatment. Therefore, the aim of this study was to determine the prevalence of abnormal myocardial perfusion in asymptomatic type 2 diabetic patients using myocardial perfusion imaging.Methods
Fifty-nine patients with type 2 diabetes, who did not have any history of CAD, but did have risk factors underwent myocardial perfusion single-photon emission computed tomography (SPECT) imaging using 99mTc-tetrofosmin and a 2-day stress–rest protocol. Two nuclear medicine specialists independently interpreted the images. Statistical analysis was performed to determine if there is a correlation between the presence of perfusion abnormalities and the history of diabetes (duration of disease, type of treatment, level of control, and presence and type of complications). The influence of other factors such as age, sex, smoking history, and family history of CAD, with abnormal scans were also studied.Results
Of the 59 patients, abnormal scans were detected in 22 (37%) including 16 with reversible defects due to stress-induced ischemia. Hence the prevalence was 37%. Duration of diabetes, use of insulin, nephropathy, and neuropathy were significantly associated with abnormal scans (p = 0.048, p = 0.045, p = 0.006, and p = 0.03, respectively). Additionally, positive family history of CAD was highly associated with perfusion abnormalities (p < 0.001). No significant association was found between other risk factors, such as hyperlipidemia and the presence of perfusion defects.Conclusions
We found a high prevalence of myocardial perfusion abnormalities in asymptomatic type 2 diabetic patients. Perfusion abnormalities on myocardial perfusion SPECT images were associated with disease duration, insulin use, nephropathy, and neuropathy. Asymptomatic diabetic patients might be candidates with CAD abnormalities that can be studied using myocardial perfusion SPECT. 相似文献16.
Vinni Faber Rasmussen Esben Thyssen Vestergaard Ole Hejlesen Camilla Urup Noe Andersson Simon Lebech Cichosz 《Primary Care Diabetes》2018,12(5):453-459
Aim
This study investigates the prevalence of smell and taste impairment in adults with diabetes and potential risk factors for sense deterioration and its influence of daily food intake.Methods
Data from the NHANES 2013-2014 were analyzed. Smell impairment was defined as failing to identify?≥3 of 8 odors in NHANES Pocket Smell Test. Taste impairment was defined as being unable to identify quinine or NaCl in NHANES Tongue Tip and Whole-mouth Test.Results
A total of 3204 people (428 patients with diabetes, 2776 controls) were suitable to be included. The prevalence of smell impairment in patients with diabetes was higher compared to the controls: 22% versus 15% (p < 0.001). The difference prevailed after adjustment for age, BMI, alcohol misuse and smoking status. Taste was not impaired in patients with diabetes (p = 0.29). Patients with diabetes and smell impairment had a lower daily calorie intake compared to patients with diabetes and normal smell function. The duration of diabetes, diabetic complications and other potential risk factors were not associated with smell dysfunction.Conclusions
Smell dysfunction appears with a higher prevalence in patients with diabetes, and this seems to negatively affect daily food intake. 相似文献17.
Srujitha Marupuru Padmanav Senapati Swathi Pathadka Sonal Sekhar Miraj Mazhuvancherry Kesavan Unnikrishnan Mohan K. Manu 《The Brazilian journal of infectious diseases》2017,21(3):312-316
Background
World Health Organization estimated that people with diabetes (DM) are at 2–3 times higher risk for tuberculosis (TB). Studies have shown that DM not only increases the risk of active TB, but also puts co-affected persons at increased risk of poor outcomes.Objectives
To determine the protective effect of metformin against TB in DM patients and also, to investigate the relationship between poor glycemic control and TB.Methods
A case–control study was conducted over 8 months, where cases and controls were selected based on the inclusion and exclusion criteria of the study. The diabetics diagnosed with TB were selected as study group (SG = 152) and without TB were as control group (CG = 299). Exposure status of metformin in both groups were analyzed.Results
The mean (SD) age of both CG and SG were 55.54 ± 11.82 and 52.80 ± 11.75, respectively. Majority of the subjects in the study were males. The mean hospital stay of SG and CG were 7 days and 6 days, respectively. Poor glycemic control (HbA1c > 8) observed in SG (51.7%) vs CG (31.4%). HbA1c value <7 is associated protective factor for TB occurrence [OR = 0.52 (95% CI 0.29–0.93)]. The protective effect of metformin against TB was 3.9-fold in diabetics (OR = 0.256, 0.16–0.40).Conclusion
Poor glycemic control among diabetics is a risk factor for TB occurrence. The result shows metformin use is a protective agent against TB infection in diabetics. Hence, incorporation of metformin into standard clinical care would offer a therapeutic option for the prevention of TB. 相似文献18.
Christophe E.M. De Block Bharati Shivalkar Wouter Goovaerts Tim Brits Ken Carpentier An Verrijken Viviane Van Hoof Paul M. Parizel Chris Vrints Luc F. Van Gaal 《Journal of diabetes and its complications》2018,32(3):271-278
Aims
Type 1 diabetic patients (T1DM) experience a higher cardiovascular disease and mortality risk than controls. We investigated whether visceral adipose tissue (VAT) contributes to coronary artery calcifications (CAC) and cardiac dysfunction in T1DM.Methods
A cross-sectional study of 118 T1DM patients without a history of cardiovascular disease (men/women: 68/50, age 46 ± 12 years, HbA1c 7.6 ± 0.9%, BMI 25.8 ± 4.1 kg/m2) was conducted. CAC and VAT were measured using a CT scan. CAC was scored using the Agatston method. Cardiac functional abnormalities were assessed by echocardiography.Results
CAC scored ≥ 10 in 42% of patients. Systolic function was normal in all, but diastolic dysfunction was present in 75%. Forty-six percent had VAT ≥ 100 cm2. CAC score ≥ 10 occurred more often in subjects with VAT ≥ 100 cm2 (54% vs 31%; p = 0.01). Age (OR = 1.10; p < 0.0001), diabetes duration (OR = 1.10; p = 0.008), gender (OR = 4.28; p = 0.016), LDL-cholesterol (OR = 1.03; p = 0.009) and metabolic syndrome (OR = 5.79; p = 0.005) were independently associated with a CACS ≥ 10. Subjects with CACS ≥ 10 were more prone to have diastolic dysfunction (84 vs 54%; p = 0.03). Factors independently associated with diastolic dysfunction were age (OR = 1.11; p = 0.002), waist circumference (OR = 1.10; p = 0.016) and VAT (OR = 0.99; p = 0.035).Conclusions
Excess VAT in T1DM, present in 46%, is associated with diastolic dysfunction and CAC, present in respectively 75% and 42% of patients. Timely detection might improve future cardiovascular risk. 相似文献19.
Hui Fang Xiao-yu Xu Rui-zhe Xu Yan-feng Zhen Gang Xu Yu-kai Li 《Journal of diabetes and its complications》2018,32(1):56-60
Background
Basic and clinical researches have suggested that type 2 diabetes (T2DM) is associated with cognitive impairment, and diabetes mellitus increases the risk of cognitive impairment and dementia. Recently, some reports found that undercarboxylated osteocalcin (ucOC) could affect brain functions, and decreased in patients with T2DM. We aimed to investigate the association of serum ucOC with cognitive impairment in T2DM patients.Methods
A total of 196 male T2DM patients without medications known to affect bone metabolism or history of bone fracture, aged ≥ 18 years were recruited and divided into impaired cognition group and normal cognition group. We use the scores of Minimum Mental State Examination (MMSE) to evaluate the subjects' cognitive function. Detailed cognitive performance was also evaluated by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Serum ucOC was measured by Enzyme-Linked Immunosorbent Assay (ELISA) kit.Results
Compared to male T2DM patients with normal cognition, the mean osteocalcin concentrations were significantly lower in male T2DM patients with impaired cognition (P < 0.05). RBANS total and all indexes scores were also lower in patients with impaired cognition (all P < 0.05). After adjusted effects of confounding factors, serum ucOC was positively correlated with a variety indexes of RBANS except visuospatial/constructional.Conclusions
The serum ucOC is positively correlated with RBANS scores in male T2DM patients. It suggests that serum ucOC may be involved in the development and progression of cognitive dysfunction in T2DM patients. 相似文献20.
Seydahmet Akın Cem Bölük Ülkü Türk Börü Mustafa Taşdemir Tuğçe Gezer Fatma Gülhan Şahbaz Özcan Keskin 《Primary Care Diabetes》2019,13(1):87-91