共查询到20条相似文献,搜索用时 156 毫秒
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Uridine reverses the toxicity of 3''-azido-3''-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity. 总被引:1,自引:4,他引:1 下载免费PDF全文
J P Sommadossi R Carlisle R F Schinazi Z Zhou 《Antimicrobial agents and chemotherapy》1988,32(7):997-1001
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Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitor 下载免费PDF全文
Ferris RG Hazen RJ Roberts GB St Clair MH Chan JH Romines KR Freeman GA Tidwell JH Schaller LT Cowan JR Short SA Weaver KL Selleseth DW Moniri KR Boone LR 《Antimicrobial agents and chemotherapy》2005,49(10):4046-4051
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Anti-Human Immunodeficiency Virus Type 1 Activity, Intracellular Metabolism, and Pharmacokinetic Evaluation of 2′-Deoxy-3′-Oxa-4′-Thiocytidine 下载免费PDF全文
Jean-Marc de Muys Henriette Gourdeau Nghe Nguyen-Ba Debra L. Taylor Parvin S. Ahmed Tarek Mansour Celine Locas Nathalie Richard Mark A. Wainberg Robert F. Rando 《Antimicrobial agents and chemotherapy》1999,43(8):1835-1844
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Njai HF Lewi PJ Janssen CG Garcia S Fransen K Kestens L Vanham G Janssen PA 《Antiviral therapy》2005,10(2):255-262
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Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine 下载免费PDF全文
Nakata H Amano M Koh Y Kodama E Yang G Bailey CM Kohgo S Hayakawa H Matsuoka M Anderson KS Cheng YC Mitsuya H 《Antimicrobial agents and chemotherapy》2007,51(8):2701-2708
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Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2''-deoxy-3''-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog. 总被引:2,自引:13,他引:2 下载免费PDF全文
H Soudeyns X I Yao Q Gao B Belleau J L Kraus N Nguyen-Ba B Spira M A Wainberg 《Antimicrobial agents and chemotherapy》1991,35(7):1386-1390
We describe a novel nucleoside analog, 2'-deoxy-3'-thiacytidine (BCH-189), in which the 3' carbon of the ribose ring of 2'-deoxycytidine has been replaced by a sulfur atom. In MT-4 T cells, this compound had significant time- and dose-dependent antiviral activity against five different strains of human immunodeficiency virus type 1 (HIV-1) (mean 50% inhibitory dose, 0.73 microM); known 3'-azido-3'-deoxythymidine (AZT)-resistant HIV-1 variants did not exhibit cross-resistance to it. BCH-189 also suppressed HIV-1 replication in the U937 monocytoid cell line as well as in primary cultures of human peripheral blood mononuclear cells; in these latter systems, suppression was fuller and longer lasting than that induced by AZT. Moreover, BCH-189 was less toxic than AZT in cell culture. BCH-189 may be a promising drug for the treatment of HIV-1-associated disease. 相似文献
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(-)-2''-deoxy-3''-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro. 下载免费PDF全文
J A Coates N Cammack H J Jenkinson A J Jowett M I Jowett B A Pearson C R Penn P L Rouse K C Viner J M Cameron 《Antimicrobial agents and chemotherapy》1992,36(4):733-739
The (-)-enantiomer of 2'-deoxy-3'-thiacytidine (3TC) was found to be a potent and selective inhibitor of human immunodeficiency virus types 1 (HIV-1) and 2 (HIV-2) in vitro. We determined its antiviral activity against a number of laboratory strains of HIV-1 and HIV-2 in a range of CD4-bearing lymphocyte cell lines (mean 50% inhibitory concentration [IC50] range, 4 nM to 0.67 microM). 3TC was also active against a range of HIV-1 strains in peripheral blood lymphocytes (mean IC50 range, 2.5 to 90 nM). The IC50 for cytotoxicity in seven lymphocyte cell cultures, including human peripheral blood lymphocytes, ranged from 0.5 to 6 mM. 3TC had no detectable antiviral activity against a range of other viruses or in cells chronically infected with HIV-1 or HIV-2. The effects of time of addition of the compound and varying the multiplicity of infection on the antiviral activity of 3TC were determined. The results showed that 3TC is a potent and selective inhibitor of HIV-1 and HIV-2 replication in vitro. 相似文献
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Synergistic inhibition of human immunodeficiency virus type 1 replication in vitro by two-drug and three-drug combinations of 3''-azido-3''-deoxythymidine, phosphonoformate, and 2'',3''-dideoxythymidine. 下载免费PDF全文
X B Kong Q Y Zhu R M Ruprecht K A Watanabe J M Zeidler J W Gold B Polsky D Armstrong T C Chou 《Antimicrobial agents and chemotherapy》1991,35(10):2003-2011
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Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates 下载免费PDF全文
Meyer PR Matsuura SE Schinazi RF So AG Scott WA 《Antimicrobial agents and chemotherapy》2000,44(12):3465-3472
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In vitro antiviral activity of the novel, tyrosyl-based human immunodeficiency virus (HIV) type 1 protease inhibitor brecanavir (GW640385) in combination with other antiretrovirals and against a panel of protease inhibitor-resistant HIV 下载免费PDF全文
Hazen R Harvey R Ferris R Craig C Yates P Griffin P Miller J Kaldor I Ray J Samano V Furfine E Spaltenstein A Hale M Tung R St Clair M Hanlon M Boone L 《Antimicrobial agents and chemotherapy》2007,51(9):3147-3154
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TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1 下载免费PDF全文
Andries K Azijn H Thielemans T Ludovici D Kukla M Heeres J Janssen P De Corte B Vingerhoets J Pauwels R de Béthune MP 《Antimicrobial agents and chemotherapy》2004,48(12):4680-4686