二乙酰基莲心碱抗实验性心律失常的作用

目的研究二乙酰基莲心碱抗心律失常的药理作用.方法采用乌头碱、哇巴因、氯化钙3种抗心律失常模型.结果二乙酰基莲心碱5mg     

心律宁片(苦参总碱)抗心律失常临床研究

苦参(Sophora flavescens Ait)是一种传统中药,历代本草多有记述。有清热、燥湿、杀虫、利水之功。苦参中含有多种有效成分,我们对其中的生物碱进行了实验性心律失常的研究。证明总生物碱对药物诱发的动物心律失常有较好的治疗和预防作用。为进一步研究苦参总碱抗心律失常作用,我们用苦参总碱制成的片剂(心律宁片)对各种心脏病并发心律失常进行了234例临床疗效观察。     

胃复安对实验性心律失常的作用

MCP有对抗氯化钡诱发大白鼠心律失常的作用;对抗氯仿-肾上腺素诱发家兔的心律失常,能提高乌头碱诱发大鼠心律失常的用量、致室颤量和致死量、但对哇巴因诱发的心律失常无影响,不能改善结扎大白鼠冠状动脉造成的缺血性心律失常。有局部麻醉作用。     

氧化苦参碱抗大鼠实验性心律失常的作用探讨

目的观察氧化苦参碱的抗心律失常作用。方法将SD大鼠随机分为两组,制作乌头碱诱发大鼠室性心律失常模型和结扎左冠状动脉前降支诱发的大鼠室性心律失常,以及对氯仿所致大鼠的室颤,一组静脉注射生理盐水,另一组静注氧化苦参碱,观察两组心律失常的变化。结果氧化苦参(OM)20 mg/kg能明显对抗乌头碱和结扎左冠状动脉前降支诱发的大鼠室性心律失常,也能预防对氯仿所致小鼠的室颤的发生。结论氧化苦参碱对大鼠有明显的抗心律失常作用,此实验为氧化苦参碱的临床应用提供了实验依据。     

二苯甲酰莲心碱抗实验性心律失常的作用

目的：研究二苯甲酰莲心碱抗实验性心律失常的作用。方法：采用乌头碱、哇巴因、氯化钙3种抗心律失常模型。结果：二苯甲酰莲心碱5mg.kg^1可明显提高乌头碱所致大鼠，哇巴因致豚鼠发生室性早搏，室性心动过速，室颤及心脏停搏用量，延长氯化钙诱发大鼠出现心律失常的时间，缩短窦律恢复时间，提高窦律恢复律，延长死亡时间及降低死亡率，结论：二苯甲酰莲心碱具有广泛的抗心律失常作用。     

磷酸喹哌抗实验性心律失常作用

磷酸喹哌(PQP)9mg·kg~(-1)iv明显降低小鼠室颤的死亡率;PQP 18mg·kg~(-1)ip对氯仿诱发小鼠室颤具有保护作用;PQP 6.3mg·kg~(-1)ip显著增加恒速(10mg·L~(-1)·min~(-1)滴注乌头碱引起麻醉大鼠室性早搏(VE)、室性心动过速(VT)、室性纤颤(VF)所需的乌头碱用量;PQP5.4 mg·kg~(-1)iv显著增加恒速(50mg·L~(-1)·min~(-1))滴注哇巴因引起麻醉豚鼠VE、VT和VF所需哇巴因用量;PQP3.36mg·kg~(-1)iv明显缩短肾上腺素诱发家兔室性心律失常的持续时间.结果表明PQP具有抗心律失常作用。小鼠PQPLD_(50)iv为93.33 mg·kg~(-1)。     

北豆根总碱注射液抗实验性心律失常作用

采用五种实验动物心律失常模型观察了北豆根总碱（Ｔｏｔａｌ Ａｌｋａｌｏｉｄ ｏｆ Ｍｅｎｉｓｐｅｒｍｕｍ Ｄａｕｒｉｃｕｍ,简称ＴＡＭＤ）注射液的抗心失常作用。结果表明ｉｖ ５ｍｇ／ｋｇ＾－１ＴＡＭＤ对氯化钡诱发大鼠心失常的治疗作用明显优于１０ｍｇ／ｋｇ＾－１奎尼丁,对乌头碱诱发心失常预防作用优于利多卡因,对抗喹因诱发豚鼠的心律失常与利多卡因相似,对氯仿诱发小鼠室颤有保护作用且优于硅尼丁;对大鼠冠     

硫酸镁抗实验性心律失常作用

硫酸镁250mg/kg静脉注射能降低小鼠吸入氯仿诱发室颤的发生率,也能缩短BaCl_2诱发的家兔心律失常持续时间,并对抗氯仿一肾上腺素所致的家兔心律失常,明显延长乌头碱引起的大鼠室早和室速发生时间,并阻止其引起的室颤发生。     

峨嵋唐松草碱抗实验性心律失常作用

峨嵋唐松草碱10mg/kg,可以显著提高乌头碱诱发大鼠及哇巴因诱发豚鼠致心律失常用量;能明显地预防氯仿所致小鼠心室纤颤的发生;能显著对抗大鼠心肌缺血复灌引起的心律失常。峨嵋唐松草碱对大鼠心电图的影响,表现为显著的减慢大鼠心率,延长P—R及Q—Tc间期。     

二对氯苯甲酰莲心碱对实验性心律失常的影响

目的　研究二对氯苯甲酰莲心碱抗心律失常的药理作用。方法　采用乌头碱、哇巴因、氯化钙 3种抗心律失常模型。结果　二对氯苯甲酰莲心碱 5mg·kg-1iv可明显提高乌头碱致大鼠、哇巴因致豚鼠发生室性早搏、室性心动过速、室颤及心脏停搏用量 ;延长氯化钙诱发大鼠心律失常的出现时间 ,减少早搏、室颤的发生率及死亡率。结论　二对氯苯甲酰莲心碱具有广泛的抗心律失常作用     

阿魏酸钠抗实验性心律失常的作用

目的　探讨阿魏酸钠抗实验性心律失常的机制。方法　应用各种心律失常动物模型观察药物对实验性心律失常的作用。结果　阿魏酸钠 0 6 g·kg-1iv可对抗哇巴因、肾上腺素诱发的室性心律失常 (P <0 0 1) ,亦可对抗心肌缺血诱发的心律失常 (P <0 0 5 ) ,但不能拮抗乌头碱所诱发的心律失常 (P >0 0 5 )。结论　阿魏酸钠具有抗多种实验性心律失常的作用 ,其机制可能与钾离子通道及 β受体的阻断作用有关     

Effects of Adrenergic P-Blockers and a Membrane Stabilizing Agent on Ouabain-Induced Cardiac Arrhythmias in Anaesthetized Guinea Pigs

Abstract The antiarrhythmic effects of dl-propranolol, d-propranolol, metoprolol and lidocaine against ouabain-induced cardiac arrhythmias were studied. It was found that contrary to earlier findings in the dog, the effects of the adrenergic β-blockers against ouabain-arrhythmias in guinea pigs were due to β-blocking activity and not the membrane-stabilizing activity of the compounds. The cardioselective β-blocker, metoprolol, was more or equally effective as dl-propranolol against ouabain-induced arrhythmias in guinea pigs.     

白藜芦醇抗心律失常和抗心肌缺血作用研究

白藜芦醇（Resveratrol，RVL）为多酚类物质，是广泛存在于水果、中药和葡萄酒中的一种植物抗毒素。随着对RVL研究的深入，人们发现它具有多种药理学活性，其中RVL的心血管保护作用逐渐成为研究热点，但其有关抗心律失常及抗心肌缺血作用鲜见报道。本文就RVL对实验性心律失常和急性心肌缺血的保护作用进行研究。     

草乌中有毒生物碱的提取分离

针对药材中乌头碱,中乌头碱、次乌头碱的提取分离方法进行了研究,本方法提取回收率与碱性苯溶液提取方法相似.方法中所用试剂成本低、毒性小,适用于乌头碱、中乌头碱、次乌头碱的提取分离以及对照品的制备.     

Discovery of N-(3,5-bis(1-pyrrolidylmethyl)-4-hydroxybenzyl)-4-methoxybenzenesulfamide (sulcardine) as a novel anti-arrhythmic agent

Aim:

To investigate the anti-arrhythmic effects of sulfamide analogues of changrolin and to characterize the sulfate of compound 6f (sulcardine sulfate, Sul) as a novel anti-arrhythmic agent.

Methods:

The anti-arrhythmic effects of compounds were studied against aconitine-induced arrhythmias in rats and ouabain-induced arrhythmias in guinea pigs. The effects of Sul on transmembrane action potentials were investigated in isolated rabbit sinoatrial nodes and guinea-pig papillary muscles using intracellular recording. With a whole-cell recording technique, the effects of Sul on sodium current, calcium current, and potassium currents were examined in isolated single guinea-pig ventricular myocytes.

Results:

In aconitine-induced arrhythmias of rats, sulfamide analogues of changrolin (4, 5, and 6a–6p) exhibited various anti-arrhythmic activities. The sulfate of compound 6f (Sul) increased the amount of aconitine required to induce arrhythmias in each treated animal. The ED₅₀ value of Sul in rats was 196 mg/kg. In ouabain-induced arrhythmias of guinea pigs, 25, 50, and 100 mg/kg doses of Sul increased the dose of ouabain required to induce VP, VT, and VF in a dose-dependent manner. In papillary preparations, Sul produced a concentration-dependent decrease in APA and V_max, prolonged APD₉₀ and ERP, whereas RP was unaffected. In the spontaneously beating sinus nodes, Sul reduced APA and V_max in a concentration-dependent manner. The whole-cell recording studies revealed that Sul produced a reversible reduction in I_Na (IC₅₀=26.9 μmol/L) and I_Ca,L(IC₅₀=69.2 μmol/L), whereas the inward rectifier (I_K1) and the delayed rectifier potassium currents (I_K) were unaffected.

Conclusion:

As a multi-ion channel blocker, Sul may have potent efficacy in anti-atrial and ventricular arrhythmias.     

Study on Metabolites of Aconitum Alkaloids in Human Urine

TheaconitebelongstoplantsofgenusAconituminfamilyofRanunculaceaandhavenotableclinicalfunctionsintreatingrheumaticarthritis ,heartfailure ,etc .However,accidentsofaconitine(fromaconite)poisoningfrequentlyoccurtomanypeopletakingtheseherbs .Theplantsofthisfamilycontainaconitine ,mesaconitine ,hypaconitineandotheraco nitumalkaloids .Theyarehighlytoxic ,andtheirtreatmentdoseapproachestothetoxicdoseorlethaldose .Duringtheperiodfrom 1989- 1995 ,morethan 30casesofpoisoningcausedbyaconitineinsometradit…     

参附汤体内代谢化学成分的初步研究

为了确定口服参附汤后体内吸收成分的化学结构 ,分离并鉴定了参附汤的组成成分之一———黑附片的主要成分 ;通过大鼠整体实验方法研究了参附汤体内代谢情况。结果显示 :口服参附汤后 ,乌头类生物碱卡米查林 (carmichaeline ,Ⅰ )、塔拉胺 (talatisamine ,Ⅱ )、附子灵 (fuziline ,Ⅲ )以原形形式被吸收 ,人参皂苷经肠内细菌代谢后以代谢产物CompoundK形式吸收进入体内     

蝙蝠葛酚性碱对实验性心肌缺血血流动力学的影响

目的: 观察蝙蝠葛酚性碱对实验性心肌缺血血流动力学的影响.方法: 结扎大鼠左冠状动脉前降支制备急性心肌缺血模型. 结果: 蝙蝠葛酚性碱可显著抑制心肌缺血所致LVEDP的升高和MBP、 dp/dtmax、-dp/dtmax、CO的降低.结论: 蝙蝠葛酚性碱能改善心肌缺血时血流动力学的紊乱,提示蝙蝠葛酚性碱对心肌缺血具有保护作用.