IBMTR/ABMTR 2001 Oral Presentations

TRANSPLANTATION OF UNRELATED UMBILICAL CORD BLOOD TO CORRECT GENETIC DISEASES IN PEDIATRIC PATIENTS Kurtzberg, J.; Howrey, R.P.; Szabolcs, P.M.; Driscoll, T.A.; Ciocci, G.; Wood, S.; Stevens, C.E.; Rubinstein,P.; Martin,P.L.REASSESSMENT OF ABO-INCOMPATIBILITY IN HEMATOPOIETIC STEM CELL TRANSPLANTATION Stussi, G.; Muntwyler, J.; Seebach, L.; Passweg, J.; Schanz, U.; Gratwohl, A.; Gmur, J.; Seebach, J.DECREASED TRANSPLANT RELATED MORTALITY AFTER THYMOGLOBULINE CONDITIONING BEFORE BONE MARROW TRANSPLANTATION USING UNRELATED DONORS. RESULTS FROM A MATCHED COHORT STUDY Remberger, M.; Storer, B.; Ringdén, O.; Anasetti, C.IMMUNE RECONSTITUTION AFTER ALLOGENEIC MARROW VERSUS BLOOD STEM CELL TRANSPLANTATION Storek, J.; Dawson, M.A.; Storer, B.; Stevens-Ayers, T.; Maloney, D.G.; Boeckh, M.QUALITY OF LIFE AND SEXUAL LIFE IN PATIENTS POST HEMATOPOIETIC STEM CELL TRANSPLANTATION Park, E.; Lee, M.H.; Yoon, S.S.; Kim, W.S.; Park, C.SYNGENEIC STEM CELL TRANSPLANTATION FOR METASTATIC BREAST CANCER Williams, S.; Rizzo, D.; Wu, J.; Antman,K.     

Acute respiratory diseases/influenza sentinel 2000/2001

A sentinel surveillance system of the public health service for acute respiratory diseases (ARD), especially influenza, has been realized in the Free State of Saxony of Germany for 25 years. The epidemiological sentinel is based on weekly registration of morbidity and mathematical-statistical calculations. For a microbiological sentinel, a fast diagnosis by nucleic acid amplification techniques and improvements of sample management in connection with the rapid transmission of results have been introduced. In the present report, the ARD/influenza sentinel is demonstrated for the season 2000/2001. The sentinel system provides scientific and practical information for a prophylactic and therapeutic control program. Economic significance has been proved by verifiable numerical data derived from several epidemiological and microbiological investigations. The realized system has been considered superior to the influenza surveillance scheme of the Arbeitsgemeinschaft Influenza (AGI, Marburg, Germany) for all Germany and another system of a pharmaceutical company which is under construction.     

The nucleotide sequence of foot-and-mouth disease virus O/FRA/1/2001 and comparison with its British parental strain O/UKG/35/2001

The complete nucleotide sequence of foot-and-mouth disease virus (FMDV) O/FRA/1/2001 (bovine isolate) was determined from five cDNA clones covering most of the genome and compared with the British porcine isolate (O/UKG/35/2001) it originated from. Seven substitutions, out of which three resulted in amino acid changes (in the leader protease, 3A protein and 3D RNA-dependent RNA polymerase sequences) were identified and confirmed by direct sequencing of RT-PCR products obtained from in vitro infected cells and skin vesicles of an infected cow. RACE amplification allowed determination of the exact 3' end of the genome. These changes and possibly the unusual 3A substitution between the British and its French derivate may account for the consecutive species shifts.