HYPOTHALAMIC DIGOXIN,HEMISPHERIC DOMINANCE,AND NEUROBIOLOGY OF LOVE AND AFFECTION

The human hypothalamus produces an endogenous membrane Na+-K+ ATPase inhibitor, digoxin, which can regulate neuronal transmission. The digoxin status and neurotransmitter patterns were studied in individuals with a predilection to fall in love. It was also studied in individuals with differing hemispheric dominance to find out the role of cerebral dominance in this respect. In individuals with a predilection to fall in love there was decreased digoxin synthesis, increased membrane Na+-K+ ATPase activity, decreased tryptophan catabolites (serotonin, quinolinic acid, and nicotine), and increased tyrosine catabolites (dopamine, noradrenaline, and morphine). This pattern correlated with that obtained in left hemispheric chemical dominance. Hemispheric dominance and hypothalamic digoxin could regulate the predisposition to fall in love.     

CLASSICAL AND ATYPICAL NEUROLEPTICS,AND BONE MINERAL DENSITY,IN PATIENTS WITH SCHIZOPHRENIA

There are some reports that classical neuroleptics may lead to osteoporosis or reduced bone mineral density (BMD). However, there is no adequate information about the effects of atypical neuroleptics on BMD. The aim of this study was to measure BMD in schizophrenic patients taking class -ical and atypical neuroleptics, compared to healthy controls. Seventy- five patients with schizophrenia (40 taking classical neuroleptics [CN], 35 taking atypical neuroleptics [AN]) and 20 healthy controls (HC) were included in the study. Spine (L1 L4) BMD was measured by dual-energy X-ray absorptiometry. ANOVA showed that BMD was higher in HC than AN and CN. In addition, there was a negative correlation between the duration of neuroleptic treatment and BMD and the duration of the illness. These findings suggest that atypical neuroleptics may be safer than the classical neuroleptics in terms of reduced BMD.     

YELLOW FILTERS,MAGNOCELLULAR RESPONSES,AND READING

It has been suggested that yellow filters may increase magnocellular responsivity. This suggestion was, in large part, based on the assumption that the S-cones inhibit the magnocellular system. However, the evidence invoked to justify this assumption is only indirect. A previously reported direct electrophysiological investigation of this issue has found that S-cone input to the magnocellular system actually sum with L-and M-cone inputs. Therefore, the notion that yellow filters enhance magnocellular responses by reducing inhibition from S-cones cannot be maintained.