Treatment of intestinal amebiasis with paromomycin

Summary Results are presented on the effect of paromomycin on chronic intestinal amebiasis in 35 patients. Thirty-four (97.1%) were free of parasites after a single 12-day treatment; 14 were followed for 3 months, and 20 for 6 months. The importance of very careful, prolonged observation, with examination of stool specimens is emphasized.The authors wish to thank the Parke, Davis Laboratories, Buenos Aires, for the Humatin used in this study.     

Gastric malignant lymphoma with superimposed amebiasis

A case of primary B, large cell lymphoma of the stomach with superimposed amebiasis due to Entamoeba histolytica is reported. This represents the second recorded case of such an association. A review of the subject and possible mechanisms of infection are discussed.     

The treatment of pleuropulmonary amebiasis with metronidazole

One hundred forty patients with pleuropulmonary amebiasis were classified radiographically in order to rationalize therapy based on the use of metronidazole. Amebic testing with gel diffusion, serial chest x-ray films, and observation of the patient's response to treatment have dominated management of the patients, 135 of whom made a successful recovery. Five patients died. Sixty percent of the surviving patients have been reviewed at a follow-up clinic, and there has been no instance of recurrence of amebiasis.     

Diagnosis of amebiasis

Summary and Conclusions A review of the present day status of the diagnosis of amebiasis has been presented. It is probable that the teamwork of the alert physician and the expert parasitologist will result in a correct diagnosis in 90 per cent of cases. Read at the meeting of the New Jersey Proctologic Society, April 1958.     

Acute,fulminating amebiasis with multiple complications

Summary A case has been presented in which the patient had acute fulminating amebiasis, complicated by hemorrhage, perforation of the colon, obstruction of the small bowel, pleuropulmonary disease and hepatic involvement. Treatment is discussed in the light of known therapeutic types of management which were altered to meet the demands of a combination of complications. Treatment was begun by administration of chloroquine, Diodoquin? and tetracycline orally. When vomiting intervened, emetine and tetracycline were administered parenterally. Hemorrhage responded to antiamebic treatment and anemia was corrected by blood replacement. Perforation was treated by administration of high doses of broad-spectrum antibiotic agents, emetine and fluids. Obstruction of the small bowel, subsequent to perforation, was bypassed by a jejunoileostomy and transverse colostomy after repair of traumatically-induced perforation of the friable bowel. Pneumonitis, amebic pleural effusion and hepatic involvement were treated by administration of emetine and chloroquine.     

Current problems of amebiasis in Japan and recent advances in amebiasis research

Amebiasis is epidemic in two major populations in Japan: male homosexuals and institutionalized people. Currently available diagnostic, chemotherapeutic, and prophylactic measures and their problems are discussed. Recent advances in basic research on amebiasis are also described with new findings of unique metabolisms and intracellular structures and organization. Discoveries and analyses of the unique features presented by this parasitic protist help in our elucidation of the pathogenic mechanisms of the parasite and may eventually lead to the development of new drugs and vaccines against amebiasis.