吻合血管的股前外侧皮瓣移植修复足踝部皮肤软组织缺损(附4例报告)

目的探讨股前外侧皮瓣修复足踝部皮肤软组织缺损的临床应用价值。方法采用吻合血管的股前外侧皮瓣游离移植修复足踝部皮肤软组织缺损。切取皮瓣最大18cm×10cm,血管蒂长10cm,动脉口径约2mm,静脉口径约3mm。结果4例皮瓣完全成活。随访6～18个月,皮瓣厚薄适中,无臃肿,足踝部活动正常。结论股前外侧皮瓣是修复足踝部皮肤软组织大块缺损的有效方法之一。     

远端蒂腓肠神经筋膜皮瓣修复小腿下段与足踝部软组织缺损

目的探讨应用远端蒂腓肠神经筋膜皮瓣修复小腿下段与足踝部软组织缺损的方法和临床效果。方法应用远端蒂腓肠神经筋膜皮瓣修复小腿下段与足踝部软组织缺损29例,修复部位:小腿下1／3及跟腱区13例,外踝及足背外侧区7例,内踝及足内侧区6例,足跟及足底3例。皮瓣面积最大为13 cm×8 cm,最小为6 cm×3 cm,蒂长4-11 cm。结果29例术后皮瓣全部成活,术后27例获6个月至3年随访,其中24例皮瓣外观、血运、质地、色泽、弹性好,3例皮瓣经Ⅱ期修整,外形改善,皮瓣供受区无严重并发症发生。结论远端蒂腓肠神经筋膜皮瓣修复小腿下段与足踝部软组织缺损操作简便,不需牺牲小腿主要动脉,皮瓣成活率高,并发症少,是修复足踝部软组织缺损的较好方法。     

股前外侧皮瓣的临床应用

目的 探讨利用股前外侧皮瓣修复皮肤软组织缺损的临床疗效.方法 对2012年3月-2016年3月苏州大学附属第一医院收治的32例皮肤软组织缺损患者采用股前外侧皮瓣游离移植修复.皮瓣切取范围为12 cm×6 cm~22 cm×13 cm.结果 该组32例皮瓣全部成活,创面均Ⅰ期愈合.术后无1例发生血管危象.随访6~24个月,平均16个月.所有皮瓣外形及功能均满意.结论 临床应用股前外侧皮瓣游离移植修复皮肤软组织缺损是一种较为理想的方法.     

股前外侧皮瓣移植修复四肢皮肤软组织缺损12例分析

目的:探讨应用股前外侧皮瓣移植来修复四肢皮肤软组织缺损的方法和临床效果。方法:应用吻合血管的股前外侧皮瓣移植修复四肢皮肤软组织缺损12例,皮肤缺损面积最大23cm×14cm,最小18cm×9cm。结果:术后12例皮瓣全部成活,软组织修复效果好,随访6~24个月,局部功能完全恢复,皮肤无缺损。结论:股前外侧皮瓣血管解剖恒定,厚薄适中美观,部位隐蔽,可切取面积较大,容易切取,是修复四肢皮肤软组织缺损的有效方法。     

股前外侧皮瓣游离移植修复足踝部组织缺损

目的观察游离股前外侧皮瓣移植修复足踝部组织缺损的临床效果.方法应用游离股前外侧皮瓣移植治疗足踝部组织缺损27例,缺损面积12cm×7cm-25cm ×15cm.术前、术中受区创面彻底清创,切取股前外侧皮瓣修复创面,术后常规三抗治疗,及时处理血管危象.结果27例均获随访,时间6-36个月.出现血管危象2例,经及时处理后皮瓣恢复血液循环1例,1例探查失败,皮瓣修薄成游离全厚皮移植全部成活.结论游离股前外侧皮瓣供区隐蔽,成活率高,皮瓣质地优良,特别适合足底、足跟及足踝部皮肤软组织缺损以及肌腱、骨外露患者,是修复足踝部皮肤软组织缺损的理想皮瓣.     

股前外侧皮瓣移植修复小腿前外侧软组织缺损8例护理体会

目的:总结应用股前外侧皮瓣游离移植修复小腿前外侧软组织缺损的临床效果及护理体会。方法:应用股前外侧皮瓣游离移植修复创伤性小腿皮肤软组织缺损、骨及内固定物外露8例。结果:8例共移植16个皮瓣,缺损面积5.0 cm×8.0 cm～15.0 cm×23.0 cm,移植面积7.0 cm×10.0 cm～17.0 cm×25.0 cm;皮瓣携带的穿支数3支2例,2支5例,1支1例,单个穿支最大切取面积12.0cm×20.0 cm;血管蒂长5.5～14.5cm,16个皮瓣全部成活。结论:游离股前外侧皮瓣血管蒂长、切取面积大,可携带股外侧肌形成肌皮瓣,是修复小腿大面积软组织缺损的理想皮瓣,因此类手术精细,时间较长,故围手术期护理对于皮瓣成活至关重要。     

游离股前外侧(肌)皮瓣修复手背部软组织缺损的疗效分析

探讨游离股前外侧(肌)皮瓣移植修复手背部软组织缺损的临床疗效。2015年6月～2017年1月,设计游离股前外侧(肌)皮瓣修复手背部皮肤软组织、肌腱及内在肌缺损、骨缺损共17例,并参照术前计划切取皮瓣修复缺损,缺损范围为5cm×3cm～20cm×8cm,皮瓣切取范围为6cm×4cm～21cm×9cm。 17例(肌)皮瓣全部成活,无一例皮瓣出现坏死或部分坏死,均获随访6～24个月,随访期间,皮瓣外形及功能良好。因此,游离股前外侧(肌)皮瓣修复术是修复手背部软组织缺损较为理想的方式之一。     

带腓动脉后外侧穿支蒂的腓肠神经营养岛状皮瓣修复足踝部皮肤缺损

目的　探讨带腓动脉后外侧穿支蒂的腓肠神经营养岛状皮瓣修复小腿、足踝部皮肤缺损的效果。方法　自2010年12月到2014年5月,采用带腓动脉后外侧穿支蒂的腓肠神经营养岛状皮瓣修复小腿、足踝部皮肤缺损8例,其中男性7例,女性1例,年龄33～50岁,平均年龄40.5岁。结果　8例患者皮瓣全部成活,创面封闭。皮瓣最大面积15　cm×13　cm,最小6　cm×5　cm。随访半年至1年皮瓣质地良好,厚度适中,外形及功能较为良好,术区全部I期愈合。结论　带腓动脉后外侧穿支蒂的腓肠神经营养岛状皮瓣是修复小腿、足踝部皮肤缺损的理想选择之一。     

腓肠神经营养血管皮瓣修复小腿及足踝部皮肤缺损

为观察应用腓肠神经营养血管皮瓣修复小腿及足踝部皮肤缺损的临床效果,分析16例应用腓肠神经营养血管皮瓣修复小腿下段及足踝部软组织缺损患者资料。均为筋膜皮瓣,皮瓣面积最小5cm×6.5cm,最大为12cm×16cm。行暗道转移5例,其余11例行明道转移。结果,所有病例皆出现程度不同的皮瓣肿胀,暗道较明道明显。皮瓣边缘坏死1例。1例皮瓣部分坏死,后经游离植皮愈合。表明腓肠神经营养血管皮瓣修复小腿及足踝部皮肤缺损,带蒂转移,成功率高,修复范围广,是一种简单、实用、可靠的治疗方法。     

胸脐皮瓣修复足踝部巨大软组织缺损的应用

目的:探讨应用胸脐皮瓣移植修复足踝部巨大软组织缺损的临床效果。方法:在腹壁下血管解剖学研究基础上,应用游离胸脐皮瓣修复21例足踝部巨大软组织缺损。创面面积(38 cm×28 cm)～(10 cm×25 cm)。结果:临床应用21例,除1例皮瓣远端小部分坏死,2例皮缘远端部分表皮坏死,均经过植皮或换药逐渐愈合外,其余皮瓣完全成活,术后经过2～36个月随访,效果满意。结论:胸脐皮瓣修复小腿及足踝部大面积皮肤软组织缺损是一种较为理想的治疗方法。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.