低强度半导体激光对糖尿病大鼠伤口愈合时间的影响

目的：观察低强度半导体激光（LISCL）辐照创面疗法对糖尿病大鼠伤口愈合时间的影响。方法：创面制备24h后应用LISCL分别照射A组、B组、C组糖尿病大鼠一侧创面,光斑直径约3cm,照射时间每次10min,光纤末端输出功率分别为51mW（A组）、14mW（B组）、7mw（C组）（每次照射前均用激光功率计校验输出功率值）,功率密度分别为45．11mW／cm2（A组）、12．38mW／cm2（B组）、6．19mW／cm2（C组）,能量密度分别为27.07J／cm2（A组）、7．43J／cm2（B组）、3、72J／cm2（C组）,每日照射】次,共14次,照射侧随机选择左侧或右侧,对侧作为对照不做任何处理。结果：对照组间比较F=0．29P）0．05,实验组间比较P（0．05B组实验组与A、C两组实验组间P（0.05,A组实验组与C组实验组间P〉0．05。结论：B组实验组创面经激光照射后,创面愈合时间较对照组和A组、C组实验组缩短,差异有统计学意义,提示功率密度12．38mW／cm2、能量密度7．43J／cm2的低强度半导体激光能够促进创面愈合。     

半导体激光治疗根管充填后疼痛的临床研究

目的 :比较半导体激光和抗生素与非甾体类抗炎药联合应用在治疗牙根管充填后疼痛的疗效。方法 :对行根管充填的 4 87例患牙中出现疼痛的 5 9例患牙随机分为两组 ,分别用半导体激光和抗生素与非甾体类抗炎药联合治疗 ,比较疼痛级别变化。结果 :半导体激光照射后有 87.1 0 %的患者止痛 ,而抗生素与非甾体类抗炎药则为 6 4 .2 9% ,疼痛减轻前者明显优于后者 (P<0 .0 1 )。结论 :半导体激光是治疗根管充填后疼痛的优选方法之一。     

半导体激光治疗带状疱疹

半导体激光是近年发展起来的一门新技术 ,我们采用ＬＨＨ-5 0 0半导体激光治疗仪治疗 15例带状疱疹患者 ,并与 15例未使用此治疗方法的带状疱疹患者进行了比较 ,总结如下。1　临床资料1.1　一般资料30例带状疱疹患者均来自我院皮肤科门诊 ,表现为皮疹伴疼痛。随机分为两组 ,Ⅰ组为激光加常规治疗组 ,15例 ,男 4例 ,女11例 ,年龄 12～ 71岁 ;Ⅱ组为常规治疗组 ,15例 ,男 7例 ,女 8例 ;年龄 14～ 71岁。两组基本情况及病情匹配 ,均在发病后 3～ 7ｄ内接受治疗。肿瘤、结核、结缔组织病、孕妇及哺乳期妇女及重症感染伴高热的患者除外。观察指标…     

低强度脉冲激光治疗糖尿病大鼠神经病理性疼痛的实验研究

目的:系统阐明830 nm波长的低强度脉冲激光对于神经病理性疼痛的治疗效果。方法:30只雄性SPF级Wistar大鼠平均等分至空白对照组、糖尿病周围神经病理性疼痛(DNP)组、糖尿病周围神经病理性疼痛协同激光治疗(DNP+Laser)组。对DNP组和DNP+Laser组通过腹腔注射链脲佐菌素(STZ)构建糖尿病模型,DNP+Laser组施加激光干预(700 Hz、60 mW),每天刺激3次,每次50 s,连续刺激8周。分别于STZ注射的第0、2、4、6和8周对各组实验动物的足底机械痛阈值和热痛阈值进行检测,并通过植入电极测量大鼠的感觉神经和运动神经传导速率。结果:DNP+Laser组足底机械痛阈值和热痛阈值在STZ注射的第4、6、8周显著高于DNP组(P<0.05),且DNP+Laser组感觉神经传导速率和运动神经传导速率在第4、6、8周也显著高于DNP组(P<0.05)。结论:低强度激光对于延缓糖尿病大鼠神经病理性疼痛的发病进程具有积极的作用效果,提示低强度脉冲激光疗法有望成为临床糖尿病神经病理疼痛治疗的一种有效的物理因子作用方案。     

低功率半导体激光治疗止痛效果临床观察

诸症之中，痛为要症。人们因痛影响生活、工作、情绪，导致健康受损。对疼痛治疗，临床方法颇多，如药物、理疗、封闭、针炙等，其效果各不尽同。随着医用激光器技术的不断进步，低功率激光广泛应用于临床治疗，激光中崭新光源的半导体激光，其止痛效果迅速、且无痛、无副作用，患者乐于接受，但报道尚少。我们采用不同波长，不同功率的半导体激光治疗以疼痛为主要症状的软组织疾病，观察了止痛效果，现报告如下。1 资料与方法1） 临床资料：所有病例随机分为两组：（1）第一组（简称810组）25例，男11例，女14例。年龄18～79岁。18～30岁4…     

低功率半导体激光对口腔溃疡局部β -EP的影响

目的 观察低功率半导体激光对口腔溃疡局部组织内β -EP的影响,探讨激光止痛机制.方法 健康新西兰大白兔34只,4只用于空白对照,其余30只建立口腔溃疡模型后进行自身对照,实验侧作激光治疗,对照侧不做处理,用放免法检测β -EP的含量变化.结果 实验侧与对照侧β-EP含量均显著高于空白对照组(P＜0.05),实验侧与对照侧之间差异无统计学意义.结论 激光照射并未使口腔溃疡局部组织中β -EP释放增多,有关激光止痛机制仍需进一步研究.     

低强度半导体激光血管内照射对内耳病患者听力学和免疫机能的影响

目的:探讨低强度半导体激光血管内照射对内耳病患者听力学和免疫机能的影响。方法:收集内耳病完整病例55例(73耳),随机对患者进行低强度半导体激光血管内照射并继续药物治疗31例(41耳),单独用药治疗作为对照组24例(32耳)。两组治疗前后均做听力学(纯音侧听,SISI重震反应试验,耳鸣匹配等)检查,并做有关的免疫学(CD3+,CD4+,CD8+,CD4+/CD8+比值及CIC等项目)监测和照射后可随访病例的追踪观察。结果:经激光血管内照射后纯音测听结果证实听力逐步恢复至正常者4例,纯音听力上升15dB～45dB者16例;未见听力提高的13例(21耳),有效率为48.8%。SISI由阳性变化成为阴性的5耳,耳鸣消失或减轻的12例(16耳),眩晕缓解者6例。本组激光照射后对正常健侧耳的听力未见任何不良反应的主诉及其听生理测试之异常。单独用药的对照组中有6例(7耳)听力提高或恢复正常;听力无改善者18例(25耳)。有效率为22%。两组病例中伴有免疫学异常的内耳病共发现38例,激光照射疗程后有条件做复查的11例,以细胞性免疫为主恢复或趋于正常数据的9例,无明显变化的2例。结论:低强度半导体激光血管内照射在听力损伤修复过程中可能起重要作用,并可调节机体的免疫异常,药物并用激光治疗内耳病优于既往单独药物疗法。     

针刺治疗脑卒中后痉挛性瘫痪疗效比较的系统评价与Meta分析

目的:系统评价针刺治疗脑卒中后痉挛性瘫痪的疗效。方法:电子检索国内外数据库中针刺治疗脑卒中后痉挛性瘫痪的随机对照试验(Randomized Controlled Trial,RCT),并由两名评价者按照Cochrane Handboo5.1.0中的方法独立进行文献筛选和质量评估,运用Rev Man5.3软件进行数据统计和Meta分析。结果:最终纳入15个RCT,共包括940例患者。Meta分析显示:(1)有效率:试验组高于对照组,有统计学意义[OR=1.88,95%CI(1.35,2.61)];(2)MAS评分:针刺(综合)组疗效优于康复组,有统计学意义[WMD=-0.58,95%CI(-0.77,-0.39)];(3)FMA评分:试验组疗效优于对照组,有统计学意义[WMD=10.90,95%CI(8.69,13.11)]。结论:针刺治疗脑卒中后痉挛性瘫痪有一定的疗效,在与康复结合时更能凸显优势。但是由于纳入文献研究质量不足,目前不能对其疗效得出肯定性结论,需要以更多高质量的多中心随机对照试验进一步证实。     

Blood-Letting Therapy for Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Objective: To evaluate the efficacy and safety of blood-letting therapy (BLT) in treatment of hypertension. Methods: A comprehensive electronic and manual bibliographic searches were performed in Cochrane Central Register of Controlled Trials, Excerpt Medica Database (EMBASE), PubMed, China National Knowledge Infrastructure, Chinese Scientific Journal Database, Chinese Biomedical Literature Database, and Wanfang Database to identify randomized controlled trials (RCTs) in which hypertensive patients were treated with BLT or BLT plus antihypertensive drugs (BPAD) against placebo, no treatment or antihypertensive drugs. The Cochrane Risk Assessment Tool was used to assess the methodological quality of trials. The Review Manager 5.3 software was used for meta-analysis. Results: A total of 7 RCTs with 637 hypertensive patients from 1989 to 2017 were identified. Compared with antihypertensive drugs, blood pressure was significantly reduced by BLT (RR=1.21, 95% CI: 1.01 to 1.44, P=0.03; heterogeneity: P=0.06, I2=60%) and BPAD (RR=1.25, 95% CI, 1.02 to 1.53, P=0.03; heterogeneity: P= 0.01, I2=71%). Moreover, a significant improvement in Chinese medicine syndrome by BLT (RR=1.32; 95% CI: 1.14 to 1.53, P=0.0002; heterogeneity: P=0.53, I2=0%) and BPAD (RR=1.47; 95% CI: 1.06 to 2.04, P=0.02; heterogeneity: P=0.13, I2=56%) was identified. The reported adverse effects were well tolerated. Conclusions: Although some positive findings were identified, no definite conclusions regarding the efficacy and safety of BLT as complementary and alternative approach for treatment of hypertension could be drew due to the generally poor methodological design, significant heterogeneity, and insufficient clinical data. Further rigorously designed trials are warranted to confirm the results.     

Effectiveness of Auricular Acupressure for Acute Postoperative Pain after Surgery: A Systematic Review and Meta-Analysis

Objective: To identify the effectiveness of auricular acupressure(AA) in patients with acute postoperative pain after surgery by systematic review. Methods: A search of randomized controlled trials was conducted in 5 English medical electronic databases and 4 Chinese databases. Two reviewers independently retrieved related studies, assessed the methodological quality, and extracted data with a standardized data form. Meta-analyses were performed using all time-points meta-analysis. Results: A total of 26 studies with 1,682 participants were included. Results showed that compared with conventional therapy, AA significantly improved the total effective rate [risk ratio=1.25, 95% confidence interval(CI), 1.13 to 1.37, P0.0001; heterogeneity: P0.0001, I~2=85%]. In the subgroup analysis, the results changed in different follow-up time and surgery categories. The pain relief in the AA group might be the most significant at 72 h after surgery(mean difference=–0.85, 95% CI, –1.20 to –0.50, P0.0001) and in abdominal surgery(mean difference=–1.15, 95% CI, –1.41 to –0.90, P0.0001). Sensitivity analysis demonstrated that the results of this meta-analysis were stable. No serious adverse effects were recorded. Conclusions: It was recommended to provide AA to patients with acute postoperative pain. However, a more accurate estimate of the effect requires further rigorously designed large-scale and high-quality RCTs for improving acute postoperative pain after surgery.     

Clinical Efficacy and Safety of Miniscalpel-Needle Treatment for Tension-Type Headache: A Systematic Review and Meta-Analysis

Objective: To investigate the clinical efficacy and safety of miniscalpel-needle(MSN) treatment for tension-type headache(TTH). Method: Seven medical databases were searched to identify randomized controlled trials(RCTs) evaluating the effect and safety of MSN treatment. All articles published up to November 15, 2018 were retrieved. A meta-analysis was conducted for the included studies, and the risk of bias was assessed. Primary outcomes were visual analogue scale(VAS) or numeric rating scale(NRS) score. Secondary outcomes were clinical effective rates including total effective rate(TER), markedly effective rate(MER), and totally cured rate(TCR) determined by improvement in clinical symptoms or VAS scores, the frequency of adverse events(AEs) that occurred during the study, and participant quality of life(QOL). Results: Seven RCTs involving 724 participants were included. MSN treatment showed significantly higher MER and TCR [relative risk(RR) 1.27, 95% confidence interval(CI) 1.01 to 1.61; RR 1.31, 95% CI 1.09 to 1.57, respectively], but not TER(RR 1.03, 95% CI 0.96 to 1.10) compared to acupuncture. MSN treatment plus conventional treatment showed significant lower VAS and higher TER, MER, and TCR(mean difference –3.54, 95% CI –3.80 to –3.28; RR 1.14, 95% CI 1.06 to 1.23; RR 2.31, 95% CI 1.50 to 3.58; RR 3.01, 95% CI 2.25 to 4.02, respectively) compared to conventional treatment. Conclusions: According to current evidence, MSN treatment as a monotherapy or as an adjunctive treatment to other existing treatments might have benefits on treating TTH. However, since the number and the sample size of studies included were both small and the methodological quality was poor, the findings of this review should be interpreted with great caution, and our confidence in the results is low. A high quality RCT using objective outcomes should be performed on this topic.     

Efficacy and Safety of Lianhua Qingwen for Patients with COVID-19: A Systematic Review and Meta-Analysis

Background: Corona virus disease 2019(COVID-19) has spread around the world since its outbreak, and there is no ascertained effective drug up to now. Lianhua Qingwen(LHQW) has been widely used in China and overseas Chinese, which had some advantages in the treatment of COVID-19. Objective: To evaluate the efficacy and safety of LHQW for COVID-19 by conducting a systematic review with meta-analysis. Methods: A comprehensive literature search was conducted in 12 electronic databases from their est...     

针灸治疗泌尿系结石的系统评价和Meta分析

目的:评价针灸治疗泌尿系结石的有效性和安全性。方法:检索国内外数据库,收集关于针灸治疗泌尿系结石的RCT文献,并进行筛选及数据提取,采用RevMan 5.3软件进行Meta分析。结果:共纳入16篇文献2 324例患者,Meta分析结果显示针灸治疗组与对照组相比在总有效率、治愈率、镇痛起效时间、结石排出时间等方面的差异均有统计学意义(P<0.05)。结论:针灸治疗泌尿系结石疗效较好,但现有研究文献质量较低,有待开展高质量临床研究。     

中医药疗法治疗艾滋病合并抑郁症的系统评价与Meta分析

目的 系统评价中医药疗法治疗艾滋病合并抑郁症的疗效与安全性.方法 检索包括中国知网、万方数据库、维普数据库、Sinomed、PubMed、Cochrane Library、EMbase、Web of Science建库以来至2020年2月收录的有关于中医药疗法治疗艾滋病合并抑郁症的随机对照试验,并对其进行筛选和资料提取...     

Chuna Therapy for Musculoskeletal Pain: A Systematic Review of Randomized Clinical Trials in Korean Literature

Objective

To evaluate the effectiveness of Chuna for the treatment of musculoskeletal pain as reported in Korean literature.

Methods

We conducted an electronic literature search using seven Korean databases and manually searched six traditional Korean medicine journals. Risk of bias was assessed with the Cochrane criteria.

Results

Six randomized controlled trials (RCTs) were included in the study. Compared with standard care, three RCTs suggested favorable effects of Chuna on neck pain due to a hypolordotic cervical spine, low back pain caused by traffic accidents, and low back pain. In contrast, compared with standard care, three RCTs failed to show positive effects on temporomandibular joint disorder, mandibular movement, and neck pain caused by traffic accidents.

Conclusions

Currently, the evidence of the effectiveness of Chuna for the treatment of musculoskeletal pain is not convincing. Further rigorously designed trials are warranted to determine its effectiveness.     

Pregnancy Benefit of Acupuncture on in vitro Fertilization: A Systematic Review and Meta-Analysis

Background:Currently,more and more infertility couples are opting for combined acupuncture to improve success rate of in vitro fertilization(IVF).However,evidence from acupuncture for improving IVF pregnancy outcomes remains a matter of debate.Objective:To quantitatively summarized the evidence of the efficacy of acupuncture among women undergoing IVF by means of systematic review and meta-analysis.Methods:Four English(PubMed,Web of Science,EMBASE,and Cochrane Register of Controlled Clinical Tri...     

Rituximab Treatment Strategy for Patients with Diffuse Large B-Cell Lymphoma after First-Line Therapy: A Systematic Review and Meta-Analysis

Background:Rituximab in combination with cyclophosphamide,doxorubicin,vincristine,and prednisone (CHOP) significantly prolonged event-free survival in first-line chemotherapy for patients with diffuse ...