Lipoprotein -- an independent risk factor for CVD

A case control study done to evaluate the Lipoprotein(a) [LP(a)] as a risk factor for CVD (cerebrovascular disease). 150 non-smokers, non-alcoholic subjects free from DM, renal disease, thyroid disease and liver disease were included in the study. Among them 120 were CVD cases and 30 were age and sex matched healthy control. Subjects were grouped as group-I (30, healthy control), Group-II (60, Hemorrhagic CVD) and group-III (60, Ischemic CVD). Fasting (12 hr) blood samples were collected from all subjects and in CVD cases samples were collected after 24 hr of attack. Lipid profile and LP(a) conc. were measured in all samples. Mean serum LP(a) conc. in Group-I, Group-II and Group-III were found to be 17.6 7.4 mg/dl, 31.9 15.6 mg/dl and 44.8 24.0 mg/dl respectively. Both the groups of CVD cases showed significantly higher level of serum LP(a) conc. compared to healthy control. CVD cases did not differ statistically in respect of their lipid profile when compared with control. Moreover the serum LP (a) conc. of CVD cases found to show no correlation with their lipid profile, suggesting the serum LP(a) conc. a possible independent risk factor for CVD.     

Serum immunoglobulins in leukaemia and malignant lymphoma

The serum immunoglobulin levels were studied in 25 healthy control subjects and 23 cases of leukaemia (6 cases of acute lymphatic leukaemia, 5 cases of acute myeloid leukaemia, 2 cases of chronic lymphatic leukaemia and 10 cases of chronic myeloid leukaemia) and 17 cases of malignant lymphoma (13 cases of Hodgkin's lymphoma and 4 cases of non-Hodgkin lymphoma). The mean levels of IgG, IgA and IgM in 25 control subjects were 1573.56 +/- 91.45 mg/dl, 209.64 +/- 12.55 mg/dl and 109.81 +/- 10.03 mg/dl respectively, those in 23 cases of leukaemia were 1338.23 +/- 109.74 mg/dl, 195.53 +/- 20.72 mg/dl and 127.47 +/- 13.29 mg/dl respectively and those in 17 cases of malignant lymphoma were 996.99 +/- 99.50 mg/dl, 147.47 +/- 19.61 mg/dl and 129.35 +/- 19.95 mg/dl respectively. The mean levels of IgG and IgA were found to be decreased in cases of leukaemia with elevated levels of IgM, however, it was found to be insignificant (p less than 0.4). The mean IgG, IgA and IgM levels were found to be almost identical in different leukaemia irrespective of cytological types except in 2 cases of chronic lymphatic leukaemia which showed low levels of IgG and IgA. The mean levels of IgG and IgA were found to be significantly decreased in malignant lymphoma (p less than 0.02). IgM levels were found to be increased in 3 cases of non-Hodgkin lymphoma.     

Study of serum electrolytes in pregnancy induced hypertension

Hypertension complicating pregnancy is an important cause of foetal and maternal mortality and morbidity. Serum sodium, potassium, calcium and magnesium were evaluated in cases with gestational hypertension and pre-eclampsia and compared with normotensive pregnant women of corresponding period of gestation. Taking urinary micro-albumin creatinine ratio as standard to predict pregnancy induced hypertension, the role of serum electrolytes to predict the same was studied. A total of 200 patients were evaluated. There were no change in serum sodium and potassium in gestational hypertensive cases as well as in pre-eclamptic cases when compared with control group. Similar results were obtained when serum calcium level was evaluated. Mean serum magnesium level (1.53 +/- 0.29 mg/dl) was significantly low in cases of pre-eclampsia, while it was 1.79 +/- 0.25 mg/dl in patients with gestational hypertension and 2.19 +/- 0.2 mg/dl in control group. Patients having gestational hypertension along with increased micro-albumin creatinine ratio had significantly low mean magnesium level (1.68 +/- 0.1 mg/dl) when compared with gestational hypertensive patients with normal microalbumin creatinine ratio (serum magnesium level 1.87 +/- 0.1 mg/dl).     

围手术期肠外营养支持对不同营养状态Crohn病患者免疫球蛋白、体重以及与感染有关并发症的影响

目的探讨围手术期肠外营养支持对不同营养状态Crohn病患者的免疫球蛋白、体重和并发症的影响.方法将在本院确诊、计划手术治疗的32例Crohn病患者按术前有无营养不良分组,体重下降在15%～30%者为营养不良组,共16例;体重下降＜15%者为对照组,共16例.两组患者均在手术前1周和手术后3周应用肠外营养(PN)支持(共4周);于PN前后测定血清中IgM、IgG和IgA水平、肝功及体重变化.监测术后并发症.结果两组患者的IgM水平于PN前均高于正常值[对照组(133±16)mg/dl,营养不良组(139±41)mg/dl;正常值(110±35)mg/dl;P=0.04];PN治疗后营养不良组患者明显下降[(105±29)mg/dl,P=0.02)],达到正常水平,对照组无明显变化[(129±13)mg/dl,P=0.34].两组患者的IgA和IgG水平于PN前在正常范围,PN后无明显变化(P值在0.20～0.57之间).体重对照组PN前后无明显变化[PN前(55.6±6.1)kg,PN后(56.3±6.0)kg;P=0.46],营养不良组较PN前升高[(PN前(45.8±8.9)kg,PN后(48.0±8.8)kg;P=0.005)].对照组患者与感染有关性并发症较营养不良组多(对照组4例,25%;营养不良组2例,12.5%;P=0.13),但无统计学差别.结论围手术期应用肠外营养支持,能改善有明显营养不良Crohn病患者的体液免疫状态,增加体重;而无明显营养不良的患者获益较少.     

代谢综合征组分组合对心脑血管疾病风险预测的比较研究

目的探讨代谢综合征(MS)组分组合对心脑血管疾病(CVD)的预测能力。方法应用美国Fram-ingham Risk Score(FRS)和中国人群的心血管病综合危险度简易评估工具——缺血性心血管病(ischemic cardiovasculardiseases,ICVD)两种模型分别对CVD事件做出预测,并比较不同MS组分组合人群CVD事件的危险度。结果 MS的4种组分同时存在时CVD发病风险最大,其FRS和ICVD预测CVD的绝对风险中位数分别为14.0%和10.3%。MS组CVD 10年发病绝对风险均高于MS高危组和对照组(P<0.01),FRS模型预测MS组中危及高危能力高于ICVD模型(P<0.05),特别是>60岁MS患者。结论 FRS和ICVD两个模型均可以区分不同人群CVD的危险度,FRS模型长于对中危、高危人群CVD的预测,而ICVD模型长于对低危人群CVD的预测。从而为制定有针对性的危险因素控制策略、减少CVD的发生提供科学依据。     

β-FIBRINOGEN PROMOTER-455 G／A （HaeⅢ） POLYMORPHISM PREDICTION OF PLASMA FIBRINOGEN BUT NOT OF ISCHEMIC CEREBROVASCULAR DISEASE

Objective The-455 G/A (HaeⅢ) polymorphism of β-fibrinogen gene influences levels of plasma fibrinogen. We further investigated whether it influences the risk of isehemie cerebrovaseular disease. Methods We accumulated 134 acute isehemic eerebrovaseular disease (ICVD) eases and compared their -455 G/A status with a control group (n=166). The β-fibrinogen gene -455 G/A polymorphism was analyzed for all subjects by PCR-RFLP with the restrictive enzyme HaeⅢ. Results Plasma fibrinogen was higher in AA homozygous participants (341mg/dL) than in participants carrying the G allele: GA (290mg/dL), GG (298mg/dL) in the control group. Plasma fibrinogen was also higher in AA homozygous patients (353mg/dL) than in eases carrying the G allele: GA (287mg/dL), GG (302mg/dL) in the ICVD group. However, there was no significant association between β-fibrinogen gene -455 G/A polymorphism and ICVD group. Conclusions Although a small effect cannot be excluded, β-fibrinogen gene -455 G/A polymorphism is an independent predictor of plasma fibrinogen, but not of isehemie cerebrovaacular disease.     

Fluidity of erythrocyte membranes in patients with ischemic cerebral vascular disease

Measurement of fluidity of erythrocyte membrane (FEM) in thirty-six patients with ischemic cerebral vascular disease (ICVD) by fluorescence polarization of DPH (1,6,-Diphenyl-1,3,5-hexatriene) labelled on lipo-region in intact erythrocyte membrane. Twenty one healthy subjects without any stagnation of blood as control. Also research on coefficient of multiple correlation among the FEM and other factors in whole blood or plasma by using stepwise multi-regression analysis. The results revealed that: (1) FEM of patients with ICVD was 3.55 +/- 0.21 (eta), which was significantly higher than that of healthy subjects (2.77 +/- 0.12 eta), P less than 0.001. (2) The FEM of patients with ICVD were positive correlation with RBC electrophoresis rate, whole blood viscosity and low density lipo-proteins and were negative correlation with high density lipo-proteins. These findings suggested that it would be available for preventing ICVD by increasing of the surface charge on erythrocyte and of the high density lipo-proteins.     

Levels of plasma fibrinogen and D-dimer in subjects with subclinical hyperthyroidism.

BACKGROUND: During the last 15 years, several risk markers for atherosclerosis, such as fibrinogen and D-dimer, have been identified. The role of elevated fibrinogen levels as an independent risk factor for coronary, cerebral, and peripheral vascular disease is well established on the basis of clinical and epidemiological studies. Increased D-dimer levels are associated with increased risk of future myocardial infarction, stroke, and peripheral vascular disease. The aim of this study was to evaluate the alterations in fibrinogen and D-dimer, which indicates overall thrombotic activity, in subjects with subclinical hyperthyroidism. MATERIAL/METHODS: Thirty-six subclinical hyperthyroidic subjects and 36 euthyroidic control subjects matched for age, gender, and body mass index were selected. The levels of plasma fibrinogen and D-dimer in all subjects were measured. RESULTS: The level of fibrinogen was significantly higher in the subclinical hyperthyroidic group than in the euthyroidic group (296.9+/-74.3 mg/dl vs. 255.0+/-41.7 mg/dl, p<0.001). The level of D-dimer was significantly higher in the subclinical hyperthyroidic group than in the euthyroidic group (261.9+/-47.8 mg/dl vs. 216.4+/-32.1 mg/dl, p<0.000). CONCLUSIONS: The results suggest that subjects with subclinical hyperthyroidism present a relatively hypercoagulable state. This state could contribute to increased thromboembolic risk in subclinical hyperthyroidism.     

Serum thyroglobulin autoantibody titres and immunoglobulin concentrations in Nigerians with goitre

Using the tanned turkey red blood cell haemaglutination test, blood samples from 327 Nigerians with goitre were screened for the presence of thyroglobulin autoantibody. 15 (4.6%) were found to have significantly positive autoantibody titres while none of the 50 age and sex-matched normal controls and autoantibody. Of the 15 with significantly positive thyroglobulin autoantibody titres, only 2 were males, giving a male:female ratio of 1 to 6.5. The mean serum concentration of IgG in the positive cases (4,163 +/- 53.5 mg/100 ml) was significantly higher than either that of normal controls (3,044 +/- 147.6 mg/100 ml) of goiterous subjects with no thyroglobulin autoantibody (2,196 +/- 116.5mg/100ml). It was found that thyroglobulin autoantibody is an IgG immunoglobulin. It is concluded that autoimmune thyroid disease occurs in Nigerians with goitre and that females are affected more than males.     

缺血性脑血管病患者外周血炎症因子的变化

目的：研究缺血性脑血管病患者炎性因子（hsCRP、IL-6以及TNFα）的表达情况,以探讨炎性因子在缺血性脑血管病发展过程中的意义。方法：选择本院神经内科患者41例。其中实验组（缺血性脑血管病组,ICVD组）31例,为缺血性脑血管疾病住院患者。对照组10例,为非缺血性脑血管疾病住院患者。所有研究对象均检测血浆IL-6、hsCRP及TNF-α含量。结果：正常对照组、ICVD组血浆hsCRP、IL-6以及TNFα水平在两组间比较差异有显著性意义（t hsCRP＝-3.896、tIL-6＝-5.081、t TNFα＝-2.837,均P <0.001）。结论：ICVD患者体内存在着炎症反应和免疫活化,外周血血浆hsCRP、IL-6以及TNFα水平较正常人明显升高,可能在缺血性脑血管病发展过程中发挥重要作用。     

Sustained-release theophylline-uniphyllin in nocturnal asthmatics

For a period of six months, we collected 12 cases of nocturnal asthmatics (7 males, 5 females); their ages ranged from 20 to 66 (the average age is 49). We found that administration of Uniphyllin (10 mg/kg) once a day at 6 PM could maintain the blood level of theophylline within therapeutic range at least 12 to 24 hrs. The peak expiratory flow rate of the 6 cases we collected, were significantly improved. The result of pharmokinetic parameters: 1) The average of a single dose (12 cases) is AUC (ug. hr/ml) 275.1 +/- 62. k; Kel (hr-1) 0.068 +/- 0.019; Ka (hr-1) 0.33 +/- 0.07); Tmax (hr) 6.3 +/- 1.4; T 1/2 (hr) 11.2 +/- 4.4; Clearance/F (ml/kg/hr) 37.9 +/- 9.0.2). The average of steady state (12 cases) is Css (mg/L) 5. 7 +/- 2.6; Cmax-Cmin (mg/L) 10.09 +/- 1.46.3). The average of relative bioavailability (3 cases) is 82%, 83%, 102%. However, the extent of absorption data is available for only 3 subjects. There are too few subjects to draw any meaningful conclusions about this relative bioavailability. Four cases show slight symptoms, including 1 case of dizziness, 2 cases of nausea, and 1 case gaseousness. It is suggested that the drug be administered at about 6-8 PM to coincide peak levels in the early morning in nocturnal asthmatics.     

Renal handling of uric acid in patients with type 1 diabetes in relation to glycemic control

BACKGROUND: The aim of the study was to compare the renal handling of uric acid (UA) in 16 patients with type 1 diabetes without renal failure (age 34.8 +/- 13.3 years) and in 15 healthy subjects (age 34.9 +/- 12.6 years). METHODS: Creatinine clearance (Cr-Cl), clearance of uric acid (UA-Cl), fractional excretion of uric acid (UA-FE), and 24-h urinary UA excretion (UA-U) were determined. Glycemic control was assessed using fasting glucose, glycated hemoglobin and fructosamine tests. RESULTS: Patients with diabetes had significantly (p < 0.0001) lower serum UA concentrations compared to control group (2.8 +/- 0.7 vs. 5.7 +/- 0.8 mg/dl), and higher urinary UA excretion (813 +/- 107 vs. 423 +/- 40 mg/day), UA clearance (21.9 +/- 7.1 vs. 5.2 +/- 0.9 mL/min) and fractional UA excretion (17.1 +/- 5.5 vs. 4.8 +/- 1.3%), with higher creatinine clearance (129 +/- 16 vs. 111 +/- 12 mL/min, p < 0.005). In patients with diabetes there was a strong negative correlation between serum UA concentration and UA 24-h excretion (R = -0.79; p < 0.001). Fractional UA excretion correlated with fasting glycemia and HbA1c (R = +0.51 and +0.53; p < 0.05). CONCLUSIONS: In type 1 diabetes there is significant UA renal clearance increase, which is higher with poor glycemic control. It leads to hypouricemia despite an approximately twofold UA excretion increase and therefore despite increased UA synthesis.     

Relationship between iron deficiency anaemia and serum lipid levels in Indian adults

Both iron deficiency anaemia and dyslipidaemia are widely prevalent public health problems, especially in the Indian population. Some link has been suggested between the two potentially morbid conditions but a sufficient Indian study could not be found in this regard. This study was planned to find the changes in serum lipid profile in adult Indian patients with iron deficiency anaemia and the effect of oral iron therapy on them. Seventy patients with iron deficiency anaemia and 70 age and sex matched healthy controls, in the age group of 18-35 years were investigated for any possible changes in serum lipid profile ie, triglycerides, total cholesterol, high density lipoprotein cholesterol, very low density lipoprotein cholesterol and low density lipoprotein cholesterol. The patients were followed up after 3 months of oral iron therapy. The results are shown as mean +/- standard deviation. Triglycerides and very low density lipoprotein cholesterol levels were found to be significantly (p < 0.001) elevated in the iron deficiency anaemia group (151.87 +/- 48.06 mg/dl and 30.40 +/- 9.71 mg/dl) as compared to controls (109.99 +/- 30.81 mg/dl and 21.96 +/- 6.69 mg/dl), whereas levels of low density lipoprotein cholesterol were found to be significantly (p = 0.02) lower in patients (90.96 +/- 41.55 mg/dl) as compared to controls (105.24 +/- 26.45 mg/dl). However, after treatment (in 43 patients) there was significant (p < 0.001) reduction in the levels of triglycerides and very low density lipoprotein cholesterol (111.56 +/- 26.87 mg/dl and 22.30 +/- 5.36 mg/dl) when compared to their pretreatment levels (154.70 +/- 53.89 mg/dl and 30.93 +/- 10.84 mg/dl), whereas low density lipoprotein cholesterol levels did not show any significant change. These findings indicate that iron deficiency anaemia in Indian adults is attended by abnormal serum lipid profile, which responds significantly to iron therapy.     

THE RELATIONSHIP BETWEEN SERUM LIPID LEVELS AND NUTRIENT INTAKE IN HEALTHY INHABITANTS OF URBAN AND RURAL SHANGHAI

The serum lipid levels (mean +/- SD) of 3312 healthy urban and rural inhabitants over 40 years of age in Shanghai were studied. The results were: cholesterol 166.7 +/- 30.9 mg/ml, triglyceride 81.1 +/- 42.3 mg/dl, HDL-cholesterol (HDLc) 57.4 +/- 11.6 mg/dl, HDL2c 20.6 +/- 9.8 mg/dl and HDL3c 37.1 +/- 7.8 mg/dl. Dietary surveys were carried out in 512 of these subjects and their average daily nutrient intake was estimated to be: total calories 2,577 Kcal, proteins 656 g (50.7 g of vegetable proteins), fat 69.1 g (P/S ratio 0.70), carbohydrates 423 g, cholesterol 282 mg, dietary fibres 23.5 g, sodium 4993 mg, potassium 2,618 mg and magnesium 575 mg. The serum lipid levels of urban and rural inhabitants were compared. Total cholesterol levels were significantly higher in urban inhabitants of all age groups and of both sexes, while triglyceride levels were significantly higher in urban inhabitants of certain age groups. However, HDLc levels, particularly HDL2c levels were significantly higher in rural inhabitants of most age groups and of both sexes. The above differences were probably the result of differences in dietary patterns and nutrient intake between urban and rural inhabitants.     

Renal effects of gadopentetate dimeglumine in patients with normal and impaired renal function

Gadolinium chelates are widely used in magnetic resonance imaging as contrast medium in patients with nephropathy. However, only few studies have investigated the effect of gadolinium on serum creatinine concentration and estimated GFR as surrogate markers of renal function. This study was performed to evaluate the effect of gadopentetate dimeglumine in a dose sufficient for diagnostic and interventional purposes on renal function in a large sample of patients. We analyzed serum creatinine and serum-urea levels before and after the administration of gadopentetate dimeglumine in patients with normal and patients with pre-existing impaired renal function. Age, height, body mass, sex, medication and preexisting illnesses such as diabetes, renal artery stenosis and heart disease were monitored. In 181 patients with normal renal function, there was no statistically significant change in serum creatinine concentration after the administration of gadopentetate dimeglumine (at baseline: 0.72 +/- 0.18 mg/dl, after gadolinium: 0.73 +/- 0.22 mg/dl). In contrary, serum creatinine levels decreased significantly after the administration of gadolinium in 198 patients with pre-existing renal impairment (1.82 +/- 1.03 mg/dl before and 1.72 +/- 1.03 mg/dl after gadolinium) (p < 0.01). According to this surrogate marker of renal function, the change of estimated GFR in patients with normal baseline renal function was not significant, while in patients with impaired renal function, GFR increased after the administration of gadolinium (p < 0.001). The high diagnostic value of gadolinium contrast media is associated with a very small risk of adverse reactions. Our findings show that the administration of gadolinium even is associated with a decrease of serum creatinine in patients with pre-existing renal impairment. In conclusion, the use of gadolinium-based contrast media may be considered as a safe alternative in patients with impaired renal function for whom use of iodine-based contrast agents is prone to a high rate of radiocontrast-induced nephropathy.     

高血压患者凝血、纤溶活性变化及硝苯地平缓释剂对它的影响

OBJECTIVE: To investigate the changes of coagulation and fibrinolysis status in patients with essential hypertension (EH) and observe the therapeutic effect of sustained-release nifedipine. METHODS: Ninety-nine EH patients were divided according to their diastolic blood pressure (DBP) into mild group (48 cases), moderate group (29 cases) and severe group (22 cases), and 25 patients among the groups were chosen at random to receive sustained-release nifedipine for 2 weeks. Twenty healthy subjects served as control group. Plasma D-dimer (DD), fibrin monomer (FM) and tissue-type plasminogen activator (tPA) levels were determined in all the subjects by enzyme-linked immunosorbent assay (ELISA). RESULTS: The plasma DD and FM levels were much higher, while tPA level was much lower in hypertensives than those of normal controls, exacerbating with the severity of the disease. DBP was positively correlated with plasma FM level (r=0.374,P<0.001). In patients with left ventricular hypertrophy, left ventricular enlargement and left atrial enlargement, higher levels of DD, FM and tPA were detected. Nifedipine treatment produced significant reduction in plasma DD and FM levels along with the increase in tPA level [DD: (40.7+/-23.5) mg/dl vs (23.8+/-16.5) mg/dl; FM: (7.0+/-1.6) ng/microliter vs (4.8+/-1.5) ng/microliter tPA: (0.31+/-0.14) ng/ml vs(0.41+/-0.05) ng/ml, P<0.001]. CONCLUSION: Enhanced coagulative activity and lowered fibrinolytic activity characterize EH patients and nifedipine may correct this disorder.     

Preliminary report on various symptoms of chronic hepatitis treated with radix Astragali and its regulative effect on levels of serum hormone

67 cases of chronic hepatitis were treated with Radix Astragali. After treatment (2-month course), the clinical improvement rates in 38 cases of the Gan-Yu Pi-Xu type and in 26 cases of the Gan-Shen Yin-Xu type were 92.1% and 88.5% respectively, more effective than that of the control group (P less than 0.05). The regulative effect to the levels of serum hormone was observed in the patients of Gan-Yu Pi-Xu type with this medicine. The results showed that the levels of serum T3, E2 (female) and T (male) were increased after treatment (1.40 +/- 1.38 ng/dl, 129.30 +/- 1.23 pg/ml and 496.24 +/- 1.47 ng/dl respectively) than that before treatment (1.22 +/- 1.49 ng/dl, 104.60 +/- 1.45 pg/ml and 398.17 +/- 1.55 ng/dl respectively, P less than 0.05); however, the level of serum PRL (2.75 +/- 4.46 ng/ml) was lower after treatment than that (3.20 +/- 3.82 ng/ml) before treatment (P less than 0.05). No obvious changes were observed in the levels of serum FSH, LH, TSH, T4; T3U and F after treatment.     

Serum triglyceride level in IUGR babies and its comparison with preterm AGA and term normal babies

Intrauterine growth and birth weight are probably the most important factors that affect in survival and future quality of life. Intrauterine growth retardation causes program changes in body systems specially lipid metabolism that creates various problems of which coronary heart disease is important. Higher serum triglyceride (TG) level in IUGR babies relates to increase incidence of coronary heart disease. This cross sectional study was conducted in Bhangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh during July 2004 to June 2005. Serum TG levels were estimated among three groups: IUGR (n=30), preterm appropriate for gestational age (AGA) (n=30) and term normal (n=30) new born babies. Blood samples were collected from the study population in the neonatal unit and serum TG level were measured with all accuracy in a computerized automated biochemical analyzer in Biochemistry department of BSMMU. Statistical analysis were done by using student's 't' test. It was observed that serum TG level (54.4 +/- 11.2 mg/dl) in IUGR babies were significantly higher than that of term normal babies (38.7 +/- 5.8 mg/dl), p value < 0.05. This implicate future coronary heart disease in these babies as shown by others in long term prospective studies.     

人血清载脂蛋白CⅡ单向免疫扩散测定法

A radial immunodiffusion assay (RID) for quantitation of human serum apolipoprotein CII (apoCII) was developed. Antiserum to apoCII was raised in goats with purified apoCII. The antibody-gel plate was prepared with 1% agarose. 5 microliters of each sample or standard serum was added in a well. Diffusion was performed at 25 degrees C or 37 degrees C for 48 h. The standard curve with a working range of 0.8-4.5 mg/dl was plotted. The minimum measurable concentration of apoCII was 40 ng. The intra-assay and inter-assay CV were 1.4-3.5% and 1.3-3.6% respectively. The recovery of the assay was 92.38-104.35%. The concentrations of apoCII for healthy adults and patients with hyperlipidemia were 3.9 +/- 1.7 mg/dl (M +/- SD, n = 67) and 5.9 +/- 2.5 mg/dl (n = 43) respectively.     

高同型半胱氨酸血症与缺血性脑血管病的相关性

目的：探讨高同型半胱氨酸血症（HHCY）与缺血性脑血管病（ICVD）的相关性。方法：选取2011年9月～2015年12月我院神经内科收治的130例脑梗死（CI）患者、67例短暂性脑缺血发作（TIA）患者以及同期我院体检科确诊的90例非 ICVD 患者（对照组）作为研究对象,采用循环酶法检测所有研究对象的血清同型半胱氨酸（HCY）,分析血清 HCY 水平与 ICVD 病变类型、病情严重度的相关性。结果：①三组研究对象血清 HCY 水平相比差异有统计学意义,对照组血清 HCY 水平显著低于 CI 组与 TIA 组,CI 组与 TIA 组之间血清 HCY 水平相比差异无统计学意义。② ICVD 患者血清 HCY 水平与其美国国立卫生院神经功能缺损量表（NIHSS）评分之间无相关性。③三组研究对象高甘油三酯血症、高胆固醇血症、糖尿病、高血压等危险因素百分率相比差异有统计学意义,对照组上述危险因素百分率均显著低于 CI 组与 TIA 组,CI 组与 TIA 组上述危险因素百分率相比差异无统计学意义。④采用多因素 Logistic 回归分析 ICVD 发生的危险因素,HHCY、高甘油三酯血症、高血压等3个指标具有统计学意义,高胆固醇血症、糖尿病等2个指标无统计学意义。结论：HHCY 是 ICVD 发生的独立危险因素,但 HHCY 与ICVD 病变类型、病情严重度无相关性。