共查询到18条相似文献,搜索用时 65 毫秒
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报告1例头皮肉芽肿性蕈样肉芽肿。患者女,76岁。头皮红斑和溃疡2年,背部红斑3年就诊。皮肤科检查:头皮大片状红色斑块,边缘略隆起,皮损内可见粗大分枝状血管、糜烂、结痂及毛发脱落,红斑约占头皮面积80%。左侧腰、背部一浸润性红色斑块,上覆少许干燥鳞屑。头皮皮损组织病理检查:表皮萎缩变薄,可见淋巴细胞浸润及Pautrier微脓肿形成;真皮内弥漫性淋巴细胞、组织细胞及多核巨细胞浸润,可见肉芽肿形成;部分淋巴细胞有异形性。免疫组化:淋巴细胞CD3、CD4、CD5及CD7均阳性,CD8散在阳性,组织细胞CD68阳性,增殖核抗原(Ki-67)约20%阳性。T细胞受体(TCR)基因重排:TCRβ及TCRγ重排阳性。诊断:肉芽肿性蕈样肉芽肿。 相似文献
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Fargnoli MC Peris K Francesconi F Cantonetti M Cerroni L Chimenti S 《European journal of dermatology : EJD》2002,12(5):479-481
We report a 61-year-old woman with a 1-year-history of widespread erythematous scaly patches and plaques as well as red/purplish to brownish confluent plaques. Ulcerated lesions with a purulent, hemorrhagic exudate and sharp elevated borders were located on the lower extremities. Diagnosis of granulomatous mycosis fungoides was supported by histopathologic findings showing an inflammatory reaction with epithelioid and large giant cells associated with features characteristic of mycosis fungoides. Immunohistochemical studies showed a T-helper phenotype of neoplastic cells (CD3+, CD4+, CD45RO+) with expression of the cytotoxic protein TIA-1. Molecular analysis of TCRgamma gene demonstrated a monoclonal rearrangement in the lesional skin. After failure of conventional therapies, 6 cycles of gemcitabine treatment produced partial remission of cutaneous lesions and stable disease throughout a 12-month follow-up period, suggesting that gemcitabine is a promising chemotherapeutic agent for refractory mycosis fungoides. 相似文献
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K. Morihara† N. Katoh† H. Takenaka† K. Kihara T. Morihara‡ S. Kishimoto† 《Clinical and experimental dermatology》2009,34(6):718-720
Granulomatous mycosis fungoides (MF) is a rare subtype of MF, characterized by the histological presence of a granulomatous reaction, but distinct clinical characteristics are not present. A 41-year-old healthy man presented with poikiloderma, ichthyosis and erythematous scaly plaque. Histological examination of a biopsy taken from poikilodermic skin showed a granulomatous reaction to epidermotropic atypical lymphocytes. However, in other areas there were only findings of conventional MF without granuloma. Granulomatous MF may be associated with poikiloderma. 相似文献
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Catharina Maria Freire de Lucena Pousa Natália Solon Nery Danielle Mann Daniel Lago Obadia Maria de Fátima Gon?alves Scotelaro Alves 《Anais brasileiros de dermatologia》2015,90(4):554-556
Granulomatous mycosis fungoides is a rare subtype of T-cell cutaneous lymphoma. Due
to its clinical heterogenicity the diagnosis is delayed and based on
histopathological and immuno-histochemical findings, sometimes requiring gene
rearrangement studies for confirmation. We report the case of a patient who was
submitted to several biopsies before diagnostic conclusion. 相似文献
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Gutte R Kharkar V Mahajan S Chikhalkar S Khopkar U 《Indian journal of dermatology, venereology and leprology》2010,76(6):686-690
Granulomatous mycosis fungoides (GMF) is a rare type of cutaneous T cell lymphoma. A 38-year-old married male presented with decreased sweating all over the body for last 8 years, progressive redness and scaling over body for 2 years and multiple noduloulcerative lesions over the body for 1 year. Cutaneous examination revealed generalized erythema and scaling with poikilodermatous changes over chest and upper back along with multiple noduloulcerative lesions. Skin biopsy from a nodular lesion revealed dense granulomatous infiltrate of atypical lymphocytes with epidermotropism and sparing of appendages. Diagnosis of GMF was made. Computed tomographic scan of thorax, abdomen and pelvis revealed axillary and inguinal lymphadenopathy. Immunohistochemistry revealed leukocyte common antigen and CD3 positivity suggestive of T cell origin. Patient was started on CHOP (Cyclophosphamide, Hydroxydaunorubicin, Oncovin and Prednisolone) regimen of chemotherapy with marked improvement after three cycles of chemotherapy. This case had some clinical resemblance to lepromatous leprosy. 相似文献
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A 40-year-old woman presented with a 5-year history of a mass overlying her right pectoralis major muscle. Histopathology of the lesion revealed a florid granulomatous infiltrate including an atypical lymphocytic component with marked epidermotropism consistent with granulomatous mycosis fungoides. Staging investigations demonstrated the tumour to be localized to the right chest. Consequently, the patient was treated with radiotherapy (50 Gy) to the lesion with good clinical effect. However, she soon developed a clinically palpable lesion on the left chest outside the radiotherapy field. Positron emission tomography scanning demonstrated an extensive left-sided chest wall tumour and also residual tumour on the right. This left-sided lesion failed to respond to systemic chemotherapy. Further radiotherapy (50 Gy) has recently been administered to the left chest lesion; the response is being monitored. While granulomatous inflammation has been previously described in cutaneous T-cell lymphomas, it is rare and is often associated with a delay in the diagnosis and difficulty with clinical staging. The clinical presentation can be extremely variable and consequently, diagnosis rests with histological features, immunohistochemical studies and gene rearrangement analysis. 相似文献
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We report a case of a 69-year-old gentleman who presented with a 3-month history of unexplained fevers and malaise who developed generalized pruritus, alopecia and an ichthyosiform erythematous eruption on his forearms, legs, chest and back. Skin histology, immunophenotyping and molecular features were consistent with granulomatous mycosis fungoides. He has been successfully treated with twice weekly PUVA photochemotherapy. 相似文献
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Z B Argenyi J A Goeken W W Piette K C Madison 《The American Journal of dermatopathology》1992,14(3):200-210
Granulomatous mycosis fungoides is a rare form of mycosis fungoides with controversial histogenesis. Early reports seemed to indicate a favorable prognosis for these patients. We report two cases of granulomatous mycosis fungoides, both of which had other unusual clinical features. The cases were studied with routine light microscopy, immunohistochemistry, electron microscopy, and gene probe studies. Despite some clinical and histopathologic similarities, the results of the immunohistochemical and molecular biologic studies were diverse. These results suggest that granulomatous mycosis fungoides does not define a single subset of cases, immunophenotypically or biologically. 相似文献
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Granulomatous mycosis fungoides with small intestinal involvement and a fatal outcome 总被引:2,自引:0,他引:2
We report a case of granulomatous mycosis fungoides that progressed into fatal gastrointestinal involvement 4 years after the onset of skin lesions, despite improvement of the skin lesions in response to a combination of PUVA and systemic interferon-gamma therapy. Histological examination showed Pautrier's microabscesses with granuloma annulare-like features and sarcoidal granuloma formation in the plaque stage, proliferation of blast-transformed atypical lymphocytes with persistent granuloma formation in the tumour stage, and metastatic lesions. A literature review of granulomatous mycosis fungoides revealed that 11 of the 24 reported cases died of the disease, and like our case, seven died within 5 years. We suggest that mycosis fungoides with granulomatous reactions does not indicate a favourable prognosis. 相似文献