共查询到18条相似文献,搜索用时 234 毫秒
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目的 分析2016-2021年淄博市宫颈癌发病、死亡情况及疾病负担变化趋势,为开展宫颈癌防治提供建议。方法 分析2016-2021年淄博市宫颈癌(ICD-10)发病和死亡资料,计算发病、死亡及疾病负担指标。结果 淄博市宫颈癌发病率由2016年的14.77/10万升至2021年的17.54/10万(APC=4.51%,t=3.37,P=0.028);标化发病率由12.13/10万升至14.83/10万(APC=4.85%,t=3.92,P=0.017);发病率随年龄增长先升高后降低,45~54岁组发病率升至高峰。沂源县25~44岁年龄组发病率由2016年的12.60/10万升至2021年的30.63/10万(APC=24.73%,t=3.87,P=0.018)。宫颈癌病死率随年龄增长而升高。2016-2021年宫颈癌所致伤残损失寿命年(YLD)率由0.72‰升到0.86‰,年度变化百分比(APC)为4.50%;城市中宫颈癌所致伤残调整寿命年(DALY)率高于农村;城市与农村宫颈癌所致过早死亡损失寿命年(YLL)率在DALY率中的占比均呈下降趋势,APC分别为-3.70%、-5.40%;城... 相似文献
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目的 探究江苏省昆山市1981-2014年全死因死亡率、平均期望寿命时间趋势及主要死因构成,为卫生部门循证决策提供依据。方法 历年全死因死亡病例来源于全死因监测,计算分性别的全死因死亡率和平均期望寿命,使用2000年全国人口普查年龄构成为标准计算年龄标化死亡率;使用年度变化百分比(APC)评价各个指标在年份之间变化趋势。结果 男女合计人群中全死因年龄标化死亡率由1981年的726.26/10万下降到2014年的258.40/10万(APC=-3.33%,95%CI:-3.54%~-3.12%);男性人群中由1981年的830.16/10万下降到2014年的289.30/10万(APC=-3.44%,95%CI:-3.68%~-3.20%);女性人群中由1981年的654.63/10万下降到2014年的226.40/10万(APC=-3.38%,95%CI:-3.60%~-3.16%)。男女合计人群平均期望寿命由1981年的69.67岁上升到2014年的82.26岁(APC=0.57%,95%CI:0.53%~0.61%)。恶性肿瘤(30.33%)、脑血管病(17.22%)、心血管病(9.09%)、呼吸系统疾病(15.30%)及损伤和中毒(8.08%)是当前影响居民死亡的主要原因。结论 昆山市1981-2014年全死因死亡率逐渐下降,平均期望寿命逐步提升,但恶性肿瘤、循环与呼吸系统疾病以及损伤与中毒仍是当前影响居民健康的主要原因。 相似文献
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目的 分析上海市浦东新区居民2008-2014年肺结核发病情况并预测其发展趋势, 为肺结核防治策略提供参考。方法 以2008-2014年上海市浦东新区常住户籍居民为研究对象, 按1985年世界标准人口和1982年中国标准人口计算TB及涂阳TB标化发病率、死亡率(age-standardized rate, ASR), 并应用Join-point regression program分析率值的年均变化百分比(annual percent change, APC)并进行趋势分析。结果 浦东新区2008-2014年肺结核新发5548例, 世界标化发病率为20.34/10万, 中国标化发病率为18.92/10万, 趋势平稳(APC=0.84%, Z=1.68,P=0.15), 年龄组发病率呈双高峰, 分别在20~24岁(36.72/10万)和80~84岁 (68.55/10万);共报告涂阳肺结核2285例, 世界标化发病率为7.32/10万, 中国标化发病率为6.45/10万, 呈明显下降趋势(APC=-4.22%, Z=3.41,P=0.01), 其中男性下降明显(APC=-4.51%, Z=6.77, P0.01), 女性趋势平稳(APC=-2.20%, Z=1.16,P=0.29)。结论 肺结核防控应分年龄段关注重点人群, 并采取有效措施积极探索发病相关危险因素, 从而降低肺结核的发病率。 相似文献
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上海市区肺癌的流行现状和趋势 总被引:12,自引:0,他引:12
目的:探索上海市区肺癌的发病和死亡情况以及变化趋势。方法:收集上海市肿瘤登记中的肺癌发病和死亡资料,计算发病率和死亡率;用线性回归和非线性回归拟合方法研究肺癌的流行趋势以及变化特点。结果:(1)1999年上海市区男性肺癌标化发病率和死亡率分别为53.10/10万和42.15/10万,女性分别为19.90/10万和14.77/10万。(2)肺癌发病和死亡例数50岁以上分别占91.9%和93.8%;且发病和死亡粗率随年龄增加而呈指数上升(Y=0.079 e^0.115x和Y=0.097 e^0.108x)。(3)无论发病率和死亡率,在成年人中男性均高于女性,男女平均比分别为2.54:1。(4)1980-1999年间,发病和死亡人数上升趋势非常显。发病和死亡粗率上升也较明显。标化发病率无显性变化。而死亡率显下降趋势。结论:1980-1999年,上海市区肺癌的发病和死亡粗率显上升,而趋势分析显示上海市区女性肺癌的标化死亡率均有下降趋势。 相似文献
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目的 了解我国2010—2021年人群自杀疾病负担现状与趋势,为相关预防措施和政策制定提供参考依据。方法 利用2010—2021中国死因监测数据,计算不同组别自杀粗死亡率、标化死亡率、早死损失寿命年(YLL)率;采用Joinpoint 4.9.0软件描述不同组别自杀标化死亡率和标化YLL率变化趋势。结果 2010—2021年自杀死亡率总体呈下降趋势(APC=-4.60%,P<0.001),标化死亡率由的9.94/10万下降至5.71/10万。其中男性和女性总体均呈现下降趋势,年度变化百分比(APC)分别为-3.89%和-5.62%(均P<0.001)。2017—2021年10~24岁年龄组自杀死亡率呈现上升趋势(APC=17.17%,P<0.001);2010—2021年25~44和75岁及以上年龄组均呈下降趋势,APC分别为-4.97%和-7.22%(均P<0.001);2010—2021年45~59和60~74岁年龄组均呈下降趋势,APC分别为-5.69%和-8.65%(均P<0.001)。2010—2021年YLL率总体呈下降趋势(APC=-3.21... 相似文献
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目的 分析2010—2021年北京市海淀区户籍人口恶性肿瘤死亡特征及变化趋势,为恶性肿瘤防控提供参考依据。方法 收集2010—2021年海淀区户籍人口恶性肿瘤死亡资料,计算构成比、死亡粗率及标化率、早死寿命损失(YLL)率及其标化率,应用Joinpoint回归模型估计平均年度变化趋势。结果 2010—2021年海淀区户籍人口恶性肿瘤居全死因首位,全死因占比30.23%,年均粗死亡率142.47/10万,标化死亡率93.32/10万;粗死亡率男性高于女性,差异有统计学意义(t=11.18,P<0.05),各年份标化死亡率男性均高于女性;相比2010年,2021年恶性肿瘤死因构成降至26.77%(降幅-15.37%),总人群、男性、女性粗死亡率呈逐年上升趋势[平均年度变化百分比(AAPC)分别为1.62%、1.82%、1.42%,均P<0.01],标化死亡率呈逐年下降趋势(AAPC分别为-1.50%、-1.13%、-1.85%,均P<0.01)。前10位死因以肺癌和消化道恶性肿瘤为主,前6位死因顺位基本无变化,依次为肺癌、结直肠癌、肝癌、胃癌、胰腺癌、乳腺癌;膀胱癌、乳腺... 相似文献
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目的 分析1990—2019年中国人群高低密度脂蛋白胆固醇(高LDL-C)归因疾病负担变化趋势。方法 提取2019年全球疾病负担(GBD 2019)中归因于高LDL-C的死亡、伤残调整寿命年(DALYs)、过早死亡损失寿命年(YLLs)、伤残损失寿命年(YLDs)等疾病负担指标,采用GBD 2019全球标准人口进行年龄标准化,采用年度变化百分比(APC)分析率的变化趋势。结果 1990—2019年,我国高LDL-C疾病负担随着年龄增长总体呈上升趋势。男性各年龄段死亡率、DALYs率和YLLs率高于女性,而YLDs率低于女性。Joinpoint回归结果显示,1990—2019年中国高LDL-C归因死亡率(APC=3.4%,P<0.05)、DALYs率(APC=2.4%,P<0.05)、YLLs率(APC=2.4%,P<0.05)、YLDs率(APC=2.9%,P<0.05)、标化死亡率(APC=0.8%,P<0.05)和标化YLDs率(APC=0.7%,P<0.05)均呈上升趋势。从年龄上看,死亡率、DALYs率和YLLs率在70岁以上年龄段呈上升趋势... 相似文献
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BACKGROUND AND STUDY AIMS: The incidence of oesophageal adenocarcinoma has increased significantly in recent years. While surveillance of people with Barrett's oesophagus, its usual precursor, has been advocated in order to detect dysplasia and early cancer in those considered to be at greatest risk, the impact of such a strategy on survival from oesophageal adenocarcinoma is unclear. This study aimed to determine the effect of surveillance on mortality from oesophageal adenocarcinoma in a group of patients considered to be at high risk of developing Barrett's oesophagus and adenocarcinoma. PATIENTS AND METHODS: After performing a Medline search of the literature published between 1985 and 2004 for studies on gastro-oesophageal reflux disease, Barrett's oesophagus and adenocarcinoma, we examined the impact of surveillance on mortality from oesophageal adenocarcinoma in a hypothetical sample of 100 high-risk patients (men aged over 50 with Barrett's oesophagus but without high-grade dysplasia at entry). RESULTS: Four patients in this high-risk group developed adenocarcinoma during surveillance, with survival rates of 78.9% (95%CI 64.9%-88.5%) at 2 years and 78.6% (95%CI 62.8%-89.2%) at 5 years. Meanwhile, between 515 and 2060 patients with Barrett's oesophagus were not detected or surveyed by this strategy and between 16 and 61 of these developed adenocarcinoma, with much lower survival rates of 37.1% (95%CI 25.4%-50.3%) at 2 years and 16.7% (95%CI 9%-28.3%) at 5 years. Although surveillance in the high-risk group resulted in the long-term survival of three patients who would not otherwise have survived, this gain was dramatically offset by the 13 to 51 patients, excluded from surveillance by this strategy, who died from oesophageal adenocarcinoma. CONCLUSIONS: A surveillance programme based on current concepts of risk cannot have an impact on mortality from oesophageal adenocarcinoma. To be effective, it will be necessary for surveillance programmes to utilise more precise methods for the identification of those who are most at risk of progression to adenocarcinoma. 相似文献
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目的应用Meta分析方法评价口服造影剂胃超声检查诊断胃癌的准确性。 方法检索PubMed、Web of Science、万方资源数据库、中国期刊全文数据库(CNKI),收集2000年1月至2019年12月公开发表的胃超声检查诊断胃癌准确性的研究,根据文献纳入和排除标准筛选出符合条件的文章,并采用QUADAS-2量表对纳入的文献进行质量评价。运用R统计软件对以诊断准确性为结局指标的文献进行Meta分析,运用Stata 15软件对以四格表为结局的文献进行Meta分析。 结果最终纳入文献30篇,共3613例研究对象。胃超声检查诊断胃癌的准确性为94%(95%CI:92%~95%),其中对早期胃癌的诊断准确性为81% (95%CI:74%~87%)。Meta回归分析发现研究设计可能是诊断准确性结果的异质性来源,亚组分析后,前瞻性设计的研究文献诊断准确性为96%(95%CI:95%~97%)。根据文献检索策略,最终纳入研究的30篇文献中,5篇可提供完整的诊断四格表数据,共计纳入研究对象1675例,5篇文献合并敏感度为0.93(95%CI:0.89~0.95),特异度为0.98(95%CI:0.86~1.00),阳性似然比为37.19(95%CI:6.40~216.23),阴性似然比为0.07(95%CI:0.05~0.11),诊断优势比为507.18(95%CI:91.18~2821.10),综合受试者工作特征(SROC)曲线下面积为0.95(95%CI:0.92~0.96)。 结论通过Meta分析得出口服造影剂胃超声检查诊断胃癌的准确性较高,作为一种低成本、非侵入性诊断技术值得临床普及推广应用,并可对此开展健康人群胃癌初筛和风险评估研究。 相似文献
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目的系统评价放化疗联合热疗治疗中晚期宫颈癌的疗效和安全性。方法计算机检索h e Cochrane Library(2013年7期)、PubMed、EMbase、CBM、VIP、CNKI和WanFang Data数据库,检索时限均为从建库至2013年7月,纳入有关放化疗联合热疗治疗中晚期宫颈癌的文献。由2名评价员按照纳入与排除标准独立筛选文献、提取资料和评价质量后,采用RevMan 5.2软件进行Meta分析。结果共纳入9个RCT,693例患者。Meta分析结果显示:与放化疗组相比,放化疗联合热疗组的1年生存率[OR=3.05,95%CI(1.70,6.68),P=0.005]、2年生存率[OR=2.29,95%CI(1.19,4.38),P=0.01]、总有效率[OR=3.66,95%CI(2.31,5.81),P<0.000 01]均明显上升,且差异有统计学意义,但两组不良反应发生率差异无统计学意义。结论放化疗联合热疗能明显提高中晚期宫颈癌患者的远期和近期疗效。但受纳入研究数量和质量的限制,上述结论仍有待更多高质量的研究予以验证。 相似文献
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Yansen Bai Xiaoliang Li Ke Wang Shi Chen Suhan Wang Zhuowang Chen 《Annals of medicine》2016,48(8):641-651
Background: Few studies investigated the combined effects of night-shift work, daytime napping, and nighttime sleep on cancer incidence and mortality.Methods: A total of 25,377 participants were included in this study. Information on sleep habits, cancer incidences, and mortalities were collected. Cox proportional hazards models were used to calculate the adjusted hazard ratios and 95% confidence intervals (HRs, 95%CIs).Results: Male subjects experienced ≥20 years of night-shift work, or without daytime napping had an increased risk of cancer, when compared with males who did not have night-shift work or napped for 1–30?min [HR (95%CI)?=?1.27 (1.01–1.59) and 2.03 (1.01–4.13), respectively]. Nighttime sleep for ≥10?h was associated with a separate 40% and 59% increased risk of cancer [HR (95%CI)?=?1.40 (1.04–1.88)] and cancer-caused mortality [HR (95%CI)?=?1.59 (1.01–2.49)] than sleep for 7–8?h/night. Combined effects of three sleep habits were further identified. Male participants with at least two above risk sleep habits had a 43% increased risk of cancer [HR (95%CI)?=?1.43 (1.07–2.01)] and a 2.07-fold increased cancer-caused mortality [HR (95%CI)?=?2.07 (1.25–3.29)] than those who did not have any above risk sleep habits. However, no significant associations were observed among women.Conclusions: Long night-shift work history, without daytime napping, and long nighttime sleep duration were independently and jointly associated with higher cancer incidence among males.
- KEY MESSAGES
Night-shift work of ≥20 years, without napping, and nighttime sleep of ≥10?h were associated with increased cancer incidence.
Nighttime sleep ≥10?h was associated with a 2.07-fold increased cancer-caused mortality among males.
Combined effects of night-shift work ≥20 years, without napping, and nighttime sleep ≥10?h on increasing cancer incidence were existed among males.
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目的系统评价国内外存活蛋白(Survivin)表达水平与宫颈癌及其临床病理特征的关系。方法计算机检索h e Cochrane Library(2013年第1期)、PubMed、MEDLINE(Ovid)、CNKI、CBM及WanFang Data,并手工检索相关杂志,查找国内外公开发表的关于Survivin蛋白表达与宫颈癌及其临床病理特征相关性的病例-对照研究,检索时限均为从建库至2013年5月。按照纳入和排除标准筛选文献、提取资料并评价质量,然后采用RevMan 5.1软件进行Meta分析。结果最终纳入13个病例-对照研究,共计1530例受试者,其中包括658例宫颈癌患者、563例宫颈上皮内瘤变患者和309例正常妇女。Meta分析结果显示:①Survivin在宫颈癌组与宫颈上皮内瘤变组[OR=4.63,95%CI(3.49,6.13),P<0.000 01]、宫颈癌组与正常宫颈组[OR=38.23,95%CI(23.92,61.11),P<0.00001]、宫颈上皮内瘤变组与正常宫颈组[OR=9.61,95%CI(6.11,15.09),P<0.00001]的表达差异均有统计学意义。②Survivin在临床分期Ⅰ~Ⅱ期与Ⅲ~Ⅳ期[OR=0.17,95%CI(0.07,0.41),P<0.0001]、淋巴结转移组与非淋巴结转移组[OR=3.57,95%CI(2.20,5.78),P<0.00001]、高分化组与中低分化组[OR=0.31,95%CI(0.13,0.76),P=0.01]、浅肌层浸润组与深肌层浸润组[OR=0.12,95%CI(0.02,0.68),P=0.02]的表达差异均有统计学意义。而在宫颈癌有宫旁或脉管浸润组与宫颈癌无宫旁或脉管浸润组[OR=24.15,95%CI(0.07,8199.76),P=0.28]的表达差异无统计学意义。结论目前国内外证据表明,Survivin蛋白的表达与宫颈癌及其临床病理特征有显著相关性,提示Survivin参与了宫颈癌发生、发展的全过程,但尚不能作为判断宫颈癌预后的独立因素。受纳入研究质量限制,上述结论尚需更多大样本、设计严谨的高质量研究加以验证。 相似文献
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Skogberg K Lyytik?inen O Ollgren J Nuorti JP Ruutu P 《Clinical microbiology and infection》2012,18(6):E170-E176
Bloodstream infections (BSI) are a major cause of mortality, morbidity and medical cost, but few population-based studies have concomitantly evaluated BSI incidence and mortality. Data on BSI episodes reported to national, population-based surveillance by all clinical microbiology laboratories in Finland during 2004-07 were linked to vital statistics. Age-, sex and microbe-specific incidence and mortality rates were calculated. During 2004-07, 33 473 BSI episodes were identified; BSI incidence increased from 147 to 168 per 100 000 population (average annual increase, 4.4%; p <0.001). Rates were highest among persons ≥65 years and <1 year, and higher among male patients than female patients (166 versus 152 per 100 000). The most common aetiologies were Escherichia coli (27%) and Staphylococcus aureus (13%). Among male patients, 52% of BSI were caused by gram-positive bacteria compared with 42% among female patients (p <0.001). The overall 30-day case-fatality was 13%. Of the deaths, 32% occurred within 2 days, 70% were among people aged 65 years or more and 33% were caused by E. coli or S. aureus infections. The BSI mortality rate increased from 19 to 22 per 100 000 (average annual increase: 4.0%, p 0.01). Among people aged 25 years or more, the mortality rate was 1.4-fold higher in men than women (34 versus 25 per 100 000 population). Overall excess annual mortality from BSI in the population was 18 per 100 000. The substantial BSI burden among the elderly and among adult men highlights the need for developing and implementing effective interventions, particularly for BSI caused by E. coli and S. aureus. One-third of BSI deaths occurred early, emphasizing the importance of early identification and treatment. 相似文献
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Nirav Thosani Subhas Banerjee Vikesh Khanijow Bhavana Rao Priyanka Priyanka Atilla Ertan Sushovan Guha 《World Journal of Meta-Analysis》2015,3(6):232-253
AIM: To assess the safety and efficacy of self-expandable metal stents(SEMSs) for malignant colorectal obstruction. METHODS: Data regarding technical success, clinical success, and procedure related complications were collected from included studies. Der Simonian-Laird random effects model was used to generate the overall outcome. Thirty international studies with a total of 2058 patients with malignant colorectal obstruction were included. RESULTS: The technical and clinical success rates for SEMS placement were 94%(95%CI: 92-96) and 91%(95%CI: 88-93), respectively. Overall complication rate for SEMS was 23%(95%CI: 18-29). Stent migration8%(95%CI: 6-10) and stent obstruction 8%(95%CI: 6-11) were the most common complications, followed by perforation 5%(95%CI: 4%-7%). Surgical or endoscopic re-interventions were needed in 14%(95%CI: 10-18) of patients. Endoscopic repeat stent placement was required in 8%(95%CI: 6-10), while surgical intervention was needed in 6%(95%CI: 4-8).CONCLUSION: SEMS are effective when used as palliation or bridge to surgery for malignant colorectal obstruction with high technical and clinical success. About 14% of patients require repeat endoscopic or surgical intervention for stent failure or to manage stent related complications. 相似文献
18.
We compared the average annual age-adjusted, sex- and site-specific cancer mortality rates among Kentuckians during two five-year time periods: 1971 to 1975 and 1976 to 1980. Lung cancer alone showed a statistically significant increase in mortality rates for both sexes, but significant increases were also found for skin cancer and leukemias among men and for pancreatic cancer and lymphomas among women. Significant decreases in mortality rates were observed for cancer of the rectum and stomach in both sexes, lymphomas among men, and leukemias and liver and uterine (corpus and cervix) cancer among women. Increased lung cancer mortality rates occurred for all age groups of women aged 35 and over, but in men, decreased lung cancer mortality rates were observed for ages 35 to 49 and increased rates only after age 50. All age groups of women experienced substantial declines in cervical cancer mortality rates. Without the dramatic increase in lung cancer mortality during this period, overall cancer mortality rates would have shown almost no change among Kentucky men and would have decreased among Kentucky women. 相似文献