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流行病学研究证明,低密度脂蛋白(LDL)和高密度脂蛋白(HDL)是调整心血管疾病风险的独立因子,如何升高HDL日益受到人们的重视。研究表明胆固醇酯转运蛋白(CETP)抑制剂具有较强的升高HDL和抗动脉粥样硬化作用,本文对CETP抑制剂的研究进展综述如下。 相似文献
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流行病学研究证明,低密度脂蛋白(LDL)和高密度脂蛋白(HDL)是调整心血管疾病风险的独立因子,如何升高HDL日益受到人们的重视。研究表明胆固醇酯转运蛋白(CETP)抑制剂具有较强的升高HDL和抗动脉粥样硬化作用,本文对CETP抑制剂的研究进展综述如下。 相似文献
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血浆尿酸与心血管病死亡率:1971~1992年NHANES 1流行病学随访研究 总被引:2,自引:0,他引:2
沈泽宁 《国外医学:心血管疾病分册》2000,(6)
尽管许多流行病学研究提示血浆中尿酸值水平的升高,是心血管病死亡的一个危险因子,但它们之间的关系尚不十分清楚。为确定血浆尿酸值水平与心血管病死亡的关系,以1971~1975年间首次国际健康与营养体检调查(NHANES 1)作为基线资料,同NHANES 1流行病学随访研究(NHEFS)资料作流行病学随访的交叉分段基础人群研究。 相似文献
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<正>血脂异常主要表现为LDL-C、TG水平升高和HDL-C水平下降。流行病学研究显示,LDL-C单一达标只能降低30%~45%的主要冠状动脉事件,低HDL-C水平同样具有高心血管事件风险,HDL-C每升高1%,心血管事件的发生率可降低2%~3%。HDL的功能是参与胆固醇逆向转运, 相似文献
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膳食纤维与冠心病的研究现状 总被引:1,自引:0,他引:1
膳食纤维(dietary fiber,DF)1953年由英国流行病学专家提出。自20世纪70年代Burkitt和Trowell的研究指出糖尿病和心血管疾病等的发病率升高可能与膳食纤维摄入量减少有关以来,DF便成为营养学家、流行病学家以及食品科学家研究的热点。认识到补充DF可能是过去15年美国冠心病死亡率下降30%的重要原凶,人们更加关注DF在维持健康和预防疾病中的作用。目前国外已有大量关于DF在防治便秘、控制体重、抗癌、降低血胆固醇、预防和控制糖尿病、降低心血管疾病危险性以及提高人体肠道免疫力等方面的流行病学和临床医学研究。 相似文献
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Mackay IR 《Internal medicine journal》2003,33(4):195-202
Abstract
Humanism includes, among its many contexts, the ideal of the universal perfection of health. Procedures for alleviation of disease existed through all epochs of human history, but efficacy was mostly lacking. The prototypic humanism of the Renaissance ( ad 1300−1600) scarcely involved the medical sciences other than human anatomy. The Enlightenment of the seventeenth century included discovery of the circulation of the blood, and applications of microscopy. Discoveries relevant to medical practice began in the nineteenth century, ushered in by vaccination and the germ theory of disease. This 200-year period saw a transformation of human health according to the surrogate marker of increased life-expectancy. This has been variously attributed to: (i) increased prosperity following the industrial revolution, (ii) efforts of humanistic social and public health reformers and, more recently, (iii) advances in medical science. Yet the beneficiaries remain a minority of the world's population. The nexus between poverty, illness and low life-expectancy between and within nations is the major challenge for the future. Contemporary science is providing ever-expanding knowledge on means to achieve the goal of perfection of human health, but the need for humanism is as great as at any previous age. Fortunately, however, the targets are more clearly visible than during the periods of poverty, plagues and pestilence of the past. (Intern Med J 2003; 33: 195−202) 相似文献
Humanism includes, among its many contexts, the ideal of the universal perfection of health. Procedures for alleviation of disease existed through all epochs of human history, but efficacy was mostly lacking. The prototypic humanism of the Renaissance ( ad 1300−1600) scarcely involved the medical sciences other than human anatomy. The Enlightenment of the seventeenth century included discovery of the circulation of the blood, and applications of microscopy. Discoveries relevant to medical practice began in the nineteenth century, ushered in by vaccination and the germ theory of disease. This 200-year period saw a transformation of human health according to the surrogate marker of increased life-expectancy. This has been variously attributed to: (i) increased prosperity following the industrial revolution, (ii) efforts of humanistic social and public health reformers and, more recently, (iii) advances in medical science. Yet the beneficiaries remain a minority of the world's population. The nexus between poverty, illness and low life-expectancy between and within nations is the major challenge for the future. Contemporary science is providing ever-expanding knowledge on means to achieve the goal of perfection of human health, but the need for humanism is as great as at any previous age. Fortunately, however, the targets are more clearly visible than during the periods of poverty, plagues and pestilence of the past. (Intern Med J 2003; 33: 195−202) 相似文献
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Barrett RK 《AIDS patient care》1995,9(5):240-244
The phenomena of self-initiated isolation and social withdrawal of people dying from AIDS is described and explained in the context of its irony and detriment to the patients' well being, minimizing access to social support resources. The psychological and the therapeutic relevance of social support during the critical transition phase is explored. Recommendations for curbing the phenomena of self-imposed social death in PWAs, as well as suggestions for future research on the value of psychosocial support to the PWA's well being during the transition phase, are also discussed. 相似文献
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目的探索老年人大肠息肉的临床特征。方法收集在上海中医药大学附属曙光医院2006年1月-2019年12月行电子结肠镜检查并且病理证实为大肠息肉的患者1000例,进行回顾性研究,按年龄分为老年组576例,中青年组424例。统计分析老年大肠息肉患者的临床症状、息肉大小、形态、部位、数目、息肉病理分型及其与息肉癌变的相关性,同时与中青年组比较。结果老年组最常见的临床表现为便血或粪隐血阳性(48.1%)及腹胀(45.8%),中青年组主要表现为腹胀(26.7%)和便秘(25.7%);2组患者均以无蒂、多发息肉多见,左半结肠是息肉好发部位;2组均以<2 cm的息肉多见;老年组≥2 cm的息肉多于中青年组(6.2%vs 3.6%,P=0.008);2组病理分型均以管状腺瘤为主,老年组管状绒毛状腺瘤比例高于中青年组(12.6%vs 7.6%,P=0.000);癌变率男女性间无差异;老年组息肉癌变率高于中青年组(9.7%vs 4.7%,P=0.004),左半结肠息肉、无蒂息肉、绒毛状腺瘤、>2 cm息肉癌变率高;老年组<2 cm息肉癌变率高于中青组(2.4%vs 1.0%,P=0.014)。结论腹胀、便血或粪隐血阳性是老年大肠息肉患者常见临床表现,老年患者大肠息肉癌变率高于中青年患者,大肠息肉的癌变率与年龄、息肉大小、部位、病理分型密切相关。 相似文献
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