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1.
Schaefer NG Strobel K Taverna C Hany TF 《European journal of nuclear medicine and molecular imaging》2007,34(1):60-67
Purpose To evaluate the diagnostic impact and clinical significance of FDG-avid bone lesions detected by FDG-PET/CT in patients with
lymphoma.
Methods The study population comprised 50 consecutive patients (mean age 41.7±15.5 years; 27 female, 23 male; 41 staging, 9 restaging)
with Hodgkin’s disease (n=22) or aggressive non-Hodgkin’s lymphoma (n=28) in whom FDG-avid bone lesions were detected by FDG-PET/CT. All patients had either direct biopsy of the FDG-avid bone
lesion (n=18), standard bone marrow biopsy at the iliac crest (BMB; n=43) or both procedures (n=11). In 15 patients, additional MRI of the bone lesions was performed. All patients underwent FDG-PET/CT after the end of
treatment. All CT images of FDG-PET/CT scans were analysed independently regarding morphological osseous changes and compared
with FDG-PET results.
Results In the 50 patients, 193 FDG-avid lesions were found by PET/CT. The mean standardised uptake value was 6.26 (±3.22). All direct
bone biopsies (n=18) of the FDG-avid lesions proved the presence of lymphomatous infiltration. BMB (n=43) was positive in 12 patients (27.9%). In CT, 32 of 193 (16.6%) lesions were detected without the PET information. No additional
morphological bone infiltration was detected on CT compared with FDG-PET. All morphological bone alterations on CT scans persisted
after the end of therapy. Additional PET/CT information regarding uni- or multifocal bone involvement resulted in lymphoma
upstaging in 21 (42%) patients compared with the combined information provided by CT and BMB.
Conclusion In patients with FDG-avid bone lesions, FDG-PET is superior to CT alone or in combination with unilateral BMB in detecting
bone marrow involvement, leading to upstaging in a relevant proportion of patients. 相似文献
2.
Background and purpose
Evaluation of bone marrow infiltration is an essential step in the staging of lymphoma. The accuracy of 18F-fluorodeoxyglucose-positron emission tomography (18F-FDG PET), combined 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) and magnetic resonance imaging (MRI) in diagnosing bone marrow involvement of lymphoma has never been systematically assessed, and the present systematic review was aimed at this issue.Methods
MEDLINE, EMBASE, Cochrane library and some other databases, from January 1995 to July 2010, were searched for initial studies. All the studies published in English or Chinese relating to the diagnostic value of 18F-FDG PET, PET/CT and MRI for patients with bone marrow involvement of lymphoma were collected. We extracted data to calculate sensitivity, specificity, SROC curves and AUC and to test for heterogeneity. The statistic software called “Meta-Disc 1.4” was used for data analysis.Result
In 32 included studies, PET/CT had the highest pooled sensitivity, 91.6% (95%CI: 85.1, 95.9) and highest pooled specificity, 90.3% (95%CI: 85.9, 93.7). PET/CT also had the highest pooled DOR, 68.89 (95%CI: 15.88, 298.92). The AUC of PET, PET/CT, and MRI were 0.9430, 0.9505 and 0.8764. There was heterogeneity among studies and no evidence of publication bias.Conclusion
PET/CT was a highly sensitive and specific modality in diagnosing patients with bone marrow involvement in lymphoma. Compared with MRI and PET alone, PET/CT can play important roles in the staging of lymphoma. 相似文献3.
Byun BH Na II Cheon GJ Kang HJ Kim KM Lee SS Ryoo BY Choi CW Lim SM Yang SH 《Annals of nuclear medicine》2008,22(8):645-651
Objective This pilot study was launched to explore the utility of positron emission tomography scans, at the time of diagnosis, for
clinical outcomes in patients with primary extranodal non-Hodgkin’s lymphoma (PENHL) in the head and neck, retrospectively.
Methods Twenty-two patients with a diffuse large B cell lymphoma (DLBCL) among those with a PENHL were included. We retrospectively
evaluated the clinical outcomes of patients according to the maximum standardized 18F-fluoro-2-deoxy-glucose (18F-FDG) uptake value of the primary lesion (SUVp). The SUVp was initially analyzed as a continuous variable. The cut-offvalue of SUVp was obtained from receiver-operating characteristic analysis to predict event-free survival. Using this value, patients were
divided into those with a low and high SUV.
Results Seventeen patients (59%) were men and the median age was 50 years. Most primary sites were in Waldeyer’s ring (73%). The SUVp ranged from 3.3 to 23.7. The international prognostic index (IPI < 2 vs. ≥ 2) was associated with the SUVp (P = 0.014). Patients with low SUVp showed favorable survival (P = 0.015). After IPI scores were stratified, the survival difference remained significant (P = 0.029).
Conclusions The results of this pilot investigation indicate that 18F-FDG uptake of the primary lesion may be related with survival outcomes in patients with extranodal DLBCL in the head and
neck. Further studies are needed to confirm and extend these results.
I.I. Na and G.J. Cheon contributed equally to this work. 相似文献
4.
Kim S Krynyckyi BR Machac J Kim CK 《European journal of nuclear medicine and molecular imaging》2008,35(5):984-989
Objectives It has been reported that the prevalence of 18F fluorodeoxyglucose (FDG) uptake in brown adipose tissue (BAT) is related to outdoor temperature, i.e., more frequent during
the colder periods of the year. The purpose of this study was to assess the temporal relationship between BAT FDG uptake and
temperature. We correlated the prevalence of BAT with average temperatures (divided into five temperature ranges) of seven
different durations.
Methods One thousand four hundred ninety-five consecutive FDG Positron emission tomography (PET) studies in 1,159 patients (566 male
and 593 female, mean age = 60.4 years) were retrospectively reviewed. FDG uptake with distinct patterns compatible with BAT
was identified by a consensus of two readers. The local daily average temperature from January 2000 to November 2003 (beginning
60 days before the date of first PET scan) were obtained, and 2-, 3-, 7-, 14-, 30-, and 60-day average temperatures before
the date of a PET study were calculated. The prevalence of BAT FDG uptake was correlated with these various average temperatures.
Results The daily, 2-day, 3-day, and 7-day average temperature had an inverse relation with the prevalence of BAT, i.e., the lower
the temperature, the higher prevalence of BAT. When the temperature was averaged over 14 days or longer, this inverse relationship
between the temperature and the prevalence of BAT was no longer preserved.
Conclusions Our data suggest that increased FDG uptake in BAT occurs more often as an acute response to cold weather (1–7 days) rather
than to prolonged periods of average cold weather. 相似文献
5.
目的:探讨原发性乳腺弥漫性大B细胞淋巴瘤的MRI表现及其临床病理特征.方法:回顾性分析18例经组织病理学证实的原发性乳腺弥漫性大B细胞淋巴瘤的临床、MRI及病理学特征.结果:18例患者均为女性,平均年龄51岁.临床触及肿块18例,6例在短期内迅速增大.MRI检查共发现病灶25处,其中单发病灶13例,单侧多发病灶2例,双侧多发病灶3例.病灶在T1 WI上呈等或略低信号,T2 WI呈高或稍高信号.增强后呈肿块样强化19处(76.0%),其中形态呈椭圆形或不规则形16处(84.2%),内部均匀强化14处(73.7%);非肿块样强化6处,其中内部不均匀强化3处(50.0%);10处病灶内可见“血管造影征”.伴有皮肤增厚7例,同侧腋窝淋巴结肿大10例.病理学镜下表现为肿瘤性淋巴样细胞较大或中等大小,弥漫性分布,部分呈单行索条状排列.结论:原发性乳腺弥漫性大B细胞淋巴瘤的病理学基础决定了其MRI表现有一定特征性,MRI检查有助于本病的诊断及鉴别诊断. 相似文献
6.
7.
Koya Nakatani Yuji Nakamoto Tsuneo Saga Tatsuya Higashi Kaori Togashi 《European journal of radiology》2011,79(1):29-35
Purpose
The clinical value of positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) for follow-up or suspected recurrence of renal cell carcinoma (RCC) has not been fully evaluated. The purpose of this study was to assess the diagnostic performance of FDG-PET for postoperative assessment in patients with RCC.Methods
We reviewed 28 scans in 23 patients who had undergone FDG-PET scans after surgery for RCC. Diagnostic accuracy of visually interpreted PET was evaluated based on final diagnoses obtained histologically or by clinical follow-up at least 6 months. Also, additional information over CT, influence on treatment decisions, and the accuracy of FDG uptake as a predictor of survival were assessed.Results
Recurrence of renal carcinoma was histologically (n = 15) or clinically (n = 6) confirmed in 21 of 28 cases. Overall, the sensitivity, specificity, and diagnostic accuracy using FDG-PET were 81%, 71%, and 79%, respectively. In papillary RCC, the sensitivity was 100%; however, that was 75% in clear cell RCC in patient-basis. PET correctly detected local recurrence and metastases in all cases in the peritoneum, bone, muscle and adrenal gland. Additional information was obtained from scans in 6 cases (21%), which influenced therapeutic management in 3 cases (11%). Cumulative survival rates over 5 years in the PET-positive vs. the PET-negative group were 46% vs. 83%, respectively (p = 0.17).Conclusions
FDG-PET would be useful for postoperative surveillance in patients with RCC, although its impact on treatment decisions may be limited. Further investigations are necessary to conclude whether PET has a prognostic value. 相似文献8.
Comparison of [18F]FDG-PET and L-3[123I]-iodo-alpha-methyl tyrosine (I-123 IMT)-SPECT in primary lung cancer 总被引:2,自引:0,他引:2
Willkomm P Bangard M Guhlke S Sartor J Bender H Gallkowski U Reichmann K Biersack HJ 《Annals of nuclear medicine》2002,16(7):503-506
OBJECTIVE: The aim of this study was to evaluate L-3[123I]-iodo-alpha-methyl tyrosine (IMT)-SPECT and FDG-PET in pulmonary lesions suspected to be lung cancer. METHODS: Whole body PET (measured transmission corrected emission scans) was performed 45 minutes after i.v. injection of 222-370 MBq (6-10 mCi) 18F-FDG on a Siemens PET scanner (ECAT EXACT 47) including 5-6 bed positions. 123I-IMT-SPECT (chest) was performed after injection of 370 MBq (10 mCi) with a dual head camera (Picker Prism 2000) and commercially available reconstruction algorithms. Ten patients (6 male and 4 female) with suspected lung cancer were investigated. The results were compared to histological findings after surgery or bronchoscopic biopsies and CT. RESULTS: 123I-IMT-SPECT and FDG-PET were able to detect all 9 cases of lung cancer (1-8 cm in diameter). One case was true negative. Both imaging methods were true positive with respect to mediastinal lymph node metastases in one patient. The tumor/background ratio was higher with PET (8.20 vs. 2.84). CONCLUSION: Despite the limited number of patients it may be concluded that IMT-SPECT as well as FDG-PET are suited to correctly diagnose lung cancer. Nevertheless, FDG-PET, if available, seems to be better suited because of the higher tumor/background ratio and better resolution. 相似文献
9.
Chatterton BE Ho Shon I Baldey A Lenzo N Patrikeos A Kelley B Wong D Ramshaw JE Scott AM 《European journal of nuclear medicine and molecular imaging》2009,36(3):354-361
Objectives The aims of this study were (1) to determine the incremental information provided by 18F-FDG positron emission tomography (PET) in staging patients with oesophageal cancer, and (2) to determine the impact of PET
staging on post-PET clinical management of oesophageal cancer, and on prognosis.
Methods In a multicentre, single-arm open study, patients with proved oesophageal cancer without definite distant metastases and regarded
as suitable for potentially curative treatment were examined by PET. Clinicians were requested to supply a management plan
before and another plan after being supplied with the PET scan results. Patients were followed for at least 1 year for outcome
analysis.
Results A total of 129 patients (104 men, mean age 67 y) were recruited. PET detected additional sites of disease in 53 patients (41%).
Significant changes in management (high or medium impact) were observed in 38% of patients, primarily as a result of identifying
additional sites of disease and/or confirming previously equivocal regional and distant metastases. Progression-free survival
was significantly shorter in patients found to have additional lesions on PET (p < 0.05), but was not related to SUVmax.
Conclusion These findings demonstrate the significant impact of PET on the clinical management of patients with newly diagnosed oesophageal
carcinoma, and on prognostic stratification of these patients.
This work was presented in abstract form at the SNM Annual Meeting 2007: J Nucl Med 2007;48 (Supplement 2):26P. 相似文献
10.
Yukyung Lee Kyung Hoon Hwang Junshik Hong Jinny Park Jae Hoon Lee Jeong Yeal Ahn Ji Hyun Kim Haejun Lee Seog Gyun Kim Ji Young Shin 《Nuclear Medicine and Molecular Imaging》2012,46(4):269-277
Purpose
To assess the usefulness of 18F-fluorodeoxyglucose PET/CT in the detection of bone marrow (BM) involvement of high-grade non-Hodgkin’s lymphoma (NHL).Methods
One hundred twenty patients with newly diagnosed diffuse large B-cell lymphoma or peripheral T-cell lymphoma between January 2007 and June 2011, who received BM trephine biopsy and 18F-FDG PET/CT before chemotherapy, were included in this retrospective study. We reviewed their 18F-FDG PET/CT images and bone marrow biopsy (BMB) results. After reviewing the images, we reviewed the medical records and radiological findings of interesting patients.Results
There were 23 18F-FDG PET/CT scans in which the marrow was considered to be abnormal (either positive or equivocal), and 97 18F-FDG PET/CT scans were regarded as having negative FDG uptake. Of 120 patients, 100 (83.3 %) had a concordant result of BM interpretation between 18F-FDG PET/CT and BMB, and the remaining 20 patients had discordant results. Among 23 patients with either positive or equivocal 18F-FDG PET/CT scans, 1 of 12 patients with ‘positive’ 18F-FDG PET/CT had a lymphomatous involvement on BMB. In contrast, 10 of 11 patients with ‘equivocal’ BM hypermetabolism were reported as having positive involvement by BMB. Patients with abnormal 18F-FDG PET/CT had significantly higher mSUVhighest than those with normal FDG-PET/CT.Conclusions
18F-FDG PET/CT and BMB are complementary techniques in assessing the presence of BM involvement in patients with high-grade NHL. The increasing availability of 18F-FDG PET/CT will raise the need for additional biopsy for FDG-avid lesions, especially in patients with negative standard BMBs. 18F-FDG PET/CT can be useful as a decision-making tool for determining whether to perform a standard BMB or targeted biopsy to the FDG-avid lesion as an initial staging procedure. A direct bone biopsy for FDGpositive bone lesions should be included in staging guidelines in future. In 18F-FDG PET/CT-negative cases, BMB is still a powerful procedure, but BMB alone is insufficient for full evaluation of BM. 相似文献11.
Flavio Forrer Eric P. Krenning Peter P. Kooij Bert F. Bernard Mark Konijnenberg Willem H. Bakker Jaap J. M. Teunissen Marion de Jong Kirsten van Lom Wouter W. de Herder Dik J. Kwekkeboom 《European journal of nuclear medicine and molecular imaging》2009,36(7):1138-1146
Purpose Adequate dosimetry is mandatory for effective and safe peptide receptor radionuclide therapy (PRRT). Besides the kidneys,
the bone marrow is a potentially dose-limiting organ. The radiation dose to the bone marrow is usually calculated according
to the MIRD scheme, where the accumulated activity in the bone marrow is calculated from the accumulated radioactivity of
the radiopharmaceutical in the blood. This may underestimate the absorbed dose since stem cells express somatostatin receptors.
We verified the blood-based method by comparing the activity in the blood with the radioactivity in bone marrow aspirates.
Also, we evaluated the absorbed cross-dose from the source organs (liver, spleen, kidneys and blood), tumours and the so-called
“remainder of the body” to the bone marrow.
Methods Bone marrow aspirates were drawn in 15 patients after treatment with [177Lu-DOTA0,Tyr3]octreotate. Radioactivity in the bone marrow was compared with radioactivity in the blood drawn simultaneously. The nucleated
cell fraction was isolated from the bone marrow aspirate and radioactivity was measured. The absorbed dose to the bone marrow
was calculated. The results were correlated to the change in platelet counts 6 weeks after treatment.
Results A strong linear correlation and high agreement between the measured radioactivities in the bone marrow aspirates and in the
blood was found (r=0.914, p<0.001). No correlation between the calculated absorbed dose in the bone marrow and the change in platelets was found. There
was a considerable contribution from other organs and the remainder of the body to the bone marrow absorbed dose.
Conclusion (1) After PRRT with [177Lu-DOTA0,Tyr3]octreotate, the radioactivity concentration in the bone marrow is identical to that in the blood; (2) There is no significant
binding of the radiopharmaceutical to bone marrow precursor stem cells; (3) The contribution of the cross dose from source
organs and tumours to the bone marrow dose is significant; and (4) There is considerable variation in bone marrow absorbed
dose between patients. These findings imply that for individual dose optimization, individual calculation of the bone marrow
absorbed dose is necessary. 相似文献
12.
Comparison of MET-PET and FDG-PET for differentiation between benign lesions and malignant tumors of the lung 总被引:5,自引:1,他引:4
Masayuki Sasaki Yasuo Kuwabara Tsuyoshi Yoshida Makoto Nakagawa Hirofumi Koga Kazutaka Hayashi Kouichirou Kaneko Tao Chen Yuichi Ichiya Kouji Masuda 《Annals of nuclear medicine》2001,15(5):425-431
OBJECTIVE: We retrospectively assessed and compared the usefulness of 11C-methionine (MET)-PET with that of 18F-FDG-PET for the differentiation between benign lesions and malignant tumors of the lung. METHODS: We examined 101 patients with a suspected lung tumor including 79 patients with primary lung cancer and 22 patients with benign lesions. One hundred and forty PET studies (46 studies with MET-PET and 94 studies with FDG-PET) were performed. Both MET-PET and FDG-PET were performed on 39 patients. The MET-PET was performed 15 minutes after the administration of 67-740 MBq of MET, and FDG-PET 45 minutes after the administration of 30-437 MBq of FDG. The results were then evaluated by the standardized uptake value (SUV). RESULTS: The MET uptake in lung cancer was 3.69+/-1.22 (n = 37) which was significantly higher than that in benign lesions 1.81+/-1.04 (n = 9) (p < 0.001). The sensitivity, specificity and accuracy of MET-PET were 83.8%, 88.9% and 84.8%, respectively, when 2.66 of SUV was used as the cutoff value. The FDG uptake in lung cancer was 5.94+/-2.89 (n = 75) and was also significantly larger than that in benign lesions 2.46+/-1.01 (n = 19) (p < 0.001). The sensitivity, specificity and accuracy of FDG-PET were 81.3%, 78.9% and 80.9%, respectively (cutoff = 3.20). The MET uptake in the lesions correlated significantly with FDG uptake (r = 0.71, p < 0.001). According to an ROC analysis, the area under the curve for MET-PET (area = 0. 833) was higher than that for FDG-PET (area = 0.828), but the difference was not statistically significant. Furthermore, the combined use of MET-PET and FDG-PET did not improve the diagnostic ability. CONCLUSIONS: In conclusion, both MET-PET and FDG-PET were considered to be equally useful for the differential diagnosis of lung tumors. Furthermore, MET uptake in lung lesions was found to correlate significantly with FDG uptake. 相似文献
13.
淋巴瘤骨髓浸润的18F-FDG PET显像研究 总被引:6,自引:2,他引:6
目的 用^18F-脱氧葡萄糖(FDG)PET显像研究淋巴瘤细胞骨髓浸润。方法 恶性淋巴癌患者30例,其中非霍奇金淋巴瘤(NHL)20例、霍奇金病(HD)10例,进行全身^18F-FDG PET显像。局灶性边缘清楚的淋巴结相应区域^18F-FDG浓聚视为恶性淋巴结显影。利用灰度色标,视觉分析骨髓及肝脏内^18F-FDG浓聚情况。骨髓的^18F-FDG分布不均,摄取高于肝脏,判断为骨髓^18F-FDG摄取异常;骨髓的^18F-FDG分布均匀,摄取低于或等于肝脏,判断为骨髓^18F-FDG摄取正常。所有患者均行髂棘的骨髓活组织检查。结果 30例中18例有淋巴结摄取^18F-FDG;12例淋巴结摄取^18F-FDG阴性患者中,8例NHL,4例HD。有26例患者的骨髓^18F-FDG摄取情况与骨髓组织学检查结果一致,其中骨髓有淋巴细胞浸润7例,无淋巴细胞浸润19例。有3例骨髓组织学检查阴性的患者,^18F-FDG PET示骨髓^18F-FDG摄取异常、骨髓有淋巴细胞浸润;1例NHL患者,骨髓组织学检查阳性但^18F-FDG PET示骨髓^18F-FDG摄取正常。结论 ^18F-DG PET全身显像能正确评价骨髓淋巴细胞浸润情况,减少对淋巴瘤分期所进行的骨髓组织学检查。 相似文献
14.
Objective It has been shown that [18F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) can identify macrophage-rich high-risk
atherosclerotic plaques in animal models as well as in patients with atherosclerotic plaques in the carotid arteries. The
development of inflamed macrophage-rich plaques over time is not well known. This study was performed to determine the variability
of such FDG-accumulating plaques between consecutive PET/CT examinations.
Methods Twenty-eight patients who underwent two whole-body FDG-PET/CT examinations within 7 months for malignant diseases were re-evaluated
for atherosclerotic lesions in major arterial segments. The plaques were identified as active, inactive, or mixed depending
on their appearance on PET and CT. Every identified plaque was compared with that of the other examination to evaluate the
time-to-time correlation.
Results The time-to-time correlation was close to 100% for calcified inactive plaques and about 50% for FDG-accumulating active plaques,
with a high consistency between all examined arterial segments in this material.
Conclusions A large proportion of FDG-accumulating plaques can be identified on consecutive FDG-PET/CT examinations within 7 months. 相似文献
15.
Hugo J. A. Adams Thomas C. Kwee Bart de Keizer Rob Fijnheer John M. H. de Klerk Rutger A. J. Nievelstein 《European journal of nuclear medicine and molecular imaging》2014,41(3):565-574
Purpose
To systematically review and meta-analyse published data on the diagnostic performance of 18F-FDG PET/CT in detecting bone marrow involvement in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL).Methods
PubMed/MEDLINE and Embase were systematically searched for relevant studies. The methodological quality of each study was assessed. Sensitivities and specificities of FDG PET/CT in individual studies were calculated and meta-analysed with a random effects model. A summary receiver operating characteristic curve (sROC) was constructed with the Moses-Shapiro-Littenberg method. Weighted summary proportions of discrepancies between the FDG PET/CT and (blind) bone marrow biopsy (BMB) results among all patients were calculated.Results
Seven studies, with a total of 654 patients with newly diagnosed DLBCL, were included. Overall, the quality of the included studies was moderate. The sensitivity and specificity of FDG PET/CT for detecting bone marrow involvement ranged from 70.8 % to 95.8 % and from 99.0 % to 100 %, with pooled estimates of 88.7 % (95 % confidence interval, CI, 82.5 – 93.3 %) and 99.8 % (95 % CI 98.8 – 100 %), respectively. The area under the sROC curve was 0.9983. The weighted summary proportion of FDG PET/CT-negative patients with positive BMB findings among all patients was 3.1 % (95 % CI 1.8 – 5.0 %) and the weighted summary proportion of FDG PET/CT-positive patients with negative BMB findings among all patients was 12.5 % (95 % CI 8.4 – 17.3 %).Conclusion
FDG PET/CT is accurate and complementary to BMB for detecting bone marrow involvement in patients with newly diagnosed DLBCL. A negative FDG PET/CT scan cannot rule out the presence of bone marrow involvement, but positive FDG PET/CT findings obviate the need for BMB for the detection of bone marrow involvement in these patients. 相似文献16.
Ji Yeon Kang Won Woo Lee Young So Byung Chul Lee Sang Eun Kim 《Nuclear Medicine and Molecular Imaging》2010,44(1):55-61
Purpose
18F-fluoride bone positron emission tomography (PET) has been reported as a useful bone imaging modality. However, no clinical bone PET study had been performed previously in Korea. The authors investigated the usefulness of 18F-fluoride bone PET in Korean patients with malignant or benign bone disease.Methods
Eighteen consecutive patients (eight women, ten men; mean age, 55 ± 12 years) who had undergone 18F-fluoride bone PET for the evaluation of bone metastasis (n = 13) or benign bone lesions (n = 5) were included. The interpretation of bone lesions on 18F-fluoride bone PET was determined by consensus of two nuclear medicine physicians, and final results were confirmed using combination of all imaging studies and/or clinical follow-up. The analysis was performed on the basis of lesion group.Results
Thirteen patients with malignant disease had 15 lesion groups, among which seven were confirmed as metastatic bone lesions and eight were confirmed as non-metastatic lesions. 18F-fluoride bone PET correctly identified six of seven metastatic lesions (sensitivity, 86%), and seven of eight non-metastatic lesions (specificity, 88%). On the other hand, five patients with benign conditions had five bone lesion groups; four were confirmed as benign bone diseases and the other one was confirmed as not a bone lesion. 18F-fluoride bone PET showed correct results in all the five lesion groups.Conclusions
18F-fluoride bone PET showed promising potential for bone imaging in Korean patients with malignant diseases as well as with various benign bone conditions. Therefore, further studies are required on the diagnostic performance and cost-effectiveness of 18F-fluoride bone PET. 相似文献17.
18.
Bone marrow changes in beta-thalassemia major: quantitative MR imaging findings and correlation with iron stores 总被引:2,自引:0,他引:2
The purpose of this study is to describe the MR imaging features of bone marrow in beta-thalassemia major and investigate
their relation to ferritin, liver and spleen siderosis. Spinal bone marrow was prospectively assessed on abdominal MR studies
of 40 transfused beta-thalassemic patients and 15 controls using T1-w, Pd, T2*-w Gradient Echo (GRE) and T1-w turbo Spin Echo
(TSE) sequences. Signal intensity (SI) ratios of liver, spleen and bone marrow to paraspinous muscles (L/M, S/M, B/M respectively)
and the respective T2 relaxation rates (1/T2) were calculated. Serum ferritin levels were recorded. Bone marrow hypointensity
in at least T2*-w GRE sequence was noted in 29/40 (72.5%) patients. Eleven/40 patients exhibited normal B/M on all MR sequences.
Five/40 patients had normal B/M and low L/M. B/M correlated with L/M in T1-w TSE sequence only (r = 0.471, p = 0.05). B/M correlated with S/M and mean ferritin values in all sequences (r > 0.489, p < 0.01 and r > − 0.496, p < 0.03 respectively). Marrow 1/T2 did not correlate with ferritin values or liver and spleen 1/T2. B/M in transfused beta-thalassemic
patients is related to splenic siderosis and ferritin levels. Although marrow is usually hypointense, it may occasionally
display normal SI coexisting with liver hypointensity, a pattern typical of primary hemochromatosis. 相似文献
19.
The aim of this study was to differentiate normal, hypercellular, and neoplastic bone marrow based on its MR enhancement after intravenous administration of superparamagnetic iron oxides in patients with cancer of the hematopoietic system. Eighteen patients with cancer of the hematopoietic system underwent MRI of the spine before and after infusion of ferumoxides ( n=9) and ferumoxtran ( n=9) using T1- and T2-weighted turbo spin-echo (TSE) and short tau inversion recovery sequences (STIR). In all patients diffuse or multifocal bone marrow infiltration was suspected, based on iliac crest biopsy and imaging such as conventional radiographs, MRI, and positron emission tomography. In addition, all patients had a therapy-induced normocellular ( n=7) or hypercellular ( n=11) reconversion of the normal non-neoplastic bone marrow. The MRI data were analyzed by measuring pre- and post-contrast signal intensities (SI) of hematopoietic and neoplastic marrow and by calculating the enhancement as deltaSI(%) data and the tumor-to-bone-marrow contrast as contrast-to-noise ratios (CNR). Changes in bone marrow signal intensity after iron oxide administration were more pronounced on STIR images as compared with T1- and T2-weighted TSE images. The STIR images showed a strong signal decline of normal and hypercellular marrow 45-60 min after iron oxide infusion, but no or only a minor signal decline of neoplastic bone marrow lesions; thus, deltaSI% data were significantly higher in normal and hypercellular reconverted marrow compared with neoplastic bone marrow lesions ( p<0.05). Additionally, the contrast between focal or multifocal neoplastic bone marrow infiltration and normal bone marrow, quantified by CNR data, increased significantly on post-contrast STIR images compared with precontrast images ( p<0.05). Superparamagnetic iron oxides are taken up by normal and hypercellular reconverted bone marrow, but not by neoplastic bone marrow lesions, thereby providing significantly different enhancement patterns on T2-weighted MR images; thus, superparamagnetic iron oxides are useful to differentiate normal and neoplastic bone marrow and to increase the bone marrow-to-tumor contrast. 相似文献
20.
MR imaging in adults with Gaucher disease type I: evaluation of marrow involvement and disease activity 总被引:1,自引:0,他引:1
George Hermann M.D. Robert S. Shapiro M.D. I. Fikry Abdelwahab M.D. Gregory Grabowski M.D. 《Skeletal radiology》1993,22(4):247-251
An investigation was conducted to determine the usefulness of magnetic resonance imaging (MRI) in the evaluation of bone marrow involvement in patients with Gaucher disease type I. T1- and T2-weighted images were obtained of the lower extremities of 29 adult patients. Patients were classified into one of three groups based on marrow signal patterns on T1- and T2-weighted images as well as change in signal intensity from T1- to T2-weighted images. An increase in signal intensity from T1- to T2-weighted images was the criterion for an active process within the bone marrow. Classification of the 29 patients produced the following results: group A: normal, 4 patients; group B: marrow infiltration, 16 patients; group C: marrow infiltration plus active marrow process, 9 patients. Correlation with clinical findings revealed that all nine patients with evidence of an active marrow process on MRI (group C) had acute bone pain. Conversely, only one of the remaining 20 patients (groups A and B) had bone pain. There was no correlation between disease activity and findings on conventional radiographs. We conclude the MRI provides an excellent noninvasive assessment of the extent and activity of marrow involvement in type I Gaucher disease. 相似文献