光学相干断层扫描仪深度增强成像测量糖尿病视网膜病变患者黄斑脉络膜厚度的变化

目的应用光学相干断层扫描(OCT)仪深度增强成像(EDI)模式检测正常人和糖尿病视网膜病变(DR)患者的黄斑脉络膜厚度,探讨不同程度病变对脉络膜形态的影响。方法选择168例2型糖尿病患者(试验组)和30例正常志愿者(对照组),试验组根据视网膜病变程度分为无DR(NDR)组47例、非增殖性DR(NPDR)组54例和增殖性DR(PDR)组67例。应用海德堡SPECTRALIS-OCT EDI模式行黄斑区扫描,分别测量上方、下方、鼻侧、颞侧黄斑中心凹边缘(距中心小凹175μm)、旁中心凹区边缘(距中心小凹675μm)的脉络膜厚度。统计学分析脉络膜厚度与年龄、部位的关系,检测不同程度DR患者脉络膜厚度的差异。结果随着年龄的增加,正常人黄斑区脉络膜厚度逐渐减小,志愿者不同年龄组之间差异显著(F=7.55,P0.01;P均0.05)。黄斑中心凹边缘平均脉络膜厚度大于旁中心凹区边缘(t=3.13,P0.01)。对照组、NDR组、NPDR组和PDR组黄斑区平均脉络膜厚度分别为:(278.52±28.31)μm,(258.36±25.73)μm,(231.34±21.90)μm,(211.25±23.47)μm,各组之间差异显著(F=66.69,P0.01)。随着DR程度的增加,黄斑区脉络膜厚度明显减小,各组内比较差异显著(P0.05)。结论 EDI OCT能清晰显示脉络膜结构特点。糖尿病患者脉络膜厚度变薄,且随着DR程度的加重而更加显著。     

基于OCTA技术的单侧RVO患者健侧眼黄斑区微血管血流密度、视网膜和脉络膜厚度变化

目的 基于光学相干断层扫描血管成像（OCTA）技术,观察单侧视网膜静脉阻塞（RVO）患者健侧眼黄斑区微血管血流密度、视网膜和脉络膜厚度变化。方法 单侧RVO患者38例共76只眼,其中患眼38只记为患侧眼组,健侧眼38只记为健侧眼组。另选取同期体检健康者25例的25只正常眼作为对照组。采用美国光视公司RTVue XR 100光学相干断层扫描仪进行黄斑区微血管血流密度、视网膜和脉络膜厚度测量,包括浅层毛细血管丛（SCP）全层、上半侧、下半侧、中心凹、旁中心凹、旁中心凹上半侧、旁中心凹下半侧、旁中心凹颞侧、旁中心凹上方、旁中心凹鼻侧、旁中心凹下方的血流密度（VD）,深层毛细血管丛（DCP）全层、上半侧、下半侧、中心凹、旁中心凹、旁中心凹上半侧、旁中心凹下半侧、旁中心凹颞侧、旁中心凹上方、旁中心凹鼻侧、旁中心凹下方的VD,黄斑中心凹无血管区（FAZ）面积和周长、非圆度指数（AI）,黄斑中心凹为中心周围300μm区域的视网膜（FD300）的VD,黄斑区视网膜厚度（CMT）,黄斑中心凹下脉络膜厚度（SFCT）。结果 与对照组组相比,健侧眼组SCP上半侧VD、SCP旁中心凹上半侧VD、DCP旁中心凹...     

糖尿病视网膜病变黄斑厚度定量分析

目的：研究糖尿病视网膜病变（DR）患者黄斑水肿情况及与荧光渗漏和视功能关系。方法：应用视网膜厚度分析仪（RTA）对18例（25眼）单纯型糖尿病视网膜病变的黄斑区视网膜进行扫描并对其厚度进行定量测量，并与荧光造影结果及视力进行对比分析，结果：RTA检查可清晰的观察到DR患者黄斑区的形态改变；矫正视力负对数之间呈现正相关关系。结论：DR患者黄斑区毛细血管渗漏与组织再吸收失衡是引起黄斑水肿的关键因素，黄斑水肿是导致视力下降的重要原因，RTA检查可为糖尿病黄斑水肿提供客观和精确的诊断依据。     

糖尿病患者视网膜神经节细胞复合体和神经纤维层厚度的变化

目的观察2型糖尿病(T2DM)患者中视网膜神经纤维层(RNFL)和神经节细胞复合体(GCC)厚度的变化,分析其神经结构与微循环之间的相关关系。方法采用横断面回顾性研究,入选2型糖尿病患者45例71眼、健康受试者36例68眼。采用光学相干断层扫描血管成像技术(OCTA)检测黄斑部的GCC厚度、视盘周围RNFL厚度、视网膜脉络膜毛细血管丛的微血管密度。观察不同分期糖尿病视网膜病变(DR)患眼中RNFL和GCC厚度变化,分析它们与微血管密度的相关关系。结果与对照组相比,NDR组(无DR的糖尿病患者)GCC中局部丢失体积(FLV,P=0.00)、整体丢失体积(GLV,P=0.00)显著升高,可能是视网膜神经结构损伤的早期敏感指标。与对照组相比,轻中度非增殖性糖尿病视网膜病变(NPDR)组的下侧和鼻侧象限RNFL显著变薄(P=0.00),可能是RNFL丢失的敏感区域。重度NPDR组中鼻侧象限RNFL仍然显著变薄,但下侧、颞侧象限RNFL显著增厚(P=0.00)。增殖性糖尿病视网膜病变(PDR)组中RNFL和GCC大部分参数普遍增厚(P=0.00),可能与视网膜水肿导致的视网膜增厚有关。Spearman分析显示GCC、RNFL厚度与视网膜厚度呈正相关。此外,GCC及RNFL厚度与视网膜脉络膜毛细血管包括浅层毛细血管丛(SCP)、深层毛细血管丛(DCP)和脉络膜层毛细血管丛(CCP)的密度呈负相关。结论 GCC的FLV和GLV局限性丢失,可能是评价早期视网膜神经结构损伤的敏感指标。随DR的进展,RNFL厚度呈现先变薄后增厚的趋势,还需要扩大样本量进一步研究。     

血糖水平与超声乳化白内障吸除术后黄斑区视网膜厚度的相关性

目的探讨血糖水平对超声乳化白内障吸除术后黄斑区视网膜的影响。方法选择行超声乳化白内障吸除术且术前、术中无并发症的糖尿病老年性白内障患者129例（129眼）,于术前和术后1周分别进行光学相干断层成像检查,比较手术前后黄斑中心凹视网膜厚度的变化。结果129例黄斑中心凹视网膜厚度术前为（155．90±16．67）μm,术后1周为（157．79±17．20）μm,两者比较差异无统计学意义（P〉0．05）。血糖水平与手术前后黄斑中心凹视网膜厚度无关（r分别为o．016、0．012,P均〉0．05）。结论尚不能认为血糖水平与视网膜神经上皮层厚度有线性关系。     

微脉冲激光疗法治疗急性中心性浆液性脉络膜视网膜病变效果观察

目的 观察微脉冲激光疗法治疗急性中心性浆液性脉络膜视网膜病变（CSC）的疗效。方法 选取急性CSC患者14例（14眼）,均采用577 nm微脉冲激光疗法治疗,比较治疗后视网膜下液（SRF）完全消退情况及治疗前后最佳矫正视力（BCVA）、黄斑中心凹视网膜厚度（CMT）、视网膜下液高度（SRFH）、黄斑中心凹无血管区面积（FAZ）、黄斑中心凹无血管区周长（PERIM）和黄斑区视网膜血流密度。结果 治疗后1个月SRF完全消退5例（35.71%）,治疗后2个月时完全消退9例（64.29%）,治疗后3个月时完全消退12例（85.71%）。治疗前后BCVA分别为0.32±0.15、0.02±0.06,CMT分别为（441.21±111.46）、（231.00±15.44）μm,SRFH分别为（225.79±103.67）、（18.79±56.40）μm,治疗前后比较,P均<0.05。治疗前后FAZ、PERIM及黄斑区整体、不同分区视网膜血流密度比较均无统计学差异（P均>0.05）。结论 微脉冲激光疗法治疗急性CSC可以促进SRF吸收,降低CMT,提高最佳矫正视力,而不影响黄斑中心凹视网...     

基于OCTA的糖尿病患者视网膜及脉络膜血流变化分析

目的 应用光学相干断层扫描血管成像技术（optical coherence tomography angiography, OCTA）观察及评价糖尿病患者视网膜及脉络膜微循环血流密度的变化和临床意义。方法 选取2019年4月—2020年10月于广西医科大学附属柳州市人民医院就诊的150例2型糖尿病合并轻度非增殖性糖尿病视网膜病变（nonproliferativediabetic retinopathy, NPDR）患者50例（100眼）作为NPDR组,选取同期无糖尿病视网膜病变（diabetic retinopathy, DR）的2型糖尿病患者50例（100眼）作为NDR组以及健康者50名（100眼）作为对照组。采用OCTA对所有受试者行双眼扫描,利用自带软件进行视网膜自动分层,观察黄斑中心凹视网膜厚度（CRT）、黄斑区浅层血管（SCP）、黄斑区深层血管（DCP）、脉络膜血流（CBF）、黄斑中心无血管区（FAZ）面积的变化及差异,分析与视力的相关性。结果 与对照组及NDR组比较,NPDR组BCVA值增大,SCP、DCP、CBF降低,CRT、FAZ增大,差异有统计学意义（P<0.0...     

561 nm与532 nm激光光凝治疗重度非增生性糖尿病视网膜病变的临床疗效比较

［摘要］　目的　比较561 nm、532 nm激光光凝治疗重度非增生性糖尿病视网膜病变（NPDR）的临床疗效。方法　招募2021年6月至2022年8月惠州市第三人民医院收治的重度NPDR不合并黄斑水肿的患者46例（82眼）,均行全视网膜激光光凝（PRP）治疗。采用随机数字表法将其分为观察组（23例,42眼）和对照组（23例,40眼）。观察组和对照组激光光凝治疗波长分别为561 nm和532 nm。比较两组治疗前,以及治疗后2周、1个月、3个月、6个月的最佳矫正视力（BCVA）、中央黄斑厚度（CMT）、视网膜神经纤维层（RNFL）厚度。比较两组不良反应发生情况。结果　治疗后两组BCVA较治疗前显著提高（P<0.05）,但两组各时间点BCVA比较差异无统计学意义（P>0.05）。治疗后,两组患眼CMT、RNFL厚度均呈下降趋势（P<0.05）,且观察组在治疗后2周、1个月、3个月、6个月的CMT较对照组薄,RNFL厚度较对照组厚,差异有统计学意义（P<0.05）。治疗后两组继发黄斑水肿、玻璃体积血和新生血管性青光眼发生率比较差异无统计学意义（P>0.05）。结论　561 nm激光光凝治疗重度NPDR安全、有效,对CMT及RNFL厚度影响较532 nm激光小,有利于保存视功能。     

2型糖尿病患者视网膜厚度的检测及其临床意义

目的　探讨 2型糖尿病患者黄斑区中心凹视网膜厚度的变化。方法　用光学相干断层扫描成像仪对 3 6例 2型糖尿病病人和 16例正常人 (对照组 )进行视网膜厚度的测量 ,同时检查眼底。根据视网膜病变的程度将 3 6例糖尿病患者分为三组 :正常视网膜组 (NR组 )、背景性视网膜病变组 (BR组 )、增殖性视网膜病变组 (PR组 )。结果　对照组黄斑区中心凹视网膜厚度为 (168± 18) μm ,糖尿病患者黄斑区中心凹视网膜厚度较正常人显著增高 (P <0 .0 5或P <0 .0 1) ,NR组视网膜厚度为 (2 0 5± 3 5 ) μm ,BR组视网膜厚度为 (2 77± 69) μm ,PR组视网膜厚度为 (3 5 4± 3 3 ) μm。结论　 2型糖尿病患者黄斑区中心凹视网膜厚度随视网膜病变程度的加重而显著增加     

2型糖尿病患者视网膜神经纤维层厚度与同型半胱氨酸相关性研究

目的 探讨T2DM患者视网膜神经纤维层（RNFL）厚度与同型半胱氨酸（HCY）的相关性。方法 选取2016年8月至2020年8月于北京顺义空港医院内分泌科诊断为T2DM患者582例1164眼,另选取同期于我院体检及眼科就诊的健康者176例342眼为正常对照（NC）组。根据荧光素眼底血管造影（FFA）结果分为DR临床前期组（NDR组）、非增生期DR组（NPDR组）、增生期DR组（PDR组）。应用光学相干断层扫描（OCT）测量受试者视网膜上方、下方、颞侧、鼻侧及全周360°RNFL厚度。结果 与NC组比较,其他三组DM病程、FPG、HbA1c升高（P<0.05）,NDR组上方平均值（SA）、全周360°RNFL平均厚度（mean360°）降低（P<0.05）,NPDR组SA、下方平均值（IA）、鼻侧平均值（NA）、mean360°降低（P<0.05）,PDR组SA、IA、NA、颞侧平均值（TA）、mean360°升高（P<0.05）。与NDR组比较,PDR组DM病程、FPG、UAlb、HCY、TG、SA升高（P<0.05）,IA、mean360°降低（P<...     

Reproducibility of peripapillary retinal nerve fiber layer and macular retinal thickness measurements using optical coherence tomography

We investigated the interoperator reproducibility of peripapillary retinal nerve fiber layer (RNFL) and macular retinal thickness measurements using optical coherence tomography (OCT) in healthy Taiwanese eyes. In this study, OCT-3 was used by three trained and experienced operators to measure peripapillary RNFL and macular retinal thickness in a randomly chosen single eye from each normal subject. Mean thickness levels and the differences in thickness measurements among the three operators were calculated and compared. The eyes of 39 subjects (24 females and 15 males) were enrolled. The mean age of the subjects was 30.4 +/- 16.1 years (range, 11-46 years). The mean pupil diameter after pupillary dilation was 7.4 +/- 0.6mm (range, 6-9 mm). Comparing peripapillary RNFL and macular retinal thickness measurements after pupillary dilation, there were no significant differences in: superior, inferior, temporal, and nasal peripapillary areas; 6 mm total macular volume and foveal thickness; and 1, 3 and 6 mm perifoveal areas among the three operators. In this study, OCT thickness measurements showed good interoperator reproducibility among three trained and experienced operators.     

Disorganization of retinal inner layers correlates with ellipsoid zone disruption and retinal nerve fiber layer thinning in diabetic retinopathy

PurposeTo study the correlation between disorganization of inner retinal layer (DRIL) and macular thickness parameters, ellipsoid zone (EZ) disruption and retinal nerve fiber layer (RNFL) thickness on spectral domain optical coherence tomography (SD-OCT) in diabetic retinopathy (DR), for the first time.MethodsA tertiary care center-based cross-sectional study was undertaken. One hundred and four consecutive study subjects of type 2 diabetes mellitus were included: diabetes mellitus with no retinopathy (No DR) (n = 26); non-proliferative DR (NPDR) (n = 26); proliferative DR (PDR) (n = 26) and healthy controls (n = 26). Best Corrected Visual Acuity (BCVA) was measured on the logarithm of the minimum angle of resolution (logMAR) scale. Clinician-friendly, SD-OCT based, grading systems were created for DRIL and EZ disruption, within the macular cube. DRIL was graded as: grade 0, DRIL absent; and grade 1, DRIL present. EZ disruption was graded as; Grade 0: Intact EZ; Grade 1: Focal disruption and Grade 2: Global disruption. Every study subject underwent RNFL thickness analysis.ResultsDRIL was significantly associated with increase in severity of DR.Pearson correlation analysis showed significant positive correlation between DRIL and CST CAT and grades of EZ disruption . However, a significant negative correlation was found between DRIL and RNFL thickness .ConclusionPresence of DRIL correlates with severity of DR, EZ disruption and RNFL thinning.     

OSAHS 患者视网膜神经纤维层厚度的研究

目的：评估 OSAHS 患者视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度变化。方法收集2014年6~10月于秦皇岛市第一医院初次应用多导睡眠监测仪诊断 OSAHS 患者共30例,选取健康体检患者15例,年龄30~50岁,无视野缺损,进行病例对照研究。应用光学相干断层成像(optical coherence tomography,OCT)测量患者视网膜神经纤维层厚度来评估 OSAHS 的 RNFL情况。结果与正常对照组比较,OSAHS 患者平均视网膜神经纤维层厚度降低,且差异有统计学意义,对照组(121.5±7.9)μm,OSHSA 组(116.3±8.3)μm (P <0.01),同样鼻侧也是降低的, OSAHS (70.4±3.8)μm,对照组(70.7±6.7)μm (P <0.05)。而上侧 OSAHS 组(140.2±8.3)μm,对照组(140.0±9.0)μm (P >0.05),下侧 OSAHS 组(140.5±8.3)μm,对照组(140.3±7.5)μm (P >0.05),颞侧 OSAHS 组(72.5±6.2)μm,对照组(72.2±5.3)μm 差异无统计学意义(P >0.05)。根据呼吸暂停低通气指数(apnea hypopnea index,AHI)将患者分为三组,重度OSAHS 患者较轻度、中度 OSAHS 患者 RNFL 平均值明显降低(P <0.01),而轻度与中度组比较差异无统计学意义(P >0.05)。而三组患者上侧、下侧及颞侧 RNFL 差异无统计学意义。OSAHS 组黄斑厚度(173.3±4.7μm)与对照组比较(173.3±4.6)μm 变化不明显(P >0.05)。OSAHS 组与对照组黄斑体积差异无统计学意义,分别为(6.9±0.3)mm3,(6.8±0.3)mm3(P >0.05)。OSAHS患者 AHI 与 RNFL 呈负相关(r =-0.554,P <0.01)。夜间最低血氧饱和度与 RNFL 平均值成正相关(r =0.510,P <0.01)。结论 OSAHS 患者 RNFL 厚度平均值及鼻侧是降低的,RNFL 厚度与AHI 呈负相关,与夜间最低血氧饱和度呈正相关。     

白内障超声乳化吸除手术对老年白内障合并糖尿病患者眼底RNFL厚度的影响

目的观察白内障超声乳化吸除手术（Phaco）对老年白内障合并糖尿病患者眼底盘周视网膜神经纤维层（RNFL）厚度的影响。方法选取老年白内障合并糖尿病患者30例（45只眼）,均成功施行Phaco联合人工晶状体植入手术;利用光学相干断层扫描仪（OCT）定量测量术前及术后3d、2周、1个月、3个月、6个月眼底盘周RNFL厚度,观察术后矫正视力、视乳头水肿发生情况。结果术前及术后3d、2周、1个月、3个月、6个月盘周RNFL厚度分另0为（93．24±8．46）、（91．71±8．19）、（95．49±8．53）、（192．00±8．10）、（105．91±7．15）、（102．02±7．10）μm;术后2周及1、3、6个月RNFL厚度较术前增加（P均〈0．05）;术后2周及1、3、6个月RNFL厚度较术后3d增加（P均〈0．05）;术后1、3、6个月RNFL厚度较术后2周增加（P均〈0．01）;其余时间点各组两两比较差异无统计学意义。术前及术后3d、2周、1个月、3个月、6个月矫正视力分别为0．16、0．44、0．54、0．51、0．56、0．67。术后3d、2周、1个月、3个月、6个月视乳头水肿发生率分别为0、42％、55％、62％、31％。结论老年白内障合并糖尿病患者Phaco术后眼底盘周RNFL厚度增加,手术可能对眼底视神经造成了损伤。     

2型糖尿病住院患者2 454例视网膜病变的危险因素分析

目的调查上海地区2型糖尿病住院患者糖尿病视网膜病变（DR）的患病率及其特点,并探讨影响DR的危险因素。方法入选2型糖尿病住院患者共2454例,收集详细临床资料,并对其进行免散瞳眼底摄片以确定DR及其分级。应用趋势检验及logistic逐步回归等方法分析DR患者分布特点及危险因素。结果2型糖尿病住院患者DR的患病率为32．7％。随着年龄的增长、病程的延长及HbA1C水平的增高,DR患者比率逐渐增高（P〈0．05）。糖尿病病程（0R=1．107,95％CI1．089～1．125,P〈0．0001）,HbA1C水平（0R=1．071,95％CI1．0241．119,P=0．0026）,收缩压水平（OR=1．016,95％CI1．010～1．022,P〈0．0001）是2型糖尿病患者发生DR的独立危险因素,诊断年龄与DR发生风险也具有关联趋势（OR=0．991,95％C10．981～1．000,P=0．0556）。结论住院患者DR患病率较高。病程长、血糖情况控制差及高血压是影响2型糖尿病住院患者发生DR的独立危险因素。     

Quantitative measurement of retinal thickness in patients with diabetic macular edema is useful for evaluation of therapeutic agents

The effect of lisinopril (an angiotensin-converting enzyme inhibitor) on diabetic macular edema (DME) was investigated by quantitative measurement of macular thickness. In a nonrandomized clinical trial, 19 normotensive type 2 diabetic patients with DME prospectively received oral lisinopril therapy for 2 months. Another 10 normotensive type 2 diabetic patients with similar DME were prospectively followed for two months without treatment. Central macular thickness was measured with a retinal thickness analyzer (RTA). In the lisinopril group, visual acuity improved by two lines or more in two out of 19 eyes (11%), was unchanged in 15 eyes (78%), and deteriorated by two lines or more in two eyes (11%). The mean central macular thickness was significantly reduced after 2 months of treatment (381.3 +/- 121.1 microm) compared with that before administration (475.2 +/- 171.0 microm, P = 0.0093). In the control group, central macular thickness was not significantly decreased after 2 months (458.5 +/- 113.7 microm, P = 0.2178) compared with the baseline value (464.7 +/- 152.2). Fluorescein angiography showed that macular leakage was decreased in 10 patients from the lisinopril group (53%) and was unchanged in nine patients (47%). There was a significant difference of central macular thickness between the patients with and without improvement of macular leakage (P = 0.0040). Lisinopril therapy may reduce macular thickness in patients with DME, as shown by this quantitative study. In addition, quantitative measurement of retinal thickness is useful when evaluating therapeutic agents for DME.     

黄芩苷对糖尿病大鼠组织醛糖还原酶活性及视网膜细胞凋亡的影响

取大鼠40只,随机分为NC组、DM组、依帕司他治疗组、黄芩苷治疗组。治疗16周后,测定视网膜组织醛糖还原酶（AR）活性及Bcl-2和Bax蛋白表达水平,发现AR活性在DM组明显升高,治疗组明显降低（P均〈0.01）。视网膜Bcl-2、Bax蛋白表达在DM组明显增加,治疗组明显减少。结果表明AR激活促进Bcl-2、Bax蛋白的表达,诱导细胞凋亡,参与DR的发生发展。醛糖还原酶抑制剂抑制AR活性,降低Bax、Bcl-2的表达,从而抑制细胞凋亡,延缓DR的发展。     

血压与2型糖尿病患者视网膜神经纤维层厚度的相关性

目的 探讨血压与2型糖尿病(T2DM)视网膜神经纤维层(RNFL)厚度的相关性.方法 选取2017年1月至2018年12月就诊于哈尔滨医科大学附属第一医院内分泌科的123例T2DM患者,根据荧光素眼底血管造影结果,按糖尿病性视网膜病变新的国际临床分级标准(2002年),将患者分为无糖尿病视网膜病变(NDR)组65例和非...     

The Association Between Macular Thickness and Peripapillary Retinal Nerve Fiber Layer Thickness in Chinese Children

To investigate the association between macular thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in Chinese children.This cross-sectional study recruited consecutive cases of healthy pediatric subjects aged 4 to 18 from Caritas Medical Centre in Hong Kong Special Administrative Region, China, from 2013 to 2014. Subjects with only eye, ocular tumors, congenital glaucoma, congenital cataract, congenital nystagmus, microphthalmos, optic nerve or retinal disease, active ocular infections, corneal scars, and severe visual impairment of any cause were excluded. Peripapillary RNFL thickness and macular thickness at 1-mm-diameter fovea center (C1), 3-mm-diameter temporal quadrant (T3), and 3-mm- diameter nasal quadrant (N3) were measured with optical coherence tomography. Best-corrected visual acuity, axial length, and cycloplegic refraction were also recorded. Spearman correlation was used to analyze the association between T3, C1, and N3 with each of the following: average and quadrant RNFL thickness, axial length, and spherical equivalent.In 179 subjects, the mean age was 7.9 ± 3.6 years. There were 90 male and 89 female subjects, all of Chinese ethnicity. The mean spherical equivalent was −0.1 ± 3.1 D and mean axial length was 22.9 ± 1.4 mm. There were significant and positive correlations of the average (T3: r = 0.20, P = 0.04; N3: r = 0.2, P = 0.005), superior (T3: r = 0.20, P = 0.03; N3: r = 0.2, P = 0.03), and inferior (T3: r = 0.20, P = 0.02; N3: r = 0.2, P = 0.01) peripapillary RNFL thicknesses with the T3 and N3 macular thicknesses but not C1. The nasal peripapillary RNFL thickness was also positively correlated with T3 (r = 0.20, P = 0.01). There were no significant associations between the macular thickness (T3, C1, N3) with neither the spherical equivalent (P > 0.2) nor the axial length (P > 0.3).The macular thickness was positive correlated with the peripapillary RNFL thickness in a population of healthy Chinese children.     

Evaluation of retinal nerve fiber layer thickness in diabetic retinopathy after panretinal photocoagulation

Retinal nerve fiber layer (RNFL) thickness analysis has been used in glaucoma and some other ocular diseases. In this study, we measured RNFL thickness using scanning laser polarimetry in 27 eyes with diabetic retinopathy after panretinal photocoagulation (PRP). Symmetry, ellipse modulation, ellipse average, average thickness, number (a measure of RNFL change), and superior, inferior, nasal, and temporal average RNFL thicknesses were measured. Mean symmetry was 0.90, mean ellipse modulation 1.80, mean ellipse average 63.6 microns, mean average thickness 63.0 microns, and mean number 45.8. Average superior RNFL was 65.8 microns, average inferior RNFL 75.1 microns, average nasal RNFL 44.47 microns, and average temporal RNFL 38.78 microns. The superior/temporal and inferior/temporal ratios were 1.77 and 2.00, respectively; superior/nasal and inferior/nasal ratios were 1.51 and 1.72, respectively. Retinal edema did not increase laser retardation. The superior/temporal and inferior/temporal ratios were more reliable in evaluating nerve fiber analyzer data in patients with diabetic retinopathy after PRP.