博利康尼超声电导透皮给药佐治儿童哮喘的临床观察

目的探讨博利康尼超声电导透皮给药佐治儿童哮喘的疗效。方法将120例哮喘发作期患儿随机分成三组，采用博利康尼不同剂型，分别以超声电导（Ⅰ组）、超声雾化（Ⅱ组）和口服（Ⅲ组）三种给药方式，对比观察疗效。结果Ⅰ组与Ⅱ组、Ⅰ组与Ⅲ组比较临床控制率及总有效率均有显著差异（P〈0．05）；Ⅱ组与Ⅲ组比较临床控制率及总有效率均无显著差异（P〉0．05）。结论博利康尼超声电导透皮给药为哮喘患儿发作期最佳辅助给药方式之一。     

沐舒坦经超声电导透皮给药治疗小儿支气管肺炎效果分析

目的：观察沐舒坦经超声电导透皮给药治疗小儿支气管肺炎的临床疗效。方法：选择我院自2013年1月～2013年12月收治的54例支气管肺炎患儿的临床资料,根据随机的原则,将患儿分为治疗组27例与对照组27例,全部患儿均给予常规治疗。治疗组患儿给予沐舒坦超声电导仪局部导入治疗,对照组患者同样的药液配给方式,给予雾化吸入给药。结果：2组患者临床有效率比较,结果具有显著性差异（P〈0.05）,2组患儿在不良反应发生方面对比,结果具有显著性差异（P〈0.05）。结论：采用沐舒坦经超声电导透皮给药可减少毒副作用,对患儿的要求低,可得到患儿的配合,尤其适合儿科临床应用。     

沐舒坦经超声电导透皮给药治疗小儿支气管肺炎的疗效分析

目的探讨沐舒坦经超声电导透皮给药对小儿支气管肺炎的治疗效果。方法选取小儿支气管肺炎患儿105例随机分为A、B、C三组,每组35例。A组患者沐舒坦注射液雾化吸入给药,B组患者超声电导透皮给药,C组患者静脉推注给药。比较三组的发热、咳嗽、喘憋、肺部哮鸣音消失时间、平均住院时间及治疗效果。结果B组的有效率明显高于A、C组,差异有统计学意义（P〈0．05）;三组的临床症状及平均住院时间比较,差异有统计学意义（P〈0．05）,其中B组发热、咳嗽、喘憋、肺部哮鸣音消失时间及平均住院时间明显短于A、C两组（19〈0．05）。结论沐舒坦采用超声电导透皮给药方式治疗小儿支气管肺炎能够明显缩短患儿的病程,且不良反应少,可以作为一种治疗新途径在临床推广应用。     

超声电导经皮靶向给药治疗慢性前列腺炎(Ⅲa型)

目的 比较超声电导经皮靶向给药和口服给药对慢性前列腺炎(Ⅲa型)的治疗效果.方法 40例慢性前列腺炎(Ⅲa型)患者随机分为2组:治疗组20例采用超声电导经皮靶向给药,对照组20例采用口服药物治疗.观察和评定治疗效果及副反应.结果 两组均取得一定疗效,治疗组有效率为85%,明显优于对照组的55%,两组比较差异有统计学意义(P<0.05),超声电导经皮靶向给药治疗基本无痛苦,疗程短,副反应少.结论 超声电导经皮靶向给药治疗慢性前列腺炎(Ⅲa型)有较好的疗效,优于口服给药方式.     

超声电导靶向经皮给药治疗Ⅲ型慢性前列腺炎疗效观察

目的 观察超声电导经皮给药治疗Ⅲ型慢性前列腺炎(CP/CPPS)的疗效.方法 CP/CPPS患者随机分为超声电导经皮给药组(观察组)和传统的口服用药治疗组(对照组),给予相同的抗生素、扩血管药物和解痉镇痛药物,观察治疗后不同时间的疗效.结果 对两组治疗效果进行分析,治疗2个疗程超声电导经皮给药和口服用药组的总有效率分别为88.9%和46.5%,NIH-CPSI分别下降了53.1%和33.1%,两组间疗效比较差异有统计学意义.结论 与传统口服给药相比,同类药物经超声电导经皮给药治疗CP/CPPS疗效更好,是一种安全、有效的治疗方法 .     

沐舒坦联合肝素雾化吸入治疗毛细支气管炎的疗效观察

目的观察沐舒坦联合肝素氧气驱动雾化吸入治疗毛细支气管炎的疗效。方法将符合诊断标准的毛细支气管炎的住院患儿49例随机分为治疗组(25例)与对照组(24例)。在综合治疗的基础上,治疗组给予沐舒坦联合肝素氧气驱动雾化吸入,对照组给予沐舒坦氧气驱动雾化吸入。结果治疗组显效13例(52.0%),有效9例(36.0%),无效3例(12.0%),总有效率88.0%;对照组显效7例(29.2%),有效8例(33.3%),无效9例(37.5%),总有效率62.5%。结论氧气驱动雾化吸入治疗毛细支气管炎,沐舒坦联合肝素雾化吸入疗效优于沐舒坦雾化。。     

沐舒坦不同给药途径佐治婴幼儿肺炎疗效观察

目的探讨沐舒坦雾化吸入佐治婴幼儿肺炎的临床疗效。方法90例随机分为3组(每组30例)。3组均按肺炎防治方案治疗,在此基础上:A组(雾化吸入组)用生理盐水2ml加沐舒坦7.5mg雾化吸入,2次/d。B组(静脉滴注组)静脉滴注沐舒坦:0~2岁7.5mg 2次/d;2~3岁7.5mg 3次/d;C组(口服沐舒坦组)口服沐舒坦糖浆:2~6个月1.5ml2次/d;6个月~2岁2.5ml 2次/d;2~3岁2.5ml 3次/d。疗程5d。结果A组显效25例(83.33%),有效5例(16.67%),无效0例(0),总有效率100%;B组显效18例(60.00%),有效12例(40.00%),无效(0),总有效率100%;C组显效16例(53.33%),有效13例(43.33%),无效1例(3.33%),总有效率96.7%。3组的总有效率无统计学意义(P>0.05),但显效率有统计学意义(P<0.05)。且咳嗽、气促、痰鸣音消失、湿音减少时间及平均住院天数雾化吸入组<静脉组<口服组,且雾化吸入组与静脉组、口服组比较有统计学意义(P<0.01)。结论沐舒坦通过压力雾化器形成的药物微粒,随患儿的吸气进入深部呼吸道,能更有效地在病灶局部起作用,操作简单、安全性强,而且无不良反应,因此是一种较佳的婴幼儿肺炎辅助治疗方法。     

沐舒坦治疗新生儿肺透明膜病30例

目的观察沐舒坦治疗新生儿肺透明膜病的疗效。方法静脉滴注沐舒坦,按30mg/(kg.d),分3~4次给药。症状好转后减量用至7d停用。结果显效20例、有效9例、无效1例,有效率96.7%。结论应用沐舒坦治疗新生儿肺透明膜病疗效显著,无严重并发症,明显提高了新生儿成活率,大大降低了新生儿死亡率及致残率,值得在基层推广。     

分析慢性支气管炎急性发作在氧驱动雾化吸入沐舒坦治疗下的疗效

目的分析慢性支气管炎急性发作在氧驱动雾化吸入沐舒坦治疗下的临床治疗效果。方法选取2012年10月-2014年10月在我院住院治疗的慢性支气管炎急性发作患者245例,根据沐舒坦不同的给药方式分成3组:甲组应用氧驱动雾化吸入(n=82),乙组应用空气压缩泵驱动雾化吸入(n=82),丙组应用超声雾化吸入(n=81)。连续治疗7 d后分析对比3组的治疗效果与不良反应。结果甲组患者的总有效率为93.90%,明显高于乙组(84.15%)和丙组(75.31%),差异有显著统计学意义(P0.01);甲组的不良反应发生率与乙、丙组对比差异有统计学意义(P0.05)。结论沐舒坦应用氧驱动雾化吸入治疗慢性支气管炎急性发作的疗效明显优于应用空气压缩泵驱动雾化吸入或超声雾化吸入,可快速有效缓解患者临床症状和体征,且不良反应少,安全性指数高,临床应用价值大,值得推广应用。     

沐舒坦超声雾化吸入治疗小儿肺炎疗效观察

目的:观察沐舒坦(Mucosolvan)超声雾化吸入治疗小儿肺炎的临床疗效。方法:在常规抗感染治疗的基础上,加用沐舒坦7.5mg加入20ml生理盐水超声雾化吸入,2次/d。结果:治疗组36例中显效25例,有效8例,无效3例,显效率69.4%;对照组32例,显效10例,有效16例,无效6例,显效率31.5%。两组相比P<0.01,差异有显著性。两组止咳天数,音吸收天数,住院天数比较,P<0.01,差异有显著性。结论:沐舒坦超声雾化吸入治疗小儿肺炎临床疗效好。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.