内镜下注射治疗消化性溃疡出血的临床研究

Objective To evaluate the effect of endoscopic sclerosing agent injection for treatment of Peptic Ulcer Bleeding. Methods From July 2009 to July 2010,120 patients with haematemesis and/or hematochezia diagnosed as peptic ulcer by immediate endoscopy were randomly divided into two groups:endoscopic treated by the same endoscopist. Results The rate of hemostasis in therapy group was 96. 67% (58/60) , that in control group was 92.99% (P ＞ 0.05). The re-bleeding rates of the earler 3 h in the therapy group and control group were 1.72% (1/58) and 3.77% (2/53) , respectively, there was not significant differencein (P ＞0.05). The re-bleeding rates between 3 h and 24 h in the therapy group and control group were 3.45 % (2/58)and 16. 98% (9/53) ,respectively ,there was significant difference(P＜ 0.05). 2 months of follow up was made for the two groups, re-bleeding rates in the therapy group and control group were 1.72% (1/58) and 1.89% (1/53) ,respectively ,there was not significant difference(P ＞ 0.05). After 6 months of the observed, no one was found rebleeding. No complications related with treatment occurred in the two groups of patients. No significant differences are observed between the 2 groups in hospital stay, surgery and mortality. Conclusion Endoscopic treating peptic ulcer bleeding, and the effect of aethoxysklerol is better than epinephrine, they deserved for further application.     

肠内营养对重型破伤风患者营养支持的探讨

Objective To study the effect of enteral nutrition on patients with severe tetanus. Methods The patients totaled 60 cases were divided into two groups with 30 cases in each. The patients in EN group were treated with enteral nutrition on basis of routine treatment, control group was treated with total parenteral nutrition (TPN). The indicators values of BMI, TSF, MAMC, TP, PAm, m, ALB and Hb were tested on the day before nutrition supports and after nutrition supports 10 days later in two groups. Adverse reaction and the treatment effect were observed simultaneously. Results With nutritional supports 10 days later, two groups had no obvious decline in BMI, TSF and MAMC. TP, PA, ALB and Hb of EN group were higher than those of control group (P＜0.05) . Complication rate of EN group was lower than that of control group, there was significant differences (P＜0.05) . Conclusions Early EN may improve protein metabo lism in patients with severe tetanus and nutritional status.     

肠内营养对重型破伤风患者营养支持的探讨

Objective To study the effect of enteral nutrition on patients with severe tetanus. Methods The patients totaled 60 cases were divided into two groups with 30 cases in each. The patients in EN group were treated with enteral nutrition on basis of routine treatment, control group was treated with total parenteral nutrition (TPN). The indicators values of BMI, TSF, MAMC, TP, PAm, m, ALB and Hb were tested on the day before nutrition supports and after nutrition supports 10 days later in two groups. Adverse reaction and the treatment effect were observed simultaneously. Results With nutritional supports 10 days later, two groups had no obvious decline in BMI, TSF and MAMC. TP, PA, ALB and Hb of EN group were higher than those of control group (P＜0.05) . Complication rate of EN group was lower than that of control group, there was significant differences (P＜0.05) . Conclusions Early EN may improve protein metabo lism in patients with severe tetanus and nutritional status.     

生脉注射液对血透相关性低血压患者的疗效观察

Objective To observe clinical effect of Shengmai injection on dialysis-related hypotension.Methods Seventy patients with dialysis-related hypotension were divided into two groups:experimental group (35 cases)and control group (35 cases). Patients in experimental group was treated with Shengmai injection,while patients in control group were given with conventional treatments. Effective rate and hemodynamics changes were measured in both groups. Results The effective rate in experimental group was significantly higher than control group (P＜ 0.05), while frequency of treatment was lower than control group (P＜ 0. 05). There were no significant difference between experimental group and control group in systolic pressure, diastolic pressure and heart rate (P ＞ 0.05). Conclusion Shengmai injection is effective and safe in dialysis-related hypotension.     

前列地尔注射液治疗椎动脉型颈椎病的短期疗效观察

Objective To study the short term effects of Alprostadil Injection on cervical spondylotic vertebral arteriopathy(CSA). Methods 52 cases of patients with CSA, average age of 47 years old, were ran-domly divided into treatment group (n=28 ) with Alprostadil Injection and control group (n=24). The control group were treated with cervical traction, physical therapy, functional exercise, and 20 ml Danshen solusion plus 500 ml Dextran 40 iv drop once a day for 10 days. The treatment group were treated with 20 μg Alprostadil In-jection plus 250 ml 5% glucose iv drop, besides control group treatments, once a day for 10 days. The curative effects of Alprostadil Injection were evaluated by CSA functional scale, compared before and after treatment in the same group and between two groups after treatment. Results The reshs display significant difference before and after treatment both in the treatment group and the control group(P<0.05) ;while the effects of the treat-ment group are better than the control group (P<0.05 ). Conclusion Alprostadil Injection shows significant short term effects on CSA.     

前列地尔注射液治疗椎动脉型颈椎病的短期疗效观察

Objective To study the short term effects of Alprostadil Injection on cervical spondylotic vertebral arteriopathy(CSA). Methods 52 cases of patients with CSA, average age of 47 years old, were ran-domly divided into treatment group (n=28 ) with Alprostadil Injection and control group (n=24). The control group were treated with cervical traction, physical therapy, functional exercise, and 20 ml Danshen solusion plus 500 ml Dextran 40 iv drop once a day for 10 days. The treatment group were treated with 20 μg Alprostadil In-jection plus 250 ml 5% glucose iv drop, besides control group treatments, once a day for 10 days. The curative effects of Alprostadil Injection were evaluated by CSA functional scale, compared before and after treatment in the same group and between two groups after treatment. Results The reshs display significant difference before and after treatment both in the treatment group and the control group(P<0.05) ;while the effects of the treat-ment group are better than the control group (P<0.05 ). Conclusion Alprostadil Injection shows significant short term effects on CSA.     

前列地尔注射液治疗椎动脉型颈椎病的短期疗效观察

Objective To study the short term effects of Alprostadil Injection on cervical spondylotic vertebral arteriopathy(CSA). Methods 52 cases of patients with CSA, average age of 47 years old, were ran-domly divided into treatment group (n=28 ) with Alprostadil Injection and control group (n=24). The control group were treated with cervical traction, physical therapy, functional exercise, and 20 ml Danshen solusion plus 500 ml Dextran 40 iv drop once a day for 10 days. The treatment group were treated with 20 μg Alprostadil In-jection plus 250 ml 5% glucose iv drop, besides control group treatments, once a day for 10 days. The curative effects of Alprostadil Injection were evaluated by CSA functional scale, compared before and after treatment in the same group and between two groups after treatment. Results The reshs display significant difference before and after treatment both in the treatment group and the control group(P<0.05) ;while the effects of the treat-ment group are better than the control group (P<0.05 ). Conclusion Alprostadil Injection shows significant short term effects on CSA.     

高压氧对脑梗死患者血浆SOD和CRP的影响及临床意义

Objective To study the effect of hyperbaric oxygenation(HBO) therapy on the activities of serum SOD and CRP of patients with cerebral infarction and its clinical significance. Methods 78 patients with cerebral infarction were randomly divided into hyperbaric oxygen group (HBO Group, 40 cases)and clinical group (38 cases). The clinical group was treated with clinical conventional treatment only. HBO group was treated with HBO combined with clinical conventional treatment. 21 healthy volunteers were assigned to control group. Before and after treatment, the activities of serum SOD and CRP level were measured, and the curative effect were evaluated. Results The pretreatment serum SOD and CRP of the HBO group and clinical group were significantly different from the control group (P＜ 0. 01). Compared with the pretreatment and posttreatment serum level of the HBO group, SOD raised, CRP lowered, the difference was significant(P＜ 0. 01).Compared with clinical group, SOD raised, CRP lowered and the total cure rate of the HBO group were more significant different(P ＜0.01). Conclusion HBO therapy raised the activities of SOD and lower the level of CRP in serum of the patients with cerebral infarction, and improved the free radicals scavenging ability in the body. Therefore, HBO therapy has a good effect for cerebral infarction. The experiment suggests that the activities of SOD and CRP level in serum can be used to judge the curative effect and prognosis of HBO therapy for cerebral infarction.     

心理干预联合高压氧治疗对脑卒中后抑郁患者生命质量的影响

Objective To investigate the effect of the psychological intervention combined with hyperbaric oxygen therapy on the mental status and the quality of life of patients with depression after cerebral stroke.Methods 45 patients with depression after cerebral stroke were randomly divided into the study group (n = 22)and the control group(n = 23). The two groups had the same clinical routine treatments including improving cerebral cirulation, reducing intracranial pressure, drugs to anti-infection, nervous nutrition and corresponding operation for 8 weeks as a course of treatment, and psychological behavior intervention combined with hyperbaric oxygen therapy was added to the study group. The scores of Hamilton depression rating scale (HAMD) on both groups were evaluated before and spitzer' s quality of life index(QL-INDEX) were used and investigated on two groups at the end of 8 weeks. Results There was no significant difference on the scores of HAMD between the two groups before therapy (P ＞ 0. 05). The scores on HAMD of the study group after the treatment notably dropped compared to the control group (P＜ 0. 01). The difference of the scores on group index of quality of life between the study group (8.57 ± 1.94) and the control group (7.30 ± 1.98) had statistical significance (P ＜0. 05). Conclusion Psychological intervention combined with hyperbaric oxygen therapy plays an important role in the treatment of patient with depression after cerebral stroke to improve their mental status, treatment effectiveness and quality of life.     

黄芪注射液对严重脓毒症患者的疗效观察

Objective To observe the effects of Radix Astragali injection on severe septic patients. Method This was a prospective study. Fifty severe septic patients admitted in ICU from 2006 to 2008 were col-lected, malignent disease like carcinoma, pregnant ones were excluded. They were randomly divided into two groups: Radix Astragali injection treatment group (n = 30) and control one (n = 20). The data of the two groups were comparable. With the same basic therapy, the experimental group treated with additional Radix Astragali in-jection. Then, APACHE Ⅱ scores were calculated on day 0(before therapy), day 7 and day 14 after treatment with Radix Astragali injection, and the 28th day mortality was also calculated for both groups. Blood CD4, CD8, CD4/CD8, NK-cell expression level was measured by direct immunofluorescence, IL-1β, IL-6, TNF-α level was tested by ELASA. SPSS 11.5 software, was used for statistic. Results The APACHE Ⅱ scores in Radix Astragali treatment group were 20.73±5.06, while in control groups were 35.00±3.70 after treatment for 14 days, and mortality in the 28th day was 25.3% and 41.6% respectively, there were significant deferences between the two groups (P < 0.05). At 14 days after treatment, the level of CD4, CD4/CD8 and NK-cell in the Radix Astragali treatment group was significantly increased, with (34.11±14.09) %, (2.05±0.98) %, (28.83±8.08) %, re-spectively, and compared with control group, there were significant differences (P < 0.01). Though, the level of CD8, IL-6 and TNF-α was showed (20.84±9.84) %,(710.87±313.52) pg/mL,(14.63±30.38) pg/mL respectively, significantly decreased after treatment with Radix Astragali injection, there were also significant dif-ferences between the two groups (P < 0.01). Conclusions Radix Astragali injection can improve the immunity disorder of severe septic patients, it will be a hopeful therapy for severe sepsis.