维拉帕米二甲双胍联合用药对高血压合并Ⅱ型糖尿病患者降压及降糖作用临床观察

Objective To observe blood pressure lowering effect and the blood glucose lowering effect on the combination of Verapamil and Metformin therapy for hypertensive patients with type 2 diabetes mellitus (diabetes mellitus, DM). Methods 129 cases of hypertension in patients with type 2 DM were divided into two groups, Verapamil treatment group, 98 cases in the control group 31 cases. (1) Verapamil treatment groups: Verapamil hydrochloride sustained-release capsules 180 mg/d, Metformin 750 ～ 1500 mg/d,Valsartan 80 ～ 160 mg/d, A Division horses Lin 100 mg/d, (2) control group, Valsartan 80 ～ 160 mg/d, Verapamil hydrochloride sustained-release capsules 180 mg/d, Aspirin 100 mg/d. (3) Blood pressure observation: Subjects in patients as early as 7: 00 and 22: 00 evening, measured two times a day and record systolic blood pressure blood pressure decreased significantly compared with those before treatment,4,6 weeks after the blood pressure weeks treatment their difference was significant (P<0.01), but the blood pressure has not dropped to normal ment review TC, TG, LDL decreased significantly after treatment, the difference was significant (P<0.05),HDL increased after treatment of (2.73±0.17), after treatment there was significant difference between improved (P<0.05), Verapamil treatment group was significantly better than the control group. Conclusion The combination of Verapamil and Metformin therapy for hypertensive patients with type 2 diabetes mellitus (DM) patients has good blood pressure lowering effect and blood glucose lowering effect.     

心脑血管疾病患者血清同型半胱氨酸检查与血脂检查分析

Objective To investigate the cardiovascular and cerebrovascular diseases, check serum homocysteine compared with the lipids examined. Methods with the hospital over the same period 200 cases of healthy persons(control group)to observe the control group and study group before treatment and after 15 of serum homocysteine and serum lipids were compared. Results In control group and study group before treatment Hcy comparison(P ＜0. 01)significant difference. Control group and study group after treatment compared Hcy (P ＞ 0.05) no significant difference. Blood lipid control group and study group were compared (P ＞ 0.05) no significant difference. Conclusion In this group of patients with cardiovascular disease examination and serum homocysteine blood examination, observation early in the disease was significantly higher Hcy, Hcy after treatment basically reduced to normal levels, while the study group and control group blood lipid no significant difference, compared to no significant difference. Fully illustrated examination of serum homocysteine in patients with cardiovascular and cerebrovascular diseases are the extent of disease and healing guidance, Hcy higher the more severe the illness, a higher probability of complications, in short, check the heart of serum homocysteine and cerebrovascular detected in patients has important significance, is worthy of extensive development and application.     

Pilon骨折的治疗与临床康复

AIM: To analyze the effect of three kinds of method on different types of Pilon fracture and advance the best treatment plan. METHODS: From March 1989 to August 2000,107 patients were regarded as having Pilon fracture by two hospitals, among which 76 cases were followed up. They were divided into three groups according to treatment method. A group included 24 cases with the treatment of manual reduction, traction of calcaneus and plaster ex-opexy. B group included 30 cases with the treatment of AO key-shaped anatomical steal plate. C group included 22 cases with the treatment of limited internal fixation combined with exopexy stand. RESULTS: After 6 months to 8 years follow-up, it was found that three kinds of treatment methods had obvious differences on the complications and effects of different types of fracture. In A group, the excellent and good rate of treatment on I type fracture was 70%, II type was 25%, Ⅲ type was 0%. In B group, the excellent and good rate of treatment on I type fracture was 7     

2型糖尿病合并高血压患者胰岛素低抗

The fasting glucose(FBG),TG,CHO,HDL,LDL,ApoA1,ApoB,FIn and insulin sensitiviry index in patients with with type II diabetes mellitus complicated with hypertension were evaluated in the current study.The relationship between hypertension and abnomal level of blood lipid and insulin resistance. 1 Subjects and methods 1.1 Subjects 114 patients with type II diabetes mellitus were selected according to the WHO standards.All the patients were divided into 2 groups,normal blood pressure gr…     

快速型心房颤动患者静脉应用地尔硫卓和美托洛尔的疗效观察

Objective To compare the effectiveness between dilfiazem and metoprolol administered intra-venously on controlling the ventricular tachy-cardia in patients with atrial fibrillation (AF). Method From Jan-uaxy 2003 to July 2006, 48 AF patients in the Second Hospital, Jilin University, with a ventricular rate > 120 beats per minute and systolic blood pressure > 100 mmHg were enrolled and divided into dihiazem group (10 mg, Ⅳ, n = 24) or metoprolol group (5 mg, Ⅳ, n = 24). Blood pressure and heart rote were re-checked at different inter-vals of 5, 10, 15 and 30 minutes,respectively. Successful treatment was defined as ventricular rate < 100 beat/ min or decrease > 20% of the pre-treatment level, or restoumtion of sinus rhythm. Results Compared with pre-treatment value, a significant deceleration in ventricular response to AF was observed after treatment in both groups at each interval (P < 0.01). However, the ventricular rate in the diltiazem group was significantly lower than that in the metoprolol group (P <0.05) at all intervals but 30 minutes. A slight decrease in blood pressure was ob-served in both groups. The drop of blood pressure between two groups was comparable. The successful treatment at the interval of 30 minutes was achieved in 91.7% of patients in dihiazem group and 83.3% of patients in metopro-lol group (P < 0.05). Conclusions Both diltiazem (10 mg, Ⅳ) and metoproiol (5 mg, Ⅳ) are effective on con-trolling the accelerated ventricular response to AF, in particular, the effect of diltiazem seems much superior to ahat of metoprolol.     

降糖药物对新发2型糖尿病患者胫前动脉弹性影响的初步探讨

目的 探讨降糖药物对新发2型糖尿病患者胫前动脉弹性的影响.方法 随机选取新发2型糖尿病患者100例,分为对照组50例和病例组50例.计算胫前动脉的应变-血压指数(SBPI),所有患者服用降糖药物6个月后再次计算胫前动脉的SBPI,并进行组间和组内对比分析.结果 对照组胫前动脉SBPI治疗后高于治疗前(P<0.05).病例组胫前动脉SBPI治疗前后比较差异无统计学意义(P>0.05).病例组胫前动脉SBPI在治疗前和治疗后均低于对照组(P<0.05).结论 降糖药物对不合并血管并发症的新发2型糖尿病患者胫前动脉弹性有较好的保护作用.

Abstract：

Objective To investigate the effects in elasticity of anterior tibial artery in new patients with type 2 diabetes caused by medicines of reducing blood sugar. Methods One hundred patients with type 2 diabetes were involved. The patients were divided into control group(50 cases) and case group(50 cases) according the vascular complications (including macroangiopathy and microangiopathy). Maxmum of circumferential strain(CSmax) of anterior tibial artery was acquired through strain and strain rate imaging. Local blood pressure which included local systolic blood pressure(LSBP) and local diastolic blood pressure (LDBP) of anterior tibial artery was measured at the same time. Strain-blood pressure index(SBPI) of anterior tibial artery was calculated, SBPI = CSmax/[(LSBP - LDBP)/LDBP] × 100%. It took six months for each patient to take medicines of reducing blood sugar. Then SBPI of anterior tibial artery was calculated again. Parameters were compared inter- and intra-groups. Results SBPI of anterior tibial artery after therapy was higher than that before therapy in control group( P<0. 05). There was no significant difference between SBPI of anterior tibial artery before therapy and that after therapy in case group( P >0. 05). SBPI of anterior tibial artery in case group was lower than that in control whatever before and after therapy( P < 0. 05). Conclusions The protection of medicines of reducing blood sugar on elasticity of anterior tibial artery in new diabetic patients without vascular complications was better.     

高压氧对脑梗死患者血浆SOD和CRP的影响及临床意义

Objective To study the effect of hyperbaric oxygenation(HBO) therapy on the activities of serum SOD and CRP of patients with cerebral infarction and its clinical significance. Methods 78 patients with cerebral infarction were randomly divided into hyperbaric oxygen group (HBO Group, 40 cases)and clinical group (38 cases). The clinical group was treated with clinical conventional treatment only. HBO group was treated with HBO combined with clinical conventional treatment. 21 healthy volunteers were assigned to control group. Before and after treatment, the activities of serum SOD and CRP level were measured, and the curative effect were evaluated. Results The pretreatment serum SOD and CRP of the HBO group and clinical group were significantly different from the control group (P＜ 0. 01). Compared with the pretreatment and posttreatment serum level of the HBO group, SOD raised, CRP lowered, the difference was significant(P＜ 0. 01).Compared with clinical group, SOD raised, CRP lowered and the total cure rate of the HBO group were more significant different(P ＜0.01). Conclusion HBO therapy raised the activities of SOD and lower the level of CRP in serum of the patients with cerebral infarction, and improved the free radicals scavenging ability in the body. Therefore, HBO therapy has a good effect for cerebral infarction. The experiment suggests that the activities of SOD and CRP level in serum can be used to judge the curative effect and prognosis of HBO therapy for cerebral infarction.     

依达拉奉对急性大面积脑梗死患者高敏C反应蛋白影响的临床研究

Objective To explore the effects of edaravone on high sensitivity C-reaction protein (hsCRP) in patients with acute massive cerebral infarction. Methods 86 cases with acute massive cerebral infarction were selected from December 2006 to December 2008. all the cases were divided into two groups, control group and cure group. routine treatment was used to the control group, on the basis of control group'therapy,edaravone was given to cure group. the level of hsCRP was detected before and after treatment, and the results of cure was compared. Results ①the total effective rate in two groups existed statistical difference (P<0.05);② the level of hsCRP in two groups before treatment and in the 7th and the 14th of treatment existed statistical difference(P<0.01), the level of hsCRP in the 7th and the 14th of treatment in cure group existed statistical difference(P<0.05). Conclusion Edaravone can decrease the level of hsCRP in patients with massive cerebral infarction, and has significant clinical efficacy,which should be the reference for the doctors.     

Effect of Durogesic in the treatment of cancer pain

Objective To evaluate the effectiveness of transdermal fentanyl (Durogesic)in the treatment of cancer pain.Methods 30 cases of patients with moderate to servere cancer pain were treated using Durogesic,and 30 patients were treated using sustained-release hydrochloride morphine tablets as control group.Durogesic began from the dosage of 25μg/h to individual doses,and hydrochloride morphine began from 30 mg to individual doses.The duration of treating time was 3 weeks,Results The response rate of pain relief was 80.0% in Durogesic group and 83.3% in hydrochloride morphine group,respectively;Quality of life scores were(27.27&#177;3.53)before treatment and (32.67&#177;2.88)after treatment(P&lt;0.05)in Durogesic group;The main side effect were dizziness,nausea and somnolence.Conclusion Durogesic is effective in the treatment of cancer pain,it can improve the quality of life scores and the side effect is mild to tolerate.     

Clincal research of HA program combimed co-α-2b interferon on treatment of chronic myeloid leukemia

Objective To observe the HA program (3 harringtonine and Ara-C) co-α-2b interferon treatment of chronic myeloid leukemia in the feasibility and safety. Methods In our hospital from December 2005 to January 2009 out-patient and hospitalization in patients with CML were randomly assigned according to the principle of 51 cases were divided into 26 cases of the observation group and control group 25 cases. The control group were treated with α-2b interferon 3 × 106U subcutaneously or intramuscularly 3 times per week,intramuscularly 1 to 12 months to ease later changed to 2 times per week to maintain; treatment group therapy in the control group based on the GC small dose of HA programs: subcutaneous injection of Ara-C 20 mg,every 12 h one time; homoharringtonine alkaline 2 mg/d plus 5 % glucose solution 500 mL, by intravenous infusion over 4 h,in conjunction with the 7 ～ 14 d for a course of treatment monthly repeated a times, after 12 months depending on the circumstances every 2 to 3 months a time. Results The observation group and the control group,hematological remission total effective rates were 96.15% (25/26) and 72.0% (18/25),the observation group than the control group,2 group, the difference was significant (P<0.05); the observation group cytogenetic response overall response rates were 76.92% (20/26) and 20.0% (5 / 25), the observation group cytogenetic response overall response rate than the control group, 2 group, the difference was significant sex (P<0.05);two groups of patients with adverse reactions can be tolerated, does not affect the treatment. Conclusion Small dose of HA regimen combined with recombinant in terferon α-2b treatment of CML than single recombinant interferon α-2b high efficacy, with lower white blood cell effects of apparent high rate of hematologic response, no increase in adverse reactions and survival prolonged and so on.