子宫内膜异位症术后辅助药物治疗的临床研究

Objective To study the clinical effects and safety of mifepristone and gestrinone as postoperative auxiliary medicine to patients with endometriosis.Methods 120 patients were randomly divided into postoperation with mife~stone group,postoperation with gestrinone group and non-postoperation medicine group,40 cages for each group.A retrospective analysis was carried out to compare the clinical effects,adverse drug reaction and relapse conditions:Results The symptom of patients in all groups was impmved with remission in various degree.The adverse reaction of mifcpristone group was less than that of gestrinone group.And there was no significant difference in curative effects in these two groups(P＞0.05).But the curative effects of mffepristone and gestrinone groups were significantly better than that of nonpostoperation medicine group(P＞0.05).The recurrence rates of mifepristone,gestrinorle and nonpostoperatlon medicine groups were 15%.12.5%and 30%respectively.Conclusion It showed that the mlfepristone and gestdnone used as postoperative auxiliary medicine to patients with endometrinsis have the advantages of economic and practical,safe.effective,less adverse reaction,and can obviously reduce the recurrence rate,which is a effective method,     

子宫内膜异位症术后辅助药物治疗的临床研究

Objective To study the clinical effects and safety of mifepristone and gestrinone as postoperative auxiliary medicine to patients with endometriosis.Methods 120 patients were randomly divided into postoperation with mife~stone group,postoperation with gestrinone group and non-postoperation medicine group,40 cages for each group.A retrospective analysis was carried out to compare the clinical effects,adverse drug reaction and relapse conditions:Results The symptom of patients in all groups was impmved with remission in various degree.The adverse reaction of mifcpristone group was less than that of gestrinone group.And there was no significant difference in curative effects in these two groups(P＞0.05).But the curative effects of mffepristone and gestrinone groups were significantly better than that of nonpostoperation medicine group(P＞0.05).The recurrence rates of mifepristone,gestrinorle and nonpostoperatlon medicine groups were 15%.12.5%and 30%respectively.Conclusion It showed that the mlfepristone and gestdnone used as postoperative auxiliary medicine to patients with endometrinsis have the advantages of economic and practical,safe.effective,less adverse reaction,and can obviously reduce the recurrence rate,which is a effective method,     

子宫内膜异位症术后辅助药物治疗的临床研究

Objective To study the clinical effects and safety of mifepristone and gestrinone as postoperative auxiliary medicine to patients with endometriosis.Methods 120 patients were randomly divided into postoperation with mife~stone group,postoperation with gestrinone group and non-postoperation medicine group,40 cages for each group.A retrospective analysis was carried out to compare the clinical effects,adverse drug reaction and relapse conditions:Results The symptom of patients in all groups was impmved with remission in various degree.The adverse reaction of mifcpristone group was less than that of gestrinone group.And there was no significant difference in curative effects in these two groups(P＞0.05).But the curative effects of mffepristone and gestrinone groups were significantly better than that of nonpostoperation medicine group(P＞0.05).The recurrence rates of mifepristone,gestrinorle and nonpostoperatlon medicine groups were 15%.12.5%and 30%respectively.Conclusion It showed that the mlfepristone and gestdnone used as postoperative auxiliary medicine to patients with endometrinsis have the advantages of economic and practical,safe.effective,less adverse reaction,and can obviously reduce the recurrence rate,which is a effective method,     

中青年男性冠心病患者PCI前后性生活质量的变化

Objective To investigate the effect of percutaneous coronary intervention (PCI) on the sexual quality of life among young and middle-aged male patients with coronary heart disease (CHD) by using Sexual Life Quality Questionnaire(SLQQ).Mothods 78 patients cured by PCI were kept in operation group and the drug therapy group contained 80 patients.The sexual quality of life one day before hospitalization and six months after discharge was surveyed with a retrospective questionnaire in both two groups.Results The sexual quality of life in 6 months after discharge in both groups was better than before hospitalization (P＜0.01);the operation group improved more obviously compared to the drug group (P＜0.01).Conclusions PCI can significantly improve the sexual quality of life among young and middle-aged male patients with CHD.     

临床护理路径模式对重症病毒性脑炎患儿康复的效果评估

Objective To study the effectiveness of clinical nursing pathway using methodsand overall intervention to rehabilitation of the children with severe viral encephalitis.Methods With parental consent,80 children patients admitted with severe encephalitis from June 2008 to Julv 2010 were randomly divided into two groups,one control group using conventional methods of care;another experimental group using holistic nursing intervention based on the usual care.30 d after the nursing care the rehabilitation conditions of children patients were assessed by Fugl-Meyer score(including the sensory tunction,range of motion and pain function,motor function)and the incidence of children with disabilities Was also compared between these two groups one year after recovery.Rtaults The Fugl-Meyer score before nursing care was 65 points without significant difference between two groups(P＞0.05);after care the experimental group Was 145 points,while the control group 90 points,with statistically significant difference compared with each other(P＜0.05).The incidence of children with disability one year later was signifieantlylower than the that of control group(P＜0.05).conclusion The clinical nursing care path mode can efiectively restore the corresponding function of children with severe encephalitis,reduce their disabilitv rates,and improve their quality of life.     

临床护理路径模式对重症病毒性脑炎患儿康复的效果评估

Objective To study the effectiveness of clinical nursing pathway using methodsand overall intervention to rehabilitation of the children with severe viral encephalitis.Methods With parental consent,80 children patients admitted with severe encephalitis from June 2008 to Julv 2010 were randomly divided into two groups,one control group using conventional methods of care;another experimental group using holistic nursing intervention based on the usual care.30 d after the nursing care the rehabilitation conditions of children patients were assessed by Fugl-Meyer score(including the sensory tunction,range of motion and pain function,motor function)and the incidence of children with disabilities Was also compared between these two groups one year after recovery.Rtaults The Fugl-Meyer score before nursing care was 65 points without significant difference between two groups(P＞0.05);after care the experimental group Was 145 points,while the control group 90 points,with statistically significant difference compared with each other(P＜0.05).The incidence of children with disability one year later was signifieantlylower than the that of control group(P＜0.05).conclusion The clinical nursing care path mode can efiectively restore the corresponding function of children with severe encephalitis,reduce their disabilitv rates,and improve their quality of life.     

七氟醚复合丙泊酚在小儿气道异物取出术中的麻醉效果

Objective To observe the anesthetic effect of sevoflurane combined with propofol total general anaesthesia in children undergoing tracheal foreign body removal. Methods Sixty patients aged from 1 to 4 years admitted for tracheal foreign body removal were randomly divided into two groups : sevoflurane group (n = 30) and ketamine group (n = 30). In the sevoflurane group, anaesthesia was induced and maintained with inhalation of sevoflurane and propofol [1.5 mg/(kg · h)] was administered continuously for anesthesia maintenance by micro-pump during operation. The ketamine group were pre-medicated with ketamine 6 mg/kg i. m for sedation, then an-aesthesia was induced with midazolam 0.1 mg/kg and ketamine 1.5 mg/kg i. v and was maintained with intravenous bolus of ketamine. Systolic blood pressure(SBP), Diastolic blood pressure(DBP) ,heart rate(HR) and saturation of percutaneous oxygen(SPO2) were monitored in both groups before anaesthesia inducation (T0) , after anaesthesia inducation and before operation (T1), at the time point of bronchial endoscopy(T2) ,endoscope remoral (T3) ,con-sciousness recovery(T4). The operation condition was evaluated by surgeons, and the incidence of bronchial spasm, glossal drop, nausea and vomiting were recorded both during operation and after operation. Results The SBP and HR increased at the time point of bronchial endoscopy in two groups and decreased after anaesthesia inducation in aevoflurane group. The SPO2 increased in two group after anaesthesia inducation. Compared with ketamine group, the time of consciousness recovery was shorter markedly in sevoflurane group. The occurrence of postoperative glossal drop was higher in ketamine group. Conclusion Sevoflurane combined with propofol is safe and effective during general anaesthesia of children undergoing tracheal foreign body removal.     

冠心病患者介入治疗前后焦虑抑郁障碍的心理干预与评价

Objective To discuss the effect of psychological intervention of depression in coronary heart disease after percutaneous coronary intervention (PCI). Methods The depression of 105 cases of coronary heart disease after PCI treatment was investigated. One hundred and five patients were randomly divided into intervention group and control group. The patientsin intervention group were treated with psychological intervention before and after PCI. The patients in control group were treated with normal treatment. Results There was not significant difference of incidence of depression an self-rating depression scale score between two groups. The depression in intervention group was less severe than that in control group ( P ＜ 0.01 ). Multivariate analysis showed: education level, the recent negative life events, household income, length of stay and sequelae of catheter intervention had significantly correlated with depression in coronary heart disease. Conclusion Psychological intervention can reduce the ratio of depression in coronary heart disease after PCI.     

临床护理路径模式对重症病毒性脑炎患儿康复的效果评估

Objective To study the effectiveness of clinical nursing pathway using methodsand overall intervention to rehabilitation of the children with severe viral encephalitis.Methods With parental consent,80 children patients admitted with severe encephalitis from June 2008 to Julv 2010 were randomly divided into two groups,one control group using conventional methods of care;another experimental group using holistic nursing intervention based on the usual care.30 d after the nursing care the rehabilitation conditions of children patients were assessed by Fugl-Meyer score(including the sensory tunction,range of motion and pain function,motor function)and the incidence of children with disabilities Was also compared between these two groups one year after recovery.Rtaults The Fugl-Meyer score before nursing care was 65 points without significant difference between two groups(P＞0.05);after care the experimental group Was 145 points,while the control group 90 points,with statistically significant difference compared with each other(P＜0.05).The incidence of children with disability one year later was signifieantlylower than the that of control group(P＜0.05).conclusion The clinical nursing care path mode can efiectively restore the corresponding function of children with severe encephalitis,reduce their disabilitv rates,and improve their quality of life.     

七氟醚复合丙泊酚在小儿气道异物取出术中的麻醉效果

Objective To observe the anesthetic effect of sevoflurane combined with propofol total general anaesthesia in children undergoing tracheal foreign body removal. Methods Sixty patients aged from 1 to 4 years admitted for tracheal foreign body removal were randomly divided into two groups : sevoflurane group (n = 30) and ketamine group (n = 30). In the sevoflurane group, anaesthesia was induced and maintained with inhalation of sevoflurane and propofol [1.5 mg/(kg · h)] was administered continuously for anesthesia maintenance by micro-pump during operation. The ketamine group were pre-medicated with ketamine 6 mg/kg i. m for sedation, then an-aesthesia was induced with midazolam 0.1 mg/kg and ketamine 1.5 mg/kg i. v and was maintained with intravenous bolus of ketamine. Systolic blood pressure(SBP), Diastolic blood pressure(DBP) ,heart rate(HR) and saturation of percutaneous oxygen(SPO2) were monitored in both groups before anaesthesia inducation (T0) , after anaesthesia inducation and before operation (T1), at the time point of bronchial endoscopy(T2) ,endoscope remoral (T3) ,con-sciousness recovery(T4). The operation condition was evaluated by surgeons, and the incidence of bronchial spasm, glossal drop, nausea and vomiting were recorded both during operation and after operation. Results The SBP and HR increased at the time point of bronchial endoscopy in two groups and decreased after anaesthesia inducation in aevoflurane group. The SPO2 increased in two group after anaesthesia inducation. Compared with ketamine group, the time of consciousness recovery was shorter markedly in sevoflurane group. The occurrence of postoperative glossal drop was higher in ketamine group. Conclusion Sevoflurane combined with propofol is safe and effective during general anaesthesia of children undergoing tracheal foreign body removal.     

杯状子宫操作器辅助腹腔镜在全子宫切除术中的应用

目的 探讨杯状子宫操作器辅助腹腔镜在全子宫切除术中的优越性及安全性.方法 将全子宫切除术患者180例随机分为杯状子宫操作器辅助腹腔镜组（治疗组）和传统进腹组（对照组）,观察两组患者术中出血量、术后并发症和患者恢复等情况.结果 与对照组相比,治疗组明显改善患者生活质量,在肛门排气时间、平均住院日、术后恢复日常生活时间等方面有统计学意义（均P＜0.05）,两组均无严重并发症.结论 杯状子宫操作器辅助腹腔镜下全子宫切除术是一种安全可行的术式,有利于减轻患者损伤,改善患者生活质量.     

子宫动脉栓塞术治疗子宫肌瘤的临床应用

目的探讨子宫动脉栓塞术治疗子宫肌瘤的疗效。方法对70例子宫肌瘤患者进行选择性子宫动脉栓塞治疗。结果术后随访12个月，月经量减少至术前的（48．2±15．4）％（P〈0．01）。伴有贫血者血红蛋白含量术后3个月恢复至（115．1±8．6）g／L（P〈0．01）（未使用补血药）。子宫肌瘤体积术后1年缩小至（35．6±10．2）cm^3（P〈0．01）。所有病例无严重并发症。结论子宫动脉栓塞治疗子宫肌瘤具有创伤小、愈合快：可保留子宫、显著缓解症状等特点。     

医源性子宫损伤26例临床分析

目的从26例医源性子宫损伤的病例分析中吸取教训,以减少其发生率。方法回顾性的分析26例医源性子宫损伤(4例合并多处肠管损伤)的原因、诊断、治疗,提出预防和减少医源性子宫损伤的措施。结果25例治愈,死亡1例。结论医源性子宫损伤发病急,若处理不及时往往危及生命;提高业务水平,操作及处理的规范化,树立良好的职业道德,加强卫生执法管理是其预防的关键。     

浅谈头位难产剖宫产的时机选择

目的总结头位难产剖宫产的最佳时机。方法对2003年1月～2005年12月产妇480例,随机分成剖宫产组和阴道分娩组各240例,对剖宫产的时机进行回顾性分析。结果剖宫产组和阴道分娩组在新生儿出生体重有显著性差异(P<0.05);两组胎位异常发生率有显著性差异(P<0.05)。结论新生儿出生体重偏大和胎位异常是头位难产的主要因素,准确地掌握剖宫产的时机是治疗的关键。     

宫腔镜下行子宫纵隔切除手术与妊娠结局分析

目的分析宫腔镜下行子宫纵隔切除手术的效果与术后妊娠结局。方法选取2000年1月～2010年1月收治的60例子宫纵隔患者,分为A组与B组,分别采用宫腔镜下及传统开腹行子宫纵隔切除手术治疗;对两组手术情况及术后妊娠结局进行对比分析。结果 A组患者术中出血量少于B组,且手术时间与住院时间均短于B组;A组患者未见明显并发症,B组并发症发生率为6.7%;A组患者术后妊娠率为80.0%,其中妊娠后流产率为4.2%,顺利分娩率为95.8%;B组患者术后妊娠率为70.0%,其中妊娠后流产率为14.3%,顺利分娩率为85.7%;两组间比较,差异有统计学意义（P〈0.05）。结论宫腔镜下行子宫纵隔切除手术临床效果更为明显,术后对患者的妊娠结局改善更明显,值得推广应用。     

非脱垂子宫经阴道切除术的临床分析

目的探讨非脱垂子宫经阴道切除的临床价值。方法回顾性分析98例非脱垂子宫切除术，其中28例经阴道子宫切除、33例经腹腔镜子宫切除、37例经腹子宫切除，比较术前术后情况，包括年龄、产次、盆腔手术史、子宫大小以及术后子宫重量、术中出血量、手术时间、输血情况、住院时间、住院总费用等。结果28例经阴道子宫切除无1例中转开腹，无术中并发症发生。3组比较，切除的子宫重量无统计学意义；经阴道子宫切除组在手术时间、排气时间、住院总费用方面优于其他两组；住院时间经阴道组与经腹腔镜组相近，均优于开腹组。结论非脱垂子宫经阴道切除术可行、创伤小、费用低，值得临床推广。     

The managed immune system: protecting the womb to delay the tomb

The developing immune system serves as a novel target for disruption by environmental chemicals and drugs, and one that can significantly influence later-life health risks. Specific immune maturational events occur during critical windows of pre- and early postnatal development that are not effectively modeled using adult exposure-assessment or general developmental toxicity screens. The range of postnatal health risks linked to developmental immunotoxicity (DIT) is influenced, in part, by the natural progression of prenatal-neonatal development. In this progression, the pregnancy itself imposes a Th2-bias in utero, and this produces a delay in the acquisition of Th1 functional capacity in the newborn. The status of Th1 regulatory and Th17 populations may also be important in immune function/dysfunction considerations. The necessary shift from a Th2 preferred capacity in late gestation to a more balance functional capacity in the neonate can be disrupted by xenobiotics leaving the child with increased vulnerability to a range of potential diseases. Knowledge of environmental factors that facilitate effective immune functional maturation as well as those xenobiotics capable of disrupting the process is important in strategies to reduce the incidence of diseases such as childhood asthma. Because hormesis has been shown to be an important factor in modulation of the adult immune system, it becomes even more important to understand potentially opposing dose-response effects for the immune system of the fetus, neonate, and juvenile. The direct linkage between immune dysfunction and chronic disease has become abundantly apparent in recent years. Therefore, a more comprehensive and effective approach for the protection of the developing immune system can help to reduce the incidence of later-life chronic diseases.     

腹式横切口改良筋膜内子宫切除术80例临床分析

目的 探讨子宫良性病变实施腹式横切口改良筋膜内子宫切除术的可行性和安全性。方法 将该院2002年10月至2004年10月收治的子宫良性病变患者、随机选择腹式横切口改良筋膜内子宫切除术80例为研究组，选择传统纵切口子宫切除术90例为对照组．两组患者年龄、病种、子宫大小及盆腔粘连等差异无统计学意义，分析手术时间、术中出血量、切口疼痛情况、术后排气时间、术后病率、术后住院时间及术后性生活情况等。结果研究组的术中出血量、切口疼痛、术后排气时间、术后病率均明显低于对照组（P〈0．05），且术后未发现阴道残端异常、阴道壁松弛或脱垂，性生活满意度明显优于对照组（P〈0．05）。结论 对子宫良性病变实施腹式横切口改良筋膜内子宫切除术是安全、可行的。     

葛石胶囊对去卵巢大鼠子宫和阴道的影响

目的 明确葛石胶囊对主要分布雌激素α受体的子宫和阴道的影响.方法采用模拟人类妇女绝经期的雌性切除双侧卵巢大鼠模型,随机分成正常组、假手术组、模型组、雌激素组及葛石胶囊大、中、小剂量组.手术后第2周开始给药,持续6周.结果模型组子宫和阴道的湿重及指数明显减少;雌激素可使其增加至正常范围,葛石胶囊各组也可使其有不同程度增加...